메뉴 건너뛰기




Volumn 132, Issue 4, 2011, Pages 187-194

Impaired in vivo CD4+ T cell expansion and differentiation in aged mice is not solely due to T cell defects: Decreased stimulation by aged dendritic cells

Author keywords

Aging; Antigen presentation; Dendritic cells; Immunosenescence; T cells

Indexed keywords

CD40 ANTIGEN; CD86 ANTIGEN; GAMMA INTERFERON; HERMES ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN;

EID: 79955758952     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2011.03.005     Document Type: Article
Times cited : (56)

References (54)
  • 3
    • 0028152942 scopus 로고
    • B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells
    • Caux C., Vanbervliet B., Massacrier C., Azuma M., Okumura K., Lanier L.L., Banchereau J. B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells. J. Exp. Med. 1994, 1805:1841-1847.
    • (1994) J. Exp. Med. , vol.1805 , pp. 1841-1847
    • Caux, C.1    Vanbervliet, B.2    Massacrier, C.3    Azuma, M.4    Okumura, K.5    Lanier, L.L.6    Banchereau, J.7
  • 4
    • 33846046984 scopus 로고    scopus 로고
    • Peripheral blood dendritic cells and monocytes are differently regulated in the elderly
    • Della Bella S., Bierti L., et al. Peripheral blood dendritic cells and monocytes are differently regulated in the elderly. Clin. Immunol. 2007, 1222:220-228.
    • (2007) Clin. Immunol. , vol.1222 , pp. 220-228
    • Della Bella, S.1    Bierti, L.2
  • 5
    • 11844275234 scopus 로고    scopus 로고
    • Age-related defects in CD4 T cell cognate helper function lead to reductions in humoral responses
    • 20012
    • Eaton S.M., Burns E.M., Kusser K., Randall T.D., Haynes L. Age-related defects in CD4 T cell cognate helper function lead to reductions in humoral responses. J. Exp. Med. 2004, 20012:1613-1622.
    • (2004) J. Exp. Med. , pp. 1613-1622
    • Eaton, S.M.1    Burns, E.M.2    Kusser, K.3    Randall, T.D.4    Haynes, L.5
  • 6
    • 0027493906 scopus 로고
    • In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39
    • Foy T.M., Shepherd D.M., Durie F.H., Aruffo A., Ledbetter J.A., Noelle R.J. In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39. J. Exp. Med. 1993, 1785:1567-1575.
    • (1993) J. Exp. Med. , vol.1785 , pp. 1567-1575
    • Foy, T.M.1    Shepherd, D.M.2    Durie, F.H.3    Aruffo, A.4    Ledbetter, J.A.5    Noelle, R.J.6
  • 7
    • 33645986483 scopus 로고    scopus 로고
    • Mycobacteria induce IFN-gamma production in human dendritic cells via triggering of TLR2
    • Fricke I., Mitchell D., et al. Mycobacteria induce IFN-gamma production in human dendritic cells via triggering of TLR2. J. Immunol. 2006, 1769:5173-5182.
    • (2006) J. Immunol. , vol.1769 , pp. 5173-5182
    • Fricke, I.1    Mitchell, D.2
  • 8
    • 0031944607 scopus 로고    scopus 로고
    • CD40 and CD154 in cell-mediated immunity
    • Grewal I.S., Flavell R.A. CD40 and CD154 in cell-mediated immunity. Annu. Rev. Immunol. 1998, 16:111-135.
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 111-135
    • Grewal, I.S.1    Flavell, R.A.2
  • 10
    • 0030848546 scopus 로고    scopus 로고
    • Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides
    • Grubin C.E., Kovats S., deRoos P., Rudensky A.Y. Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides. Immunity 1997, 72:197-208.
    • (1997) Immunity , vol.72 , pp. 197-208
    • Grubin, C.E.1    Kovats, S.2    deRoos, P.3    Rudensky, A.Y.4
  • 11
    • 0024950174 scopus 로고
    • Membrane signal transduction in T cells in aging humans
    • Gupta S. Membrane signal transduction in T cells in aging humans. Ann. N.Y. Acad. Sci. 1989, 568:277-282.
    • (1989) Ann. N.Y. Acad. Sci. , vol.568 , pp. 277-282
    • Gupta, S.1
  • 12
    • 2142644403 scopus 로고    scopus 로고
    • Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo
    • Haynes L., Eaton S.M., Burns E.M., Rincon M., Swain S.L. Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo. J. Immunol. 2004, 1729:5194-5199.
    • (2004) J. Immunol. , vol.1729 , pp. 5194-5199
    • Haynes, L.1    Eaton, S.M.2    Burns, E.M.3    Rincon, M.4    Swain, S.L.5
  • 13
    • 0033975580 scopus 로고    scopus 로고
    • The defects in effector generation associated with aging can be reversed by addition of IL-2 but not other related gamma(c)-receptor binding cytokines
    • Haynes L., Eaton S.M., Swain S.L. The defects in effector generation associated with aging can be reversed by addition of IL-2 but not other related gamma(c)-receptor binding cytokines. Vaccine 2000, 1816:1649-1653.
    • (2000) Vaccine , vol.1816 , pp. 1649-1653
    • Haynes, L.1    Eaton, S.M.2    Swain, S.L.3
  • 14
    • 0036198306 scopus 로고    scopus 로고
    • Effect of age on naive CD4 responses: impact on effector generation and memory development
    • Haynes L., Eaton S.M., Swain S.L. Effect of age on naive CD4 responses: impact on effector generation and memory development. Semin. Immunopathol.(Springer) 2002, 241:53-60.
    • (2002) Semin. Immunopathol.(Springer) , vol.241 , pp. 53-60
    • Haynes, L.1    Eaton, S.M.2    Swain, S.L.3
  • 15
    • 33744996006 scopus 로고    scopus 로고
    • Why aging T cells fail: implications for vaccination
    • Haynes L., Swain S.L. Why aging T cells fail: implications for vaccination. Immunity 2006, 246:663-666.
    • (2006) Immunity , vol.246 , pp. 663-666
    • Haynes, L.1    Swain, S.L.2
  • 16
    • 0033609681 scopus 로고    scopus 로고
    • Expression of neurofilament L-promoter green-fluorescent protein constructs in immortalized Schwann cell-neuron coculture
    • Haynes L.W., Schmitz S., Clegg J.C., Fooks A.R. Expression of neurofilament L-promoter green-fluorescent protein constructs in immortalized Schwann cell-neuron coculture. Neurosci. Lett. 1999, 2713:155-158.
    • (1999) Neurosci. Lett. , vol.2713 , pp. 155-158
    • Haynes, L.W.1    Schmitz, S.2    Clegg, J.C.3    Fooks, A.R.4
  • 17
    • 70449732252 scopus 로고    scopus 로고
    • Dendritic cell subsets in primary and secondary T cell responses at body surfaces
    • Heath W.R., Carbone F.R. Dendritic cell subsets in primary and secondary T cell responses at body surfaces. Nat. Immunol. 2009, 1012:1237-1244.
    • (2009) Nat. Immunol. , vol.1012 , pp. 1237-1244
    • Heath, W.R.1    Carbone, F.R.2
  • 18
    • 0035339882 scopus 로고    scopus 로고
    • Differential production of IL-12, IFN-alpha, and IFN-gamma by mouse dendritic cell subsets
    • Hochrein H., Shortman K., Vremec D., Scott B., Hertzog P., O'Keeffe M. Differential production of IL-12, IFN-alpha, and IFN-gamma by mouse dendritic cell subsets. J. Immunol. 2001, 1669:5448-5455.
    • (2001) J. Immunol. , vol.1669 , pp. 5448-5455
    • Hochrein, H.1    Shortman, K.2    Vremec, D.3    Scott, B.4    Hertzog, P.5    O'Keeffe, M.6
  • 19
    • 33745673358 scopus 로고    scopus 로고
    • The dynamics of dendritic cell-T cell interactions in priming and tolerance
    • Hugues S., Boissonnas A., Amigorena S., Fetler L. The dynamics of dendritic cell-T cell interactions in priming and tolerance. Curr. Opin. Immunol. 2006, 184:491-495.
    • (2006) Curr. Opin. Immunol. , vol.184 , pp. 491-495
    • Hugues, S.1    Boissonnas, A.2    Amigorena, S.3    Fetler, L.4
  • 20
    • 0037769037 scopus 로고    scopus 로고
    • Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity
    • Itano A.A., McSorley S.J., Reinhardt R.L., Ehst B.D., Ingulli E., Rudensky A.Y., Jenkins M.K. Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. Immunity 2003, 191:47-57.
    • (2003) Immunity , vol.191 , pp. 47-57
    • Itano, A.A.1    McSorley, S.J.2    Reinhardt, R.L.3    Ehst, B.D.4    Ingulli, E.5    Rudensky, A.Y.6    Jenkins, M.K.7
  • 21
    • 0035056185 scopus 로고    scopus 로고
    • In vivo activation of antigen-specific CD4 T cells
    • Jenkins M.K., Khoruts A., et al. In vivo activation of antigen-specific CD4 T cells. Annu. Rev. Immunol. 2001, 19:23-45.
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 23-45
    • Jenkins, M.K.1    Khoruts, A.2
  • 22
    • 34247136761 scopus 로고    scopus 로고
    • Aging affects initiation and continuation of T cell proliferation
    • Jiang J., Gross D., Elbaum P., Murasko D.M. Aging affects initiation and continuation of T cell proliferation. Mech. Ageing Dev. 2007, 1284:332-339.
    • (2007) Mech. Ageing Dev. , vol.1284 , pp. 332-339
    • Jiang, J.1    Gross, D.2    Elbaum, P.3    Murasko, D.M.4
  • 23
    • 0033486007 scopus 로고    scopus 로고
    • T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal
    • Kalinski P., Hilkens C.M., Wierenga E.A., Kapsenberg M.L. T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunol. Today 1999, 2012:561-567.
    • (1999) Immunol. Today , vol.2012 , pp. 561-567
    • Kalinski, P.1    Hilkens, C.M.2    Wierenga, E.A.3    Kapsenberg, M.L.4
  • 24
    • 78349286392 scopus 로고    scopus 로고
    • Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/PD-L1 pathway
    • Lages C.S., Lewkowich I., Sproles A., Wills-Karp M., Chougnet C. Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/PD-L1 pathway. Aging Cell 2010, 95:785-798.
    • (2010) Aging Cell , vol.95 , pp. 785-798
    • Lages, C.S.1    Lewkowich, I.2    Sproles, A.3    Wills-Karp, M.4    Chougnet, C.5
  • 25
    • 0029826636 scopus 로고    scopus 로고
    • Antigen-independent changes in naive CD4 T cells with aging
    • Linton P.J., Haynes L., Klinman N.R., Swain S.L. Antigen-independent changes in naive CD4 T cells with aging. J. Exp. Med. 1996, 1845:1891-1900.
    • (1996) J. Exp. Med. , vol.1845 , pp. 1891-1900
    • Linton, P.J.1    Haynes, L.2    Klinman, N.R.3    Swain, S.L.4
  • 26
    • 20344374699 scopus 로고    scopus 로고
    • Intrinsic versus environmental influences on T-cell responses in aging
    • Linton P.J., Li S.P., Zhang Y., Bautista B., Huynh Q., Trinh T. Intrinsic versus environmental influences on T-cell responses in aging. Immunol. Rev. 2005, 205:207-219.
    • (2005) Immunol. Rev. , vol.205 , pp. 207-219
    • Linton, P.J.1    Li, S.P.2    Zhang, Y.3    Bautista, B.4    Huynh, Q.5    Trinh, T.6
  • 28
    • 0035838984 scopus 로고    scopus 로고
    • Dendritic cells: specialized and regulated antigen processing machines
    • Mellman I., Steinman R.M. Dendritic cells: specialized and regulated antigen processing machines. Cell 2001, 1063:255-258.
    • (2001) Cell , vol.1063 , pp. 255-258
    • Mellman, I.1    Steinman, R.M.2
  • 29
    • 0026334486 scopus 로고
    • Aging and immune function
    • Miller R.A. Aging and immune function. Int. Rev. Cytol. 1991, 124:187-215.
    • (1991) Int. Rev. Cytol. , vol.124 , pp. 187-215
    • Miller, R.A.1
  • 30
    • 0030035583 scopus 로고    scopus 로고
    • The aging immune system: primer and prospectus
    • 2735271
    • Miller R.A. The aging immune system: primer and prospectus. Science 1996, 2735271:70-74.
    • (1996) Science , pp. 70-74
    • Miller, R.A.1
  • 31
    • 34848908792 scopus 로고    scopus 로고
    • IFN-gamma-producing dendritic cells are important for priming of gut intraepithelial lymphocyte response against intracellular parasitic infection
    • Moretto M.M., Weiss L.M., Combe C.L., Khan I.A. IFN-gamma-producing dendritic cells are important for priming of gut intraepithelial lymphocyte response against intracellular parasitic infection. J. Immunol. 2007, 1794:2485-2492.
    • (2007) J. Immunol. , vol.1794 , pp. 2485-2492
    • Moretto, M.M.1    Weiss, L.M.2    Combe, C.L.3    Khan, I.A.4
  • 33
    • 19344376093 scopus 로고    scopus 로고
    • Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response
    • 20110
    • Obst R., van Santen H.M., Mathis D., Benoist C. Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response. J. Exp. Med. 2005, 20110:1555-1565.
    • (2005) J. Exp. Med. , pp. 1555-1565
    • Obst, R.1    van Santen, H.M.2    Mathis, D.3    Benoist, C.4
  • 34
    • 77951886965 scopus 로고    scopus 로고
    • Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response
    • Panda A., Qian F., et al. Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. J. Immunol. 2010, 1845:2518-2527.
    • (2010) J. Immunol. , vol.1845 , pp. 2518-2527
    • Panda, A.1    Qian, F.2
  • 35
    • 27144496045 scopus 로고    scopus 로고
    • CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
    • Parry R.V., Chemnitz J.M., et al. CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol. Cell. Biol. 2005, 2521:9543-9553.
    • (2005) Mol. Cell. Biol. , vol.2521 , pp. 9543-9553
    • Parry, R.V.1    Chemnitz, J.M.2
  • 36
    • 58149346177 scopus 로고    scopus 로고
    • Alterations in dendritic cell function in aged mice: potential implications for immunotherapy design
    • Paula C., Motta A., Schmitz C., Nunes C.P., Souza A.P., Bonorino C. Alterations in dendritic cell function in aged mice: potential implications for immunotherapy design. Biogerontology 2009, 101:13-25.
    • (2009) Biogerontology , vol.101 , pp. 13-25
    • Paula, C.1    Motta, A.2    Schmitz, C.3    Nunes, C.P.4    Souza, A.P.5    Bonorino, C.6
  • 37
    • 0036584494 scopus 로고    scopus 로고
    • T cells and aging, January 2002 update
    • Pawelec G., Barnett Y., et al. T cells and aging, January 2002 update. Front. Biosci. 2002, 7:d1056-d1183.
    • (2002) Front. Biosci. , vol.7
    • Pawelec, G.1    Barnett, Y.2
  • 39
    • 77749279764 scopus 로고    scopus 로고
    • Mature dendritic cells use endocytic receptors to capture and present antigens
    • Platt C.D., Ma J.K., et al. Mature dendritic cells use endocytic receptors to capture and present antigens. Proc. Natl. Acad. Sci. U.S.A. 2010, 1079:4287-4292.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.1079 , pp. 4287-4292
    • Platt, C.D.1    Ma, J.K.2
  • 40
    • 0027402746 scopus 로고
    • Effect of age on cytotoxic T lymphocyte memory as well as serum and local antibody responses elicited by inactivated influenza virus vaccine
    • Powers D.C., Belshe R.B. Effect of age on cytotoxic T lymphocyte memory as well as serum and local antibody responses elicited by inactivated influenza virus vaccine. J. Infect. Dis. 1993, 1673:584-592.
    • (1993) J. Infect. Dis. , vol.1673 , pp. 584-592
    • Powers, D.C.1    Belshe, R.B.2
  • 41
    • 0034852360 scopus 로고    scopus 로고
    • A crucial role for CD44 in inflammation
    • Pure E., Cuff C.A. A crucial role for CD44 in inflammation. Trends Mol. Med. 2001, 75:213-221.
    • (2001) Trends Mol. Med. , vol.75 , pp. 213-221
    • Pure, E.1    Cuff, C.A.2
  • 44
    • 0036436469 scopus 로고    scopus 로고
    • Circulating, interferon-producing plasmacytoid dendritic cells decline during human ageing
    • Shodell M., Siegal F.P. Circulating, interferon-producing plasmacytoid dendritic cells decline during human ageing. Scand. J. Immunol. 2002, 565:518-521.
    • (2002) Scand. J. Immunol. , vol.565 , pp. 518-521
    • Shodell, M.1    Siegal, F.P.2
  • 45
    • 77349100571 scopus 로고    scopus 로고
    • The CD8+ dendritic cell subset
    • Shortman K., Heath W.R. The CD8+ dendritic cell subset. Immunol. Rev. 2010, 2341:18-31.
    • (2010) Immunol. Rev. , vol.2341 , pp. 18-31
    • Shortman, K.1    Heath, W.R.2
  • 46
    • 0031214007 scopus 로고    scopus 로고
    • FLT3 ligand induces the generation of functionally active dendritic cells in mice
    • Shurin M.R., Pandharipande P.P., et al. FLT3 ligand induces the generation of functionally active dendritic cells in mice. Cell. Immunol. 1997, 1792:174-184.
    • (1997) Cell. Immunol. , vol.1792 , pp. 174-184
    • Shurin, M.R.1    Pandharipande, P.P.2
  • 48
    • 77349088003 scopus 로고    scopus 로고
    • Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance
    • Swiecki M., Colonna M. Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance. Immunol. Rev. 2010, 2341:142-162.
    • (2010) Immunol. Rev. , vol.2341 , pp. 142-162
    • Swiecki, M.1    Colonna, M.2
  • 49
  • 50
    • 33751231753 scopus 로고    scopus 로고
    • Murine [corrected] myeloid dendritic cell-dependent toll-like receptor immunity is preserved with aging
    • Tesar B.M., Walker W.E., et al. Murine [corrected] myeloid dendritic cell-dependent toll-like receptor immunity is preserved with aging. Aging Cell 2006, 56:473-486.
    • (2006) Aging Cell , vol.56 , pp. 473-486
    • Tesar, B.M.1    Walker, W.E.2
  • 51
    • 0035801933 scopus 로고    scopus 로고
    • Mechanisms of dendritic cell-induced T cell proliferation in the primary MLR assay
    • Tourkova I.L., Yurkovetsky Z.R., Shurin M.R., Shurin G.V. Mechanisms of dendritic cell-induced T cell proliferation in the primary MLR assay. Immunol. Lett. 2001, 782:75-82.
    • (2001) Immunol. Lett. , vol.782 , pp. 75-82
    • Tourkova, I.L.1    Yurkovetsky, Z.R.2    Shurin, M.R.3    Shurin, G.V.4
  • 52
    • 51349099789 scopus 로고    scopus 로고
    • Antigen-presentation properties of plasmacytoid dendritic cells
    • Villadangos J.A., Young L. Antigen-presentation properties of plasmacytoid dendritic cells. Immunity 2008, 293:352-361.
    • (2008) Immunity , vol.293 , pp. 352-361
    • Villadangos, J.A.1    Young, L.2
  • 53
  • 54
    • 77958611660 scopus 로고    scopus 로고
    • Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors
    • Zhu J., Paul W.E. Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors. Immunol. Rev. 2010, 2381:247-262.
    • (2010) Immunol. Rev. , vol.2381 , pp. 247-262
    • Zhu, J.1    Paul, W.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.