Role of carbonyl modifications on aging-associated protein aggregation

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Tanase, Maya ^a,b   Urbanska, Aleksandra M ^a   Zolla, Valerio ^a   Clement, Cristina C ^a   Huang, Liling ^a   Morozova, Kateryna ^a   Follo, Carlo ^a   Goldberg, Michael ^a   Roda, Barbara ^b,c   Reschiglian, Pierluigi ^b,c   Santambrogio, Laura ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c ByFlow Srl   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; PROTEIN AGGREGATE; REACTIVE OXYGEN METABOLITE;

AGING; ANIMAL; BONE MARROW CELL; FEMALE; METABOLISM; MOUSE; OXIDATIVE STRESS; PATHOLOGY; PROTEIN CARBONYLATION; PROTEINOSIS; SPLEEN;

AGING; ANIMALS; BONE MARROW CELLS; FEMALE; MICE; OXIDATIVE STRESS; PROTEIN AGGREGATES; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN CARBONYLATION; PROTEINS; REACTIVE OXYGEN SPECIES; SPLEEN;

EID: 84955106488     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep19311     Document Type: Article

References (45)

1. Tyedmers, J., Mogk, A., & Bukau, B. Cellular strategies for controlling protein aggregation. Nat Rev Mol Cell Biol 11, 777-788, doi: 10.1038/nrm2993 (2010
2. Kamhi-Nesher, S., et al. A novel quality control compartment derived from the endoplasmic reticulum. Mol Biol Cell 12, 1711-1723 (2001
3. Kruse, K. B., Brodsky, J. L., & McCracken, A. A. Characterization of an ERAD gene as VPS30/ATG6 reveals two alternative and functionally distinct protein quality control pathways: one for soluble Z variant of human alpha-1 proteinase inhibitor (A1PiZ) and another for aggregates of A1PiZ. Mol Biol Cell 17, 203-212, doi: 10.1091/mbc.E04-09-0779 (2006
4. Kiffin, R., Christian, C., Knecht, E., & Cuervo, A. M. Activation of chaperone-mediated autophagy during oxidative stress. Mol Biol Cell 15, 4829-4840, doi: 10.1091/mbc.E04-06-0477 (2004
5. Lelouard, H., et al. Transient aggregation of ubiquitinated proteins during dendritic cell maturation. Nature 417, 177-182, doi: 10.1038/417177a (2002
6. Kaushik, S., & Cuervo, A. M. Chaperone-mediated autophagy: a unique way to enter the lysosome world. Trends Cell Biol 22, 407-417, doi: 10.1016/j.tcb.2012.05.006 (2012
7. Shelkovnikova, T. A., et al. [Proteinopathies-forms of neurodegenerative disorders with protein aggregation-based pathology]. Mol Biol (Mosk) 46, 402-415 (2012
8. Corrochano, S., et al. alpha-Synuclein levels modulate Huntington?s disease in mice. Human molecular genetics 21, 485-494, doi: 10.1093/hmg/ddr477 (2012
9. Renna, M., Jimenez-Sanchez, M., Sarkar, S., & Rubinsztein, D. C. Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. The Journal of biological chemistry 285, 11061-11067, doi: 10.1074/jbc.R109.072181 (2010
10. Richter-Landsberg, C., & Leyk, J. Inclusion body formation, macroautophagy, and the role of HDAC6 in neurodegeneration. Acta neuropathologica 126, 793-807, doi: 10.1007/s00401-013-1158-x (2013
11. Rubinsztein, D. C., et al. Autophagy and its possible roles in nervous system diseases, damage and repair. Autophagy 1, 11-22 (2005
12. Kopito, R. R. Aggresomes, inclusion bodies and protein aggregation. Trends Cell Biol 10, 524-530 (2000
13. Nixon, R. A. The role of autophagy in neurodegenerative disease. Nat Med 19, 983-997, doi: 10.1038/nm.3232 (2013
14. Perlmutter, D. H. The role of autophagy in alpha-1-Antitrypsin deficiency: a specific cellular response in genetic diseases associated with aggregation-prone proteins. Autophagy 2, 258-263 (2006
15. Riley, B. E., et al. Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection. J Cell Biol 191, 537-552, doi: 10.1083/jcb.201005012 (2010
16. Cannizzo, E. S., Clement, C. C., Sahu, R., Follo, C., & Santambrogio, L. Oxidative stress, inflamm-Aging and immunosenescence. Journal of proteomics 74, 2313-2323, doi: 10.1016/j.jprot.2011.06.005 (2011
17. David, D. C., et al. Widespread protein aggregation as an inherent part of aging in C. elegans. PLoS biology 8, e1000450, doi: 10.1371/journal.pbio.1000450 (2010
18. Reschiglian, P., et al. Hollow-fiber flow field-flow fractionation with multi-Angle laser scattering detection for aggregation studies of therapeutic proteins. Analytical and bioanalytical chemistry, doi: 10.1007/s00216-013-7462-4 (2013
19. Tanase, M., et al. Hydrodynamic-size based separation and characterization of protein aggregates from total cell lysates. Nature Protocols (2014
20. Kalia, L. V., Kalia, S. K., McLean, P. J., Lozano, A. M., & Lang, A. E. alpha-Synuclein oligomers and clinical implications for Parkinson disease. Ann Neurol 73, 155-169, doi: 10.1002/ana.23746 (2013
21. Cuervo, A. M., Stefanis, L., Fredenburg, R., Lansbury, P. T., & Sulzer, D. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305, 1292-1295, doi: 10.1126/science.1101738 (2004
22. Lemere, C. A., et al. The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology. Nat Med 2, 1146-1150 (1996
23. Phiel, C. J., Wilson, C. A., Lee, V. M., & Klein, P. S. GSK-3alpha regulates production of Alzheimer?s disease amyloid-beta peptides. Nature 423, 435-439, doi: 10.1038/nature01640 (2003
24. Wong, E. S., et al. Autophagy-mediated clearance of aggresomes is not a universal phenomenon. Human molecular genetics 17, 2570-2582, doi: 10.1093/hmg/ddn157 (2008
25. DiFiglia, M., et al. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 277, 1990-1993 (1997
26. Fiumara, F., Fioriti, L., Kandel, E. R., & Hendrickson, W. A. Essential role of coiled coils for aggregation and activity of Q/N-rich prions and PolyQ proteins. Cell 143, 1121-1135, doi: 10.1016/j.cell.2010.11.042 (2010
27. Zhang, Y., & Calderwood, S. K. Autophagy, protein aggregation and hyperthermia: a mini-review. Int J Hyperthermia 27, 409-414, doi: 10.3109/02656736.2011.552087 (2011
28. Bence, N. F., Sampat, R. M., & Kopito, R. R. Impairment of the ubiquitin-proteasome system by protein aggregation. Science 292, 1552-1555, doi: 10.1126/science.292.5521.1552 (2001
29. Berke, S. J., & Paulson, H. L. Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration. Curr Opin Genet Dev 13, 253-261 (2003
30. Cummings, C. J., et al. Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1. Nat Genet 19, 148-154, doi: 10.1038/502 (1998
31. Demasi, M., & Davies, K. J. Proteasome inhibitors induce intracellular protein aggregation and cell death by an oxygen-dependent mechanism. FEBS Lett 542, 89-94 (2003
32. Lu, M., Echeverri, F., & Moyer, B. D. Endoplasmic reticulum retention, degradation, and aggregation of olfactory G-protein coupled receptors. Traffic 4, 416-433 (2003
33. Wyttenbach, A., et al. Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington?s disease. Proc Natl Acad Sci USA 97, 2898-2903 (2000
34. Cannizzo, E. S., et al. Age-related oxidative stress compromises endosomal proteostasis. Cell reports 2, 136-149, doi: 10.1016/j. celrep.2012.06.005 (2012
35. Scharf, B., et al. Age-related carbonylation of fibrocartilage structural proteins drives tissue degenerative modification. Chemistry & biology 20, 922-934, doi: 10.1016/j.chembiol.2013.06.006 (2013
36. Silveira, J. R., et al. The most infectious prion protein particles. Nature 437, 257-261, doi: 10.1038/nature03989 (2005
37. Arena, S., Salzano, A. M., Renzone, G., D?Ambrosio, C., & Scaloni, A. Non-enzymatic glycation and glycoxidation protein products in foods and diseases: an interconnected, complex scenario fully open to innovative proteomic studies. Mass Spectrom Rev 33, 49-77, doi: 10.1002/mas.21378 (2014
38. Gillery, P. [Oxidative stress and protein glycation in diabetes mellitus]. Ann Biol Clin (Paris) 64, 309-314 (2006
39. Lapolla, A., Molin, L., & Traldi, P. Protein glycation in diabetes as determined by mass spectrometry. Int J Endocrinol 2013, 412103, doi: 10.1155/2013/412103 (2013
40. Perkins, B. A., et al. Serum levels of advanced glycation endproducts and other markers of protein damage in early diabetic nephropathy in type 1 diabetes. PloS one 7, e35655, doi: 10.1371/journal.pone.0035655 (2012
41. Simm, A. Protein glycation during aging and in cardiovascular disease. Journal of proteomics 92, 248-259, doi: 10.1016/j. jprot.2013.05.012 (2013
42. Haigis, M. C., & Yankner, B. A. The aging stress response. Mol Cell 40, 333-344, doi: 10.1016/j.molcel.2010.10.002 (2010
43. Wong, E., et al. Molecular determinants of selective clearance of protein inclusions by autophagy. Nat Commun 3, 1240, doi: 10.1038/ncomms2244 (2012
44. Johann, C., et al. A novel approach to improve operation and performance in flow field-flow fractionation. Journal of chromatography. A 1218, 4126-4131, doi: 10.1016/j.chroma.2010.12.077 (2011
45. Kawahara, K., & Tanford, C. Viscosity and density of aqueous solutions of urea and guanidine hydrochloride. The Journal of biological chemistry 241, 3228-3232 (1966