Changes of CD4+CD25+Foxp3+ regulatory T cells in aged Balb/c mice

Journal of Leukocyte Biology

Volumn 81, Issue 6, 2007, Pages 1386-1394

  Zhao, Liang ^a   Sun, Liguang ^a   Wang, Hongjun ^a   Haixia, Ma ^a   Liu, Guangwei ^a   Zhao, Yong ^a  

^a INSTITUTE OF ZOOLOGY   (China)

Author keywords

Aging; Immune tolerance

Indexed keywords

CD4 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; PADGEM PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

AGING; ANALYTIC METHOD; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL COUNT; CELL FUNCTION; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE;

AGING; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; FORKHEAD TRANSCRIPTION FACTORS; HYPERSENSITIVITY, DELAYED; INTERFERON TYPE II; INTERLEUKIN-2; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; T-LYMPHOCYTES, REGULATORY; THYMUS GLAND;

MUS;

EID: 34249713646     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0506364     Document Type: Article

References (49)

1. Herrero, C., Marques, L., Lloberas, J., Celada, A. (2001) IFN-γ-dependent transcription of MHC class II IA is impaired in macrophages from aged mice. J. Clin. Invest. 107, 485-493.
2. Ortiz-Suarez, A., Miller, R. A. (2002) A subset of CD8 memory T cells from old mice have high levels of CD28 and produce IFN-γ. Clin. Immunol. 104, 282-292.
3. Licastro, F., Candore, G., Lio, D., Porcellini, E., Colonna-Romano, G., Franceschi, C., Caruso, C. (2005) Innate immunity and inflammation in ageing: a key for understanding age-related diseases. Immun. Ageing 2, 8.
4. Miller, R. A. (1996) The aging immune system: primer and prospectus. Science 273, 70-74.
5. Plackett, T. P., Boehmer, E. D., Faunce, D. E., Kovacs, E. J. (2004) Aging and innate immune cells. J. Leukoc. Biol. 76, 291-299.
6. Kapasi, Z. F., Murali-Krishna, K., McRae, M. L., Ahmed, R. (2002) Defective generation but normal maintenance of memory T cells in old mice. Eur. J. Immunol. 32, 1567-1573.
7. Hobbs, M. V., Weigle, W. O., Ernst, D. N. (1994) Interleukin-10 production by splenic CD4+ cells and cell subsets from young and old mice. Cell. Immunol. 154, 264-272.
8. Hobbs, M. V., Ernst, D. N., Torbett, B. E., Glasebrook, A. L., Rehse, M. A., McQuitty, D. N., Thoman, M. L., Bottomly, K., Rothermel, A. L., Noonan, D. J. (1991) Cell proliferation and cytokine production by CD4+ cells from old mice. J. Cell. Biochem. 46, 312-320.
9. Goronzy, J. J., Fujii, H., Weyand, C. M. (2006) Telomeres, immune aging and autoimmunity. Exp. Gerontol. 41, 246-251.
10. McLeod, J. D. (2000) Apoptotic capability in ageing T cells. Mech. Ageing Dev. 121, 151-159.
11. Sun, Y., Li, H., Langnas, A. N., Zhao, Y. (2004) Altered allogeneic immune responses in middle-aged mice. Cell. Mol. Immunol. 1, 440-446.
12. Engwerda, C. R., Fox, B. S., Handwerger, B. S. (1996) Cytokine production by T lymphocytes from young and aged mice. J. Immunol. 156, 3621-3630.
13. Paust, S., Cantor, H. (2005) Regulatory T cells and autoimmune disease. Immunol. Rev. 204, 195-207.
14. Wraith, D. C., Nicolson, K. S., Whitley, N. T. (2004) Regulatory CD4+ T cells and the control of autoimmune disease. Curr. Opin. Immunol. 16, 695-701.
15. Bluestone, J. A., Tang, Q. (2005) How do CD4+CD25+ regulatory T cells control autoimmunity? Curr. Opin. Immunol. 17, 638-642.
16. Wang, R. F. (2006) Immune suppression by tumor-specific CD4+ regulatory T-cells in cancer. Semin. Cancer Biol. 16, 73-79.
17. Dejaco, C., Duftner, C., Grubeck-Loebenstein, B., Schirmer, M. (2006) Imbalance of regulatory T cells in human autoimmune diseases. Immunology 117, 289-300.
18. Sakaguchi, S. (2004) Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22, 531-562.
19. Hoglund, P. (2006) Induced peripheral regulatory T cells: the family grows larger. Eur. J. Immunol. 36, 264-266.
20. Thornton, A. M. (2005) T regulatory cells. Curr. Biol. 15, R582.
21. Lepault, F., Gagnerault, M. C. (2000) Characterization of peripheral regulatory CD4+ T cells that prevent diabetes onset in nonobese diabetic mice. J. Immunol. 164, 240-247.
22. Powrie, F., Correa-Oliveira, R., Mauze, S., Coffman, R. L. (1994) Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity. J. Exp. Med. 179, 589-600.
23. Taub, D. D., Longo, D. L. (2005) Insights into thymic aging and regeneration. Immunol. Rev. 205, 72-93.
24. Pawelec, G., Remarque, E., Barnett, Y., Solana, R. (1998) T cells and aging. Front. Biosci. 3, d59-d99.
25. Dejaco, C., Duftner, C., Schirmer, M. (2006) Are regulatory T-cells linked with aging? Exp. Gerontol. 41, 339-345.
26. Gottesman, S. R., Edington, J. M., Thorbecke, G. J. (1988) Proliferative and cytotoxic immune functions in aging mice. IV. Effects of suppressor cell populations from aged and young mice. J. Immunol. 140, 1783-1790.
27. Sun, Y., Langnas, A. N., Zhao, Y. (2003) The interaction defect of accessory molecules is responsible for the poor ex vivo response to human antigens of mouse T helper cells. Scand. J. Immunol. 58, 59-66.
28. Sun, Z., Zhao, L., Wang, H., Sun, L., Yi, H., Zhao, Y. (2006) Presence of functional mouse regulatory CD4+CD25+T cells in xenogeneic neonatal porcine thymus-grafted athymic mice. Am. J. Transplant. 6, 2841-2850.
29. Liu, G., Xia, X. P., Gong, S. L., Zhao, Y. (2006) The macrophage heterogeneity: difference between mouse peritoneal exudate and splenic F4/80+ macrophages. J. Cell. Physiol. 209, 341-352.
30. Miller, R. A., Berger, S. B., Burke, D. T., Galecki, A., Garcia, G. G., Harper, J. M., Sadighi Akha, A. A. (2005) T cells in aging mice: genetic, developmental, and biochemical analyses. Immunol. Rev. 205, 94-103.
31. Khattri, R., Cox, T., Yasayko, S. A., Ramsdell, F. (2003) An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat. Immunol. 4, 337-342.
32. Hori, S., Nomura, T., Sakaguchi, S. (2003) Control of regulatory T cell development by the transcription factor Foxp3. Science 299, 1057-1061.
33. Rao, E., Zhao, Y. (2005) Foxp3: a critical transcription factor in regulatory T cell development. Prog. Biochem. Biophy. 32, 106-110.
34. Barrat, F., Haegel, H., Louise, A., Vincent-Naulleau, S., Boulouis, H. J., Neway, T., Ceredig, R., Pilet, C. (1995) Quantitative and qualitative changes in CD44 and MEL-14 expression by T cells in C57BL/6 mice during aging. Res. Immunol. 146, 23-34.
35. Gorczynski, R. M. (1987) Diversity in the lymphocyte recognition repertoire is altered during ageing. Biomed. Pharmacother. 41, 124-126.
36. Goronzy, J. J., Weyand, C. M. (2003) Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity - catalysts of autoimmunity and chronic inflammation. Arthritis Res. Ther. 5, 225-234.
37. Min, H., Montecino-Rodriguez, E., Dorshkind, K. (2005) Effects of aging on early B- and T-cell development. Immunol. Rev. 205, 7-17.
38. Wick, G., Grubeck-Loebenstein, B. (1997) The aging immune system: primary and secondary alterations of immune reactivity in the elderly. Exp. Gerontol. 32, 401-413.
39. Miller, R. A. (1991) Aging and immune function. Int. Rev. Cytol. 124, 187-215.
40. Miller, R. A. (1997) The aging immune system: subsets, signals, and survival. Aging (Milano) 9, 23-24.
41. Makinodan, T. (1980) Role of the immune system in aging. Adv. Exp. Med. Biol. 129, 213-231.
42. Chen, J., Astle, C. M., Harrison, D. E. (1998) Delayed immune aging in diet-restricted B6CBAT6 F1 mice is associated with preservation of naive T cells. J. Gerontol. A Biol. Sci. Med. Sci. 53, B330-B337.
43. Fu, S., Yopp, A. C., Mao, X., Chen, D., Zhang, N., Chen, D., Mao, M., Ding, Y., Bromberg, J. S. (2004) CD4+CD25+CD62+T-regulatory cell subset has optimal suppressive and proliferative potential. Am. J. Transplant. 4, 65-78.
44. Prelog, M. (2006) Aging of the immune system: a risk factor for autoimmunity? Autoimmun. Rev. 5, 136-139.
45. Urban, L., Bessenyei, B., Marka, M., Semsei, I. (2002) On the role of aging in the etiology of autoimmunity. Gerontology 48, 179-184.
46. Thoman, M. L. (1995) The pattern of T lymphocyte differentiation is altered during thymic involution. Mech. Ageing Dev. 82, 155-170.
47. Fontenot, J. D., Gavin, M. A., Rudensky, A. Y. (2003) Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4, 330-336.
48. Allan, S. E., Passerini, L., Bacchetta, R., Crellin, N., Dai, M., Orban, P. C., Ziegler, S. F., Roncarolo, M. G., Levings, M. K. (2005) The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs. J. Clin. Invest. 115, 3276-3284.
49. Nishioka, T., Shimizu, J., Iida, R., Yamazaki, S., Sakaguchi, S. (2006) CD4+CD25+Foxp3+ T cells and CD4+CD25-Foxp3+ T cells in aged mice. J. Immunol. 176, 6586-6593.