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Volumn 5, Issue AUG, 2014, Pages

Unbalanced neonatal CD4+ T-cell immunity

Author keywords

Defective Th1 response; Follicular helper T cells; T helper subsets; Th17; Th2 biased response; Tregs; Vaccine

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CXCR5; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 4; PROGRAMMED DEATH 1 RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 84987816136     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2014.00393     Document Type: Review
Times cited : (95)

References (95)
  • 1
    • 0005984244 scopus 로고
    • Actively acquired tolerance of foreign cells
    • Billingham RE, Brent L, Medawar PB. Actively acquired tolerance of foreign cells. Nature (1953) 172(4379):603-6. doi: 10.1038/172603a0
    • (1953) Nature , vol.172 , Issue.4379 , pp. 603-606
    • Billingham, R.E.1    Brent, L.2    Medawar, P.B.3
  • 2
    • 0020603503 scopus 로고
    • Clonal analysis of T cell unresponsiveness to alloantigens induced by neonatal injection of F1 spleen cells into parental mice
    • Feng HM, Glasebrook AL, Engers HD, Louis JA. Clonal analysis of T cell unresponsiveness to alloantigens induced by neonatal injection of F1 spleen cells into parental mice. J Immunol (1983) 131(5):2165-9.
    • (1983) J Immunol , vol.131 , Issue.5 , pp. 2165-2169
    • Feng, H.M.1    Glasebrook, A.L.2    Engers, H.D.3    Louis, J.A.4
  • 3
    • 0019860595 scopus 로고
    • Functional clonal deletion in immunological tolerance to major histocompatibility complex antigens
    • Nossal GJ, Pike BL. Functional clonal deletion in immunological tolerance to major histocompatibility complex antigens. Proc Natl Acad Sci U S A (1981) 78(6):3844-7. doi:10.1073/pnas.78.6.3844
    • (1981) Proc Natl Acad Sci U S A , vol.78 , Issue.6 , pp. 3844-3847
    • Nossal, G.J.1    Pike, B.L.2
  • 4
    • 0025160548 scopus 로고
    • Persistence of anti-donor allohelper T cells after neonatal induction of allotolerance in mice
    • Abramowicz D, Vandervorst P, Bruyns C, Doutrelepont JM, Vandenabeele P, Goldman M. Persistence of anti-donor allohelper T cells after neonatal induction of allotolerance in mice. Eur J Immunol (1990) 20(8):1647-53. doi:10.1002/eji.1830200805
    • (1990) Eur J Immunol , vol.20 , Issue.8 , pp. 1647-1653
    • Abramowicz, D.1    Vandervorst, P.2    Bruyns, C.3    Doutrelepont, J.M.4    Vandenabeele, P.5    Goldman, M.6
  • 5
    • 0025014494 scopus 로고
    • Neonatal tolerance induction by class II alloantigens activates IL-4-secreting, tolerogen-responsive T cells
    • Powell TJ Jr, Streilein JW. Neonatal tolerance induction by class II alloantigens activates IL-4-secreting, tolerogen-responsive T cells. J Immunol (1990) 144(3):854-9.
    • (1990) J Immunol , vol.144 , Issue.3 , pp. 854-859
    • Powell, T.J.1    Streilein, J.W.2
  • 6
    • 0025083358 scopus 로고
    • In vivo effects of anti-IL-4 monoclonal antibody on neonatal induction of tolerance and on an associated autoimmune syndrome
    • Schurmans S, Heusser CH, Qin HY, Merino J, Brighouse G, Lambert PH. In vivo effects of anti-IL-4 monoclonal antibody on neonatal induction of tolerance and on an associated autoimmune syndrome. J Immunol (1990) 145(8):2465-73.
    • (1990) J Immunol , vol.145 , Issue.8 , pp. 2465-2473
    • Schurmans, S.1    Heusser, C.H.2    Qin, H.Y.3    Merino, J.4    Brighouse, G.5    Lambert, P.H.6
  • 7
    • 1342265737 scopus 로고    scopus 로고
    • The role of genetic and environmental factors in the development of T-cell mediated allergic disease in early life
    • Holt PG. The role of genetic and environmental factors in the development of T-cell mediated allergic disease in early life. Paediatr Respir Rev (2004) 5(Suppl A):S27-30. doi:10.1016/S1526-0542(04)90006-1
    • (2004) Paediatr Respir Rev , vol.5 , pp. S27-S30
    • Holt, P.G.1
  • 9
    • 85044698662 scopus 로고    scopus 로고
    • IL-12 prevents neonatal induction of transplantation tolerance in mice
    • Donckier V, Flamand V, Desalle F, Vanderhaeghen ML, de Veerman M, Thielemans K, et al. IL-12 prevents neonatal induction of transplantation tolerance in mice. Eur J Immunol (1998) 28(4):1426-30. doi:10.1002/(SICI)1521-4141(199804)28:04<1426::AID-IMMU1426>3.0.CO;2-P
    • (1998) Eur J Immunol , vol.28 , Issue.4 , pp. 1426-1430
    • Donckier, V.1    Flamand, V.2    Desalle, F.3    Vanderhaeghen, M.L.4    de Veerman, M.5    Thielemans, K.6
  • 10
    • 77955499089 scopus 로고    scopus 로고
    • 2 responses and allergic inflammation through bystander activation of CD8+ T lymphocytes in early life
    • 2 responses and allergic inflammation through bystander activation of CD8+ T lymphocytes in early life. J Immunol (2010) 185(2):884-91. doi:10.4049/jimmunol.0903287
    • (2010) J Immunol , vol.185 , Issue.2 , pp. 884-891
    • Dubois, A.1    Deruytter, N.2    Adams, B.3    Kanda, A.4    Delbauve, S.5    Fleury, S.6
  • 11
    • 0037105394 scopus 로고    scopus 로고
    • Enhanced type 1 immunity after secondary viral challenge in mice primed as neonates
    • Fadel SA, Ozaki DA, Sarzotti M. Enhanced type 1 immunity after secondary viral challenge in mice primed as neonates. J Immunol (2002) 169(6):3293-300. doi:10.4049/jimmunol.169.6.3293
    • (2002) J Immunol , vol.169 , Issue.6 , pp. 3293-3300
    • Fadel, S.A.1    Ozaki, D.A.2    Sarzotti, M.3
  • 12
    • 0030012251 scopus 로고    scopus 로고
    • Induction of protective CTL responses in newborn mice by a murine retrovirus
    • Sarzotti M, Robbins DS, Hoffman PM. Induction of protective CTL responses in newborn mice by a murine retrovirus. Science (1996) 271(5256):1726-8. doi:10.1126/science.271.5256.1726
    • (1996) Science , vol.271 , Issue.5256 , pp. 1726-1728
    • Sarzotti, M.1    Robbins, D.S.2    Hoffman, P.M.3
  • 13
    • 0030786390 scopus 로고    scopus 로고
    • DNA immunization circumvents deficient induction of T helper type 1 and cytotoxic T lymphocyte responses in neonates and during early life
    • Martinez X, Brandt C, Saddallah F, Tougne C, Barrios C, Wild F, et al. DNA immunization circumvents deficient induction of T helper type 1 and cytotoxic T lymphocyte responses in neonates and during early life. Proc Natl Acad Sci U S A (1997) 94(16):8726-31. doi:10.1073/pnas.94.16.8726
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.16 , pp. 8726-8731
    • Martinez, X.1    Brandt, C.2    Saddallah, F.3    Tougne, C.4    Barrios, C.5    Wild, F.6
  • 17
    • 84878403800 scopus 로고    scopus 로고
    • 4+ T cells plays a pathogenic role in respiratory syncytial virus reinfection in mice infected initially as neonates
    • 4+ T cells plays a pathogenic role in respiratory syncytial virus reinfection in mice infected initially as neonates. J Leukoc Biol (2013) 93(6):933-42. doi:10.1189/jlb.1012498
    • (2013) J Leukoc Biol , vol.93 , Issue.6 , pp. 933-942
    • You, D.1    Marr, N.2    Saravia, J.3    Shrestha, B.4    Lee, G.5    Turvey, S.E.6
  • 19
    • 33646558632 scopus 로고    scopus 로고
    • The key regulators of adult T helper cell responses, STAT6 and T-bet, are established in early life in mice
    • Rose S, Guevara P, Farach S, Adkins B. The key regulators of adult T helper cell responses, STAT6 and T-bet, are established in early life in mice. Eur J Immunol (2006) 36(5):1241-53. doi:10.1002/eji.200535563
    • (2006) Eur J Immunol , vol.36 , Issue.5 , pp. 1241-1253
    • Rose, S.1    Guevara, P.2    Farach, S.3    Adkins, B.4
  • 20
    • 84901280025 scopus 로고    scopus 로고
    • 4+ T cells from human neonates and infants are poised spontaneously to run a nonclassical IL-4 program
    • 4+ T cells from human neonates and infants are poised spontaneously to run a nonclassical IL-4 program. J Immunol (2014) 192:5160-70. doi:10.4049/jimmunol.1302539
    • (2014) J Immunol , vol.192 , pp. 5160-5170
    • Hebel, K.1    Weinert, S.2    Kuropka, B.3    Knolle, J.4    Kosak, B.5    Jorch, G.6
  • 22
    • 0037480902 scopus 로고    scopus 로고
    • Ontogeny and innate properties of neonatal dendritic cells
    • Sun CM, Fiette L, Tanguy M, Leclerc C, Lo-Man R. Ontogeny and innate properties of neonatal dendritic cells. Blood (2003) 102(2):585-91. doi:10.1182/blood-2002-09-2966
    • (2003) Blood , vol.102 , Issue.2 , pp. 585-591
    • Sun, C.M.1    Fiette, L.2    Tanguy, M.3    Leclerc, C.4    Lo-Man, R.5
  • 23
    • 1842732225 scopus 로고    scopus 로고
    • A defect in nucleosome remodeling prevents IL-12(p35) gene transcription in neonatal dendritic cells
    • Goriely S, Van Lint C, Dadkhah R, Libin M, De Wit D, Demonte D, et al. A defect in nucleosome remodeling prevents IL-12(p35) gene transcription in neonatal dendritic cells. J Exp Med (2004) 199(7):1011-6. doi:10.1084/jem.20031272
    • (2004) J Exp Med , vol.199 , Issue.7 , pp. 1011-1016
    • Goriely, S.1    Van Lint, C.2    Dadkhah, R.3    Libin, M.4    De Wit, D.5    Demonte, D.6
  • 25
    • 33847005427 scopus 로고    scopus 로고
    • 4+ T cells is refractory to the acquisition of a repressive chromatin architecture
    • 4+ T cells is refractory to the acquisition of a repressive chromatin architecture. J Biol Chem (2007) 282(1):700-9. doi:10.1074/jbc.M609501200
    • (2007) J Biol Chem , vol.282 , Issue.1 , pp. 700-709
    • Webster, R.B.1    Rodriguez, Y.2    Klimecki, W.T.3    Vercelli, D.4
  • 26
  • 27
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature (2003) 421(6924):744-8. doi:10.1038/nature01355
    • (2003) Nature , vol.421 , Issue.6924 , pp. 744-748
    • Cua, D.J.1    Sherlock, J.2    Chen, Y.3    Murphy, C.A.4    Joyce, B.5    Seymour, B.6
  • 28
    • 13244283212 scopus 로고    scopus 로고
    • IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
    • Langrish CL, Chen Y, Blumenschein WM, Mattson J, Basham B, Sedgwick JD, et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med (2005) 201(2):233-40. doi:10.1084/jem.20041257
    • (2005) J Exp Med , vol.201 , Issue.2 , pp. 233-240
    • Langrish, C.L.1    Chen, Y.2    Blumenschein, W.M.3    Mattson, J.4    Basham, B.5    Sedgwick, J.D.6
  • 31
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature (2006) 441(7090):235-8. doi:10.1038/nature04753
    • (2006) Nature , vol.441 , Issue.7090 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6
  • 32
    • 33646560950 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces development of the T(H)17 lineage
    • Mangan PR, Harrington LE, O'Quinn DB, Helms WS, Bullard DC, Elson CO, et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature (2006) 441(7090):231-4. doi:10.1038/nature04754
    • (2006) Nature , vol.441 , Issue.7090 , pp. 231-234
    • Mangan, P.R.1    Harrington, L.E.2    O'Quinn, D.B.3    Helms, W.S.4    Bullard, D.C.5    Elson, C.O.6
  • 33
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity (2006) 24(2):179-89. doi:10.1016/j.immuni.2006.01.001
    • (2006) Immunity , vol.24 , Issue.2 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 34
    • 34547232503 scopus 로고    scopus 로고
    • IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
    • Korn T, Bettelli E, Gao W, Awasthi A, Jager A, Strom TB, et al. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature (2007) 448(7152):484-7. doi:10.1038/nature05970
    • (2007) Nature , vol.448 , Issue.7152 , pp. 484-487
    • Korn, T.1    Bettelli, E.2    Gao, W.3    Awasthi, A.4    Jager, A.5    Strom, T.B.6
  • 35
    • 34547204946 scopus 로고    scopus 로고
    • Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
    • Nurieva R, Yang XO, Martinez G, Zhang Y, Panopoulos AD, Ma L, et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature (2007) 448(7152):480-3. doi:10.1038/nature05969
    • (2007) Nature , vol.448 , Issue.7152 , pp. 480-483
    • Nurieva, R.1    Yang, X.O.2    Martinez, G.3    Zhang, Y.4    Panopoulos, A.D.5    Ma, L.6
  • 36
    • 34547188748 scopus 로고    scopus 로고
    • IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    • Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol (2007) 8(9):967-74. doi:10.1038/ni1488
    • (2007) Nat Immunol , vol.8 , Issue.9 , pp. 967-974
    • Zhou, L.1    Ivanov, I.I.2    Spolski, R.3    Min, R.4    Shenderov, K.5    Egawa, T.6
  • 37
    • 77958584113 scopus 로고    scopus 로고
    • Generation of pathogenic T(H)17 cells in the absence of TGF-beta signalling
    • Ghoreschi K, Laurence A, Yang XP, Tato CM, McGeachy MJ, Konkel JE, et al. Generation of pathogenic T(H)17 cells in the absence of TGF-beta signalling. Nature (2010) 467(7318):967-71. doi:10.1038/nature09447
    • (2010) Nature , vol.467 , Issue.7318 , pp. 967-971
    • Ghoreschi, K.1    Laurence, A.2    Yang, X.P.3    Tato, C.M.4    McGeachy, M.J.5    Konkel, J.E.6
  • 41
    • 33847206969 scopus 로고    scopus 로고
    • IL-17 family cytokines and the expanding diversity of effector T cell lineages
    • Weaver CT, Hatton RD, Mangan PR, Harrington LE. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol (2007) 25:821-52. doi:10.1146/annurev.immunol.25.022106.141557
    • (2007) Annu Rev Immunol , vol.25 , pp. 821-852
    • Weaver, C.T.1    Hatton, R.D.2    Mangan, P.R.3    Harrington, L.E.4
  • 42
    • 34347259921 scopus 로고    scopus 로고
    • 17 immunity does not result in experimental autoimmune encephalomyelitis and can protect against the disease in adulthood
    • 17 immunity does not result in experimental autoimmune encephalomyelitis and can protect against the disease in adulthood. J Neuroimmunol (2007) 187(1-2):20-30. doi:10.1016/j.jneuroim.2007.04.001
    • (2007) J Neuroimmunol , vol.187 , Issue.1-2 , pp. 20-30
    • Hofstetter, H.H.1    Kovalovsky, A.2    Shive, C.L.3    Lehmann, P.V.4    Forsthuber, T.G.5
  • 43
    • 63149156268 scopus 로고    scopus 로고
    • Impaired innate and adaptive immunity to Streptococcus pneumoniae and its effect on colonization in an infant mouse model
    • Bogaert D, Weinberger D, Thompson C, Lipsitch M, Malley R. Impaired innate and adaptive immunity to Streptococcus pneumoniae and its effect on colonization in an infant mouse model. Infect Immun (2009) 77(4):1613-22. doi:10.1128/IAI.00871-08
    • (2009) Infect Immun , vol.77 , Issue.4 , pp. 1613-1622
    • Bogaert, D.1    Weinberger, D.2    Thompson, C.3    Lipsitch, M.4    Malley, R.5
  • 44
    • 84855980146 scopus 로고    scopus 로고
    • 17 alloimmunity prevents neonatal establishment of lymphoid chimerism in IL-4-deprived mice
    • 17 alloimmunity prevents neonatal establishment of lymphoid chimerism in IL-4-deprived mice. Am J Transplant (2012) 12(1):81-9. doi:10.1111/j.1600-6143.2011.03778.x
    • (2012) Am J Transplant , vol.12 , Issue.1 , pp. 81-89
    • Debock, I.1    Delbauve, S.2    Dubois, A.3    Petein, M.4    Leo, O.5    Goldman, M.6
  • 45
    • 0029068458 scopus 로고
    • Critical role of interleukin 4 in the induction of neonatal transplantation tolerance
    • Donckier V, Wissing M, Bruyns C, Abramowicz D, Lybin M, Vanderhaeghen ML, et al. Critical role of interleukin 4 in the induction of neonatal transplantation tolerance. Transplantation (1995) 59(11):1571-6. doi:10.1097/00007890-199506000-00012
    • (1995) Transplantation , vol.59 , Issue.11 , pp. 1571-1576
    • Donckier, V.1    Wissing, M.2    Bruyns, C.3    Abramowicz, D.4    Lybin, M.5    Vanderhaeghen, M.L.6
  • 46
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    • Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell (2006) 126(6):1121-33. doi:10.1016/j.cell.2006.07.035
    • (2006) Cell , vol.126 , Issue.6 , pp. 1121-1133
    • Ivanov, I.I.1    McKenzie, B.S.2    Zhou, L.3    Tadokoro, C.E.4    Lepelley, A.5    Lafaille, J.J.6
  • 47
    • 79958083858 scopus 로고    scopus 로고
    • Blocking induction of T helper type 2 responses prevents development of disease in a model of childhood asthma
    • Siegle JS, Hansbro N, Dong C, Angkasekwinai P, Foster PS, Kumar RK. Blocking induction of T helper type 2 responses prevents development of disease in a model of childhood asthma. Clin Exp Immunol (2011) 165:19-28. doi:10.1111/j.1365-2249.2011.04392.x
    • (2011) Clin Exp Immunol , vol.165 , pp. 19-28
    • Siegle, J.S.1    Hansbro, N.2    Dong, C.3    Angkasekwinai, P.4    Foster, P.S.5    Kumar, R.K.6
  • 48
    • 77955302687 scopus 로고    scopus 로고
    • Yersinia enterocolitica promotes robust mucosal inflammatory T-cell immunity in murine neonates
    • Echeverry A, Saijo S, Schesser K, Adkins B. Yersinia enterocolitica promotes robust mucosal inflammatory T-cell immunity in murine neonates. Infect Immun (2010) 78(8):3595-608. doi:10.1128/IAI.01272-09
    • (2010) Infect Immun , vol.78 , Issue.8 , pp. 3595-3608
    • Echeverry, A.1    Saijo, S.2    Schesser, K.3    Adkins, B.4
  • 49
    • 66749092107 scopus 로고    scopus 로고
    • A liposome-based mycobacterial vaccine induces potent adult and neonatal multifunctional T cells through the exquisite targeting of dendritic cells
    • Kamath AT, Rochat AF, Christensen D, Agger EM, Andersen P, Lambert PH, et al. A liposome-based mycobacterial vaccine induces potent adult and neonatal multifunctional T cells through the exquisite targeting of dendritic cells. PLoS One (2009) 4(6):e5771. doi:10.1371/journal.pone.0005771
    • (2009) PLoS One , vol.4 , Issue.6
    • Kamath, A.T.1    Rochat, A.F.2    Christensen, D.3    Agger, E.M.4    Andersen, P.5    Lambert, P.H.6
  • 50
    • 58149235337 scopus 로고    scopus 로고
    • Adult-like anti-mycobacterial T cell and in vivo dendritic cell responses following neonatal immunization with Ag85B-ESAT-6 in the IC31 adjuvant
    • Kamath AT, Rochat AF, Valenti MP, Agger EM, Lingnau K, Andersen P, et al. Adult-like anti-mycobacterial T cell and in vivo dendritic cell responses following neonatal immunization with Ag85B-ESAT-6 in the IC31 adjuvant. PLoS One (2008) 3(11):e3683. doi:10.1371/journal.pone.0003683
    • (2008) PLoS One , vol.3 , Issue.11
    • Kamath, A.T.1    Rochat, A.F.2    Valenti, M.P.3    Agger, E.M.4    Lingnau, K.5    Andersen, P.6
  • 51
    • 14744284737 scopus 로고    scopus 로고
    • IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naive T cells in human
    • Vanden Eijnden S, Goriely S, De Wit D, Willems F, Goldman M. IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naive T cells in human. Eur J Immunol (2005) 35(2):469-75. doi:10.1002/eji.200425677
    • (2005) Eur J Immunol , vol.35 , Issue.2 , pp. 469-475
    • Vanden Eijnden, S.1    Goriely, S.2    De Wit, D.3    Willems, F.4    Goldman, M.5
  • 52
    • 73349130456 scopus 로고    scopus 로고
    • Neonatal innate TLR-mediated responses are distinct from those of adults
    • Kollmann TR, Crabtree J, Rein-Weston A, Blimkie D, Thommai F, Wang XY, et al. Neonatal innate TLR-mediated responses are distinct from those of adults. J Immunol (2009) 183(11):7150-60. doi:10.4049/jimmunol.0901481
    • (2009) J Immunol , vol.183 , Issue.11 , pp. 7150-7160
    • Kollmann, T.R.1    Crabtree, J.2    Rein-Weston, A.3    Blimkie, D.4    Thommai, F.5    Wang, X.Y.6
  • 53
    • 30944444808 scopus 로고    scopus 로고
    • Preferential production of the IL-12(p40)/IL-23(p19) heterodimer by dendritic cells from human newborns
    • Vanden Eijnden S, Goriely S, De Wit D, Goldman M, Willems F. Preferential production of the IL-12(p40)/IL-23(p19) heterodimer by dendritic cells from human newborns. Eur J Immunol (2006) 36(1):21-6. doi:10.1002/eji.200535467
    • (2006) Eur J Immunol , vol.36 , Issue.1 , pp. 21-26
    • Vanden Eijnden, S.1    Goriely, S.2    De Wit, D.3    Goldman, M.4    Willems, F.5
  • 57
    • 84902778138 scopus 로고    scopus 로고
    • 4 T cells with effector memory phenotype and function develop in the sterile environment of the fetus
    • 4 T cells with effector memory phenotype and function develop in the sterile environment of the fetus. Sci Transl Med (2014) 6(238):238ra72. doi:10.1126/scitranslmed.3008748
    • (2014) Sci Transl Med , vol.6 , Issue.238
    • Zhang, X.1    Mozeleski, B.2    Lemoine, S.3    Dériaud, E.4    Lim, A.5    Zhivaki, D.6
  • 58
    • 0033611160 scopus 로고    scopus 로고
    • 25+ cells regulate CD8 cell anergy in neonatal tolerant mice
    • 25+ cells regulate CD8 cell anergy in neonatal tolerant mice. Transplantation (1999) 68(12):1891-7. doi:10.1097/00007890-199912270-00013
    • (1999) Transplantation , vol.68 , Issue.12 , pp. 1891-1897
    • Gao, Q.1    Rouse, T.M.2    Kazmerzak, K.3    Field, E.H.4
  • 59
  • 60
    • 25844504653 scopus 로고    scopus 로고
    • Developmental regulation of Foxp3 expression during ontogeny
    • Fontenot JD, Dooley JL, Farr AG, Rudensky AY. Developmental regulation of Foxp3 expression during ontogeny. J Exp Med (2005) 202(7):901-6. doi:10.1084/jem.20050784
    • (2005) J Exp Med , vol.202 , Issue.7 , pp. 901-906
    • Fontenot, J.D.1    Dooley, J.L.2    Farr, A.G.3    Rudensky, A.Y.4
  • 61
    • 82555164969 scopus 로고    scopus 로고
    • Critical role for programmed death 1 signaling and protein kinase B in augmented regulatory T-cell induction in cord blood
    • de Roock S, Hoeks SB, Meurs L, Steur A, Hoekstra MO, Prakken BJ, et al. Critical role for programmed death 1 signaling and protein kinase B in augmented regulatory T-cell induction in cord blood. J Allergy Clin Immunol (2011) 128(6):754-6. doi:10.1016/j.jaci.2011.08.006
    • (2011) J Allergy Clin Immunol , vol.128 , Issue.6 , pp. 754-756
    • de Roock, S.1    Hoeks, S.B.2    Meurs, L.3    Steur, A.4    Hoekstra, M.O.5    Prakken, B.J.6
  • 64
    • 0028098150 scopus 로고
    • Transmission of maternal blood cells to the fetus during pregnancy: detection in mouse neofnatal spleen by immunofluorescence flow cytometry and polymerase chain reaction
    • Shimamura M, Ohta S, Suzuki R, Yamazaki K. Transmission of maternal blood cells to the fetus during pregnancy: detection in mouse neofnatal spleen by immunofluorescence flow cytometry and polymerase chain reaction. Blood (1994) 83(4):926-30.
    • (1994) Blood , vol.83 , Issue.4 , pp. 926-930
    • Shimamura, M.1    Ohta, S.2    Suzuki, R.3    Yamazaki, K.4
  • 65
    • 0034534071 scopus 로고    scopus 로고
    • Two independent pathways of maternal cell transmission to offspring: through placenta during pregnancy and by breast-feeding after birth
    • Zhou L, Yoshimura Y, Huang Y, Suzuki R, Yokoyama M, Okabe M, et al. Two independent pathways of maternal cell transmission to offspring: through placenta during pregnancy and by breast-feeding after birth. Immunology (2000) 101(4):570-80. doi:10.1046/j.1365-2567.2000.00144.x
    • (2000) Immunology , vol.101 , Issue.4 , pp. 570-580
    • Zhou, L.1    Yoshimura, Y.2    Huang, Y.3    Suzuki, R.4    Yokoyama, M.5    Okabe, M.6
  • 66
    • 70449508554 scopus 로고    scopus 로고
    • Microchimerism is strongly correlated with tolerance to noninherited maternal antigens in mice
    • Dutta P, Molitor-Dart M, Bobadilla JL, Roenneburg DA, Yan Z, Torrealba JR, et al. Microchimerism is strongly correlated with tolerance to noninherited maternal antigens in mice. Blood (2009) 114(17):3578-87. doi:10.1182/blood-2009-03-213561
    • (2009) Blood , vol.114 , Issue.17 , pp. 3578-3587
    • Dutta, P.1    Molitor-Dart, M.2    Bobadilla, J.L.3    Roenneburg, D.A.4    Yan, Z.5    Torrealba, J.R.6
  • 68
    • 57349108583 scopus 로고    scopus 로고
    • Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero
    • Mold JE, Michaelsson J, Burt TD, Muench MO, Beckerman KP, Busch MP, et al. Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science (2008) 322(5907):1562-5. doi:10.1126/science.1164511
    • (2008) Science , vol.322 , Issue.5907 , pp. 1562-1565
    • Mold, J.E.1    Michaelsson, J.2    Burt, T.D.3    Muench, M.O.4    Beckerman, K.P.5    Busch, M.P.6
  • 69
    • 51649116464 scopus 로고    scopus 로고
    • 2 responses upon exposure to low doses of NIMA-like alloantigens
    • 2 responses upon exposure to low doses of NIMA-like alloantigens. Blood (2008) 112(4):1530-8. doi:10.1182/blood-2007-08-106500
    • (2008) Blood , vol.112 , Issue.4 , pp. 1530-1538
    • Opiela, S.J.1    Levy, R.B.2    Adkins, B.3
  • 71
    • 79954847193 scopus 로고    scopus 로고
    • Specific maternal microchimeric T cells targeting fetal antigens in beta cells predispose to auto-immune diabetes in the child
    • Roy E, Leduc M, Guegan S, Rachdi L, Kluger N, Scharfmann R, et al. Specific maternal microchimeric T cells targeting fetal antigens in beta cells predispose to auto-immune diabetes in the child. J Autoimmun (2010) 36(3-4):253-62. doi:10.1016/j.jaut.2011.02.003
    • (2010) J Autoimmun , vol.36 , Issue.3-4 , pp. 253-262
    • Roy, E.1    Leduc, M.2    Guegan, S.3    Rachdi, L.4    Kluger, N.5    Scharfmann, R.6
  • 72
    • 0034606359 scopus 로고    scopus 로고
    • Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
    • Breitfeld D, Ohl L, Kremmer E, Ellwart J, Sallusto F, Lipp M, et al. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med (2000) 192(11):1545-52. doi:10.1084/jem.192.11.1545
    • (2000) J Exp Med , vol.192 , Issue.11 , pp. 1545-1552
    • Breitfeld, D.1    Ohl, L.2    Kremmer, E.3    Ellwart, J.4    Sallusto, F.5    Lipp, M.6
  • 73
    • 0034606348 scopus 로고    scopus 로고
    • CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    • Schaerli P, Willimann K, Lang AB, Lipp M, Loetscher P, Moser B. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med (2000) 192(11):1553-62. doi:10.1084/jem.192.11.1553
    • (2000) J Exp Med , vol.192 , Issue.11 , pp. 1553-1562
    • Schaerli, P.1    Willimann, K.2    Lang, A.B.3    Lipp, M.4    Loetscher, P.5    Moser, B.6
  • 74
    • 79952675131 scopus 로고    scopus 로고
    • 4 T cells (TFH)
    • 4 T cells (TFH). Annu Rev Immunol (2011) 29:621-63. doi:10.1146/annurev-immunol-031210-101400
    • (2011) Annu Rev Immunol , vol.29 , pp. 621-663
    • Crotty, S.1
  • 75
    • 69249109601 scopus 로고    scopus 로고
    • Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
    • Johnston RJ, Poholek AC, DiToro D, Yusuf I, Eto D, Barnett B, et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science (2009) 325(5943):1006-10. doi:10.1126/science.1175870
    • (2009) Science , vol.325 , Issue.5943 , pp. 1006-1010
    • Johnston, R.J.1    Poholek, A.C.2    DiToro, D.3    Yusuf, I.4    Eto, D.5    Barnett, B.6
  • 76
  • 77
    • 70049101558 scopus 로고    scopus 로고
    • The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment
    • Yu D, Rao S, Tsai LM, Lee SK, He Y, Sutcliffe EL, et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity (2009) 31(3):457-68. doi:10.1016/j.immuni.2009.07.002
    • (2009) Immunity , vol.31 , Issue.3 , pp. 457-468
    • Yu, D.1    Rao, S.2    Tsai, L.M.3    Lee, S.K.4    He, Y.5    Sutcliffe, E.L.6
  • 78
    • 79959328032 scopus 로고    scopus 로고
    • ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6
    • Choi YS, Kageyama R, Eto D, Escobar TC, Johnston RJ, Monticelli L, et al. ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity (2011) 34(6):932-46. doi:10.1016/j.immuni.2011.03.023
    • (2011) Immunity , vol.34 , Issue.6 , pp. 932-946
    • Choi, Y.S.1    Kageyama, R.2    Eto, D.3    Escobar, T.C.4    Johnston, R.J.5    Monticelli, L.6
  • 79
    • 63849275584 scopus 로고    scopus 로고
    • Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities
    • Eddahri F, Denanglaire S, Bureau F, Spolski R, Leonard WJ, Leo O, et al. Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities. Blood (2009) 113(11):2426-33. doi:10.1182/blood-2008-04-154682
    • (2009) Blood , vol.113 , Issue.11 , pp. 2426-2433
    • Eddahri, F.1    Denanglaire, S.2    Bureau, F.3    Spolski, R.4    Leonard, W.J.5    Leo, O.6
  • 80
    • 46749151286 scopus 로고    scopus 로고
    • Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    • Nurieva RI, Chung Y, Hwang D, Yang XO, Kang HS, Ma L, et al. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity (2008) 29(1):138-49. doi:10.1016/j.immuni.2008.05.009
    • (2008) Immunity , vol.29 , Issue.1 , pp. 138-149
    • Nurieva, R.I.1    Chung, Y.2    Hwang, D.3    Yang, X.O.4    Kang, H.S.5    Ma, L.6
  • 81
    • 46749115446 scopus 로고    scopus 로고
    • A fundamental role for interleukin-21 in the generation of T follicular helper cells
    • Vogelzang A, McGuire HM, Yu D, Sprent J, Mackay CR, King C. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity (2008) 29(1):127-37. doi:10.1016/j.immuni.2008.06.001
    • (2008) Immunity , vol.29 , Issue.1 , pp. 127-137
    • Vogelzang, A.1    McGuire, H.M.2    Yu, D.3    Sprent, J.4    Mackay, C.R.5    King, C.6
  • 83
    • 84857398262 scopus 로고    scopus 로고
    • The 3' enhancer CNS2 is a critical regulator of interleukin-4-mediated humoral immunity in follicular helper T cells
    • Harada Y, Tanaka S, Motomura Y, Harada Y, Ohno S, Ohno S. The 3' enhancer CNS2 is a critical regulator of interleukin-4-mediated humoral immunity in follicular helper T cells. Immunity (2012) 36(2):188-200. doi:10.1016/j.immuni.2012.02.002
    • (2012) Immunity , vol.36 , Issue.2 , pp. 188-200
    • Harada, Y.1    Tanaka, S.2    Motomura, Y.3    Harada, Y.4    Ohno, S.5    Ohno, S.6
  • 84
    • 84863393256 scopus 로고    scopus 로고
    • Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V
    • Vijayanand P, Seumois G, Simpson LJ, Abdul-Wajid S, Baumjohann D, Panduro M, et al. Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V. Immunity (2012) 36(2):175-87. doi:10.1016/j.immuni.2011.12.014
    • (2012) Immunity , vol.36 , Issue.2 , pp. 175-187
    • Vijayanand, P.1    Seumois, G.2    Simpson, L.J.3    Abdul-Wajid, S.4    Baumjohann, D.5    Panduro, M.6
  • 85
    • 58449124804 scopus 로고    scopus 로고
    • The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
    • Bauquet AT, Jin H, Paterson AM, Mitsdoerffer M, Ho IC, Sharpe AH, et al. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat Immunol (2009) 10(2):167-75. doi:10.1038/ni.1690
    • (2009) Nat Immunol , vol.10 , Issue.2 , pp. 167-175
    • Bauquet, A.T.1    Jin, H.2    Paterson, A.M.3    Mitsdoerffer, M.4    Ho, I.C.5    Sharpe, A.H.6
  • 86
    • 84880663758 scopus 로고    scopus 로고
    • Neonatal follicular Th cell responses are impaired and modulated by IL-4
    • Debock I, Jaworski K, Chadlaoui H, Delbauve S, Passon N, Twyffels L, et al. Neonatal follicular Th cell responses are impaired and modulated by IL-4. J Immunol (2013) 191(3):1231-9. doi:10.4049/jimmunol.1203288
    • (2013) J Immunol , vol.191 , Issue.3 , pp. 1231-1239
    • Debock, I.1    Jaworski, K.2    Chadlaoui, H.3    Delbauve, S.4    Passon, N.5    Twyffels, L.6
  • 87
    • 84871157894 scopus 로고    scopus 로고
    • Environmental and T cell-intrinsic factors limit the expansion of neonatal follicular T helper cells but may be circumvented by specific adjuvants
    • Mastelic B, Kamath AT, Fontannaz P, Tougne C, Rochat AF, Belnoue E. Environmental and T cell-intrinsic factors limit the expansion of neonatal follicular T helper cells but may be circumvented by specific adjuvants. J Immunol (2012) 189(12):5764-72. doi:10.4049/jimmunol.1201143
    • (2012) J Immunol , vol.189 , Issue.12 , pp. 5764-5772
    • Mastelic, B.1    Kamath, A.T.2    Fontannaz, P.3    Tougne, C.4    Rochat, A.F.5    Belnoue, E.6
  • 88
    • 61349097791 scopus 로고    scopus 로고
    • B-cell responses to vaccination at the extremes of age
    • Siegrist CA, Aspinall R. B-cell responses to vaccination at the extremes of age. Nat Rev Immunol (2009) 9(3):185-94. doi:10.1038/nri2508
    • (2009) Nat Rev Immunol , vol.9 , Issue.3 , pp. 185-194
    • Siegrist, C.A.1    Aspinall, R.2
  • 89
    • 34548632594 scopus 로고    scopus 로고
    • Neonatal B cells suppress innate toll-like receptor immune responses and modulate alloimmunity
    • Walker WE, Goldstein DR. Neonatal B cells suppress innate toll-like receptor immune responses and modulate alloimmunity. J Immunol (2007) 179(3):1700-10. doi:10.4049/jimmunol.179.3.1700
    • (2007) J Immunol , vol.179 , Issue.3 , pp. 1700-1710
    • Walker, W.E.1    Goldstein, D.R.2
  • 90
    • 34249039859 scopus 로고    scopus 로고
    • Type I interferons protect neonates from acute inflammation through interleukin 10-producing B cells
    • Zhang X, Deriaud E, Jiao X, Braun D, Leclerc C, Lo-Man R. Type I interferons protect neonates from acute inflammation through interleukin 10-producing B cells. J Exp Med (2007) 204(5):1107-18. doi:10.1084/jem.20062013
    • (2007) J Exp Med , vol.204 , Issue.5 , pp. 1107-1118
    • Zhang, X.1    Deriaud, E.2    Jiao, X.3    Braun, D.4    Leclerc, C.5    Lo-Man, R.6
  • 91
    • 84859416933 scopus 로고    scopus 로고
    • Regulatory T cells: mechanisms of differentiation and function
    • Josefowicz SZ, Lu LF, Rudensky AY. Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol (2012) 30:531-64. doi:10.1146/annurev.immunol.25.022106.141623
    • (2012) Annu Rev Immunol , vol.30 , pp. 531-564
    • Josefowicz, S.Z.1    Lu, L.F.2    Rudensky, A.Y.3
  • 92
    • 84897954312 scopus 로고    scopus 로고
    • Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development
    • Liu X, Chen X, Zhong B, Wang A, Wang X, Chu F, et al. Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development. Nature (2014) 507(7493):513-8. doi:10.1038/nature12910
    • (2014) Nature , vol.507 , Issue.7493 , pp. 513-518
    • Liu, X.1    Chen, X.2    Zhong, B.3    Wang, A.4    Wang, X.5    Chu, F.6
  • 93
    • 84883396890 scopus 로고    scopus 로고
    • Notch signaling regulates follicular helper T cell differentiation
    • Auderset F, Schuster S, Fasnacht N, Coutaz M, Charmoy M, Koch U, et al. Notch signaling regulates follicular helper T cell differentiation. J Immunol (2013) 191(5):2344-50. doi:10.4049/jimmunol.1300643
    • (2013) J Immunol , vol.191 , Issue.5 , pp. 2344-2350
    • Auderset, F.1    Schuster, S.2    Fasnacht, N.3    Coutaz, M.4    Charmoy, M.5    Koch, U.6
  • 94
    • 84892546134 scopus 로고    scopus 로고
    • Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation
    • Goenka R, Matthews AH, Zhang B, O'Neill PJ, Scholz JL, Migone TS, et al. Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation. J Exp Med (2014) 211(1):45-56. doi:10.1084/jem.20130505
    • (2014) J Exp Med , vol.211 , Issue.1 , pp. 45-56
    • Goenka, R.1    Matthews, A.H.2    Zhang, B.3    O'Neill, P.J.4    Scholz, J.L.5    Migone, T.S.6
  • 95
    • 56349154943 scopus 로고    scopus 로고
    • Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
    • Veldhoen M, Uyttenhove C, van Snick J, Helmby H, Westendorf A, Buer J, et al. Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol (2008) 9(12):1341-6. doi:10.1038/ni.1659
    • (2008) Nat Immunol , vol.9 , Issue.12 , pp. 1341-1346
    • Veldhoen, M.1    Uyttenhove, C.2    van Snick, J.3    Helmby, H.4    Westendorf, A.5    Buer, J.6


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