Neonatal innate TLR-mediated responses are distinct from those of adults

Journal of Immunology

Volumn 183, Issue 11, 2009, Pages 7150-7160

  Kollmann, Tobias R ^a   Crabtree, Juliet ^b   Rein Weston, Annie ^b   Blimkie, Darren ^a   Thommai, Francis ^a   Wang, Xiu Yu ^a   Lavoie, Pascal M ^a   Furlong, Jeff ^b   Fortuno III, Edgardo S ^a   Hajjar, Adeline M ^b   Hawkins, Natalie R ^b   Self, Steven G ^b   Wilson, Christopher B ^b,c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 6; TOLL LIKE RECEPTOR; CYTOKINE;

ADULT; ARTICLE; CELLULAR PARAMETERS; CONTROLLED STUDY; CYTOKINE PRODUCTION; GROUPS BY AGE; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; INNATE IMMUNITY; INTRACELLULAR BACTERIUM; LEUKOCYTE FUNCTION; LIGAND BINDING; MONOCYTE; NEWBORN; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; TH1 CELL; TH17 CELL; TH2 CELL; BIOSYNTHESIS; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOLOGY; INFANT;

ADULT; CYTOKINES; DENDRITIC CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; IMMUNITY, INNATE; INFANT; INFANT, NEWBORN; MONOCYTES; TOLL-LIKE RECEPTORS;

EID: 73349130456     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0901481     Document Type: Article

References (44)

1. Klein, J. O., C. J. Baker, J. S. Remington, and C. B. Wilson. 2006. Current concepts of infections of the fetus and newborn infant. In Infectious Diseases of the Fetus and Newborn Infant, 6 Ed. J. O. Klein, J. S. Remington, C. B. Wilson, and C. J. Baker, ed. Elsevier Saunders, Philadelphia, pp. 1-24.
2. Lewis, D. B., and C. B. Wilson 2006. Developmental immunology and role of host defenses in fetal and neonatal susceptibility to infection. In Infectious Diseases of the Fetus and Newborn Infant, 6 Ed. J. O. Klein, Jack S Remington, Christopher B Wilson, Carol J Baker, ed. Elsevier Saunders, Philadelphia, pp. 25-138.
3. Levy, O. 2007. Innate immunity of the newborn: basic mechanisms and clinical correlates. Nat. Rev. Immunol. 7: 379-390.
4. Willems, F., S. Vollstedt, and M. Suter. 2009. Phenotype and function of neonatal DC. Eur. J. Immunol. 39: 26-35.
5. Joyner, J. L., N. H. Augustine, K. A. Taylor, T. R. La Pine, and H. R. Hill. 2000. Effects of group B streptococci on cord and adult mononuclear cell interleukin-12 and interferon-γ mRNA accumulation and protein secretion. J. Infect. Dis. 182: 974-977.
6. La Pine, T. R., J. L. Joyner, N. H. Augustine, S. D. Kwak, and H. R. Hill. 2003. Defective production of IL-18 and IL-12 by cord blood mononuclear cells influences the T helper-1 interferon γ response to group B Streptococci. Pediatr. Res. 54: 276-281.
7. Upham, J. W., P. T. Lee, B. J. Holt, T. Heaton, S. L. Prescott, M. J. Sharp, P. D. Sly, and P. G. Holt. 2002. Development of interleukin-12-producing capacity throughout childhood. Infect. Immun. 70: 6583-6588.
8. Lee, S. M., Y. Suen, L. Chang, V. Bruner, J. Qian, J. Indes, E. Knoppel, C. van de Ven, and M. S. Cairo. 1996. Decreased interleukin-12 (IL-12) from activated cord versus adult peripheral blood mononuclear cells and up-regulation of interferon-γ, natural killer, and lymphokine-activated killer activity by IL-12 in cord blood mononuclear cells. Blood 88: 945-954.
9. Drohan, L., J. J. Harding, B. Holm, E. Cordoba-Tongson, C. L. Dekker, T. Holmes, H. Maecker, and E. D. Mellins. 2004. Selective developmental defects of cord blood antigen-presenting cell subsets. Hum. Immunol. 65: 1356-1369. (Pubitemid 39535299)
10. De Wit, D., S. Tonon, V. Olislagers, S. Goriely, M. Boutriaux, M. Goldman, and F. Willems. 2003. Impaired responses to Toll-like receptor 4 and Toll-like receptor 3 ligands in human cord blood. J. Autoimmun. 21: 277-281. (Pubitemid 37410116)
11. De Wit, D., V. Olislagers, S. Goriely, F. Vermeulen, H. Wagner, M. Goldman, and F. Willems. 2004. Blood plasmacytoid dendritic cell responses to CpG oligodeoxynucleotides are impaired in human newborns. Blood 103: 1030-1032. (Pubitemid 38129567)
12. Seghaye, M. C., W. Heyl, R. G. Grabitz, K. Schumacher, G. von Bernuth, W. Rath, and J. Duchateau. 1998. The production of pro- and anti-inflammatory cytokines in neonates assessed by stimulated whole cord blood culture and by plasma levels at birth. Biol. Neonate 73: 220-227.
13. Jansen, K., D. Blimkie, J. Furlong, A. Hajjar, A. Rein-Weston, J. Crabtree, B. Reikie, C. Wilson, and T. Kollmann. 2008. Polychromatic flow cytometric high-throughput assay to analyze the innate immune response to Toll-like receptor stimulation. J. Immunol. Methods 336: 183-192.
14. Lee, J. A., J. Spidlen, K. Boyce, J. Cai, N. Crosbie, M. Dalphin, J. Furlong, M. Gasparetto, M. Goldberg, E. M. Goralczyk, et al. 2008. MIFlowCyt: the minimum information about a flow cytometry experiment. Cytometry A 73: 926-930.
15. Perfetto, S. P., D. Ambrozak, R. Nguyen, P. Chattopadhyay, and M. Roederer. 2006. Quality assurance for polychromatic flow cytometry. Nat Protoc. 1: 1522-1530.
16. Maecker, H. T., A. Rinfret, P. D'Souza, J. Darden, E. Roig, C. Landry, P. Hayes, J. Birungi, O. Anzala, M. Garcia, et al. 2005. Standardization of cytokine flow cytometry assays. BMC Immunol. 6: 13.
17. Storey, J. D., J. E. Taylor, and D. Siegmund. 2004. Strong control, conservative point estimation and simultaneous conservative consistency of false discovery rates: a unified approach. J. R. Statist. Soc. B. 66: 187-205.
18. Team, R. D. C. 2007. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria.
19. Miller, R. G. 1981. Simultaneous Statistical Inference. Springer Verlag, New York.
20. Aitchison, J. 1986. The Statistical Analysis of Compositional Data, Blackburn Press, Caldwell, NJ.
21. Romero, R., J. Espinoza, L. F. Goncalves, J. P. Kusanovic, L. A. Friel, and J. K. Nien. 2006. Inflammation in preterm and term labour and delivery. Semin Fetal Neonatal Med. 11: 317-326. (Pubitemid 44038705)
22. Marchini, G., V. Berggren, R. Djilali-Merzoug, and L. O. Hansson. 2000. The birth process initiates an acute phase reaction in the fetus-newborn infant. Acta Paediatr. 89: 1082-1086.
23. Schultz, C., C. Rott, P. Temming, P. Schlenke, J. C. Moller, and P. Bucsky. 2002. Enhanced interleukin-6 and interleukin-8 synthesis in term and preterm infants. Pediatr Res. 51: 317-322. (Pubitemid 34174967)
24. Maecker, H. T., and J. Trotter. 2006. Flow cytometry controls, instrument setup, and the determination of positivity. Cytometry A 69: 1037-1042.
25. Theofilopoulos, A. N., R. Baccala, B. Beutler, and D. H. Kono. 2005. Type I interferons (α/β) in immunity and autoimmunity. Annu. Rev. Immunol. 23: 307-336.
26. Goriely, S., B. Vincart, P. Stordeur, J. Vekemans, F. Willems, M. Goldman, and D. De Wit. 2001. Deficient IL-12(p35) gene expression by dendritic cells derived from neonatal monocytes. J. Immunol. 166: 2141-2146. (Pubitemid 32114705)
27. Goriely, S., C. Van Lint, R. Dadkhah, M. Libin, D. De Wit, D. Demonte, F. Willems, and M. Goldman. 2004. A defect in nucleosome remodeling prevents IL-12(p35) gene transcription in neonatal dendritic cells. J. Exp. Med. 199: 1011-1016. (Pubitemid 38481092)
28. Vanden Eijnden, S., S. Goriely, D. De Wit, M. Goldman, and F. Willems. 2006. Preferential production of the IL-12(p40)/IL-23(p19) heterodimer by dendritic cells from human newborns. Eur. J. Immunol. 36: 21-26.
29. Goriely, S., and M. Goldman. 2008. Interleukin-12 family members and the balance between rejection and tolerance. Curr. Opin. Organ Transplant. 13: 4-9.
30. Goriely, S., M. F. Neurath, and M. Goldman. 2008. How microorganisms tip the balance between interleukin-12 family members. Nat. Rev. Immunol. 8: 81-86.
31. Angelone, D. F., M. R. Wessels, M. Coughlin, E. E. Suter, P. Valentini, L. A. Kalish, and O. Levy. 2006. Innate immunity of the human newborn is polarized toward a high ratio of IL-6/TNF-α production in vitro and in vivo. Pediatr. Res. 60: 205-209.
32. Levy, O., E. E. Suter, R. L. Miller, and M. R. Wessels. 2006. Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells. Blood 108: 1284-1290. (Pubitemid 44232026)
33. Vanden Eijnden, S., S. Goriely, D. De Wit, F. Willems, and M. Goldman. 2005. IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naive T cells in human. Eur. J. Immunol. 35: 469-475.
34. Makedonas, G., and M. R. Betts. 2006. Polyfunctional analysis of human T cell responses: importance in vaccine immunogenicity and natural infection. Springer Semin. Immunopathol. 28: 209-219. (Pubitemid 44764277)
35. + T cells protect against high-level replication after liver transplantation. Am. J. Transplant. 8: 2590-2599.
36. Duvall, M. G., M. L. Precopio, D. A. Ambrozak, A. Jaye, A. J. McMichael, H. C. Whittle, M. Roederer, S. L. Rowland-Jones, and R. A. Koup. 2008. Polyfunctional T cell responses are a hallmark of HIV-2 infection. Eur. J. Immunol. 38: 350-363.
37. Sun, Y., S. Santra, J. E. Schmitz, M. Roederer, and N. L. Letvin. 2008. Magnitude and quality of vaccine-elicited T cell responses in the control of immunodefi-ciency virus replication in rhesus monkeys. J. Virol. 82: 8812-8819.
38. Ciuffreda, D., D. Comte, M. Cavassini, E. Giostra, L. Buhler, M. Perruchoud, M. H. Heim, M. Battegay, D. Genne, B. Mulhaupt, et al. 2008. Polyfunctional HCV-specific T cell responses are associated with effective control of HCV replication. Eur. J. Immunol. 38: 2665-2677.
39. Schakel, K., M. von Kietzell, A. Hansel, A. Ebling, L. Schulze, M. Haase, C. Semmler, M. Sarfati, A. N. Barclay, G. J. Randolph, et al. 2006. Human 6-sulfo LacNAc-expressing dendritic cells are principal producers of early interleukin-12 and are controlled by erythrocytes. Immunity 24: 767-777.
40. Levy, O., M. Coughlin, B. N. Cronstein, R. M. Roy, A. Desai, and M. R. Wessels. 2006. The adenosine system selectively inhibits TLR-mediated TNF-α production in the human newborn. J. Immunol. 177: 1956-1966. (Pubitemid 44092536)
41. Danis, B., T. C. George, S. Goriely, B. Dutta, J. Renneson, L. Gatto, P. Fitzgerald-Bocarsly, A. Marchant, M. Goldman, F. Willems, and D. De Wit. 2008. Interferon regulatory factor 7-mediated responses are defective in cord blood plasmacytoid dendritic cells. Eur. J. Immunol. 38: 507-517.
42. Aksoy, E., V. Albarani, M. Nguyen, J. F. Laes, J. L. Ruelle, D. De Wit, F. Willems, M. Goldman, and S. Goriely. 2007. Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells. Blood 109: 2887-2893. (Pubitemid 46482085)
43. Curtis, M. M., and S. S. Way. 2009. Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens. Immunology 126: 177-185.
44. Wilson, C. B., and T. R. Kollmann. 2008. Induction of antigen-specific immunity in human neonates and infants. Nestle Nutr. Workshop Ser. Pediatr. Program. 61: 183-195.