Adult-like anti-mycobacterial T cell and in vivo dendritic cell responses following neonatal immunization with Ag85B-ESAT-6 in the IC31® adjuvant

PLoS ONE

Volumn 3, Issue 11, 2008, Pages

  Kamath, Arun T ^a   Rochat, Anne Françoise ^a   Valenti, Mario P ^a   Agger, Else Marie ^b   Lingnau, Karen ^c   Andersen, Peter ^b   Lambert, Paul Henri ^a   Siegrist, Claire Anne ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b STATENS SERUM INSTITUT   (Denmark)

^c INTERCELL AG   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM POTASSIUM SULFATE; BACTERIAL PROTEIN; BCG VACCINE; CD40 ANTIGEN; CD86 ANTIGEN; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 12P40; INTERLEUKIN 2; TUMOR NECROSIS FACTOR ALPHA; ANTIGEN 85, MYCOBACTERIUM BOVIS; BACTERIAL ANTIGEN; BACTERIAL VACCINE; ESAT 6 PROTEIN, MYCOBACTERIUM TUBERCULOSIS; ESAT-6 PROTEIN, MYCOBACTERIUM TUBERCULOSIS; HYBRID PROTEIN; UNCLASSIFIED DRUG;

AGE DISTRIBUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTIMICROBIAL ACTIVITY; ARTICLE; CD4+ T LYMPHOCYTE; CELL ACTIVATION; CELL POPULATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG FORMULATION; DRUG TARGETING; IMMUNIZATION; IMMUNOGENICITY; IN VIVO STUDY; MOUSE; MYCOBACTERIOSIS; MYCOBACTERIUM BOVIS; NEWBORN PERIOD; NONHUMAN; PROTEIN EXPRESSION; T LYMPHOCYTE; ANIMAL; C57BL MOUSE; IMMUNOLOGY; METABOLISM; NEWBORN; TUBERCULOSIS;

BACTERIA (MICROORGANISMS); MURINAE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANIMALS, NEWBORN; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BACTERIAL VACCINES; DENDRITIC CELLS; MICE; MICE, INBRED C57BL; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES; TUBERCULOSIS;

EID: 58149235337     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0003683     Document Type: Article

References (45)

1. Hoft DF (2008) Tuberculosis vaccine development: goals, immunological design, and evaluation. Lancet 372: 164-175.
2. Baumann S, Nasser Eddine A, Kaufmann SH (2006) Progress in tuberculosis vaccine development. Curr Opin Immunol 18: 438-448.
3. Flynn JL (2004) Immunology of tuberculosis and implications in vaccine development. Tuberculosis (Edinb) 84: 93-101.
4. de Jong R, Altare F, Haagen IA, Elferink DG, Boer T, et al. (1998) Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients. Science 280: 1435-1438.
5. Remus N, Reichenbach J, Picard C, Rietschel C, Wood P, et al. (2001) Impaired interferon gamma-mediated immunity and susceptibility to mycobacterial infection in childhood. Pediatr Res 50: 8-13.
6. Winthrop KL (2006) Risk and prevention of tuberculosis and other serious opportunistic infections associated with the inhibition of tumor necrosis factor. Nat Clin Pract Rheumatol 2: 602-610.
7. Darrah PA, Patel DT, De Luca PM, Lindsay RW, Davey DF, et al. (2007) Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nat Med 13: 843-850.
8. Duvall MG, Precopio ML, Ambrozak DA, Jaye A, McMichael AJ, et al. (2008) Polyfunctional T cell responses are a hallmark of HIV-2 infection. Eur J Immunol 38: 350-363.
9. Mandalakas AM, Starke JR (2005) Current concepts of childhood tuberculosis. Semin Pediatr Infect Dis 16: 93-104.
10. Trunz BB, Fine P, Dye C (2006) Effect of BCG vaccination on childhood tuberculous meningitis and miliary tuberculosis worldwide: a meta-analysis and assessment of cost-effectiveness. Lancet 367: 1173-1180.
11. Vekemans J, Amedei A, Ota MO, D'Elios MM, Goetghebuer T, et al. (2001) Neonatal bacillus Calmette-Guerin vaccination induces adult-like IFN-gamma production by CD4+ T lymphocytes. Eur J Immunol 31: 1531-1535.
12. Miles DJ, van der Sande M, Crozier S, Ojuola O, Palmero MS, et al. (2008) Effects of antenatal and postnatal environments on CD4 T-cell responses to Mycobacterium bovis BCG in healthy infants in the Gambia. Clin Vaccine Immunol 15: 995-1002.
13. Ota MO, Vekemans J, Schlegel-Haueter SE, Fielding K, Sanneh M, et al. (2002) Influence of Mycobacterium bovis bacillus Calmette-Guerin on antibody and cytokine responses to human neonatal vaccination. J Immunol 168: 919-925.
14. Soares AP, Scriba TJ, Joseph S, Harbacheuski R, Murray RA, et al. (2008) Bacillus Calmette-Guerin vaccination of human newborns induces T cells with complex cytokine and phenotypic profiles. J Immunol 180: 3569-3577.
15. Scriba TJ, Kalsdorf B, Abrahams DA, Isaacs F, Hofmeister J, et al. (2008) Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response. J Immunol 180: 1962-1970.
16. Siegrist CA (2000) Vaccination in the neonatal period and early infancy. Int Rev Immunol 19: 195-219.
17. Roduit C, Bozzotti P, Mielcarek N, Lambert PH, del Giudice G, et al. (2002) Immunogenicity and protective efficacy of neonatal vaccination against Bordetella pertussis in a murine model: evidence for early control of pertussis. Infect Immun 70: 3521-3528.
18. Adkins B, Leclerc C, Marshall-Clarke S (2004) Neonatal adaptive immunity comes of age. Nat Rev Immunol 4: 553-564.
19. Knuf M, Schmitt HJ, Wolter J, Schuerman L, Jacquet JM, et al. (2008) Neonatal vaccination with an acellular pertussis vaccine accelerates the acquisition of pertussis antibodies in infants. J Pediatr 152: 655-660, 660 e651.
20. Levy O (2007) Innate immunity of the newborn: basic mechanisms and clinical correlates. Nat Rev Immunol 7: 379-390.
21. Barrios C, Brandt C, Berney M, Lambert PH, Siegrist CA (1996) Partial correction of the TH2/TH1 imbalance in neonatal murine responses to vaccine antigens through selective adjuvant effects. Eur J Immunol 26: 2666-2670.
22. Barrios C, Brawand P, Berney M, Brandt C, Lambert PH, et al. (1996) Neonatal and early life immune responses to various forms of vaccine antigens qualitatively differ from adult responses: predominance of a Th2-biased pattern which persists after adult boosting. Eur J Immunol 26: 1489-1496.
23. Weeratna RD, Brazolot Millan CL, McCluskie MJ, Davis HL (2001) CpG ODN can re-direct the Th bias of established Th2 immune responses in adult and young mice. FEMS Immunol Med Microbiol 32: 65-71.
24. Dadaglio G, Sun CM, Lo-Man R, Siegrist CA, Leclerc C (2002) Efficient in vivo priming of specific cytotoxic T cell responses by neonatal dendritic cells. J Immunol 168: 2219-2224.
25. Regner M, Martinez X, Belnoue E, Sun CM, Boisgerault F, et al. (2004) Partial activation of neonatal CD11c+ dendritic cells and induction of adult-like CD8+ cytotoxic T cell responses by synthetic microspheres. J Immunol 173: 2669-2674.
26. Schellack C, Prinz K, Egyed A, Fritz JH, Wittmann B, et al. (2006) IC31, a novel adjuvant signaling via TLR9, induces potent cellular and humoral immune responses. Vaccine 24: 5461-5472.
27. Riedl K, Riedl R, von Gabain A, Nagy E, Lingnau K (2008) The novel adjuvant IC31 strongly improves influenza vaccine-specific cellular and humoral immune responses in young adult and aged mice. Vaccine 26: 3461-3468.
28. Weinrich Olsen A, van Pinxteren LA, Meng Okkels L, Birk Rasmussen P, Andersen P (2001) Protection of mice with a tuberculosis subunit vaccine based on a fusion protein of antigen 85b and esat-6. Infect Immun 69: 2773-2778.
29. Agger EM, Rosenkrands I, Olsen AW, Hatch G, Williams A, et al. (2006) Protective immunity to tuberculosis with Ag85B-ESAT-6 in a synthetic cationic adjuvant system IC31. Vaccine 24: 5452-5460.
30. Andersen P (2007) Tuberculosis vaccines - an update. Nat Rev Microbiol 5: 484-487.
31. Kamath AT, Valenti MP, Rochat AF, Agger EM, Lingnau K, et al. (2008) Protective anti-mycobacterial T cell responses through exquisite in vivo activation of vaccine-targeted dendritic cells. Eur J Immunol 38: 1247-1256.
32. Siegrist CA (2001) Neonatal and early life vaccinology. Vaccine 19: 3331-3346.
33. Siegrist CA (2007) The challenges of vaccine responses in early life: selected examples. J Comp Pathol 137 Suppl 1: S4-9.
34. Kovarik J, Martinez X, Pihlgren M, Bozzotti P, Tao MH, et al. (2000) Limitations of in vivo IL-12 supplementation strategies to induce Th1 early life responses to model viral and bacterial vaccine antigens. Virology 268: 122-131.
35. Lanzavecchia A, Sallusto F (2001) The instructive role of dendritic cells on T cell responses: lineages, plasticity and kinetics. Curr Opin Immunol 13: 291-298.
36. Reis e Sousa C (2006) Dendritic cells in a mature age. Nat Rev Immunol 6: 476-483.
37. Sun CM, Fiette L, Tanguy M, Leclerc C, Lo-Man R (2003) Ontogeny and innate properties of neonatal dendritic cells. Blood 102: 585-591.
38. Dakic A, Shao QX, D'Amico A, O'Keeffe M, Chen WF, et al. (2004) Development of the dendritic cell system during mouse ontogeny. J Immunol 172: 1018-1027.
39. Angelone DF, Wessels MR, Coughlin M, Suter EE, Valentini P, et al. (2006) Innate immunity of the human newborn is polarized toward a high ratio of IL-6/TNF-alpha production in vitro and in vivo. Pediatr Res 60: 205-209.
40. Brazolot Millan CL, Weeratna R, Krieg AM, Siegrist CA, Davis HL (1998) CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice. Proc Natl Acad Sci U S A 95: 15553-15558.
41. Kovarik J, Bozzotti P, Tougne C, Davis HL, Lambert PH, et al. (2001) Adjuvant effects of CpG oligodeoxynucleotides on responses against T-independent type 2 antigens. Immunology 102: 67-76.
42. Ito S, Ishii KJ, Gursel M, Shirotra H, Ihata A, et al. (2005) CpG oligodeoxynucleotides enhance neonatal resistance to Listeria infection. J Immunol 174: 777-782.
43. Gold MC, Donnelly E, Cook MS, Leclair CM, Lewinsohn DA (2006) Purified neonatal plasmacytoid dendritic cells overcome intrinsic maturation defect with TLR agonist stimulation. Pediatr Res 60: 34-37.
44. Gillis S, Ferm MM, Ou W, Smith KA (1978) T cell growth factor: parameters of production and a quantitative microassay for activity. J Immunol 120: 2027-2032.
45. Martinez X, Regner M, Kovarik J, Zarei S, Hauser C, et al. (2003) CD4-independent protective cytotoxic T cells induced in early life by a non-replicative delivery system based on virus-like particles. Virology 305: 428-435.