Plasmodium falciparum infection of the placenta impacts on the T helper type 1 (Th1)/Th2 balance of neonatal T cells through CD4 +CD25 + forkhead box P3 + regulatory T cells and interleukin-10

Clinical and Experimental Immunology

Volumn 158, Issue 3, 2009, Pages 287-293

  Bisseye, C ^a,c   Van Der Sande, M ^a,d   Morgan, W D ^b   Holder, A A ^b   Pinder, M ^a   Ismaili, J ^a,e  

^a MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^c BFA   (Burkina Faso)

^d NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^e INSTITUT DE BIOLOGIE DE LILLE   (France)

Author keywords

CBMC; Placental malaria; T regs; Th1 Th2

Indexed keywords

CD30 ANTIGEN; CELL MARKER; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 10 ANTIBODY; MEROZOITE SURFACE PROTEIN 1; PHYTOHEMAGGLUTININ; TRANSCRIPTION FACTOR FOXP3;

ADULT; AGED; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IMMUNE DYSREGULATION; IN VITRO STUDY; INTERFERON PRODUCTION; LYMPHOCYTE DEPLETION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; MALARIA FALCIPARUM; MONONUCLEAR CELL; NONHUMAN; PARASITE CULTIVATION; PARASITISM; PLACENTA; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SCHIZONT; STIMULUS RESPONSE; TH1 CELL; TH2 CELL; UMBILICAL CORD BLOOD;

ANTIGENS, PROTOZOAN; CELLS, CULTURED; FEMALE; FETAL BLOOD; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INFANT, NEWBORN; INTERFERON-GAMMA; INTERLEUKIN-10; MALARIA, FALCIPARUM; PLACENTA DISEASES; PLASMODIUM FALCIPARUM; PREGNANCY; PREGNANCY COMPLICATIONS, PARASITIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TH2 CELLS;

EID: 70350614503     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2009.04014.x     Document Type: Article

References (18)

1. Snow RW, Guerra CA, Noor AM, Myint HY, Hay SI. The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature 2005 434 : 214 217.
2. Okoko BJ, Ota MO, Yamuah LK et al. Influence of placental malaria infection on foetal outcome in The Gambia: twenty years after Ian McGregor. J Health Popul Nutr 2002 20 : 4 11.
3. McGregor IA, Wilson ME, Billewicz WZ. Malaria infection of the placenta in The Gambia, West Africa; its incidence and relationship to stillbirth, birth weight and placental weight. Trans R Soc Trop Med Hyg 1983 77 : 232 244.
4. Ismaili J, Van der Sande M, Holland MJ et al. Plasmodium falciparum infection of the placenta affects newborn immune responses. Clin Exp Immunol 2003 133 : 414 421.
5. Walther M, Tongren JE, Andrews L et al. Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria. Infect Immun 2005 23 : 287 296.
6. Hisaeda H, Maekawa Y, Iwakawa D et al. Escape of malaria parasites from host immunity requires CD4+ CD25+ regulatory T cells. Nat Med 2004 10 : 29 30.
7. Brustoski K, Moller U, Kramer M et al. Reduced cord blood immune effector-cell responsiveness mediated by CD4+ cells induced in utero as a consequence of placental Plasmodium falciparum infection. J Infect Dis 2006 193 : 146 154.
8. Greenwood BM, Amstrong JRM. Comparison of two simple methods for determining malaria parasite density. Trans R Soc Trop Med Hyg 1991 85 : 186 188.
9. Gardner JP, Pinches RA, Roberts DJ et al. Variant antigens and endothelial receptor adhesion in Plasmodium falciparum. Proc Natl Acad Sci USA 1996 93 : 3503 3508.
10. Lambros C, Vanderberg JP. Synchronization of Plasmodium falciparum erythrocytic stages in culture. J Parasitol 1979 65 : 418 420.
11. Pasvol G, Wilson RJ, Smalley ME et al. Separation of viable schizont-infected red cells of Plasmodium falciparum from human blood. Ann Trop Med Parasitol 1978 72 : 87 8.
12. Freeman RR, Holder AA. Surface antigens of malaria merozoites A high molecular weight precursor is processed to an 83,000 mol wt form expressed on the surface of Plasmodium falciparum merozoites. J Exp Med 1983 158 : 1647 1653.
13. Morgan WDB, Birdsall TA, Frenkiel MG et al. Solution structure of an EGF module pair from the Plasmodium falciparum merozoite surface protein 1. J Mol Biol 1999 289 : 113 122.
14. Malhotra AN, Wamachi PL, Mungai EM et al. Fine specificity of neonatal lymphocytes to an abundant malaria blood-stage antigen: epitope mapping of Plasmodium falciparum MSP133. J Immunol 2008 180 : 3383 3390.
15. Goriely S, Vincart B, Stordeur P et al. Deficient IL-12 (p35) gene expression by dendritic cells derived from neonatal monocytes. J Immunol 2001 166 : 2141 2146.
16. Urban BC, Ferguson DJ, Pain A et al. Plasmodium falciparum-infected erythrocytes modulate the maturation of dendritic cells. Nature 1999 400 : 73 7.
17. Jeff EM, Jakob M, Trevor D et al. Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science 2008 322 : 1562 1565.
18. Peng JC, Abu Bakar S, Richardson MM et al. IL-10 and IL-12B polymorphisms each influence IL-12p70 secretion by dendritic cells in response to LPS. Immunol Cell Biol 2006 84 : 227 232.