Induction of protective CTL responses in newborn mice by a murine retrovirus

Science

Volumn 271, Issue 5256, 1996, Pages 1726-1728

  Sarzotti, Marcelle ^a,b   Robbins, Deanna S ^a,b   Hoffman, Paul M ^a,b  

^a BALTIMORE VA MEDICAL CENTER   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE;

ANIMAL EXPERIMENT; ARTICLE; CYTOTOXIC T LYMPHOCYTE; MOUSE; MURINE LEUKEMIA VIRUS; NEWBORN; NEWBORN INFECTION; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS INFECTION; VIRUS IMMUNITY;

ANIMALIA; MURINAE; MURINE LEUKEMIA VIRUS; UNIDENTIFIED RETROVIRUS;

EID: 0030012251     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.271.5256.1726     Document Type: Article

References (48)

1. P G Spear and G. Edelman, J Exp. Med. 139, 249 (1974); D E. Mosier and B. M. Johnson, ibid 141, 216 (1975).
2. P G Spear and G. Edelman, J Exp. Med. 139, 249 (1974); D E. Mosier and B. M. Johnson, ibid 141, 216 (1975).
3. C. Y. Lu, D I Beller, E. Unanue, Proc. Natl. Acad. Sci U S A 77, 1597 (1980)
4. B Adkins, A. Ghanai, K Hamilton, J. Immunol 153, 3378 (1994)
5. L M Pilarski, J Exp. Med 146, 887 (1977).
6. M B Gardner et al , J Natl Cancer Inst 51, 1243 (1973)
7. W. P Rowe, W E. Pugh, J. W Hartley, Virology 42, 1136 (1970).
8. P M Hoffman, S K. Ruscetti, H C. Morse III, J Neuroimmunol 1, 275 (1981)
9. P. M Hoffman, D S. Robbins, H C. Morse III, J. Virol 52, 734 (1984); D S Robbins and P M. Hoffman, J. Neuroimmunol. 31, 9 (1991), P M Hoffman, E F Cimino, D S. Robbins, ibid. 33, 157 (1991)
10. P. M Hoffman, D S. Robbins, H C. Morse III, J. Virol 52, 734 (1984); D S Robbins and P M. Hoffman, J. Neuroimmunol. 31, 9 (1991), P M Hoffman, E F Cimino, D S. Robbins, ibid. 33, 157 (1991)
11. P. M Hoffman, D S. Robbins, H C. Morse III, J. Virol 52, 734 (1984); D S Robbins and P M. Hoffman, J. Neuroimmunol. 31, 9 (1991), P M Hoffman, E F Cimino, D S. Robbins, ibid. 33, 157 (1991)
12. M Sarzotti, D. S. Robbins, P M Hoffman, Viral Immunol. 6, 207 (1993).
13. J. A Byrne and M. B. A Oldstone, J. Virol. 51, 682 (1984), A E. Lukacher, V L Braciale, T J Braciale, J Exp. Med. 160, 814 (1984); B. D. Jamieson and R Ahmed, Proc. Natl Acad Sci U S A. 85, 2265 (1988); D Moskophidis, F. Lechner, H. Pircher, R M. Zinkernagel. Nature 362, 758 (1993).
14. J. A Byrne and M. B. A Oldstone, J. Virol. 51, 682 (1984), A E. Lukacher, V L Braciale, T J Braciale, J Exp. Med. 160, 814 (1984); B. D. Jamieson and R Ahmed, Proc. Natl Acad Sci U S A. 85, 2265 (1988); D Moskophidis, F. Lechner, H. Pircher, R M. Zinkernagel. Nature 362, 758 (1993).
15. J. A Byrne and M. B. A Oldstone, J. Virol. 51, 682 (1984), A E. Lukacher, V L Braciale, T J Braciale, J Exp. Med. 160, 814 (1984); B. D. Jamieson and R Ahmed, Proc. Natl Acad Sci U S A. 85, 2265 (1988); D Moskophidis, F. Lechner, H. Pircher, R M. Zinkernagel. Nature 362, 758 (1993).
16. J. A Byrne and M. B. A Oldstone, J. Virol. 51, 682 (1984), A E. Lukacher, V L Braciale, T J Braciale, J Exp. Med. 160, 814 (1984); B. D. Jamieson and R Ahmed, Proc. Natl Acad Sci U S A. 85, 2265 (1988); D Moskophidis, F. Lechner, H. Pircher, R M. Zinkernagel. Nature 362, 758 (1993).
17. P.-F. Piguet, C Irle, E. Kollatte, P. Vassalli, J Exp Med 154, 581 (1981).
18. A Oliff, S. Ruscetti, E C Douglass, E Scolnick, Blood 58, 244 (1981)
19. The cytotoxic response of mice primed with 0 3 PFU of Cas was high when tested against Cas-infected NS467 cells [85 ± 2% cytotoxicity at an effector/target (E/T) ratio of 20 1], but remained at background amounts when tested against the other targets (8 ± 2 against TP-3, 15 ± 1 against EL-4; 26 ± 4 against YAC-1 ; E/T ratio, 20:1) (mean ± SE of three to seven individually tested mice) Cytotoxic activity in splenocytes from sham-inoculated mice that were cultured in vitro with Cas-infected cells was uniformly low against all targets (14 ± 4 against NS467, 6 ± 2 against TP-3, 11 = 3 against EL-4, 23 ± 2 against YAC-1), The specificity and efficacy of the CTL response from newborn mice were the same as in adult mice (8, 17)
20. D S Robbins, M P Remington, M. Sarzotti, D St Louis P M Hoffman, J Virol. 69, 6847 (1995)
21. + population
22. M Sarzotti, D S Robbins, P M Hoffman, unpublished results
23. M. Sarzotti T A Dean, M Remington, P M Hoffman, AIDS Res Hum Retroviruses 10, 1695 (1994)
24. C R Parish Transplant Rev 13, 35 (1972). P A Bretscher G Wei, J N Menon, H Bieleteldt - Ohmann, Science 257, 539 (1992); C. Pfeiffer, J Murray, J Madri, K Bottomly, Immunol Rev 123, 65 (1991); N. A Hosken et al., J. Exp Med 182, 1579 (1995).
25. C R Parish Transplant Rev 13, 35 (1972). P A Bretscher G Wei, J N Menon, H Bieleteldt - Ohmann, Science 257, 539 (1992); C. Pfeiffer, J Murray, J Madri, K Bottomly, Immunol Rev 123, 65 (1991); N. A Hosken et al., J. Exp Med 182, 1579 (1995).
26. C R Parish Transplant Rev 13, 35 (1972). P A Bretscher G Wei, J N Menon, H Bieleteldt - Ohmann, Science 257, 539 (1992); C. Pfeiffer, J Murray, J Madri, K Bottomly, Immunol Rev 123, 65 (1991); N. A Hosken et al., J. Exp Med 182, 1579 (1995).
27. C R Parish Transplant Rev 13, 35 (1972). P A Bretscher G Wei, J N Menon, H Bieleteldt - Ohmann, Science 257, 539 (1992); C. Pfeiffer, J Murray, J Madri, K Bottomly, Immunol Rev 123, 65 (1991); N. A Hosken et al., J. Exp Med 182, 1579 (1995).
28. T. R. Mosmann and R L Coffman, Annu Rev. Immunol 7, 145 (1989)
29. T. J Powell Jr and J W. Streilein, J Immunol 144, 854 (1990); N. Chen and E H. Field, Transplantation 59, 933 (1995)
30. T. J Powell Jr and J W. Streilein, J Immunol 144, 854 (1990); N. Chen and E H. Field, Transplantation 59, 933 (1995)
31. F. P. Heinzel, M. D. Sadick, B. J. Holaday, R L. Coffman, R. M. Locksley, J. Exp. Med 169, 59 (1989); A. Sher et al., Immunol Rev. 127, 183 (1992), S. Schurmans et al., J Immunol 145, 2465 (1990).
32. F. P. Heinzel, M. D. Sadick, B. J. Holaday, R L. Coffman, R. M. Locksley, J. Exp. Med 169, 59 (1989); A. Sher et al., Immunol Rev. 127, 183 (1992), S. Schurmans et al., J Immunol 145, 2465 (1990).
33. F. P. Heinzel, M. D. Sadick, B. J. Holaday, R L. Coffman, R. M. Locksley, J. Exp. Med 169, 59 (1989); A. Sher et al., Immunol Rev. 127, 183 (1992), S. Schurmans et al., J Immunol 145, 2465 (1990).
34. + T cells. 419 ± 98 cpm, as measured with the CT.4S proliferation assay).
35. J. K. Actor et al , Proc Natl Acad Sci U.S.A. 90, 948 (1993).
36. R Zamoyska, H. Waldmann, P Matzinger, Eur. J. Immunol 19, 111 (1989)
37. M Sarzotti and D S. Robbins, in Modern Approaches to New Vaccines Including Prevention of AIDS, R M Chanock, H. S. Ginsberg, F Brown, R. A. Lerner, Eds (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1991), pp. 355-358
38. E J Fuchs and P Matzinger, Science 258, 1156 (1992); P. Matzinger, Annu Rev. Immunol. 12, 991 (1994); J P Ridge, E J. Fuchs, P. Matzinger, Science 271, 1723 (1996).
39. E J Fuchs and P Matzinger, Science 258, 1156 (1992); P. Matzinger, Annu Rev. Immunol. 12, 991 (1994); J P Ridge, E J. Fuchs, P. Matzinger, Science 271, 1723 (1996).
40. E J Fuchs and P Matzinger, Science 258, 1156 (1992); P. Matzinger, Annu Rev. Immunol. 12, 991 (1994); J P Ridge, E J. Fuchs, P. Matzinger, Science 271, 1723 (1996).
41. K. J Lafferty and A. Cunningham, Aust J Exp. Biol Med Sci 53, 27 (1975), G. R Often and R. N. Germain, Science 251, 1228 (1991); K. J. Lafferty, S. K Babcock, R. G. Gill, Prog Clin. Biol. Res. 224, 87 (1986); M. K. Jenkins and R H. Schwarte, J Exp Med. 165, 302 (1987); V. K. Kuchroo et al , Cell 80, 707 (1995).
42. K. J Lafferty and A. Cunningham, Aust J Exp. Biol Med Sci 53, 27 (1975), G. R Often and R. N. Germain, Science 251, 1228 (1991); K. J. Lafferty, S. K Babcock, R. G. Gill, Prog Clin. Biol. Res. 224, 87 (1986); M. K. Jenkins and R H. Schwarte, J Exp Med. 165, 302 (1987); V. K. Kuchroo et al , Cell 80, 707 (1995).
43. K. J Lafferty and A. Cunningham, Aust J Exp. Biol Med Sci 53, 27 (1975), G. R Often and R. N. Germain, Science 251, 1228 (1991); K. J. Lafferty, S. K Babcock, R. G. Gill, Prog Clin. Biol. Res. 224, 87 (1986); M. K. Jenkins and R H. Schwarte, J Exp Med. 165, 302 (1987); V. K. Kuchroo et al , Cell 80, 707 (1995).
44. K. J Lafferty and A. Cunningham, Aust J Exp. Biol Med Sci 53, 27 (1975), G. R Often and R. N. Germain, Science 251, 1228 (1991); K. J. Lafferty, S. K Babcock, R. G. Gill, Prog Clin. Biol. Res. 224, 87 (1986); M. K. Jenkins and R H. Schwarte, J Exp Med. 165, 302 (1987); V. K. Kuchroo et al , Cell 80, 707 (1995).
45. K. J Lafferty and A. Cunningham, Aust J Exp. Biol Med Sci 53, 27 (1975), G. R Often and R. N. Germain, Science 251, 1228 (1991); K. J. Lafferty, S. K Babcock, R. G. Gill, Prog Clin. Biol. Res. 224, 87 (1986); M. K. Jenkins and R H. Schwarte, J Exp Med. 165, 302 (1987); V. K. Kuchroo et al , Cell 80, 707 (1995).
46. 5) were cocultured for 5 days in each well of 24-well tissue culture plates in Eagle's minimal essential medium, 10% fetal bovine serum, antibiotics, 2-mercaptoethanol, and L-glutamine (8, 9, 14, 17). The cytotoxicity of the responder cells against uninfected syngeneic concanavalin A blasts was <15% and was omitted for clanty
47. J. HU-Li, J. Ohara, C. Watyson, W. Tsang, W. E Paul, J Immunol. 142, 800 (1989).
48. We thank T. A Dean and R Germain for excellent assistance; M. Sztein for cell sorting, C. Via for the CT 4S cell line; P Matzinger and A. O'Garra for sharing their unpublished data; and G. Kelsoe for critically reading the manuscript. Supported by grants from the Medical Research Service, Department of Veterans Affairs, and by the Bressler Research Fund, University of Maryland at Baltimore (to M.S.).