Defective TH17 development in human neonatal T cells involves reduced RORC2 mRNA content

Journal of Allergy and Clinical Immunology

Volumn 132, Issue 3, 2013, Pages

  De Roock, Sytze ^a   Stoppelenburg, Arie J ^a   Scholman, Rianne ^a   Hoeks, Sanne B E A ^a   Meerding, Jenny ^a   Prakken, Berent J ^a   Boes, Marianne ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD161 ANTIGEN; CELL RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 21; INTERLEUKIN 22; INTERLEUKIN 23; INTERLEUKIN 6; MESSENGER RNA; RETINOID ACID RELATED ORPHAN RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; CYTOKINE; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; RETINOID RELATED ORPHAN RECEPTOR GAMMA; RORC PROTEIN, HUMAN;

ALLERGY; ANTIGEN PRESENTING CELL; CD4+ T LYMPHOCYTE; CELL CULTURE; CELL MATURATION; CYTOKINE PRODUCTION; DOWN REGULATION; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; IMMUNE SYSTEM; IMMUNITY; INFLAMMATION; LETTER; MEMORY T LYMPHOCYTE; NEONATAL T CELL; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REGULATORY T LYMPHOCYTE; STEM CELL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH17 CELL; UMBILICAL CORD BLOOD; UPREGULATION; ADULT; CYTOLOGY; FETUS BLOOD; GENETICS; IMMUNOLOGY; METABOLISM; NEWBORN;

ADULT; CYTOKINES; FETAL BLOOD; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INFANT, NEWBORN; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; RNA, MESSENGER; T-LYMPHOCYTES, REGULATORY; TH17 CELLS; YOUNG ADULT;

EID: 84883236749     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.04.014     Document Type: Article

References (10)

1. B. Schaub, J. Liu, I. Schleich, S. Höppler, C. Sattler, and E. Von Mutius Impairment of T helper and T regulatory cell responses at birth Allergy 63 2008 1438
2. M.E. Belderbos, G.M. van Bleek, O. Levy, M.O. Blanken, M.L. Houben, and L. Schuijff Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life Clin Immunol 133 2009 228 237
3. G. Wang, Y. Miyahara, Z. Guo, M. Khattar, S.M. Stepkowski, and W. Chen "Default"generation of neonatal regulatory T cells J Immunol 185 2010 71 78
4. S. de Roock, S.B.E.A. Hoeks, L. Meurs, A. Steur, M.O. Hoekstra, and B.J. Prakken Critical role for programmed death 1 signaling and protein kinase B in augmented regulatory T-cell induction in cord blood J Allergy Clin Immunol 128 2011 1369
5. E. Bettelli, Y. Carrier, W. Gao, T. Korn, T.B. Strom, and M. Oukka Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells Nature 441 2006 235
6. A. Nitsche, M. Zhang, T. Clauss, W. Siegert, K. Brune, and A. Pahl Cytokine profiles of cord and adult blood leukocytes: differences in expression are due to differences in expression and activation of transcription factors BMC Immunol 8 2007 18
7. + T cell precursor J Exp Med 205 2008 1903 1916
8. A.J. van Beelen, Z. Zelinkova, E.W. Taanman-Kueter, F.J. Muller, D.W. Hommes, and S.A.J. Zaat Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells Immunity 27 2007 660
9. + T helper cells Cell 126 2006 1121
10. D. Unutmaz RORC2: the master of human Th17 cell programming Eur J Immunol 39 2009 1452