IL-12 prevents neonatal induction of transplantation tolerance in mice

European Journal of Immunology

Volumn 28, Issue 4, 1998, Pages 1426-1430

  Donckier, Vincent ^a   Flamand, Véronique ^a   Desalle, Fabrice ^a   Vanderhaeghen, Marie Line ^a   De Veerman, Marijke ^a   Thielemans, Kris ^a   Abramowicz, Daniel ^b   Goldman, Michel ^a,c  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^c ERASME HOSPITAL   (Belgium)

Author keywords

IL 12; Newborn; Th2; Tolerance; Transplantation

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 2; CYTOKINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; IMMUNOLOGICAL TOLERANCE; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SKIN GRAFT; SPLEEN CELL; T LYMPHOCYTE; ALLOTRANSPLANTATION; ANIMAL; BAGG ALBINO MOUSE; CELL TRANSPLANTATION; GRAFT SURVIVAL; HISTOCOMPATIBILITY; IMMUNOLOGY; TH2 CELL;

ANIMALS; ANIMALS, NEWBORN; CELL TRANSPLANTATION; CYTOKINES; GRAFT SURVIVAL; IMMUNE TOLERANCE; INTERLEUKIN-12; MICE; MICE, INBRED BALB C; TH2 CELLS; TRANSPLANTATION IMMUNOLOGY; TRANSPLANTATION, HOMOLOGOUS;

EID: 85044698662     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1521-4141(199804)28:04<1426::aid-immu1426>3.0.co;2-p     Document Type: Article

References (19)

1. Billingham, R. E., Brent, L. and Medawar, P. B., Actively acquired tolerance of foreign cells. Nature. 1953. 172: 603-606.
2. Nossal, G. J. and Pike, B. L., Functional clonal deletion in immunological tolerance to major histocompatibility complex antigens. Proc. Natl. Acad. Sd. USA 1981. 78: 3844-3847.
3. Feng, H. M., Glasebrook, A. L., Engers, H. D. and Louis, J. A., Clonal analysis of T cell unresponsiveness to alloantigens induced by neonatal injection of F1 spleen cells into parental mice. J. Immunol. 1983. 131: 2165-2169.
4. Powell, T. J. and Streilein, J. W. Neonatal tolerance induction by class II alloantigens activates IL-4 secreting, tolerogen-responsive T cells. J. Immunol. 1990,144: 854-859.
5. Schurmans, S., Heusser, C. H., Qin, H. Y., Merino, J., Brighouse, G. and Lambert, P.-H., In vivo effects of anti-IL-4 monoclonal antibody on neonatal induction of tolerance and on an associated autoimmune syndrome. J. Immunol. 1990. 145: 2465-2473.
6. Abramowicz, D., Vandervorst, P., Bruyns, C., Doutrelepont, J. M., Vandenabeele, P. and Goldman, M., Per-sistence of anti-donor allohelper T cells after neonatal induction of allotolerance in mice. Eur. J. Immunol. 1990. 20: 1647-1653.
7. Chen, N. and Field, E. H., Enhanced type 2 and diminished type 1 cytokine in neonatal tolerance. Transplantation 1995. 59: 933-941.
8. Forsthuber, T., Yip, C. and Lehmann, P.V., Induction of TH1 and TH2 immunity in neonatal mice. Science 1996. 271: 1728-1730.
9. Adkins, B., Ghanei, A. and Hamilton, K., Developmental regulation of IL-4, IL-2, and IFN-γ production by murine peripheral T lymphocytes. J. Immunol. 1993. 151:6617-6626.
10. Donckier, V., Wissing, M., Bruyns, C. Abramowicz, D., Lybin, M., Vanderhaeghen, M.-L. and Goldman, M., Critical role of interleukin-4 in the induction of neonatal transplantation tolerance. Transplantation 1995. 59: 1571-1576.
11. Trinchieri, G., Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 1995. 13: 251-276.
12. Van Parijs, L., Perez, V. L., Biuckians, A., Maki, R. G., London, C. A., and Abbas, A. K., Role of Interleukin-12 and costimulators in T cell anergy in vivo. J. Exp. Med. 1997. 186: 1119-1128.
13. Galbiati, F., Rogge, L., Quéry, J.-C., Smiroldo, S. and Adorini, L., Regulation of the IL-12R β2 subunit by soluble antigen and IL-12 in vivo. Eur, J. Immunol. 1998. 28: 209-220.
14. Donckier, V., Abramowicz, D., Bruyns, C., Florquin, S., Vanderhaeghen, M. L., Amraoui, Z., Oubois, C., Vandenabeele, P. and Goldman, M., IFN-γ prevents Th2 cell-mediated pathology after neonatal injection of semi-allogenic spleen cells in mice. J. Immunol. 1994. 153: 2361-2368.
15. Gao, Q., Chen, N., Rouse, T. M. and Field, E. H., The role of interleukin-4 in the induction phase of allogeneic neonatal tolerance. Transplantation 1996. 62: 1847-1854.
16. Vogel, L. A., Lester, T. L., Van Cleave, V. H. and Metzger, D. W., Inhibition of murine B1 lymphocytes by interleukin-12 Eur. J. Immunol. 1996. 26: 219-223.
17. Malkovsky, M., Medawar, P. B., Thatcher, D. R., Toy, J., Hunt, R., Rayfield, L. S. and Dore, C., Acquired immunological tolerance of foreign cells is impaired by recombinant interleukin-2 or vitamin A acetate. Proc. Natl. Acad. Sci. USA 1985. 82: 536-538.
18. Ridge J. P., Fuchs, E. J. and Matzinger, P., Neonatal tolerance revisited: turning on newborn T cells with dendritic cells. Science 1996. 271: 1723-1726.
19. + T cells. J. Immunol. 154: 5071-5079.