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Volumn 157, Issue , 2016, Pages 60-69

C. elegans screening strategies to identify pro-longevity interventions

Author keywords

Aging; C. elegans; Development; In vivo drug screening; Mitochondria

Indexed keywords

AGING; CAENORHABDITIS ELEGANS; CELLULAR STRESS RESPONSE; DRUG SCREENING; DRUG TARGETING; LONGEVITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; GENETICS; METABOLISM; MITOCHONDRION; MUTATION; PHYSIOLOGICAL STRESS; PHYSIOLOGY;

EID: 84982814955     PISSN: 00476374     EISSN: 18726216     Source Type: Journal    
DOI: 10.1016/j.mad.2016.07.010     Document Type: Review
Times cited : (23)

References (129)
  • 1
    • 0346434985 scopus 로고    scopus 로고
    • Molecular biology of the cell
    • 4th edition Garland Science New York
    • Alberts, B., Johnson, A., Lewis, J., et al. Molecular biology of the cell. The Mouse, 4th edition, 2002, Garland Science, New York.
    • (2002) The Mouse
    • Alberts, B.1    Johnson, A.2    Lewis, J.3
  • 3
    • 34250697119 scopus 로고    scopus 로고
    • The versatile worm: genetic and genomic resources for Caenorhabditis elegans research
    • Antoshechkin, I., Sternberg, P.W., The versatile worm: genetic and genomic resources for Caenorhabditis elegans research. Nat. Rev. Genet. 8:7 (2007), 518–532.
    • (2007) Nat. Rev. Genet. , vol.8 , Issue.7 , pp. 518-532
    • Antoshechkin, I.1    Sternberg, P.W.2
  • 4
    • 34249736779 scopus 로고    scopus 로고
    • Caenorhabditis elegans: a versatile platform for drug discovery
    • Artal-Sanz, M., de Jong, L., Tavernarakis, N., Caenorhabditis elegans: a versatile platform for drug discovery. Biotechnol. J. 1:12 (2006), 1405–1418.
    • (2006) Biotechnol. J. , vol.1 , Issue.12 , pp. 1405-1418
    • Artal-Sanz, M.1    de Jong, L.2    Tavernarakis, N.3
  • 5
    • 84861016300 scopus 로고    scopus 로고
    • The Caenorhabiditis elegans model as a reliable tool in neurotoxicology
    • Avila, D., Helmcke, K., Aschner, M., The Caenorhabiditis elegans model as a reliable tool in neurotoxicology. Hum. Exp. Toxicol. 31:3 (2012), 236–243.
    • (2012) Hum. Exp. Toxicol. , vol.31 , Issue.3 , pp. 236-243
    • Avila, D.1    Helmcke, K.2    Aschner, M.3
  • 6
    • 77952559481 scopus 로고    scopus 로고
    • The on-off switches of the mitochondrial uncoupling proteins
    • Azzu, V., Brand, M.D., The on-off switches of the mitochondrial uncoupling proteins. Trends Biochem. Sci. 35:5 (2010), 298–307.
    • (2010) Trends Biochem. Sci. , vol.35 , Issue.5 , pp. 298-307
    • Azzu, V.1    Brand, M.D.2
  • 7
    • 73649130270 scopus 로고    scopus 로고
    • Medium- and high-throughput screening of neurotoxicants using C. elegans
    • Boyd, W.A., et al. Medium- and high-throughput screening of neurotoxicants using C. elegans. Neurotoxicol. Teratol. 32:1 (2010), 68–73.
    • (2010) Neurotoxicol. Teratol. , vol.32 , Issue.1 , pp. 68-73
    • Boyd, W.A.1
  • 8
    • 84866485978 scopus 로고    scopus 로고
    • Caenorhabditis elegans as a model in developmental toxicology
    • Boyd, W.A., Smith, M.V., Freedman, J.H., Caenorhabditis elegans as a model in developmental toxicology. Methods Mol. Biol. 889 (2012), 15–24.
    • (2012) Methods Mol. Biol. , vol.889 , pp. 15-24
    • Boyd, W.A.1    Smith, M.V.2    Freedman, J.H.3
  • 9
    • 33747102410 scopus 로고    scopus 로고
    • A cell-based ultra-high-throughput screening assay for identifying inhibitors of D-amino acid oxidase
    • Brandish, P.E., et al. A cell-based ultra-high-throughput screening assay for identifying inhibitors of D-amino acid oxidase. J. Biomol. Screen 11:5 (2006), 481–487.
    • (2006) J. Biomol. Screen , vol.11 , Issue.5 , pp. 481-487
    • Brandish, P.E.1
  • 10
    • 84874591240 scopus 로고    scopus 로고
    • The role of mitochondria in aging
    • Bratic, A., Larsson, N.G., The role of mitochondria in aging. J. Clin. Investig. 123:3 (2013), 951–957.
    • (2013) J. Clin. Investig. , vol.123 , Issue.3 , pp. 951-957
    • Bratic, A.1    Larsson, N.G.2
  • 11
    • 9244251118 scopus 로고    scopus 로고
    • Caenorhabditis elegans MPP+ model of Parkinson's disease for high-throughput drug screenings
    • Braungart, E., et al. Caenorhabditis elegans MPP+ model of Parkinson's disease for high-throughput drug screenings. Neurodegener. Dis. 1:4–5 (2004), 175–183.
    • (2004) Neurodegener. Dis. , vol.1 , Issue.4-5 , pp. 175-183
    • Braungart, E.1
  • 12
    • 33847285403 scopus 로고    scopus 로고
    • Antifungal chemical compounds identified using a C. elegans pathogenicity assay
    • Breger, J., et al. Antifungal chemical compounds identified using a C. elegans pathogenicity assay. PLoS Pathog., 3(2), 2007, e18.
    • (2007) PLoS Pathog. , vol.3 , Issue.2 , pp. e18
    • Breger, J.1
  • 13
    • 0016063911 scopus 로고
    • The genetics of Caenorhabditis elegans
    • Brenner, S., The genetics of Caenorhabditis elegans. Genetics 77:1 (1974), 71–94.
    • (1974) Genetics , vol.77 , Issue.1 , pp. 71-94
    • Brenner, S.1
  • 14
    • 84885385963 scopus 로고    scopus 로고
    • Assay development guidelines for image-based high content screening, high content analysis and high content imaging
    • G.S. Sittampalam Eli Lilly & Company and the National Center for Advancing Translational Sciences Bethesda (MD)
    • Buchser, W., et al. Assay development guidelines for image-based high content screening, high content analysis and high content imaging. Sittampalam, G.S., (eds.) Assay Guidance Manual, 2004, Eli Lilly & Company and the National Center for Advancing Translational Sciences, Bethesda (MD).
    • (2004) Assay Guidance Manual
    • Buchser, W.1
  • 15
    • 84872548310 scopus 로고    scopus 로고
    • A metabolic signature for long life in the Caenorhabditis elegans Mit mutants
    • Butler, J.A., et al. A metabolic signature for long life in the Caenorhabditis elegans Mit mutants. Aging Cell 12:1 (2013), 130–138.
    • (2013) Aging Cell , vol.12 , Issue.1 , pp. 130-138
    • Butler, J.A.1
  • 16
    • 11144337431 scopus 로고    scopus 로고
    • Hormesis: a revolution in toxicology, risk assessment and medicine
    • (Sec No)
    • Calabrese, E.J., Hormesis: a revolution in toxicology, risk assessment and medicine. EMBO Rep. 5 (2004), S37–S40 (Sec No).
    • (2004) EMBO Rep. , vol.5 , pp. S37-S40
    • Calabrese, E.J.1
  • 17
    • 10944272639 scopus 로고    scopus 로고
    • Aging, tumor suppression and cancer: high wire-act!
    • Campisi, J., Aging, tumor suppression and cancer: high wire-act!. Mech. Ageing Dev. 126:1 (2005), 51–58.
    • (2005) Mech. Ageing Dev. , vol.126 , Issue.1 , pp. 51-58
    • Campisi, J.1
  • 18
    • 77953800095 scopus 로고    scopus 로고
    • Mitochondrial ion transport pathways: role in metabolic diseases
    • Cardoso, A.R., Queliconi, B.B., Kowaltowski, A.J., Mitochondrial ion transport pathways: role in metabolic diseases. Biochim. Biophys. Acta 1797:6-7 (2010), 832–838.
    • (2010) Biochim. Biophys. Acta , vol.1797 , Issue.6-7 , pp. 832-838
    • Cardoso, A.R.1    Queliconi, B.B.2    Kowaltowski, A.J.3
  • 19
    • 34447646492 scopus 로고    scopus 로고
    • Longevity determined by developmental arrest genes in Caenorhabditis elegans
    • Chen, D., et al. Longevity determined by developmental arrest genes in Caenorhabditis elegans. Aging Cell 6:4 (2007), 525–533.
    • (2007) Aging Cell , vol.6 , Issue.4 , pp. 525-533
    • Chen, D.1
  • 20
    • 84903139148 scopus 로고    scopus 로고
    • The metabolite alpha-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
    • Chin, R.M., et al. The metabolite alpha-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature 510:7505 (2014), 397–401.
    • (2014) Nature , vol.510 , Issue.7505 , pp. 397-401
    • Chin, R.M.1
  • 21
    • 34247569105 scopus 로고    scopus 로고
    • Lifespan regulation by evolutionarily conserved genes essential for viability
    • Curran, S.P., Ruvkun, G., Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet., 3(4), 2007, e56.
    • (2007) PLoS Genet. , vol.3 , Issue.4 , pp. e56
    • Curran, S.P.1    Ruvkun, G.2
  • 22
    • 84901849008 scopus 로고    scopus 로고
    • Effects of the mitochondrial respiratory chain on longevity in C. elegans
    • Dancy, B.M., Sedensky, M.M., Morgan, P.G., Effects of the mitochondrial respiratory chain on longevity in C. elegans. Exp. Gerontol. 56 (2014), 245–255.
    • (2014) Exp. Gerontol. , vol.56 , pp. 245-255
    • Dancy, B.M.1    Sedensky, M.M.2    Morgan, P.G.3
  • 23
    • 33847304164 scopus 로고    scopus 로고
    • Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice
    • Dell'agnello, C., et al. Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice. Hum. Mol. Genet. 16:4 (2007), 431–444.
    • (2007) Hum. Mol. Genet. , vol.16 , Issue.4 , pp. 431-444
    • Dell'agnello, C.1
  • 24
    • 0037147103 scopus 로고    scopus 로고
    • Rates of behavior and aging specified by mitochondrial function during development
    • Dillin, A., et al. Rates of behavior and aging specified by mitochondrial function during development. Science 298:5602 (2002), 2398–2401.
    • (2002) Science , vol.298 , Issue.5602 , pp. 2398-2401
    • Dillin, A.1
  • 25
    • 78650944949 scopus 로고    scopus 로고
    • The cell-non-autonomous nature of electron transport chain-mediated longevity
    • Durieux, J., Wolff, S., Dillin, A., The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell 144:1 (2011), 79–91.
    • (2011) Cell , vol.144 , Issue.1 , pp. 79-91
    • Durieux, J.1    Wolff, S.2    Dillin, A.3
  • 26
    • 12244261636 scopus 로고    scopus 로고
    • Anticonvulsant medications extend worm life-span
    • Evason, K., et al. Anticonvulsant medications extend worm life-span. Science 307:5707 (2005), 258–262.
    • (2005) Science , vol.307 , Issue.5707 , pp. 258-262
    • Evason, K.1
  • 27
    • 0033524413 scopus 로고    scopus 로고
    • Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron
    • Faber, P.W., et al. Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron. Proc. Natl. Acad. Sci. U. S. A. 96:1 (1999), 179–184.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , Issue.1 , pp. 179-184
    • Faber, P.W.1
  • 28
    • 0035515923 scopus 로고    scopus 로고
    • Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans
    • Feng, J., Bussiere, F., Hekimi, S., Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. Dev. Cell 1:5 (2001), 633–644.
    • (2001) Dev. Cell , vol.1 , Issue.5 , pp. 633-644
    • Feng, J.1    Bussiere, F.2    Hekimi, S.3
  • 29
    • 0034676457 scopus 로고    scopus 로고
    • Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
    • Fraser, A.G., et al. Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature 408:6810 (2000), 325–330.
    • (2000) Nature , vol.408 , Issue.6810 , pp. 325-330
    • Fraser, A.G.1
  • 30
    • 2442560613 scopus 로고    scopus 로고
    • Prednisone reduces muscle degeneration in dystrophin-deficient Caenorhabditis elegans
    • Gaud, A., et al. Prednisone reduces muscle degeneration in dystrophin-deficient Caenorhabditis elegans. Neuromuscul. Disord. 14:6 (2004), 365–370.
    • (2004) Neuromuscul. Disord. , vol.14 , Issue.6 , pp. 365-370
    • Gaud, A.1
  • 31
    • 77951672406 scopus 로고    scopus 로고
    • High-throughput screening and small animal models, where are we?
    • Giacomotto, J., Segalat, L., High-throughput screening and small animal models, where are we?. Br. J. Pharmacol. 160:2 (2010), 204–216.
    • (2010) Br. J. Pharmacol. , vol.160 , Issue.2 , pp. 204-216
    • Giacomotto, J.1    Segalat, L.2
  • 32
    • 70349993595 scopus 로고    scopus 로고
    • Evaluation of the therapeutic potential of carbonic anhydrase inhibitors in two animal models of dystrophin deficient muscular dystrophy
    • Giacomotto, J., et al. Evaluation of the therapeutic potential of carbonic anhydrase inhibitors in two animal models of dystrophin deficient muscular dystrophy. Hum. Mol. Genet. 18:21 (2009), 4089–4101.
    • (2009) Hum. Mol. Genet. , vol.18 , Issue.21 , pp. 4089-4101
    • Giacomotto, J.1
  • 33
    • 84858027407 scopus 로고    scopus 로고
    • Caenorhabditis elegans as a chemical screening tool for the study o f neuromuscular disorders. Manual and semi-automated methods
    • Giacomotto, J., et al. Caenorhabditis elegans as a chemical screening tool for the study o f neuromuscular disorders. Manual and semi-automated methods. Methods 56:1 (2012), 103–113.
    • (2012) Methods , vol.56 , Issue.1 , pp. 103-113
    • Giacomotto, J.1
  • 34
    • 0041326859 scopus 로고    scopus 로고
    • An automated high-throughput assay for survival of the nematode Caenorhabditis elegans
    • Gill, M.S., et al. An automated high-throughput assay for survival of the nematode Caenorhabditis elegans. Free Radic. Biol. Med. 35:6 (2003), 558–565.
    • (2003) Free Radic. Biol. Med. , vol.35 , Issue.6 , pp. 558-565
    • Gill, M.S.1
  • 35
    • 78649757232 scopus 로고    scopus 로고
    • Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin alpha1-antitrypsin Z
    • Gosai, S.J., et al. Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin alpha1-antitrypsin Z. PLoS One, 5(11), 2010, e15460.
    • (2010) PLoS One , vol.5 , Issue.11 , pp. e15460
    • Gosai, S.J.1
  • 36
    • 84974718006 scopus 로고    scopus 로고
    • Caenorhabditis elegans: what we can and cannot learn from aging worms
    • Gruber, J., et al. Caenorhabditis elegans: what we can and cannot learn from aging worms. Antioxid. Redox Signal. 23:3 (2015), 256–279.
    • (2015) Antioxid. Redox Signal. , vol.23 , Issue.3 , pp. 256-279
    • Gruber, J.1
  • 37
    • 22344443522 scopus 로고    scopus 로고
    • A systematic RNAi screen for longevity genes in C. elegans
    • Hamilton, B., et al. A systematic RNAi screen for longevity genes in C. elegans. Genes Dev. 19:13 (2005), 1544–1555.
    • (2005) Genes Dev. , vol.19 , Issue.13 , pp. 1544-1555
    • Hamilton, B.1
  • 38
    • 33645472504 scopus 로고    scopus 로고
    • New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen
    • Hansen, M., et al. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet. 1:1 (2005), 119–128.
    • (2005) PLoS Genet. , vol.1 , Issue.1 , pp. 119-128
    • Hansen, M.1
  • 39
    • 33846423520 scopus 로고    scopus 로고
    • Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
    • Hansen, M., et al. Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 6:1 (2007), 95–110.
    • (2007) Aging Cell , vol.6 , Issue.1 , pp. 95-110
    • Hansen, M.1
  • 40
    • 84878138385 scopus 로고    scopus 로고
    • Mitonuclear protein imbalance as a conserved longevity mechanism
    • Houtkooper, R.H., et al. Mitonuclear protein imbalance as a conserved longevity mechanism. Nature 497:7450 (2013), 451–457.
    • (2013) Nature , vol.497 , Issue.7450 , pp. 451-457
    • Houtkooper, R.H.1
  • 41
    • 70449484092 scopus 로고    scopus 로고
    • The role of mitochondria in health and disease
    • Johannsen, D.L., Ravussin, E., The role of mitochondria in health and disease. Curr. Opin. Pharmacol. 9:6 (2009), 780–786.
    • (2009) Curr. Opin. Pharmacol. , vol.9 , Issue.6 , pp. 780-786
    • Johannsen, D.L.1    Ravussin, E.2
  • 42
    • 84923082870 scopus 로고    scopus 로고
    • Multi-endpoint: high-throughput study of nanomaterial toxicity in Caenorhabditis elegans
    • Jung, S.K., et al. Multi-endpoint: high-throughput study of nanomaterial toxicity in Caenorhabditis elegans. Environ. Sci. Technol. 49:4 (2015), 2477–2485.
    • (2015) Environ. Sci. Technol. , vol.49 , Issue.4 , pp. 2477-2485
    • Jung, S.K.1
  • 43
    • 38149092669 scopus 로고    scopus 로고
    • Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans
    • Kahn, N.W., et al. Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans. Biochem. J. 409:1 (2008), 205–213.
    • (2008) Biochem. J. , vol.409 , Issue.1 , pp. 205-213
    • Kahn, N.W.1
  • 44
    • 33745223646 scopus 로고    scopus 로고
    • Finding function in novel targets: C. elegans as a model organism
    • Kaletta, T., Hengartner, M.O., Finding function in novel targets: C. elegans as a model organism. Nature, 2006.
    • (2006) Nature
    • Kaletta, T.1    Hengartner, M.O.2
  • 45
    • 33745223646 scopus 로고    scopus 로고
    • Finding function in novel targets: C. elegans as a model organism
    • Kaletta, T., Hengartner, M.O., Finding function in novel targets: C. elegans as a model organism. Nat. Rev. Drug Discov. 5:5 (2006), 387–398.
    • (2006) Nat. Rev. Drug Discov. , vol.5 , Issue.5 , pp. 387-398
    • Kaletta, T.1    Hengartner, M.O.2
  • 46
    • 78049362580 scopus 로고    scopus 로고
    • Protein synthesis and the antagonistic pleiotropy hypothesis of aging
    • Kapahi, P., Protein synthesis and the antagonistic pleiotropy hypothesis of aging. Adv. Exp. Med. Biol. 694 (2010), 30–37.
    • (2010) Adv. Exp. Med. Biol. , vol.694 , pp. 30-37
    • Kapahi, P.1
  • 47
    • 84886733138 scopus 로고    scopus 로고
    • TAF-4 is required for the life extension of isp-1, clk-1 and tpk-1 Mit mutants
    • Khan, M.H., et al. TAF-4 is required for the life extension of isp-1, clk-1 and tpk-1 Mit mutants. Aging (Albany NY) 5:10 (2013), 741–758.
    • (2013) Aging (Albany NY) , vol.5 , Issue.10 , pp. 741-758
    • Khan, M.H.1
  • 48
    • 34447636066 scopus 로고    scopus 로고
    • Functional genomic approach to identify novel genes involved in the regulation of oxidative stress resistance and animal lifespan
    • Kim, Y., Sun, H., Functional genomic approach to identify novel genes involved in the regulation of oxidative stress resistance and animal lifespan. Aging Cell 6:4 (2007), 489–503.
    • (2007) Aging Cell , vol.6 , Issue.4 , pp. 489-503
    • Kim, Y.1    Sun, H.2
  • 49
    • 0042889049 scopus 로고    scopus 로고
    • Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy
    • Kraemer, B.C., et al. Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy. Proc. Natl. Acad. Sci. U. S. A. 100:17 (2003), 9980–9985.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , Issue.17 , pp. 9980-9985
    • Kraemer, B.C.1
  • 50
    • 33646933785 scopus 로고    scopus 로고
    • A small-molecule screen in C. elegans yields a new calcium channel antagonist
    • Kwok, T.C., et al. A small-molecule screen in C. elegans yields a new calcium channel antagonist. Nature 441:7089 (2006), 91–95.
    • (2006) Nature , vol.441 , Issue.7089 , pp. 91-95
    • Kwok, T.C.1
  • 51
    • 0037971209 scopus 로고    scopus 로고
    • Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein
    • Lakso, M., et al. Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein. J. Neurochem. 86:1 (2003), 165–172.
    • (2003) J. Neurochem. , vol.86 , Issue.1 , pp. 165-172
    • Lakso, M.1
  • 52
    • 0037228016 scopus 로고    scopus 로고
    • A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
    • Lee, S.S., et al. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat. Genet. 33:1 (2003), 40–48.
    • (2003) Nat. Genet. , vol.33 , Issue.1 , pp. 40-48
    • Lee, S.S.1
  • 53
    • 38349104537 scopus 로고    scopus 로고
    • Three-dimensional cellular microarray for high-throughput toxicology assays
    • Lee, M.Y., et al. Three-dimensional cellular microarray for high-throughput toxicology assays. Proc. Natl. Acad. Sci. U. S. A. 105:1 (2008), 59–63.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , Issue.1 , pp. 59-63
    • Lee, M.Y.1
  • 54
    • 78650177082 scopus 로고    scopus 로고
    • Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity
    • Lee, S.J., Hwang, A.B., Kenyon, C., Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity. Curr. Biol. 20:23 (2010), 2131–2136.
    • (2010) Curr. Biol. , vol.20 , Issue.23 , pp. 2131-2136
    • Lee, S.J.1    Hwang, A.B.2    Kenyon, C.3
  • 55
    • 54449099444 scopus 로고    scopus 로고
    • Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology
    • Leung, M.C., et al. Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology. Toxicol. Sci. 106:1 (2008), 5–28.
    • (2008) Toxicol. Sci. , vol.106 , Issue.1 , pp. 5-28
    • Leung, M.C.1
  • 56
    • 80355128983 scopus 로고    scopus 로고
    • High-throughput screening and biosensing with fluorescent C. elegans strains
    • Leung, C.K., et al. High-throughput screening and biosensing with fluorescent C. elegans strains. J. Vis. Exp., 51, 2011.
    • (2011) J. Vis. Exp. , vol.51
    • Leung, C.K.1
  • 57
    • 84876898289 scopus 로고    scopus 로고
    • An ultra high-throughput, whole-animal screen for small molecule modulators of a specific genetic pathway in Caenorhabditis elegans
    • Leung, C.K., et al. An ultra high-throughput, whole-animal screen for small molecule modulators of a specific genetic pathway in Caenorhabditis elegans. PLoS One, 8(4), 2013, e62166.
    • (2013) PLoS One , vol.8 , Issue.4 , pp. e62166
    • Leung, C.K.1
  • 58
    • 0029906585 scopus 로고    scopus 로고
    • Assessment of normal and mutant human presenilin function in Caenorhabditis elegans
    • Levitan, D., et al. Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U. S. A. 93:25 (1996), 14940–14944.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , Issue.25 , pp. 14940-14944
    • Levitan, D.1
  • 59
    • 0028981288 scopus 로고
    • Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans
    • Link, C.D., Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans. Proc. Natl. Acad. Sci. U. S. A. 92:20 (1995), 9368–9372.
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , Issue.20 , pp. 9368-9372
    • Link, C.D.1
  • 60
    • 0029123058 scopus 로고
    • Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress
    • Lithgow, G.J., et al. Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc. Natl. Acad. Sci. U. S. A. 92:16 (1995), 7540–7544.
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , Issue.16 , pp. 7540-7544
    • Lithgow, G.J.1
  • 61
    • 4344698841 scopus 로고    scopus 로고
    • Technological advances in high-throughput screening
    • Liu, B., Li, S., Hu, J., Technological advances in high-throughput screening. Am. J. Pharmacogenom. 4:4 (2004), 263–276.
    • (2004) Am. J. Pharmacogenom. , vol.4 , Issue.4 , pp. 263-276
    • Liu, B.1    Li, S.2    Hu, J.3
  • 62
    • 26944501617 scopus 로고    scopus 로고
    • Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice
    • Liu, X., et al. Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice. Genes Dev. 19:20 (2005), 2424–2434.
    • (2005) Genes Dev. , vol.19 , Issue.20 , pp. 2424-2434
    • Liu, X.1
  • 63
    • 84898975844 scopus 로고    scopus 로고
    • Caenorhabditis elegans pathways that surveil and defend mitochondria
    • Liu, Y., et al. Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature 508:7496 (2014), 406–410.
    • (2014) Nature , vol.508 , Issue.7496 , pp. 406-410
    • Liu, Y.1
  • 64
    • 84875910045 scopus 로고    scopus 로고
    • Pharmacological lifespan extension of invertebrates
    • Lucanic, M., Lithgow, G.J., Alavez, S., Pharmacological lifespan extension of invertebrates. Ageing Res. Rev. 12:1 (2013), 445–458.
    • (2013) Ageing Res. Rev. , vol.12 , Issue.1 , pp. 445-458
    • Lucanic, M.1    Lithgow, G.J.2    Alavez, S.3
  • 65
    • 84986205358 scopus 로고    scopus 로고
    • Chemical activation of a food deprivation signal extends lifespan
    • Lucanic, M., et al. Chemical activation of a food deprivation signal extends lifespan. Aging Cell, 2016.
    • (2016) Aging Cell
    • Lucanic, M.1
  • 66
    • 84959219223 scopus 로고    scopus 로고
    • C. elegans as a model organism for human mitochondrial associated disorders
    • Maglioni, S., Ventura, N., C. elegans as a model organism for human mitochondrial associated disorders. Mitochondrion, 2016.
    • (2016) Mitochondrion
    • Maglioni, S.1    Ventura, N.2
  • 67
    • 84901832871 scopus 로고    scopus 로고
    • Mitochondrial stress extends lifespan in C. elegans through neuronal hormesis
    • Maglioni, S., et al. Mitochondrial stress extends lifespan in C. elegans through neuronal hormesis. Exp. Gerontol. 56 (2014), 89–98.
    • (2014) Exp. Gerontol. , vol.56 , pp. 89-98
    • Maglioni, S.1
  • 68
    • 84941741386 scopus 로고    scopus 로고
    • An automated phenotype-based microscopy screen to identify pro-longevity interventions acting through mitochondria in C. elegans
    • Maglioni, S., et al. An automated phenotype-based microscopy screen to identify pro-longevity interventions acting through mitochondria in C. elegans. Biochim. Biophys. Acta 1847:11 (2015), 1469–1478.
    • (2015) Biochim. Biophys. Acta , vol.1847 , Issue.11 , pp. 1469-1478
    • Maglioni, S.1
  • 69
    • 46149085878 scopus 로고    scopus 로고
    • The future of high-throughput screening
    • Mayr, L.M., Fuerst, P., The future of high-throughput screening. J. Biomol. Screen 13:6 (2008), 443–448.
    • (2008) J. Biomol. Screen , vol.13 , Issue.6 , pp. 443-448
    • Mayr, L.M.1    Fuerst, P.2
  • 70
    • 84885342784 scopus 로고    scopus 로고
    • Mitochondrial-associated metabolic disorders: foundations, pathologies and recent progress
    • McInnes, J., Mitochondrial-associated metabolic disorders: foundations, pathologies and recent progress. Nutr. Metab. (Lond.), 10(1), 2013, 63.
    • (2013) Nutr. Metab. (Lond.) , vol.10 , Issue.1 , pp. 63
    • McInnes, J.1
  • 71
    • 84960093607 scopus 로고    scopus 로고
    • Mitochondrial metabolites extend lifespan
    • Mishur, R.J., et al. Mitochondrial metabolites extend lifespan. Aging Cell 15:2 (2016), 336–348.
    • (2016) Aging Cell , vol.15 , Issue.2 , pp. 336-348
    • Mishur, R.J.1
  • 72
    • 33745912507 scopus 로고    scopus 로고
    • Identification of novel antimicrobials using a live-animal infection model
    • Moy, T.I., et al. Identification of novel antimicrobials using a live-animal infection model. Proc. Natl. Acad. Sci. U. S. A. 103:27 (2006), 10414–10419.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , Issue.27 , pp. 10414-10419
    • Moy, T.I.1
  • 73
    • 84901756876 scopus 로고    scopus 로고
    • The paradox of mitochondrial dysfunction and extended longevity
    • Munkacsy, E., Rea, S.L., The paradox of mitochondrial dysfunction and extended longevity. Exp. Gerontol. 56 (2014), 221–233.
    • (2014) Exp. Gerontol. , vol.56 , pp. 221-233
    • Munkacsy, E.1    Rea, S.L.2
  • 74
    • 79953762174 scopus 로고    scopus 로고
    • Unraveling the biological roles of reactive oxygen species
    • Murphy, M.P., et al. Unraveling the biological roles of reactive oxygen species. Cell Metab. 13:4 (2011), 361–366.
    • (2011) Cell Metab. , vol.13 , Issue.4 , pp. 361-366
    • Murphy, M.P.1
  • 75
    • 84982820878 scopus 로고    scopus 로고
    • Development of small molecular proteasome inhibitors using a Caenorhabditis elegans screen
    • Nayak, S., et al. Development of small molecular proteasome inhibitors using a Caenorhabditis elegans screen. Int. J. Med. Chem., 2014, 2014, 237286.
    • (2014) Int. J. Med. Chem. , vol.2014 , pp. 237286
    • Nayak, S.1
  • 76
    • 77950361791 scopus 로고    scopus 로고
    • RNAi screens to identify components of gene networks that modulate aging in Caenorhabditis elegans
    • Ni, Z., Lee, S.S., RNAi screens to identify components of gene networks that modulate aging in Caenorhabditis elegans. Brief Funct. Genom. 9:1 (2010), 53–64.
    • (2010) Brief Funct. Genom. , vol.9 , Issue.1 , pp. 53-64
    • Ni, Z.1    Lee, S.S.2
  • 77
    • 84913554278 scopus 로고    scopus 로고
    • Mitochondrial dynamics and mitochondrial quality control
    • Ni, H.M., Williams, J.A., Ding, W.X., Mitochondrial dynamics and mitochondrial quality control. Redox Biol. 4 (2015), 6–13.
    • (2015) Redox Biol. , vol.4 , pp. 6-13
    • Ni, H.M.1    Williams, J.A.2    Ding, W.X.3
  • 78
    • 84899930879 scopus 로고    scopus 로고
    • C. elegans in high-throughput drug discovery
    • O'Reilly, L.P., et al. C. elegans in high-throughput drug discovery. Adv. Drug Deliv. Rev. 69–70 (2014), 247–253.
    • (2014) Adv. Drug Deliv. Rev. , vol.69-70 , pp. 247-253
    • O'Reilly, L.P.1
  • 79
    • 0034772838 scopus 로고    scopus 로고
    • Oxidative stress causes abnormal accumulation of familial amyotrophic lateral sclerosis-related mutant SOD1 in transgenic Caenorhabditis elegans
    • Oeda, T., et al. Oxidative stress causes abnormal accumulation of familial amyotrophic lateral sclerosis-related mutant SOD1 in transgenic Caenorhabditis elegans. Hum. Mol. Genet. 10:19 (2001), 2013–2023.
    • (2001) Hum. Mol. Genet. , vol.10 , Issue.19 , pp. 2013-2023
    • Oeda, T.1
  • 80
    • 66149175591 scopus 로고    scopus 로고
    • Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1
    • Park, S.K., Tedesco, P.M., Johnson, T.E., Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1. Aging Cell 8:3 (2009), 258–269.
    • (2009) Aging Cell , vol.8 , Issue.3 , pp. 258-269
    • Park, S.K.1    Tedesco, P.M.2    Johnson, T.E.3
  • 81
    • 44649196430 scopus 로고    scopus 로고
    • Use of non-mammalian alternative models for neurotoxicological study
    • Peterson, R.T., et al. Use of non-mammalian alternative models for neurotoxicological study. Neurotoxicology 29:3 (2008), 546–555.
    • (2008) Neurotoxicology , vol.29 , Issue.3 , pp. 546-555
    • Peterson, R.T.1
  • 82
    • 36549006956 scopus 로고    scopus 로고
    • An antidepressant that extends lifespan in adult Caenorhabditis elegans
    • Petrascheck, M., Ye, X., Buck, L.B., An antidepressant that extends lifespan in adult Caenorhabditis elegans. Nature 450:7169 (2007), 553–556.
    • (2007) Nature , vol.450 , Issue.7169 , pp. 553-556
    • Petrascheck, M.1    Ye, X.2    Buck, L.B.3
  • 83
    • 68649084475 scopus 로고    scopus 로고
    • A high-throughput screen for chemicals that increase the lifespan of Caenorhabditis elegans
    • Petrascheck, M., Ye, X., Buck, L.B., A high-throughput screen for chemicals that increase the lifespan of Caenorhabditis elegans. Ann. N. Y. Acad. Sci. 1170 (2009), 698–701.
    • (2009) Ann. N. Y. Acad. Sci. , vol.1170 , pp. 698-701
    • Petrascheck, M.1    Ye, X.2    Buck, L.B.3
  • 84
    • 2942744904 scopus 로고    scopus 로고
    • Protein networks: pleiotropy and the evolution of senescence
    • Promislow, D.E., Protein networks: pleiotropy and the evolution of senescence. Proc. Biol. Sci. 271:1545 (2004), 1225–1234.
    • (2004) Proc. Biol. Sci. , vol.271 , Issue.1545 , pp. 1225-1234
    • Promislow, D.E.1
  • 85
    • 84982860758 scopus 로고    scopus 로고
    • A chemical screen to identify inducers of the mitochondrial unfolded protein response in C. elegans
    • Rauthan, M., Pilon, M., A chemical screen to identify inducers of the mitochondrial unfolded protein response in C. elegans. Worm, 4(4), 2015, e1096490.
    • (2015) Worm , vol.4 , Issue.4 , pp. e1096490
    • Rauthan, M.1    Pilon, M.2
  • 86
    • 35648947912 scopus 로고    scopus 로고
    • Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans
    • Rea, S.L., Ventura, N., Johnson, T.E., Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans. PLoS Biol., 5(10), 2007, e259.
    • (2007) PLoS Biol. , vol.5 , Issue.10 , pp. e259
    • Rea, S.L.1    Ventura, N.2    Johnson, T.E.3
  • 87
    • 27544439179 scopus 로고    scopus 로고
    • Metabolism in the Caenorhabditis elegans Mit mutants
    • Rea, S.L., Metabolism in the Caenorhabditis elegans Mit mutants. Exp. Gerontol. 40:11 (2005), 841–849.
    • (2005) Exp. Gerontol. , vol.40 , Issue.11 , pp. 841-849
    • Rea, S.L.1
  • 88
    • 84982796714 scopus 로고    scopus 로고
    • cold sprig harbour 1997
    • Riddle, C.elegans, vol. 2, 2016, cold sprig harbour, 1997.
    • (2016) C.elegans , vol.2
    • Riddle1
  • 89
    • 84902382985 scopus 로고    scopus 로고
    • Mitohormesis: promoting health and lifespan by increased levels of reactive oxygen species (ROS)
    • Ristow, M., Schmeisser, K., Mitohormesis: promoting health and lifespan by increased levels of reactive oxygen species (ROS). Dose Response 12:2 (2014), 288–341.
    • (2014) Dose Response , vol.12 , Issue.2 , pp. 288-341
    • Ristow, M.1    Schmeisser, K.2
  • 90
    • 77952548782 scopus 로고    scopus 로고
    • How increased oxidative stress promotes longevity and metabolic health: the concept of mitochondrial hormesis (mitohormesis)
    • Ristow, M., Zarse, K., How increased oxidative stress promotes longevity and metabolic health: the concept of mitochondrial hormesis (mitohormesis). Exp. Gerontol. 45:6 (2010), 410–418.
    • (2010) Exp. Gerontol. , vol.45 , Issue.6 , pp. 410-418
    • Ristow, M.1    Zarse, K.2
  • 91
    • 84901855878 scopus 로고    scopus 로고
    • The interplay between mitochondria and autophagy and its role in the aging process
    • Schiavi, A., Ventura, N., The interplay between mitochondria and autophagy and its role in the aging process. Exp. Gerontol. 56 (2014), 147–153.
    • (2014) Exp. Gerontol. , vol.56 , pp. 147-153
    • Schiavi, A.1    Ventura, N.2
  • 92
    • 84872566075 scopus 로고    scopus 로고
    • Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans
    • Schiavi, A., et al. Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans. Exp. Gerontol. 48:2 (2013), 191–201.
    • (2013) Exp. Gerontol. , vol.48 , Issue.2 , pp. 191-201
    • Schiavi, A.1
  • 93
    • 84937514081 scopus 로고    scopus 로고
    • Iron-starvation-induced mitophagy mediates lifespan extension upon mitochondrial stress in C. elegans
    • Schiavi, A., et al. Iron-starvation-induced mitophagy mediates lifespan extension upon mitochondrial stress in C. elegans. Curr. Biol. 25:14 (2015), 1810–1822.
    • (2015) Curr. Biol. , vol.25 , Issue.14 , pp. 1810-1822
    • Schiavi, A.1
  • 94
    • 84877794094 scopus 로고    scopus 로고
    • Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension
    • Schmeisser, S., et al. Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension. Aging Cell 12:3 (2013), 508–517.
    • (2013) Aging Cell , vol.12 , Issue.3 , pp. 508-517
    • Schmeisser, S.1
  • 95
    • 84877681309 scopus 로고    scopus 로고
    • Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension
    • Schmeisser, S., et al. Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension. Mol. Metab. 2:2 (2013), 92–102.
    • (2013) Mol. Metab. , vol.2 , Issue.2 , pp. 92-102
    • Schmeisser, S.1
  • 96
    • 35348861272 scopus 로고    scopus 로고
    • Drug discovery: here comes the worm
    • Segalat, L., Drug discovery: here comes the worm. ACS Chem. Biol. 1:5 (2006), 277–278.
    • (2006) ACS Chem. Biol. , vol.1 , Issue.5 , pp. 277-278
    • Segalat, L.1
  • 97
    • 34547689085 scopus 로고    scopus 로고
    • Loss-of-function genetic diseases and the concept of pharmaceutical targets
    • Segalat, L., Loss-of-function genetic diseases and the concept of pharmaceutical targets. Orphanet. J. Rare Dis., 2, 2007, 30.
    • (2007) Orphanet. J. Rare Dis. , vol.2 , pp. 30
    • Segalat, L.1
  • 98
    • 34248598584 scopus 로고    scopus 로고
    • Invertebrate animal models of diseases as screening tools in drug discovery
    • Segalat, L., Invertebrate animal models of diseases as screening tools in drug discovery. ACS Chem. Biol. 2:4 (2007), 231–236.
    • (2007) ACS Chem. Biol. , vol.2 , Issue.4 , pp. 231-236
    • Segalat, L.1
  • 99
    • 58149401020 scopus 로고    scopus 로고
    • Modeling molecular and cellular aspects of human disease using the nematode Caenorhabditis elegans
    • Silverman, G.A., et al. Modeling molecular and cellular aspects of human disease using the nematode Caenorhabditis elegans. Pediatr. Res. 65:1 (2009), 10–18.
    • (2009) Pediatr. Res. , vol.65 , Issue.1 , pp. 10-18
    • Silverman, G.A.1
  • 100
    • 1542298437 scopus 로고    scopus 로고
    • Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions
    • Simmer, F., et al. Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS Biol., 1(1), 2003, E12.
    • (2003) PLoS Biol. , vol.1 , Issue.1 , pp. E12
    • Simmer, F.1
  • 101
    • 84905472533 scopus 로고    scopus 로고
    • A functional genomic screen for evolutionarily conserved genes required for lifespan and immunity in germline-deficient C. elegans
    • Sinha, A., Rae, R., A functional genomic screen for evolutionarily conserved genes required for lifespan and immunity in germline-deficient C. elegans. PLoS One, 9(8), 2014, e101970.
    • (2014) PLoS One , vol.9 , Issue.8 , pp. e101970
    • Sinha, A.1    Rae, R.2
  • 102
    • 84924371233 scopus 로고    scopus 로고
    • A microfluidic device for efficient chemical testing using Caenorhabditis elegans
    • Song, P., et al. A microfluidic device for efficient chemical testing using Caenorhabditis elegans. Biomed. Microdevices, 17(2), 2015, 38.
    • (2015) Biomed. Microdevices , vol.17 , Issue.2 , pp. 38
    • Song, P.1
  • 103
    • 79952635820 scopus 로고    scopus 로고
    • Measuring and modeling apoptosis in single cells
    • Spencer, S.L., Sorger, P.K., Measuring and modeling apoptosis in single cells. Cell 144:6 (2011), 926–939.
    • (2011) Cell , vol.144 , Issue.6 , pp. 926-939
    • Spencer, S.L.1    Sorger, P.K.2
  • 104
    • 0035989388 scopus 로고    scopus 로고
    • Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster
    • Sun, J., et al. Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster. Genetics 161:2 (2002), 661–672.
    • (2002) Genetics , vol.161 , Issue.2 , pp. 661-672
    • Sun, J.1
  • 105
    • 84856250240 scopus 로고    scopus 로고
    • Adaptation of high-throughput screening in drug discovery-toxicological screening tests
    • Szymanski, P., Markowicz, M., Mikiciuk-Olasik, E., Adaptation of high-throughput screening in drug discovery-toxicological screening tests. Int. J. Mol. Sci. 13:1 (2012), 427–452.
    • (2012) Int. J. Mol. Sci. , vol.13 , Issue.1 , pp. 427-452
    • Szymanski, P.1    Markowicz, M.2    Mikiciuk-Olasik, E.3
  • 106
    • 31844439407 scopus 로고    scopus 로고
    • Sublethal mitochondrial stress with an attendant stoichiometric augmentation of reactive oxygen species may precipitate many of the beneficial alterations in cellular physiology produced by caloric restriction, intermittent fasting, exercise and dietary phytonutrients: “Mitohormesis” for health and vitality
    • Epub 2005 Oct 18. PMID: 16242247
    • Tapia, P.C., Sublethal mitochondrial stress with an attendant stoichiometric augmentation of reactive oxygen species may precipitate many of the beneficial alterations in cellular physiology produced by caloric restriction, intermittent fasting, exercise and dietary phytonutrients: “Mitohormesis” for health and vitality. Med. Hypotheses 66:4 (2006), 832–843 Epub 2005 Oct 18. PMID: 16242247.
    • (2006) Med. Hypotheses , vol.66 , Issue.4 , pp. 832-843
    • Tapia, P.C.1
  • 107
    • 77953356853 scopus 로고    scopus 로고
    • A role for p53 in mitochondrial stress response control of longevity in C. elegans
    • Torgovnick, A., et al. A role for p53 in mitochondrial stress response control of longevity in C. elegans. Exp. Gerontol. 45:7–8 (2010), 550–557.
    • (2010) Exp. Gerontol. , vol.45 , Issue.7-8 , pp. 550-557
    • Torgovnick, A.1
  • 108
    • 84885643554 scopus 로고    scopus 로고
    • Healthy aging: what can we learn from Caenorhabditis elegans?
    • Torgovnick, A., et al. Healthy aging: what can we learn from Caenorhabditis elegans?. Z. Gerontol. Geriatr. 46:7 (2013), 623–628.
    • (2013) Z. Gerontol. Geriatr. , vol.46 , Issue.7 , pp. 623-628
    • Torgovnick, A.1
  • 109
    • 0035943727 scopus 로고    scopus 로고
    • Mitochondrial respiratory chain deficiency in Caenorhabditis elegans results in developmental arrest and increased life span
    • Tsang, W.Y., et al. Mitochondrial respiratory chain deficiency in Caenorhabditis elegans results in developmental arrest and increased life span. J. Biol. Chem. 276:34 (2001), 32240–32246.
    • (2001) J. Biol. Chem. , vol.276 , Issue.34 , pp. 32240-32246
    • Tsang, W.Y.1
  • 110
    • 58149348691 scopus 로고    scopus 로고
    • Antagonistic pleiotropy and p53
    • Ungewitter, E., Scrable, H., Antagonistic pleiotropy and p53. Mech. Ageing Dev. 130:1–2 (2009), 10–17.
    • (2009) Mech. Ageing Dev. , vol.130 , Issue.1-2 , pp. 10-17
    • Ungewitter, E.1    Scrable, H.2
  • 111
    • 84869051280 scopus 로고    scopus 로고
    • Mitochondrial disorders as windows into an ancient organelle
    • Vafai, S.B., Mootha, V.K., Mitochondrial disorders as windows into an ancient organelle. Nature 491:7424 (2012), 374–383.
    • (2012) Nature , vol.491 , Issue.7424 , pp. 374-383
    • Vafai, S.B.1    Mootha, V.K.2
  • 112
    • 34249711285 scopus 로고    scopus 로고
    • Caenorhabditis elegans mitochondrial mutants as an investigative tool to study human neurodegenerative diseases associated with mitochondrial dysfunction
    • Ventura, N., Rea, S.L., Caenorhabditis elegans mitochondrial mutants as an investigative tool to study human neurodegenerative diseases associated with mitochondrial dysfunction. Biotechnol. J. 2:5 (2007), 584–595.
    • (2007) Biotechnol. J. , vol.2 , Issue.5 , pp. 584-595
    • Ventura, N.1    Rea, S.L.2
  • 113
    • 22144462536 scopus 로고    scopus 로고
    • Reduced expression of frataxin extends the lifespan of Caenorhabditis elegans
    • Ventura, N., et al. Reduced expression of frataxin extends the lifespan of Caenorhabditis elegans. Aging Cell 4:2 (2005), 109–112.
    • (2005) Aging Cell , vol.4 , Issue.2 , pp. 109-112
    • Ventura, N.1
  • 114
    • 33751437445 scopus 로고    scopus 로고
    • Long-lived C. elegans mitochondrial mutants as a model for human mitochondrial-associated diseases
    • Ventura, N., Rea, S.L., Testi, R., Long-lived C. elegans mitochondrial mutants as a model for human mitochondrial-associated diseases. Exp. Gerontol. 41:10 (2006), 974–991.
    • (2006) Exp. Gerontol. , vol.41 , Issue.10 , pp. 974-991
    • Ventura, N.1    Rea, S.L.2    Testi, R.3
  • 115
    • 67651174517 scopus 로고    scopus 로고
    • p53/CEP-1 increases or decreases lifespan: depending on level of mitochondrial bioenergetic stress
    • Ventura, N., et al. p53/CEP-1 increases or decreases lifespan: depending on level of mitochondrial bioenergetic stress. Aging Cell 8:4 (2009), 380–393.
    • (2009) Aging Cell , vol.8 , Issue.4 , pp. 380-393
    • Ventura, N.1
  • 116
    • 79959791906 scopus 로고    scopus 로고
    • The homeobox protein CEH-23 mediates prolonged longevity in response to impaired mitochondrial electron transport chain in C. elegans
    • Walter, L., et al. The homeobox protein CEH-23 mediates prolonged longevity in response to impaired mitochondrial electron transport chain in C. elegans. PLoS Biol., 9(6), 2011, e1001084.
    • (2011) PLoS Biol. , vol.9 , Issue.6 , pp. e1001084
    • Walter, L.1
  • 117
    • 0034013739 scopus 로고    scopus 로고
    • Mouse genetics/genomics: an effective approach for drug target discovery and validation
    • West, D.B., et al. Mouse genetics/genomics: an effective approach for drug target discovery and validation. Med. Res. Rev. 20:3 (2000), 216–230.
    • (2000) Med. Res. Rev. , vol.20 , Issue.3 , pp. 216-230
    • West, D.B.1
  • 118
    • 0000055057 scopus 로고
    • Pleiotropy, natural selection, and the evolution of senescence
    • Williams, G.C., Pleiotropy, natural selection, and the evolution of senescence. Evolution 11:4 (1957), 398–411.
    • (1957) Evolution , vol.11 , Issue.4 , pp. 398-411
    • Williams, G.C.1
  • 119
    • 0028950419 scopus 로고
    • Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing
    • Wong, A., Boutis, P., Hekimi, S., Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing. Genetics 139:3 (1995), 1247–1259.
    • (1995) Genetics , vol.139 , Issue.3 , pp. 1247-1259
    • Wong, A.1    Boutis, P.2    Hekimi, S.3
  • 120
    • 0004291817 scopus 로고    scopus 로고
    • The Nematode Caenorhabditis Elegans
    • cold spring harbour 1988
    • Wood, The Nematode Caenorhabditis Elegans. 2016, cold spring harbour, 1988.
    • (2016)
    • Wood1
  • 121
    • 84877804010 scopus 로고    scopus 로고
    • WormFarm: a quantitative control and measurement device toward automated Caenorhabditis elegans aging analysis
    • Xian, B., et al. WormFarm: a quantitative control and measurement device toward automated Caenorhabditis elegans aging analysis. Aging Cell, 2013.
    • (2013) Aging Cell
    • Xian, B.1
  • 122
    • 78650455712 scopus 로고    scopus 로고
    • A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans
    • Yang, W., Hekimi, S., A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans. PLoS Biol., 8(12), 2010, e1000556.
    • (2010) PLoS Biol. , vol.8 , Issue.12 , pp. e1000556
    • Yang, W.1    Hekimi, S.2
  • 123
    • 84895784407 scopus 로고    scopus 로고
    • A pharmacological network for lifespan extension in Caenorhabditis elegans
    • Ye, X., et al. A pharmacological network for lifespan extension in Caenorhabditis elegans. Aging Cell 13:2 (2014), 206–215.
    • (2014) Aging Cell , vol.13 , Issue.2 , pp. 206-215
    • Ye, X.1
  • 124
    • 84926631100 scopus 로고    scopus 로고
    • Mitochondria: the cellular hub of the dynamic coordinated network
    • Yin, F., Cadenas, E., Mitochondria: the cellular hub of the dynamic coordinated network. Antioxid. Redox Signal. 22:12 (2015), 961–964.
    • (2015) Antioxid. Redox Signal. , vol.22 , Issue.12 , pp. 961-964
    • Yin, F.1    Cadenas, E.2
  • 125
    • 4944234936 scopus 로고    scopus 로고
    • Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones
    • Yoneda, T., et al. Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. J. Cell Sci. 117:Pt 18 (2004), 4055–4066.
    • (2004) J. Cell Sci. , vol.117 , pp. 4055-4066
    • Yoneda, T.1
  • 126
    • 84900295547 scopus 로고    scopus 로고
    • Mitohormesis
    • Yun, J., Finkel, T., Mitohormesis. Cell Metab. 19:5 (2014), 757–766.
    • (2014) Cell Metab. , vol.19 , Issue.5 , pp. 757-766
    • Yun, J.1    Finkel, T.2
  • 127
    • 33947622592 scopus 로고    scopus 로고
    • Impaired respiration is positively correlated with decreased life span in Caenorhabditis elegans models of Friedreich Ataxia
    • Zarse, K., et al. Impaired respiration is positively correlated with decreased life span in Caenorhabditis elegans models of Friedreich Ataxia. FASEB J. 21:4 (2007), 1271–1275.
    • (2007) FASEB J. , vol.21 , Issue.4 , pp. 1271-1275
    • Zarse, K.1
  • 128
    • 80053157309 scopus 로고    scopus 로고
    • An efficient and novel screening model for assessing the bioactivity of extracts against multidrug-resistant Pseudomonas aeruginosa using Caenorhabditis elegans
    • Zhou, Y.M., et al. An efficient and novel screening model for assessing the bioactivity of extracts against multidrug-resistant Pseudomonas aeruginosa using Caenorhabditis elegans. Biosci. Biotechnol. Biochem. 75:9 (2011), 1746–1751.
    • (2011) Biosci. Biotechnol. Biochem. , vol.75 , Issue.9 , pp. 1746-1751
    • Zhou, Y.M.1
  • 129
    • 84857618797 scopus 로고    scopus 로고
    • Longevity and stress in Caenorhabditis elegans
    • Zhou, K.I., Pincus, Z., Slack, F.J., Longevity and stress in Caenorhabditis elegans. Aging (Albany NY) 3:8 (2011), 733–753.
    • (2011) Aging (Albany NY) , vol.3 , Issue.8 , pp. 733-753
    • Zhou, K.I.1    Pincus, Z.2    Slack, F.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.