The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

Nature

Volumn 510, Issue 7505, 2014, Pages 397-401

  Chin, Randall M ^a   Fu, Xudong ^b   Pai, Melody Y ^a   Vergnes, Laurent ^b   Hwang, Heejun ^b   Deng, Gang ^a   Diep, Simon ^b   Lomenick, Brett ^b   Meli, Vijaykumar S ^b   Monsalve, Gabriela C ^b   Hu, Eileen ^b   Whelan, Stephen A ^a   Wang, Jennifer X ^c   Jung, Gwanghyun ^b   Solis, Gregory M ^d   Fazlollahi, Farbod ^a   Kaweeteerawat, Chitrada ^a   Quach, Austin ^b   Nili, Mahta ^b   Krall, Abby S ^b   Godwin, Hilary A ^a   Chang, Helena R ^a   Faull, Kym F ^a   Guo, Feng ^b   Jiang, Meisheng ^b   Trauger, Sunia A ^c   Saghatelian, Alan ^e   Braas, Daniel ^a,b   Christofk, Heather R ^a,b   Clarke, Catherine F ^a   Teitell, Michael A ^a,b   Petrascheck, Michael ^d   Reue, Karen ^a,b   Jung, Michael E ^a   Frand, Alison R ^b   Huang, Jing ^a,b   more..

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HARVARD UNIVERSITY   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYPOXIA INDUCIBLE FACTOR 1; OLIGOMYCIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE SUBUNIT B; SOMATOMEDIN C RECEPTOR; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR FOXO; UNCLASSIFIED DRUG;

AGING; DIET; DISEASE INCIDENCE; DRUG; INHIBITION; LONGEVITY; METABOLITE; MOLECULAR ANALYSIS; NEMATODE; OXYGEN CONSUMPTION; PROTEIN;

ADULT; AGING; ARTICLE; AUTOPHAGY; CAENORHABDITIS ELEGANS; CELL ENERGY; CONTROLLED STUDY; DIET RESTRICTION; ENZYME INACTIVATION; ENZYME INHIBITION; GENE SILENCING; HUMAN; HUMAN CELL; INHIBITION KINETICS; LIFE EXTENSION; LIFESPAN; LONGEVITY; MAMMAL CELL; MASS SPECTROMETRY; METABOLITE; MICHAELIS CONSTANT; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RESPIRATORY CHAIN; STARVATION;

ANIMALIA; CAENORHABDITIS ELEGANS; MAMMALIA;

ANIMALS; CAENORHABDITIS ELEGANS; CELL LINE; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HUMANS; JURKAT CELLS; KETOGLUTARIC ACIDS; LONGEVITY; MICE; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; PROTEIN BINDING; TOR SERINE-THREONINE KINASES;

EID: 84903139148     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13264     Document Type: Article

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