메뉴 건너뛰기




Volumn 20, Issue 3, 2000, Pages 216-230

Mouse genetics/genomics: An approach for drug discovery validation target and

Author keywords

Gene targeting; Gene mapping; Genetics; Target identification; Transgenic; Use

Indexed keywords

AMINO ACID; DRUG; FURIN; HORMONE PRECURSOR; HUNTINGTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; TRANSCRIPTION FACTOR; TROGLITAZONE;

EID: 0034013739     PISSN: 01986325     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1128(200005)20:3<216::AID-MED6>3.0.CO;2-0     Document Type: Review
Times cited : (33)

References (38)
  • 1
    • 0031021132 scopus 로고    scopus 로고
    • Mouse models of human disease. Part I: Techniques and resources for genetic analysis in mice
    • Beadle MA, Jenkins NA, Copeland NG. Mouse models of human disease. Part I: techniques and resources for genetic analysis in mice. Genes Develop 1997a;11:1-10.
    • (1997) Genes Develop , vol.11 , pp. 1-10
    • Beadle, M.A.1    Jenkins, N.A.2    Copeland, N.G.3
  • 2
    • 0031028759 scopus 로고    scopus 로고
    • Mouse models of human disease. Part II: Recent progress and future directions
    • Bedell MA, Largaespada DA, Jenkins NA, Copeland NG. Mouse models of human disease. Part II: recent progress and future directions. Genes Develop 1997b;11:11-43.
    • (1997) Genes Develop , vol.11 , pp. 11-43
    • Bedell, M.A.1    Largaespada, D.A.2    Jenkins, N.A.3    Copeland, N.G.4
  • 4
    • 0028278185 scopus 로고
    • Genetic animal models of alcohol and drug abuse
    • Crabbe JC, Belknap JK, Buck KJ. Genetic animal models of alcohol and drug abuse. Science 1994;264:1715-1723.
    • (1994) Science , vol.264 , pp. 1715-1723
    • Crabbe, J.C.1    Belknap, J.K.2    Buck, K.J.3
  • 5
    • 0028844104 scopus 로고
    • Taking stock of complex trait genetics in mice
    • Frankel WN. Taking stock of complex trait genetics in mice. Trends Genet 1995;11:471-477.
    • (1995) Trends Genet , vol.11 , pp. 471-477
    • Frankel, W.N.1
  • 6
    • 0031464525 scopus 로고    scopus 로고
    • Zooming in on the human-mouse comparative map: Genome conservation re-examined on a high-resolution scale
    • Carver EA, Stubbs L. Zooming in on the human-mouse comparative map: genome conservation re-examined on a high-resolution scale. Genome Res 1997;7:1123-1137.
    • (1997) Genome Res , vol.7 , pp. 1123-1137
    • Carver, E.A.1    Stubbs, L.2
  • 12
    • 0027049534 scopus 로고
    • Molecular characterization of the mouse agouti locus
    • Bultman SJ, Michaud EJ, Woychik RP. Molecular characterization of the mouse agouti locus. Cell 1992;71:1195-1204.
    • (1992) Cell , vol.71 , pp. 1195-1204
    • Bultman, S.J.1    Michaud, E.J.2    Woychik, R.P.3
  • 17
    • 0028102898 scopus 로고
    • The agouti gene: Turned on to yellow
    • Siracusa LD. The agouti gene: turned on to yellow. Trends Genet 1994;10:423-428.
    • (1994) Trends Genet , vol.10 , pp. 423-428
    • Siracusa, L.D.1
  • 18
    • 0030893647 scopus 로고    scopus 로고
    • Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice
    • Shutter JR, Graham M, Kinsey AC, Scully S, Luthy R, Stark KL. Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes Dev 1997;11:593-602.
    • (1997) Genes Dev , vol.11 , pp. 593-602
    • Shutter, J.R.1    Graham, M.2    Kinsey, A.C.3    Scully, S.4    Luthy, R.5    Stark, K.L.6
  • 19
    • 0030764741 scopus 로고    scopus 로고
    • Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
    • Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I, Barsh GS. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 1997;278:135-138.
    • (1997) Science , vol.278 , pp. 135-138
    • Ollmann, M.M.1    Wilson, B.D.2    Yang, Y.K.3    Kerns, J.A.4    Chen, Y.5    Gantz, I.6    Barsh, G.S.7
  • 20
    • 0024508964 scopus 로고
    • Mapping mendelian factors underlying quantitative traits using RFLP linkage maps
    • Lander ES, Botstein D. Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genet 1989;121:185-199.
    • (1989) Genet , vol.121 , pp. 185-199
    • Lander, E.S.1    Botstein, D.2
  • 21
    • 0031975307 scopus 로고    scopus 로고
    • Experimental strategies for the genetic dissection of complex traits in animal models
    • Darvasi A. Experimental strategies for the genetic dissection of complex traits in animal models. Nat Genet 1998;18:19-24.
    • (1998) Nat Genet , vol.18 , pp. 19-24
    • Darvasi, A.1
  • 22
    • 0028075287 scopus 로고
    • Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model
    • West DB, Goudey-Lefevre, York B, Truett GE. Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model. J Clin Invest 1994;94:1410-1416.
    • (1994) J Clin Invest , vol.94 , pp. 1410-1416
    • West, D.B.1    Goudey-Lefevre2    York, B.3    Truett, G.E.4
  • 23
    • 0030239728 scopus 로고    scopus 로고
    • Sensitivity to dietary obesity linked to a locus on chromosome 15 in CAST/Ei x C57BL/6J F2 intercross
    • York B, Lei K, West DB. Sensitivity to dietary obesity linked to a locus on chromosome 15 in CAST/Ei x C57BL/6J F2 intercross. Mammal Genome 1996;7:677-681.
    • (1996) Mammal Genome , vol.7 , pp. 677-681
    • York, B.1    Lei, K.2    West, D.B.3
  • 24
    • 0032797709 scopus 로고    scopus 로고
    • Gene-environment interaction: A significant diet-dependent obesity locus demonstrated in a congenic segment on mouse chromosome 7
    • York B, Truett AA, Monteiro MP, Barry SJ, Warden CH, Naggert JK, Maddatu TP, West DB. Gene-environment interaction: a significant diet-dependent obesity locus demonstrated in a congenic segment on mouse chromosome 7. Mammal Genome 1999;10:457-462.
    • (1999) Mammal Genome , vol.10 , pp. 457-462
    • York, B.1    Truett, A.A.2    Monteiro, M.P.3    Barry, S.J.4    Warden, C.H.5    Naggert, J.K.6    Maddatu, T.P.7    West, D.B.8
  • 26
    • 0031831695 scopus 로고    scopus 로고
    • Genetics of quantitative and qualitative aspects of lung tumorigenesis in the mouse: Multiple interacting susceptibility to lung cancer (Slue) genes with large effects
    • Fijneman RJ, van der Valk MA, Demant P. Genetics of quantitative and qualitative aspects of lung tumorigenesis in the mouse: multiple interacting susceptibility to lung cancer (Slue) genes with large effects. Exp Lung Res 1998;24:419-436.
    • (1998) Exp Lung Res , vol.24 , pp. 419-436
    • Fijneman, R.J.1    Van Der Valk, M.A.2    Demant, P.3
  • 27
    • 0032958470 scopus 로고    scopus 로고
    • Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats
    • Aitman TJ, Glazier AM, Wallace CA, Cooper LD, Norsworthy PJ, Wahid FN, et al. Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat Genet 1999;21:76-83.
    • (1999) Nat Genet , vol.21 , pp. 76-83
    • Aitman, T.J.1    Glazier, A.M.2    Wallace, C.A.3    Cooper, L.D.4    Norsworthy, P.J.5    Wahid, F.N.6
  • 30
    • 1842537138 scopus 로고
    • Radiation genetics
    • Green EL, editor. New York: Oxford Univ
    • Green EL, Roderick TH. Radiation genetics. In: Green EL, editor. Biology of the laboratory mouse. New York: Oxford Univ; 1966. p 165-185.
    • (1966) Biology of the Laboratory Mouse , pp. 165-185
    • Green, E.L.1    Roderick, T.H.2
  • 31
    • 0031414693 scopus 로고    scopus 로고
    • Generation of radiation-induced deletion complexes in the mouse genome using embryonic stem cells
    • You Y, Browning VL, Schimenti JC. Generation of radiation-induced deletion complexes in the mouse genome using embryonic stem cells. Methods 1997;13:409-421.
    • (1997) Methods , vol.13 , pp. 409-421
    • You, Y.1    Browning, V.L.2    Schimenti, J.C.3
  • 32
    • 0031414346 scopus 로고    scopus 로고
    • Using targeted large deletions and high-efficiency N-ethyl-N-nitrosourea mutagenesis for functional analyses of the mammalian genome
    • Justice MJ, Zheng B, Woychik RP, Bradley A. Using targeted large deletions and high-efficiency N-ethyl-N-nitrosourea mutagenesis for functional analyses of the mammalian genome. Methods 1997;13:423-436.
    • (1997) Methods , vol.13 , pp. 423-436
    • Justice, M.J.1    Zheng, B.2    Woychik, R.P.3    Bradley, A.4
  • 33
    • 0030281442 scopus 로고    scopus 로고
    • Combining mutagenesis and genomics in the mouse: Closing the phenotype gap
    • Brown SDM, Peters J. Combining mutagenesis and genomics in the mouse: closing the phenotype gap. Trends Genet 1996;12:433-435.
    • (1996) Trends Genet , vol.12 , pp. 433-435
    • Sdm, B.1    Peters, J.2
  • 34
    • 0007525310 scopus 로고    scopus 로고
    • Mapping of complex traits by single-nucleotide polymorphisms
    • Zhao LP, Aragaki C, Hsu L, Quiaoit F. Mapping of complex traits by single-nucleotide polymorphisms. Am J Hum Genet 1998;63:225-240.
    • (1998) Am J Hum Genet , vol.63 , pp. 225-240
    • Zhao, L.P.1    Aragaki, C.2    Hsu, L.3    Quiaoit, F.4
  • 36
    • 0033559118 scopus 로고    scopus 로고
    • Rapid modification of bacterial artificial chromosomes by ET-recombination
    • Muyrers JP, Zhang Y, Testa G, Stewart AF. Rapid modification of bacterial artificial chromosomes by ET-recombination. Nucleic Acids Res 1999;27:1555-1557.
    • (1999) Nucleic Acids Res , vol.27 , pp. 1555-1557
    • Muyrers, J.P.1    Zhang, Y.2    Testa, G.3    Stewart, A.F.4
  • 37
    • 0028059099 scopus 로고
    • Deletion of a DNA polymerase Beta gene segment in T cells using cell type-specific gene targeting
    • Gu H, Marth JD, Orban PC, Mossmann H, Rajewsky K. Deletion of a DNA polymerase Beta gene segment in T cells using cell type-specific gene targeting. Science 1994;265:103-106.
    • (1994) Science , vol.265 , pp. 103-106
    • Gu, H.1    Marth, J.D.2    Orban, P.C.3    Mossmann, H.4    Rajewsky, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.