-
1
-
-
84901014050
-
Targeted disruption of the JAK2/STAT3 pathway in combination with systemic administration of paclitaxel inhibits the priming of ovarian cancer stem cells leading to a reduced tumor burden
-
PID: 24782986
-
Abubaker K, Luwor RB, Escalona R, McNally O, Quinn MA, Thompson EW, Findlay JK, Ahmed N (2014) Targeted disruption of the JAK2/STAT3 pathway in combination with systemic administration of paclitaxel inhibits the priming of ovarian cancer stem cells leading to a reduced tumor burden. Front Oncol 4:75
-
(2014)
Front Oncol
, vol.4
, pp. 75
-
-
Abubaker, K.1
Luwor, R.B.2
Escalona, R.3
McNally, O.4
Quinn, M.A.5
Thompson, E.W.6
Findlay, J.K.7
Ahmed, N.8
-
2
-
-
84890806562
-
Therapeutic targeting of the Jak/STAT pathway
-
PID: 24164900
-
Aittomäki S, Pesu M (2014) Therapeutic targeting of the Jak/STAT pathway. Basic Clin Pharmacol Toxicol 114:18–23
-
(2014)
Basic Clin Pharmacol Toxicol
, vol.114
, pp. 18-23
-
-
Aittomäki, S.1
Pesu, M.2
-
3
-
-
0028303977
-
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
-
COI: 1:CAS:528:DyaK2cXkslGjtLk%3D, PID: 7512451
-
Akira S, Nishio Y, Inoue M, Wang XJ, Wei S, Matsusaka T, Yoshida K, Sudo T, Naruto M, Kishimoto T (1994) Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 77:63–71
-
(1994)
Cell
, vol.77
, pp. 63-71
-
-
Akira, S.1
Nishio, Y.2
Inoue, M.3
Wang, X.J.4
Wei, S.5
Matsusaka, T.6
Yoshida, K.7
Sudo, T.8
Naruto, M.9
Kishimoto, T.10
-
4
-
-
38849199799
-
STAT3 as a target for inducing apoptosis in solid and hematological tumors
-
COI: 1:CAS:528:DC%2BD1cXhs1Omt7w%3D, PID: 18227858
-
Al Zaid Siddiquee K, Turkson J (2008) STAT3 as a target for inducing apoptosis in solid and hematological tumors. Cell Res 18:254–267
-
(2008)
Cell Res
, vol.18
, pp. 254-267
-
-
Al Zaid Siddiquee, K.1
Turkson, J.2
-
5
-
-
33846531356
-
The tumour microenvironment as a target for chemoprevention
-
COI: 1:CAS:528:DC%2BD2sXotFOjuw%3D%3D, PID: 17218951
-
Albini A, Sporn MB (2007) The tumour microenvironment as a target for chemoprevention. Nat Rev Cancer 7:139–147
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 139-147
-
-
Albini, A.1
Sporn, M.B.2
-
6
-
-
0742322913
-
Posttraumatic inflammation is a complex response based on the pathological expression of the nervous, immune, and endocrine functional systems
-
COI: 1:CAS:528:DC%2BD2cXpvFSrtQ%3D%3D
-
Aller MA, Aris JL, Nava MP, Arias J (2004) Posttraumatic inflammation is a complex response based on the pathological expression of the nervous, immune, and endocrine functional systems. Exp Biol Med 229:170–181
-
(2004)
Exp Biol Med
, vol.229
, pp. 170-181
-
-
Aller, M.A.1
Aris, J.L.2
Nava, M.P.3
Arias, J.4
-
7
-
-
4644335311
-
Cancer: an inflammatory link
-
COI: 1:CAS:528:DC%2BD2cXnslemuro%3D, PID: 15385993
-
Balkwill F, Coussens LM (2004) Cancer: an inflammatory link. Nature 431:405–406
-
(2004)
Nature
, vol.431
, pp. 405-406
-
-
Balkwill, F.1
Coussens, L.M.2
-
8
-
-
0035901090
-
Inflammation and cancer: back to Virchow?
-
COI: 1:CAS:528:DC%2BD3MXhsVKltb0%3D, PID: 11229684
-
Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow? Lancet 357:539–545
-
(2001)
Lancet
, vol.357
, pp. 539-545
-
-
Balkwill, F.1
Mantovani, A.2
-
9
-
-
84874693196
-
The tumor microenvironment at a glance
-
COI: 1:CAS:528:DC%2BC3sXkslSmsLo%3D, PID: 23420197
-
Balkwill FR, Capasso M, Hagemann T (2012) The tumor microenvironment at a glance. J Cell Sci 125:5591–5596
-
(2012)
J Cell Sci
, vol.125
, pp. 5591-5596
-
-
Balkwill, F.R.1
Capasso, M.2
Hagemann, T.3
-
10
-
-
0028029813
-
Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes
-
COI: 1:CAS:528:DyaK2MXislGqs7o%3D, PID: 7988557
-
Beadling C, Guschin D, Witthuhn BA, Ziemiecki A, Ihle JN, Kerr IM, Cantrell DA (1994) Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes. EMBO J 13:5605–5615
-
(1994)
EMBO J
, vol.13
, pp. 5605-5615
-
-
Beadling, C.1
Guschin, D.2
Witthuhn, B.A.3
Ziemiecki, A.4
Ihle, J.N.5
Kerr, I.M.6
Cantrell, D.A.7
-
11
-
-
34347230533
-
Elevated interleukin-6 and G-CSF in human pancreatic cancer cell conditioned medium suppress dendritic cell differentiation and activation
-
COI: 1:CAS:528:DC%2BD2sXmtVaitLk%3D, PID: 17545630
-
Bharadwaj U, Li M, Zhang R, Chen C, Yao Q (2007) Elevated interleukin-6 and G-CSF in human pancreatic cancer cell conditioned medium suppress dendritic cell differentiation and activation. Cancer Res 67:5479–5488
-
(2007)
Cancer Res
, vol.67
, pp. 5479-5488
-
-
Bharadwaj, U.1
Li, M.2
Zhang, R.3
Chen, C.4
Yao, Q.5
-
12
-
-
0030697807
-
PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner
-
COI: 1:CAS:528:DyaK2sXns1OgtrY%3D, PID: 9815602
-
Bos M, Mendelsohn J, Kim YM, Albanell J, Fry DW, Baselga J (1997) PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner. Clin Cancer Res 3:2099–2106
-
(1997)
Clin Cancer Res
, vol.3
, pp. 2099-2106
-
-
Bos, M.1
Mendelsohn, J.2
Kim, Y.M.3
Albanell, J.4
Fry, D.W.5
Baselga, J.6
-
13
-
-
84891620061
-
Targeting the tumor microenvironment: JAK-STAT3 signaling
-
PID: 24058812
-
Bournazou E, Bromberg J (2013) Targeting the tumor microenvironment: JAK-STAT3 signaling. JAKSTAT 2:e23828
-
(2013)
JAKSTAT
, vol.2
-
-
Bournazou, E.1
Bromberg, J.2
-
14
-
-
77956472212
-
The role of the tissue microenvironment in the regulation of cancer cell motility and invasion
-
PID: 20822526
-
Brábek J, Mierke CT, Rösel D, Veselý P, Fabry B (2010) The role of the tissue microenvironment in the regulation of cancer cell motility and invasion. Cell Commun Signal 8:22
-
(2010)
Cell Commun Signal
, vol.8
, pp. 22
-
-
Brábek, J.1
Mierke, C.T.2
Rösel, D.3
Veselý, P.4
Fabry, B.5
-
15
-
-
84959319525
-
Targeting JAK kinase in solid tumors: emerging opportunities and challenges
-
COI: 1:CAS:528:DC%2BC28XjtVOns7s%3D, PID: 25982279
-
Buchert M, Burns CJ, Ernst M (2016) Targeting JAK kinase in solid tumors: emerging opportunities and challenges. Oncogene 35:939–951
-
(2016)
Oncogene
, vol.35
, pp. 939-951
-
-
Buchert, M.1
Burns, C.J.2
Ernst, M.3
-
16
-
-
0141733147
-
Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells
-
COI: 1:CAS:528:DC%2BD3sXnsV2lsbo%3D, PID: 12842895
-
Buerger C, Nagel-Wolfrum K, Kunz C, Wittig I, Butz K, Hoppe-Seyler F, Groner B (2003) Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells. J Biol Chem 278:37610–37621
-
(2003)
J Biol Chem
, vol.278
, pp. 37610-37621
-
-
Buerger, C.1
Nagel-Wolfrum, K.2
Kunz, C.3
Wittig, I.4
Butz, K.5
Hoppe-Seyler, F.6
Groner, B.7
-
17
-
-
35448954376
-
Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression
-
COI: 1:CAS:528:DC%2BD2sXhtFOnsLrF, PID: 17942936
-
Bunt SK, Yang L, Sinha P, Clements VK, Leips J, Ostrand-Rosenberg S (2007) Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression. Cancer Res 67:10019–10026
-
(2007)
Cancer Res
, vol.67
, pp. 10019-10026
-
-
Bunt, S.K.1
Yang, L.2
Sinha, P.3
Clements, V.K.4
Leips, J.5
Ostrand-Rosenberg, S.6
-
18
-
-
84898921083
-
STAT3 target genes relevant to human cancers
-
COI: 1:CAS:528:DC%2BC2cXhs1Crs7fN, PID: 24743777
-
Carpenter RL, Lo HW (2014) STAT3 target genes relevant to human cancers. Cancers 6:897–925
-
(2014)
Cancers
, vol.6
, pp. 897-925
-
-
Carpenter, R.L.1
Lo, H.W.2
-
19
-
-
84928749945
-
New horizons in tumor microenvironment biology: challenges and opportunities
-
PID: 25857315
-
Chen F, Zhuang X, Lin L, Yu P, Wang Y, Shi Y, Hu G, Sun Y (2015) New horizons in tumor microenvironment biology: challenges and opportunities. BMC Med 13:45
-
(2015)
BMC Med
, vol.13
, pp. 45
-
-
Chen, F.1
Zhuang, X.2
Lin, L.3
Yu, P.4
Wang, Y.5
Shi, Y.6
Hu, G.7
Sun, Y.8
-
20
-
-
0028234529
-
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
-
COI: 1:CAS:528:DyaK2cXktlalsL4%3D, PID: 8197455
-
Darnell JE Jr, Kerr IM, Stark GR (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415–1421
-
(1994)
Science
, vol.264
, pp. 1415-1421
-
-
Darnell, J.E.1
Kerr, I.M.2
Stark, G.R.3
-
21
-
-
84929590468
-
Interleukin-21 sustains inflammatory signals that contribute to sporadic colon tumorigenesis
-
PID: 25839161
-
De Simone V, Ronchetti G, Franzè E, Colantoni A, Ortenzi A, Fantini MC, Rizzo A, Sica GS, Sileri P, Rossi P, MacDonald TT, Pallone F, Monteleone G, Stolfi C (2015) Interleukin-21 sustains inflammatory signals that contribute to sporadic colon tumorigenesis. Oncotarget 6:9908–9923
-
(2015)
Oncotarget
, vol.6
, pp. 9908-9923
-
-
De Simone, V.1
Ronchetti, G.2
Franzè, E.3
Colantoni, A.4
Ortenzi, A.5
Fantini, M.C.6
Rizzo, A.7
Sica, G.S.8
Sileri, P.9
Rossi, P.10
MacDonald, T.T.11
Pallone, F.12
Monteleone, G.13
Stolfi, C.14
-
22
-
-
84864917825
-
Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein
-
COI: 1:CAS:528:DC%2BC38Xnsl2msrc%3D, PID: 22650325
-
Debnath B, Xu S, Neamati N (2012) Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein. J Med Chem 55:6645–6668
-
(2012)
J Med Chem
, vol.55
, pp. 6645-6668
-
-
Debnath, B.1
Xu, S.2
Neamati, N.3
-
23
-
-
84882619034
-
Targeting the tumor microenvironment: from understanding pathways to effective clinical trials
-
COI: 1:CAS:528:DC%2BC3sXht1OisrbN, PID: 23913938
-
Fang H, Declerck YA (2013) Targeting the tumor microenvironment: from understanding pathways to effective clinical trials. Cancer Res 73:4965–4977
-
(2013)
Cancer Res
, vol.73
, pp. 4965-4977
-
-
Fang, H.1
Declerck, Y.A.2
-
24
-
-
35648946229
-
Chronic inflammation and oxidative stress in human carcinogenesis
-
COI: 1:CAS:528:DC%2BD2sXhtlShtb%2FN, PID: 17893868
-
Federico A, Morgillo F, Tuccillo C, Ciardiello F, Loguercio C (2007) Chronic inflammation and oxidative stress in human carcinogenesis. Int J Cancer 121:2381–2386
-
(2007)
Int J Cancer
, vol.121
, pp. 2381-2386
-
-
Federico, A.1
Morgillo, F.2
Tuccillo, C.3
Ciardiello, F.4
Loguercio, C.5
-
25
-
-
81855169565
-
Cancer invasion and the microenvironment: plasticity and reciprocity
-
COI: 1:CAS:528:DC%2BC3MXhsFeisrbE, PID: 22118458
-
Friedl P, Alexander S (2011) Cancer invasion and the microenvironment: plasticity and reciprocity. Cell 147:992–1009
-
(2011)
Cell
, vol.147
, pp. 992-1009
-
-
Friedl, P.1
Alexander, S.2
-
26
-
-
58149267888
-
LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model
-
COI: 1:CAS:528:DC%2BD1MXjt1Shug%3D%3D, PID: 19127268
-
Fuh B, Sobo M, Cen L, Josiah D, Hutzen B, Cisek K, Bhasin D, Regan N, Lin L, Chan C, Caldas H, DeAngelis S, Li C, Li PK, Lin J (2009) LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model. Brit J Cancer 100:106–112
-
(2009)
Brit J Cancer
, vol.100
, pp. 106-112
-
-
Fuh, B.1
Sobo, M.2
Cen, L.3
Josiah, D.4
Hutzen, B.5
Cisek, K.6
Bhasin, D.7
Regan, N.8
Lin, L.9
Chan, C.10
Caldas, H.11
DeAngelis, S.12
Li, C.13
Li, P.K.14
Lin, J.15
-
27
-
-
84925456959
-
Cancer-mediated adipose reversion promotes cancer cell migration via IL-6 and MCP-1
-
COI: 1:CAS:528:DC%2BC2MXjs1GrsL8%3D, PID: 25721605
-
Fujisaki K, Fujimoto H, Sangai T, Nagashima T, Sakakibara M, Shiina N, Kuroda M, Aoyagi Y, Miyazaki M (2015) Cancer-mediated adipose reversion promotes cancer cell migration via IL-6 and MCP-1. Breast Cancer Res Treat 150:255–263
-
(2015)
Breast Cancer Res Treat
, vol.150
, pp. 255-263
-
-
Fujisaki, K.1
Fujimoto, H.2
Sangai, T.3
Nagashima, T.4
Sakakibara, M.5
Shiina, N.6
Kuroda, M.7
Aoyagi, Y.8
Miyazaki, M.9
-
28
-
-
84897533875
-
A novel strategy for inducing the antitumor effects of triterpenoid compounds: blocking the protumoral functions of tumor-associated macrophages via STAT3 inhibition
-
PID: 24738052
-
Fujiwara Y, Takeya M, Komohara Y (2014) A novel strategy for inducing the antitumor effects of triterpenoid compounds: blocking the protumoral functions of tumor-associated macrophages via STAT3 inhibition. Biomed Res Int 2014:348539
-
(2014)
Biomed Res Int
, vol.2014
, pp. 348539
-
-
Fujiwara, Y.1
Takeya, M.2
Komohara, Y.3
-
29
-
-
84959347264
-
Strategies and Approaches of Targeting STAT3 for Cancer Treatment
-
COI: 1:CAS:528:DC%2BC28XhvVOqsA%3D%3D, PID: 26730496
-
Furtek SL, Backos DS, Matheson CJ, Reigan P (2016) Strategies and Approaches of Targeting STAT3 for Cancer Treatment. ACS Chem Biol 11:308–318
-
(2016)
ACS Chem Biol
, vol.11
, pp. 308-318
-
-
Furtek, S.L.1
Backos, D.S.2
Matheson, C.J.3
Reigan, P.4
-
30
-
-
10244279184
-
Mechanisms and functional significance of tumour-induced dendritic-cell defects
-
COI: 1:CAS:528:DC%2BD2cXhtVarsb7P, PID: 15573129
-
Gabrilovich D (2004) Mechanisms and functional significance of tumour-induced dendritic-cell defects. Nat Rev Immunol 4:941–952
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 941-952
-
-
Gabrilovich, D.1
-
31
-
-
33749319703
-
Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
-
COI: 1:CAS:528:DC%2BD28XhtVSnsrnK, PID: 17008531
-
Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce-Pagès C, Tosolini M, Camus M, Berger A, Wind P, Zinzindohoué F, Bruneval P, Cugnenc PH, Trajanoski Z, Fridman WH, Pagès F (2006) Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313:1960–1964
-
(2006)
Science
, vol.313
, pp. 1960-1964
-
-
Galon, J.1
Costes, A.2
Sanchez-Cabo, F.3
Kirilovsky, A.4
Mlecnik, B.5
Lagorce-Pagès, C.6
Tosolini, M.7
Camus, M.8
Berger, A.9
Wind, P.10
Zinzindohoué, F.11
Bruneval, P.12
Cugnenc, P.H.13
Trajanoski, Z.14
Fridman, W.H.15
Pagès, F.16
-
32
-
-
65649149328
-
Activation of signal transducers and activators of transcription 3 and focal adhesion kinase by stromal cell-derived factor 1 is required for migration of human mesenchymal stem cells in response to tumor cell-conditioned medium
-
COI: 1:CAS:528:DC%2BD1MXmt1Wnsb0%3D, PID: 19350687
-
Gao H, Priebe W, Glod J, Banerjee D (2009) Activation of signal transducers and activators of transcription 3 and focal adhesion kinase by stromal cell-derived factor 1 is required for migration of human mesenchymal stem cells in response to tumor cell-conditioned medium. Stem Cells 27:857–865
-
(2009)
Stem Cells
, vol.27
, pp. 857-865
-
-
Gao, H.1
Priebe, W.2
Glod, J.3
Banerjee, D.4
-
33
-
-
84883682803
-
Constitutive activation of signal transducer and activator of transcription 3 (STAT3) and nuclear factor κB signaling in glioblastoma cancer stem cells regulates the Notch pathway
-
COI: 1:CAS:528:DC%2BC3sXhsVWqtrzK, PID: 23902772
-
Garner JM, Fan M, Yang CH, Du Z, Sims M, Davidoff AM, Pfeffer LM (2013) Constitutive activation of signal transducer and activator of transcription 3 (STAT3) and nuclear factor κB signaling in glioblastoma cancer stem cells regulates the Notch pathway. J Biol Chem 288:26167–26176
-
(2013)
J Biol Chem
, vol.288
, pp. 26167-26176
-
-
Garner, J.M.1
Fan, M.2
Yang, C.H.3
Du, Z.4
Sims, M.5
Davidoff, A.M.6
Pfeffer, L.M.7
-
34
-
-
77950346282
-
Immunity, inflammation, and cancer
-
COI: 1:CAS:528:DC%2BC3cXlsVSgu7g%3D, PID: 20303878
-
Grivennikov SI, Greten FR, Karin M (2010) Immunity, inflammation, and cancer. Cell 140:883–899
-
(2010)
Cell
, vol.140
, pp. 883-899
-
-
Grivennikov, S.I.1
Greten, F.R.2
Karin, M.3
-
35
-
-
58149392583
-
Targeting protein-protein interactions: suppression of Stat3 dimerization with rationally designed small-molecule, nonpeptidic SH2 domain binders
-
COI: 1:CAS:528:DC%2BD1cXhsV2ls7bK, PID: 19006150
-
Gunning PT, Glenn MP, Siddiquee KA, Katt WP, Masson E, Sebti SM, Turkson J, Hamilton AD (2008) Targeting protein-protein interactions: suppression of Stat3 dimerization with rationally designed small-molecule, nonpeptidic SH2 domain binders. ChemBioChem 9:2800–2803
-
(2008)
ChemBioChem
, vol.9
, pp. 2800-2803
-
-
Gunning, P.T.1
Glenn, M.P.2
Siddiquee, K.A.3
Katt, W.P.4
Masson, E.5
Sebti, S.M.6
Turkson, J.7
Hamilton, A.D.8
-
36
-
-
84865422083
-
Interleukin-6 signaling pathway in targeted therapy for cancer
-
COI: 1:CAS:528:DC%2BC38Xnsl2rtLc%3D, PID: 22651903
-
Guo Y, Xu F, Lu T, Duan Z, Zhang Z (2012) Interleukin-6 signaling pathway in targeted therapy for cancer. Cancer Treat Rev 38:904–910
-
(2012)
Cancer Treat Rev
, vol.38
, pp. 904-910
-
-
Guo, Y.1
Xu, F.2
Lu, T.3
Duan, Z.4
Zhang, Z.5
-
37
-
-
84858590826
-
Accessories to the crime: functions of cells recruited to the tumor microenvironment
-
COI: 1:CAS:528:DC%2BC38Xkt1ykt7w%3D, PID: 22439926
-
Hanahan D, Coussens LM (2012) Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 21:309–322
-
(2012)
Cancer Cell
, vol.21
, pp. 309-322
-
-
Hanahan, D.1
Coussens, L.M.2
-
38
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
COI: 1:CAS:528:DC%2BC3MXjsFeqtrk%3D, PID: 21376230
-
Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
39
-
-
84894527895
-
Proteomic profiling of the tumor microenvironment: recent insights and the search for biomarkers
-
PID: 24713112
-
Hanash S, Schliekelman M (2014) Proteomic profiling of the tumor microenvironment: recent insights and the search for biomarkers. Genome Med 6:12
-
(2014)
Genome Med
, vol.6
, pp. 12
-
-
Hanash, S.1
Schliekelman, M.2
-
40
-
-
84959239708
-
Deaths: leading causes for 2013
-
Heron M (2016) Deaths: leading causes for 2013. Natl Vital Stat Rep 65:1–95
-
(2016)
Natl Vital Stat Rep
, vol.65
, pp. 1-95
-
-
Heron, M.1
-
41
-
-
35348960378
-
STAT3 mutations in the hyper-IgE syndrome
-
COI: 1:CAS:528:DC%2BD2sXht1SgurzL, PID: 17881745
-
Holland SM, DeLeo FR, Elloumi HZ, Hsu AP, Uzel G, Brodsky N, Freeman AF, Demidowich A, Davis J, Turner ML, Anderson VL, Darnell DN, Welch PA, Kuhns DB, Frucht DM, Malech HL, Gallin JI, Kobayashi SD, Whitney AR, Voyich JM, Musser JM, Woellner C, Schäffer AA, Puck JM, Grimbacher B (2007) STAT3 mutations in the hyper-IgE syndrome. N Engl J Med 357:1608–1619
-
(2007)
N Engl J Med
, vol.357
, pp. 1608-1619
-
-
Holland, S.M.1
DeLeo, F.R.2
Elloumi, H.Z.3
Hsu, A.P.4
Uzel, G.5
Brodsky, N.6
Freeman, A.F.7
Demidowich, A.8
Davis, J.9
Turner, M.L.10
Anderson, V.L.11
Darnell, D.N.12
Welch, P.A.13
Kuhns, D.B.14
Frucht, D.M.15
Malech, H.L.16
Gallin, J.I.17
Kobayashi, S.D.18
Whitney, A.R.19
Voyich, J.M.20
Musser, J.M.21
Woellner, C.22
Schäffer, A.A.23
Puck, J.M.24
Grimbacher, B.25
more..
-
42
-
-
84932163442
-
A novel small-molecule inhibitor targeting the IL-6 receptor β subunit, glycoprotein 130
-
COI: 1:CAS:528:DC%2BC2MXhtVagur7I, PID: 26026064
-
Hong SS, Choi JH, Lee SY, Park YH, Park KY, Lee JY, Kim J, Gajulapati V, Goo JI, Singh S, Lee K, Kim YK, Im SH, Ahn SH, Rose-John S, Heo TH, Choi Y (2015) A novel small-molecule inhibitor targeting the IL-6 receptor β subunit, glycoprotein 130. J Immunol 195:237–245
-
(2015)
J Immunol
, vol.195
, pp. 237-245
-
-
Hong, S.S.1
Choi, J.H.2
Lee, S.Y.3
Park, Y.H.4
Park, K.Y.5
Lee, J.Y.6
Kim, J.7
Gajulapati, V.8
Goo, J.I.9
Singh, S.10
Lee, K.11
Kim, Y.K.12
Im, S.H.13
Ahn, S.H.14
Rose-John, S.15
Heo, T.H.16
Choi, Y.17
-
43
-
-
84900846428
-
A small molecule compound targeting STAT3 DNA-binding domain inhibits cancer cell proliferation, migration, and invasion
-
COI: 1:CAS:528:DC%2BC2cXktVSjs74%3D, PID: 24661007
-
Huang W, Dong Z, Wang F, Peng H, Liu JY, Zhang JT (2014) A small molecule compound targeting STAT3 DNA-binding domain inhibits cancer cell proliferation, migration, and invasion. ACS Chem Biol 9:1188–1196
-
(2014)
ACS Chem Biol
, vol.9
, pp. 1188-1196
-
-
Huang, W.1
Dong, Z.2
Wang, F.3
Peng, H.4
Liu, J.Y.5
Zhang, J.T.6
-
44
-
-
84958058999
-
Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo
-
COI: 1:CAS:528:DC%2BC28Xitl2gtL8%3D, PID: 26073084
-
Huang W, Dong Z, Chen Y, Wang F, Wang CJ, Peng H, He Y, Hangoc G, Pollok K, Sandusky G, Fu XY, Broxmeyer HE, Zhang ZY, Liu JY, Zhang JT (2016) Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene 35:783–792
-
(2016)
Oncogene
, vol.35
, pp. 783-792
-
-
Huang, W.1
Dong, Z.2
Chen, Y.3
Wang, F.4
Wang, C.J.5
Peng, H.6
He, Y.7
Hangoc, G.8
Pollok, K.9
Sandusky, G.10
Fu, X.Y.11
Broxmeyer, H.E.12
Zhang, Z.Y.13
Liu, J.Y.14
Zhang, J.T.15
-
45
-
-
35648983903
-
Inflammation and cancer: an ancient link with novel potentials
-
COI: 1:CAS:528:DC%2BD2sXhtlShtb%2FM, PID: 17893866
-
Hussain SP, Harris CC (2007) Inflammation and cancer: an ancient link with novel potentials. Int J Cancer 121:2373–2380
-
(2007)
Int J Cancer
, vol.121
, pp. 2373-2380
-
-
Hussain, S.P.1
Harris, C.C.2
-
46
-
-
84938915819
-
YKL-40 regulated epithelial-mesenchymal transition and migration/invasion enhancement in non-small cell lung cancer
-
PID: 26275425
-
Jefri M, Huang YN, Huang WC, Tai CS, Chen WL (2015) YKL-40 regulated epithelial-mesenchymal transition and migration/invasion enhancement in non-small cell lung cancer. BMC Cancer 15:590
-
(2015)
BMC Cancer
, vol.15
, pp. 590
-
-
Jefri, M.1
Huang, Y.N.2
Huang, W.C.3
Tai, C.S.4
Chen, W.L.5
-
47
-
-
79953208248
-
STAT3 signaling: anticancer strategies and challenges
-
COI: 1:CAS:528:DC%2BC3MXkvVehsrk%3D, PID: 21441118
-
Johnston PA, Grandis JR (2011) STAT3 signaling: anticancer strategies and challenges. Mol Interv 11:18–26
-
(2011)
Mol Interv
, vol.11
, pp. 18-26
-
-
Johnston, P.A.1
Grandis, J.R.2
-
48
-
-
84928771999
-
T cell exclusion, immune privilege, and the tumor microenvironment
-
COI: 1:CAS:528:DC%2BC2MXls1Wmu74%3D, PID: 25838376
-
Joyce JA, Fearon DT (2015) T cell exclusion, immune privilege, and the tumor microenvironment. Science 348:74–80
-
(2015)
Science
, vol.348
, pp. 74-80
-
-
Joyce, J.A.1
Fearon, D.T.2
-
49
-
-
23444449093
-
STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells
-
COI: 1:CAS:528:DC%2BD2MXntlWiurs%3D, PID: 15919761
-
Jung JE, Lee HG, Cho IH, Chung DH, Yoon SH, Yang YM, Lee JW, Choi S, Park JW, Ye SK, Chung MH (2005) STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells. FASEB J 19:1296–1298
-
(2005)
FASEB J
, vol.19
, pp. 1296-1298
-
-
Jung, J.E.1
Lee, H.G.2
Cho, I.H.3
Chung, D.H.4
Yoon, S.H.5
Yang, Y.M.6
Lee, J.W.7
Choi, S.8
Park, J.W.9
Ye, S.K.10
Chung, M.H.11
-
50
-
-
57349168511
-
STAT3 inhibits the degradation of HIF-1alpha by pVHL-mediated ubiquitination
-
COI: 1:CAS:528:DC%2BD1cXhtlOgtb7O, PID: 18985005
-
Jung JE, Kim HS, Lee CS, Shin YJ, Kim YN, Kang GH, Kim TY, Juhnn YS, Kim SJ, Park JW, Ye SK, Chung MH (2008) STAT3 inhibits the degradation of HIF-1alpha by pVHL-mediated ubiquitination. Exp Mol Med 40:479–485
-
(2008)
Exp Mol Med
, vol.40
, pp. 479-485
-
-
Jung, J.E.1
Kim, H.S.2
Lee, C.S.3
Shin, Y.J.4
Kim, Y.N.5
Kang, G.H.6
Kim, T.Y.7
Juhnn, Y.S.8
Kim, S.J.9
Park, J.W.10
Ye, S.K.11
Chung, M.H.12
-
51
-
-
33646384428
-
Fibroblasts in cancer
-
COI: 1:CAS:528:DC%2BD28XjslGitLw%3D, PID: 16572188
-
Kalluri R, Zeisberg M (2006) Fibroblasts in cancer. Nat Rev Cancer 6:392–401
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 392-401
-
-
Kalluri, R.1
Zeisberg, M.2
-
52
-
-
54049106581
-
A small-molecule compound identified through a cell-based screening inhibits JAK/STAT pathway signaling in human cancer cells
-
COI: 1:CAS:528:DC%2BD1cXhtFSms7nP, PID: 18790749
-
Kim BH, Yin CH, Guo Q, Bach EA, Lee H, Sandoval C, Jayabose S, Ulaczyk-Lesanko A, Hall DG, Baeg GH (2008) A small-molecule compound identified through a cell-based screening inhibits JAK/STAT pathway signaling in human cancer cells. Mol Cancer Ther 7:2672–2680
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 2672-2680
-
-
Kim, B.H.1
Yin, C.H.2
Guo, Q.3
Bach, E.A.4
Lee, H.5
Sandoval, C.6
Jayabose, S.7
Ulaczyk-Lesanko, A.8
Hall, D.G.9
Baeg, G.H.10
-
53
-
-
84931411333
-
Anti-angiogenic activity of thienopyridine derivative LCB03-0110 by targeting VEGFR-2 and JAK/STAT3 Signalling
-
COI: 1:CAS:528:DC%2BC2MXhtVOnu7rL, PID: 25808463
-
Kim BH, Lee Y, Yoo H, Cui M, Lee S, Kim SY, Cho JU, Lee H, Yang BS, Kwon YG, Choi S, Kim TY (2015) Anti-angiogenic activity of thienopyridine derivative LCB03-0110 by targeting VEGFR-2 and JAK/STAT3 Signalling. Exp Dermatol 24:503–509
-
(2015)
Exp Dermatol
, vol.24
, pp. 503-509
-
-
Kim, B.H.1
Lee, Y.2
Yoo, H.3
Cui, M.4
Lee, S.5
Kim, S.Y.6
Cho, J.U.7
Lee, H.8
Yang, B.S.9
Kwon, Y.G.10
Choi, S.11
Kim, T.Y.12
-
54
-
-
28644445445
-
Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
-
COI: 1:CAS:528:DC%2BD2MXht1yisr3I, PID: 16288283
-
Kortylewski M, Kujawski M, Wang T, Wei S, Zhang S, Pilon-Thomas S, Niu G, Kay H, Mulé J, Kerr WG, Jove R, Pardoll D, Yu H (2005) Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med 11:1314–1321
-
(2005)
Nat Med
, vol.11
, pp. 1314-1321
-
-
Kortylewski, M.1
Kujawski, M.2
Wang, T.3
Wei, S.4
Zhang, S.5
Pilon-Thomas, S.6
Niu, G.7
Kay, H.8
Mulé, J.9
Kerr, W.G.10
Jove, R.11
Pardoll, D.12
Yu, H.13
-
55
-
-
84883353803
-
Progress towards the development of SH2 domain inhibitors
-
COI: 1:CAS:528:DC%2BC3sXksFems7c%3D, PID: 23396540
-
Kraskouskaya D, Duodu E, Arpin CC, Gunning PT (2013) Progress towards the development of SH2 domain inhibitors. Chem Soc Rev 42:3337–3370
-
(2013)
Chem Soc Rev
, vol.42
, pp. 3337-3370
-
-
Kraskouskaya, D.1
Duodu, E.2
Arpin, C.C.3
Gunning, P.T.4
-
56
-
-
55849107422
-
Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice
-
COI: 1:CAS:528:DC%2BD1cXht1ChsrrE, PID: 18776941
-
Kujawski M, Kortylewski M, Lee H, Herrmann A, Kay H, Yu H (2008) Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice. J Clin Invest 118:3367–3377
-
(2008)
J Clin Invest
, vol.118
, pp. 3367-3377
-
-
Kujawski, M.1
Kortylewski, M.2
Lee, H.3
Herrmann, A.4
Kay, H.5
Yu, H.6
-
57
-
-
84901767734
-
Chronic inflammation and cytokines in the tumor microenvironment
-
PID: 24901008
-
Landskron G, De la Fuente M, Thuwajit P, Thuwajit C, Hermoso MA (2014) Chronic inflammation and cytokines in the tumor microenvironment. J Immunol Res 2014:149185
-
(2014)
J Immunol Res
, vol.2014
, pp. 149185
-
-
Landskron, G.1
De la Fuente, M.2
Thuwajit, P.3
Thuwajit, C.4
Hermoso, M.A.5
-
58
-
-
33746534417
-
IL-23 promotes tumour incidence and growth
-
COI: 1:CAS:528:DC%2BD28XnsVajtbk%3D, PID: 16688182
-
Langowski JL, Zhang X, Wu L, Mattson JD, Chen T, Smith K, Basham B, McClanahan T, Kastelein RA, Oft M (2006) IL-23 promotes tumour incidence and growth. Nature 442:461–465
-
(2006)
Nature
, vol.442
, pp. 461-465
-
-
Langowski, J.L.1
Zhang, X.2
Wu, L.3
Mattson, J.D.4
Chen, T.5
Smith, K.6
Basham, B.7
McClanahan, T.8
Kastelein, R.A.9
Oft, M.10
-
59
-
-
78649789584
-
IL-6 promotes malignant growth of skin SCCs by regulating a network of autocrine and paracrine cytokines
-
COI: 1:CAS:528:DC%2BC3MXltVygsLw%3D, PID: 20726000
-
Lederle W, Depner S, Schnur S, Obermueller E, Catone N, Just A, Fusenig NE, Mueller MM (2011) IL-6 promotes malignant growth of skin SCCs by regulating a network of autocrine and paracrine cytokines. Int J Cancer 128:2803–2814
-
(2011)
Int J Cancer
, vol.128
, pp. 2803-2814
-
-
Lederle, W.1
Depner, S.2
Schnur, S.3
Obermueller, E.4
Catone, N.5
Just, A.6
Fusenig, N.E.7
Mueller, M.M.8
-
60
-
-
84920640485
-
Twist1 is a key regulator of cancer-associated fibroblasts
-
COI: 1:CAS:528:DC%2BC2MXislWgug%3D%3D, PID: 25368021
-
Lee KW, Yeo SY, Sung CO, Kim SH (2015a) Twist1 is a key regulator of cancer-associated fibroblasts. Cancer Res 75:73–85
-
(2015)
Cancer Res
, vol.75
, pp. 73-85
-
-
Lee, K.W.1
Yeo, S.Y.2
Sung, C.O.3
Kim, S.H.4
-
61
-
-
84940958476
-
Adipocytes can induce epithelial-mesenchymal transition in breast cancer cells
-
COI: 1:CAS:528:DC%2BC2MXhsVSns7fM, PID: 26285644
-
Lee Y, Jung WH, Koo JS (2015b) Adipocytes can induce epithelial-mesenchymal transition in breast cancer cells. Breast Cancer Res Treat 153:323–335
-
(2015)
Breast Cancer Res Treat
, vol.153
, pp. 323-335
-
-
Lee, Y.1
Jung, W.H.2
Koo, J.S.3
-
62
-
-
84885029891
-
Targeting wild-type and mutationally activated FGFR4 inrhabdomyosarcoma with the inhibitor ponatinib (AP24534)
-
COI: 1:CAS:528:DC%2BC3sXhsF2rs7%2FL, PID: 24124571
-
Li SQ, Cheuk AT, Shern JF, Song YK, Hurd L, Liao H, Wei JS, Khan J (2013) Targeting wild-type and mutationally activated FGFR4 inrhabdomyosarcoma with the inhibitor ponatinib (AP24534). PLoS ONE 8:e76551
-
(2013)
PLoS ONE
, vol.8
-
-
Li, S.Q.1
Cheuk, A.T.2
Shern, J.F.3
Song, Y.K.4
Hurd, L.5
Liao, H.6
Wei, J.S.7
Khan, J.8
-
63
-
-
73949111590
-
A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells
-
COI: 1:CAS:528:DC%2BC3cXmtlGhsA%3D%3D, PID: 20072652
-
Lin L, Hutzen B, Li PK, Ball S, Zuo M, DeAngelis S, Foust E, Sobo M, Friedman L, Bhasin D, Cen L, Li C, Lin J (2010a) A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells. Neoplasia 12:39–50
-
(2010)
Neoplasia
, vol.12
, pp. 39-50
-
-
Lin, L.1
Hutzen, B.2
Li, P.K.3
Ball, S.4
Zuo, M.5
DeAngelis, S.6
Foust, E.7
Sobo, M.8
Friedman, L.9
Bhasin, D.10
Cen, L.11
Li, C.12
Lin, J.13
-
64
-
-
77950190311
-
Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells
-
COI: 1:CAS:528:DC%2BC3cXjtFygtbw%3D, PID: 20215512
-
Lin L, Hutzen B, Zuo M, Ball S, Deangelis S, Foust E, Pandit B, Ihnat MA, Shenoy SS, Kulp S, Li PK, Li C, Fuchs J, Lin J (2010b) Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer Res 70:2445–2454
-
(2010)
Cancer Res
, vol.70
, pp. 2445-2454
-
-
Lin, L.1
Hutzen, B.2
Zuo, M.3
Ball, S.4
Deangelis, S.5
Foust, E.6
Pandit, B.7
Ihnat, M.A.8
Shenoy, S.S.9
Kulp, S.10
Li, P.K.11
Li, C.12
Fuchs, J.13
Lin, J.14
-
65
-
-
84881383785
-
Tanshinone IIA inhibits breast cancer stem cells growth in vitro and in vivo through attenuation of IL-6/STAT3/NF-kB signaling pathways
-
COI: 1:CAS:528:DC%2BC3sXhtFamsL%2FK, PID: 23553622
-
Lin C, Wang L, Wang H, Yang L, Guo H, Wang X (2013a) Tanshinone IIA inhibits breast cancer stem cells growth in vitro and in vivo through attenuation of IL-6/STAT3/NF-kB signaling pathways. J Cell Biochem 114:2061–2070
-
(2013)
J Cell Biochem
, vol.114
, pp. 2061-2070
-
-
Lin, C.1
Wang, L.2
Wang, H.3
Yang, L.4
Guo, H.5
Wang, X.6
-
66
-
-
84880443531
-
HIC1 interacts with and modulates the activity of STAT3
-
COI: 1:CAS:528:DC%2BC2cXpslKjug%3D%3D, PID: 24067369
-
Lin YM, Wang CM, Jeng JC, Leprince D, Shih HM (2013b) HIC1 interacts with and modulates the activity of STAT3. Cell Cycle 12:2266–2276
-
(2013)
Cell Cycle
, vol.12
, pp. 2266-2276
-
-
Lin, Y.M.1
Wang, C.M.2
Jeng, J.C.3
Leprince, D.4
Shih, H.M.5
-
67
-
-
0035902141
-
The microenvironment of the tumour-host interface
-
COI: 1:CAS:528:DC%2BD3MXktVSjs78%3D, PID: 11357145
-
Liotta LA, Kohn EC (2001) The microenvironment of the tumour-host interface. Nature 411:375–379
-
(2001)
Nature
, vol.411
, pp. 375-379
-
-
Liotta, L.A.1
Kohn, E.C.2
-
68
-
-
84894549857
-
MLS-2384, a new 6-bromoindirubin derivative with dual JAK/Src kinase inhibitory activity, suppresses growth of diverse cancer cells
-
COI: 1:CAS:528:DC%2BC2cXht12ns7nE, PID: 24100507
-
Liu L, Gaboriaud N, Vougogianopoulou K, Tian Y, Wu J, Wen W, Skaltsounis L, Jove R (2014) MLS-2384, a new 6-bromoindirubin derivative with dual JAK/Src kinase inhibitory activity, suppresses growth of diverse cancer cells. Cancer Biol Ther 15:178–184
-
(2014)
Cancer Biol Ther
, vol.15
, pp. 178-184
-
-
Liu, L.1
Gaboriaud, N.2
Vougogianopoulou, K.3
Tian, Y.4
Wu, J.5
Wen, W.6
Skaltsounis, L.7
Jove, R.8
-
69
-
-
84911004173
-
IL-6 enriched lung cancer stem-like cell population by inhibition of cell cycle regulators via DNMT1 upregulation
-
COI: 1:CAS:528:DC%2BC2cXhtVGjsLnI, PID: 24947242
-
Liu CC, Lin JH, Hsu TW, Su K, Li AF, Hsu HS, Hung SC (2015a) IL-6 enriched lung cancer stem-like cell population by inhibition of cell cycle regulators via DNMT1 upregulation. Int J Cancer 136:547–559
-
(2015)
Int J Cancer
, vol.136
, pp. 547-559
-
-
Liu, C.C.1
Lin, J.H.2
Hsu, T.W.3
Su, K.4
Li, A.F.5
Hsu, H.S.6
Hung, S.C.7
-
70
-
-
84940532833
-
High–mobility group box 1 has a prognostic role and contributes to epithelial mesenchymal transition in human hepatocellular carcinoma
-
COI: 1:CAS:528:DC%2BC2MXhvFWmsrfI, PID: 26252226
-
Liu Z, Dou C, Wang Y, Jia Y, Li Q, Zheng X, Yao Y, Liu Q, Song T (2015b) High–mobility group box 1 has a prognostic role and contributes to epithelial mesenchymal transition in human hepatocellular carcinoma. Mol Med Rep 12:5997–6004
-
(2015)
Mol Med Rep
, vol.12
, pp. 5997-6004
-
-
Liu, Z.1
Dou, C.2
Wang, Y.3
Jia, Y.4
Li, Q.5
Zheng, X.6
Yao, Y.7
Liu, Q.8
Song, T.9
-
71
-
-
35148832569
-
Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression
-
COI: 1:CAS:528:DC%2BD2sXhtFSnur7L, PID: 17909010
-
Lo HW, Hsu SC, Xia W, Cao X, Shih JY, Wei Y, Abbruzzese JL, Hortobagyi GN, Hung MC (2007) Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. Cancer Res 67:9066–9076
-
(2007)
Cancer Res
, vol.67
, pp. 9066-9076
-
-
Lo, H.W.1
Hsu, S.C.2
Xia, W.3
Cao, X.4
Shih, J.Y.5
Wei, Y.6
Abbruzzese, J.L.7
Hortobagyi, G.N.8
Hung, M.C.9
-
72
-
-
33646160623
-
Inflammation, a key event in cancer development
-
PID: 16603636
-
Lu H, Ouyang W, Huang C (2006) Inflammation, a key event in cancer development. Mol Cancer Res 4:221–233
-
(2006)
Mol Cancer Res
, vol.4
, pp. 221-233
-
-
Lu, H.1
Ouyang, W.2
Huang, C.3
-
73
-
-
80051733032
-
Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors
-
COI: 1:CAS:528:DC%2BC3MXhtVWntbbP, PID: 21751940
-
Mankan AK, Greten FR (2011) Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors. Expert Opin Investig Drugs 20:1263–1275
-
(2011)
Expert Opin Investig Drugs
, vol.20
, pp. 1263-1275
-
-
Mankan, A.K.1
Greten, F.R.2
-
74
-
-
47949096781
-
Cancer-related inflammation
-
COI: 1:CAS:528:DC%2BD1cXovV2mtbg%3D, PID: 18650914
-
Mantovani A, Allavena P, Sica A, Balkwill F (2008) Cancer-related inflammation. Nature 454:436–444
-
(2008)
Nature
, vol.454
, pp. 436-444
-
-
Mantovani, A.1
Allavena, P.2
Sica, A.3
Balkwill, F.4
-
75
-
-
0028361695
-
Association of p72 tyrosine kinase with Stat factors and its activation by interleukin-3, interleukin-6, and granulocyte colony-stimulating factor
-
COI: 1:CAS:528:DyaK2cXlslGltrg%3D, PID: 7515712
-
Matsuda T, Hirano T (1994) Association of p72 tyrosine kinase with Stat factors and its activation by interleukin-3, interleukin-6, and granulocyte colony-stimulating factor. Blood 83:3457–3461
-
(1994)
Blood
, vol.83
, pp. 3457-3461
-
-
Matsuda, T.1
Hirano, T.2
-
76
-
-
78649286584
-
Identification of a new series of STAT3 inhibitors by virtual screening
-
COI: 1:CAS:528:DC%2BC3cXos1yju7w%3D, PID: 24900220
-
Matsuno K, Masuda Y, Uehara Y, Sato H, Muroya A, Takahashi O, Yokotagawa T, Furuya T, Okawara T, Otsuka M, Ogo N, Ashizawa T, Oshita C, Tai S, Ishii H, Akiyama Y, Asai A (2010) Identification of a new series of STAT3 inhibitors by virtual screening. ACS Med Chem Lett 1:371–375
-
(2010)
ACS Med Chem Lett
, vol.1
, pp. 371-375
-
-
Matsuno, K.1
Masuda, Y.2
Uehara, Y.3
Sato, H.4
Muroya, A.5
Takahashi, O.6
Yokotagawa, T.7
Furuya, T.8
Okawara, T.9
Otsuka, M.10
Ogo, N.11
Ashizawa, T.12
Oshita, C.13
Tai, S.14
Ishii, H.15
Akiyama, Y.16
Asai, A.17
-
77
-
-
58849131828
-
Cancer and the tumor microenvironment: a review of an essential relationship
-
PID: 19083000
-
Mbeunkui F, Johann DJ Jr (2009) Cancer and the tumor microenvironment: a review of an essential relationship. Cancer Chemother Pharmacol 63:571–582
-
(2009)
Cancer Chemother Pharmacol
, vol.63
, pp. 571-582
-
-
Mbeunkui, F.1
Johann, D.J.2
-
78
-
-
84881267595
-
Therapeutic modulators of STAT signalling for human diseases
-
COI: 1:CAS:528:DC%2BC3sXht1SjtbvI, PID: 23903221
-
Miklossy G, Hilliard TS, Turkson J (2013) Therapeutic modulators of STAT signalling for human diseases. Nat Rev Drug Discov 12:611–629
-
(2013)
Nat Rev Drug Discov
, vol.12
, pp. 611-629
-
-
Miklossy, G.1
Hilliard, T.S.2
Turkson, J.3
-
79
-
-
84941213278
-
Anti-tumor effect of inhibition of IL-6 signaling in mucoepidermoid carcinoma
-
PID: 26287605
-
Mochizuki D, Adams A, Warner KA, Zhang Z, Pearson AT, Misawa K, McLean SA, Wolf GT, Nör JE (2015) Anti-tumor effect of inhibition of IL-6 signaling in mucoepidermoid carcinoma. Oncotarget 6:22822–22835
-
(2015)
Oncotarget
, vol.6
, pp. 22822-22835
-
-
Mochizuki, D.1
Adams, A.2
Warner, K.A.3
Zhang, Z.4
Pearson, A.T.5
Misawa, K.6
McLean, S.A.7
Wolf, G.T.8
Nör, J.E.9
-
80
-
-
84873695296
-
PI3 K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line
-
COI: 1:CAS:528:DC%2BC3sXkt1Khsr8%3D, PID: 23314408
-
Moon SH, Kim DK, Cha Y, Jeon I, Song J, Park KS (2013) PI3 K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line. Int J Oncol 42:921–928
-
(2013)
Int J Oncol
, vol.42
, pp. 921-928
-
-
Moon, S.H.1
Kim, D.K.2
Cha, Y.3
Jeon, I.4
Song, J.5
Park, K.S.6
-
81
-
-
84858116393
-
Role of nitrative and oxidative DNA damage in inflammation-related carcinogenesis
-
PID: 22363173
-
Murata M, Thanan R, Ma N, Kawanishi S (2012) Role of nitrative and oxidative DNA damage in inflammation-related carcinogenesis. J Biomed Biotechnol 2012:623019
-
(2012)
J Biomed Biotechnol
, vol.2012
, pp. 623019
-
-
Murata, M.1
Thanan, R.2
Ma, N.3
Kawanishi, S.4
-
82
-
-
3543070089
-
The interaction of specific peptide aptamers with the DNA binding domain and the dimerization domain of the transcription factor Stat3 inhibits transactivation and induces apoptosis in tumor cells
-
COI: 1:CAS:528:DC%2BD2cXjtFWksbs%3D, PID: 15037656
-
Nagel-Wolfrum K, Buerger C, Wittig I, Butz K, Hoppe-Seyler F, Groner B (2004) The interaction of specific peptide aptamers with the DNA binding domain and the dimerization domain of the transcription factor Stat3 inhibits transactivation and induces apoptosis in tumor cells. Mol Cancer Res 2:170–182
-
(2004)
Mol Cancer Res
, vol.2
, pp. 170-182
-
-
Nagel-Wolfrum, K.1
Buerger, C.2
Wittig, I.3
Butz, K.4
Hoppe-Seyler, F.5
Groner, B.6
-
83
-
-
84878116135
-
Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells
-
COI: 1:CAS:528:DC%2BC3sXovVCnsbY%3D, PID: 23206899
-
Nam S, Wen W, Schroeder A, Herrmann A, Yu H, Cheng X, Merz KH, Eisenbrand G, Li H, Yuan YC, Jove R (2013) Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells. Mol Oncol 7:369–378
-
(2013)
Mol Oncol
, vol.7
, pp. 369-378
-
-
Nam, S.1
Wen, W.2
Schroeder, A.3
Herrmann, A.4
Yu, H.5
Cheng, X.6
Merz, K.H.7
Eisenbrand, G.8
Li, H.9
Yuan, Y.C.10
Jove, R.11
-
84
-
-
84956572958
-
Endemic mycoses in patients with STAT3-mutated hyper-IgE (Job) syndrome
-
COI: 1:CAS:528:DC%2BC2MXhtlCqt7jP, PID: 26292779
-
Odio CD, Milligan KL, McGowan K, Rudman Spergel AK, Bishop R, Boris L, Urban A, Welch P, Heller T, Kleiner D, Jackson MA, Holland SM, Freeman AF (2015) Endemic mycoses in patients with STAT3-mutated hyper-IgE (Job) syndrome. J Allergy Clin Immunol 136:1411–1413
-
(2015)
J Allergy Clin Immunol
, vol.136
, pp. 1411-1413
-
-
Odio, C.D.1
Milligan, K.L.2
McGowan, K.3
Rudman Spergel, A.K.4
Bishop, R.5
Boris, L.6
Urban, A.7
Welch, P.8
Heller, T.9
Kleiner, D.10
Jackson, M.A.11
Holland, S.M.12
Freeman, A.F.13
-
85
-
-
84872065897
-
JAKs and STATs in immunity, immunodeficiency, and cancer
-
PID: 23301733
-
O’Shea JJ, Holland SM, Staudt LM (2013) JAKs and STATs in immunity, immunodeficiency, and cancer. N Engl J Med 368:161–170
-
(2013)
N Engl J Med
, vol.368
, pp. 161-170
-
-
O’Shea, J.J.1
Holland, S.M.2
Staudt, L.M.3
-
86
-
-
84921325808
-
The JAK-STAT pathway: impact on human disease and therapeutic intervention
-
PID: 25587654
-
O’Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A (2015) The JAK-STAT pathway: impact on human disease and therapeutic intervention. Annu Rev Med 66:311–328
-
(2015)
Annu Rev Med
, vol.66
, pp. 311-328
-
-
O’Shea, J.J.1
Schwartz, D.M.2
Villarino, A.V.3
Gadina, M.4
McInnes, I.B.5
Laurence, A.6
-
87
-
-
84862803209
-
Src tyrosine kinase inhibition prevents pulmonary ischemia-reperfusion-induced acute lung injury
-
COI: 1:CAS:528:DC%2BC38XmtFegs7w%3D, PID: 22349424
-
Oyaizu T, Fung SY, Shiozaki A, Guan Z, Zhang Q, dos Santos CC, Han B, Mura M, Keshavjee S, Liu M (2012) Src tyrosine kinase inhibition prevents pulmonary ischemia-reperfusion-induced acute lung injury. Intensive Care Med 38:894–905
-
(2012)
Intensive Care Med
, vol.38
, pp. 894-905
-
-
Oyaizu, T.1
Fung, S.Y.2
Shiozaki, A.3
Guan, Z.4
Zhang, Q.5
dos Santos, C.C.6
Han, B.7
Mura, M.8
Keshavjee, S.9
Liu, M.10
-
88
-
-
79952176419
-
Characterization of molecular recognition of STAT3 SH2 domain inhibitors through molecular simulation
-
COI: 1:CAS:528:DC%2BC3MXisV2jtr4%3D, PID: 21360612
-
Park IH, Li C (2011) Characterization of molecular recognition of STAT3 SH2 domain inhibitors through molecular simulation. J Mol Recognit 24:254–265
-
(2011)
J Mol Recognit
, vol.24
, pp. 254-265
-
-
Park, I.H.1
Li, C.2
-
89
-
-
4644249098
-
IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation
-
COI: 1:CAS:528:DC%2BD2cXnsVWksrc%3D, PID: 15356132
-
Park SJ, Nakagawa T, Kitamura H, Atsumi T, Kamon H, Sawa S, Kamimura D, Ueda N, Iwakura Y, Ishihara K, Murakami M, Hirano T (2004) IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation. J Immunol 173:3844–3854
-
(2004)
J Immunol
, vol.173
, pp. 3844-3854
-
-
Park, S.J.1
Nakagawa, T.2
Kitamura, H.3
Atsumi, T.4
Kamon, H.5
Sawa, S.6
Kamimura, D.7
Ueda, N.8
Iwakura, Y.9
Ishihara, K.10
Murakami, M.11
Hirano, T.12
-
90
-
-
38549180070
-
Mechanisms of oncogenic cooperation in cancer initiation and metastasis
-
PID: 17940619
-
Pedraza-Fariña LG (2006) Mechanisms of oncogenic cooperation in cancer initiation and metastasis. Yale J Biol Med 79:95–103
-
(2006)
Yale J Biol Med
, vol.79
, pp. 95-103
-
-
Pedraza-Fariña, L.G.1
-
91
-
-
84880691700
-
AZD1480: a phase I study of a novel JAK2 inhibitor in solid tumors
-
PID: 23847256
-
Plimack ER, Lorusso PM, McCoon P, Tang W, Krebs AD, Curt G, Eckhardt SG (2013) AZD1480: a phase I study of a novel JAK2 inhibitor in solid tumors. Oncologist 18:819–820
-
(2013)
Oncologist
, vol.18
, pp. 819-820
-
-
Plimack, E.R.1
Lorusso, P.M.2
McCoon, P.3
Tang, W.4
Krebs, A.D.5
Curt, G.6
Eckhardt, S.G.7
-
92
-
-
79956283619
-
Current status of SRC inhibitors in solid tumor malignancies
-
COI: 1:CAS:528:DC%2BC3MXht12itr3F, PID: 21521831
-
Puls LN, Eadens M, Messersmith W (2011) Current status of SRC inhibitors in solid tumor malignancies. Oncologist 16:566–578
-
(2011)
Oncologist
, vol.16
, pp. 566-578
-
-
Puls, L.N.1
Eadens, M.2
Messersmith, W.3
-
93
-
-
84887444879
-
Microenvironmental regulation of tumor progression and metastasis
-
COI: 1:CAS:528:DC%2BC3sXhslCmsrjL, PID: 24202395
-
Quail DF, Joyce JA (2013) Microenvironmental regulation of tumor progression and metastasis. Nat Med 19:1423–1437
-
(2013)
Nat Med
, vol.19
, pp. 1423-1437
-
-
Quail, D.F.1
Joyce, J.A.2
-
94
-
-
2342445635
-
The JAK/STAT signaling pathway
-
COI: 1:CAS:528:DC%2BD2cXjs1ygtbo%3D, PID: 15020666
-
Rawlings JS, Rosler KM, Harrison DA (2004) The JAK/STAT signaling pathway. J Cell Sci 117:1281–1283
-
(2004)
J Cell Sci
, vol.117
, pp. 1281-1283
-
-
Rawlings, J.S.1
Rosler, K.M.2
Harrison, D.A.3
-
95
-
-
84911370403
-
Changes in signal transducer and activator of transcription 3 (STAT3) dynamics induced by complexation with pharmacological inhibitors of Src homology 2 (SH2) domain dimerization
-
COI: 1:CAS:528:DC%2BC2cXhvFKkt7zO, PID: 25288792
-
Resetca D, Haftchenary S, Gunning PT, Wilson DJ (2014) Changes in signal transducer and activator of transcription 3 (STAT3) dynamics induced by complexation with pharmacological inhibitors of Src homology 2 (SH2) domain dimerization. J Biol Chem 289:32538–32547
-
(2014)
J Biol Chem
, vol.289
, pp. 32538-32547
-
-
Resetca, D.1
Haftchenary, S.2
Gunning, P.T.3
Wilson, D.J.4
-
96
-
-
84900102602
-
Environmental factors, genes, and the development of human cancers
-
Roy D, Dorak MT (2010) Environmental factors, genes, and the development of human cancers. Springer-Verlag 13 edition
-
(2010)
Springer-Verlag 13 edition
-
-
Roy, D.1
Dorak, M.T.2
-
97
-
-
64149112132
-
STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria
-
COI: 1:CAS:528:DC%2BD1MXks12hurc%3D, PID: 19299019
-
Samavati L, Rastogi R, Du W, Hüttemann M, Fite A, Franchi L (2009) STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria. Mol Immunol 46:1867–1877
-
(2009)
Mol Immunol
, vol.46
, pp. 1867-1877
-
-
Samavati, L.1
Rastogi, R.2
Du, W.3
Hüttemann, M.4
Fite, A.5
Franchi, L.6
-
98
-
-
36849039660
-
IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland
-
COI: 1:CAS:528:DC%2BD2sXhsValsLzK, PID: 18060036
-
Sansone P, Storci G, Tavolari S, Guarnieri T, Giovannini C, Taffurelli M, Ceccarelli C, Santini D, Paterini P, Marcu KB, Chieco P, Bonafè M (2007) IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. J Clin Invest 117:3988–4002
-
(2007)
J Clin Invest
, vol.117
, pp. 3988-4002
-
-
Sansone, P.1
Storci, G.2
Tavolari, S.3
Guarnieri, T.4
Giovannini, C.5
Taffurelli, M.6
Ceccarelli, C.7
Santini, D.8
Paterini, P.9
Marcu, K.B.10
Chieco, P.11
Bonafè, M.12
-
99
-
-
0029069145
-
Transcriptional responses to polypeptide ligands: the JAK-STAT pathway
-
COI: 1:CAS:528:DyaK2MXmsl2qtr0%3D, PID: 7574495
-
Schindler C, Darnell JE Jr (1995) Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem 64:621–651
-
(1995)
Annu Rev Biochem
, vol.64
, pp. 621-651
-
-
Schindler, C.1
Darnell, J.E.2
-
100
-
-
0026770248
-
Interferon-dependent tyrosine phosphorylation of a latentcytoplasmic transcription factor
-
COI: 1:CAS:528:DyaK38XlsV2jurs%3D, PID: 1496401
-
Schindler C, Shuai K, Prezioso VR, Darnell JE Jr (1992) Interferon-dependent tyrosine phosphorylation of a latentcytoplasmic transcription factor. Science 257:809–813
-
(1992)
Science
, vol.257
, pp. 809-813
-
-
Schindler, C.1
Shuai, K.2
Prezioso, V.R.3
Darnell, J.E.4
-
101
-
-
84894284619
-
Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling
-
COI: 1:CAS:528:DC%2BC2cXis1Cju7c%3D, PID: 24177177
-
Schroeder A, Herrmann A, Cherryholmes G, Kowolik C, Buettner R, Pal S, Yu H, Müller-Newen G, Jove R (2014) Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling. Cancer Res 74:1227–1237
-
(2014)
Cancer Res
, vol.74
, pp. 1227-1237
-
-
Schroeder, A.1
Herrmann, A.2
Cherryholmes, G.3
Kowolik, C.4
Buettner, R.5
Pal, S.6
Yu, H.7
Müller-Newen, G.8
Jove, R.9
-
102
-
-
33750982120
-
Stattic: a small-molecule inhibitor of STAT3 activation and dimerization
-
COI: 1:CAS:528:DC%2BD28Xht1Cis7fP, PID: 17114005
-
Schust J, Sperl B, Hollis A, Mayer TU, Berg T (2006) Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem Biol 13:1235–1242
-
(2006)
Chem Biol
, vol.13
, pp. 1235-1242
-
-
Schust, J.1
Sperl, B.2
Hollis, A.3
Mayer, T.U.4
Berg, T.5
-
103
-
-
23444461182
-
Regulation of gene-activation pathways by PIAS proteins in the immune system
-
COI: 1:CAS:528:DC%2BD2MXmvVClsLY%3D, PID: 16056253
-
Shuai K, Liu B (2005) Regulation of gene-activation pathways by PIAS proteins in the immune system. Nat Rev Immunol 5:593–605
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 593-605
-
-
Shuai, K.1
Liu, B.2
-
104
-
-
0027772891
-
Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins
-
COI: 1:STN:280:DyaK2c%2FnslWrsQ%3D%3D, PID: 7504784
-
Shuai K, Ziemiecki A, Wilks AF, Harpur AG, Sadowski HB, Gilman MZ, Darnell JE (1993) Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins. Nature 366:580–583
-
(1993)
Nature
, vol.366
, pp. 580-583
-
-
Shuai, K.1
Ziemiecki, A.2
Wilks, A.F.3
Harpur, A.G.4
Sadowski, H.B.5
Gilman, M.Z.6
Darnell, J.E.7
-
105
-
-
34250658084
-
Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity
-
COI: 1:CAS:528:DC%2BD2sXlslWqsbY%3D, PID: 17463090
-
Siddiquee K, Zhang S, Guida WC, Blaskovich MA, Greedy B, Lawrence HR, Yip ML, Jove R, McLaughlin MM, Lawrence NJ, Sebti SM, Turkson J (2007) Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc Natl Acad Sci USA 104:7391–7396
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 7391-7396
-
-
Siddiquee, K.1
Zhang, S.2
Guida, W.C.3
Blaskovich, M.A.4
Greedy, B.5
Lawrence, H.R.6
Yip, M.L.7
Jove, R.8
McLaughlin, M.M.9
Lawrence, N.J.10
Sebti, S.M.11
Turkson, J.12
-
106
-
-
16344380754
-
A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells
-
COI: 1:CAS:528:DC%2BD2MXjt1Oiu78%3D, PID: 15781862
-
Song H, Wang R, Wang S, Lin J (2005) A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proc Natl Acad Sci USA 102:4700–4705
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 4700-4705
-
-
Song, H.1
Wang, R.2
Wang, S.3
Lin, J.4
-
107
-
-
84902537885
-
Antitumor efficacy of the anti-interleukin-6 (IL-6) antibody siltuximab in mouse xenograft models of lung cancer
-
COI: 1:CAS:528:DC%2BC2cXps1Ojurg%3D, PID: 24922005
-
Song L, Smith MA, Doshi P, Sasser K, Fulp W, Altiok S, Haura EB (2014) Antitumor efficacy of the anti-interleukin-6 (IL-6) antibody siltuximab in mouse xenograft models of lung cancer. J Thorac Oncol 9:974–982
-
(2014)
J Thorac Oncol
, vol.9
, pp. 974-982
-
-
Song, L.1
Smith, M.A.2
Doshi, P.3
Sasser, K.4
Fulp, W.5
Altiok, S.6
Haura, E.B.7
-
108
-
-
84870301013
-
Challenges of genetic counseling in patients with autosomal dominant diseases, such as the hyper-IgE syndrome (STAT3-HIES)
-
PID: 22981789
-
Spielberger BD, Woellner C, Dueckers G, Sawalle-Belohradsky J, Hagl B, Anslinger K, Bayer B, Siepermann K, Niehues T, Grimbacher B, Belohradsky BH, Renner ED (2012) Challenges of genetic counseling in patients with autosomal dominant diseases, such as the hyper-IgE syndrome (STAT3-HIES). J Allergy Clin Immunol 130:1426–1428
-
(2012)
J Allergy Clin Immunol
, vol.130
, pp. 1426-1428
-
-
Spielberger, B.D.1
Woellner, C.2
Dueckers, G.3
Sawalle-Belohradsky, J.4
Hagl, B.5
Anslinger, K.6
Bayer, B.7
Siepermann, K.8
Niehues, T.9
Grimbacher, B.10
Belohradsky, B.H.11
Renner, E.D.12
-
109
-
-
84978523885
-
Impact of the physical microenvironment on tumor progression and metastasis
-
COI: 1:CAS:528:DC%2BC28XjtVCht7o%3D, PID: 26938687
-
Spill F, Reynolds DS, Kamm RD, Zaman MH (2016) Impact of the physical microenvironment on tumor progression and metastasis. Curr Opin Biotechnol 40:41–48
-
(2016)
Curr Opin Biotechnol
, vol.40
, pp. 41-48
-
-
Spill, F.1
Reynolds, D.S.2
Kamm, R.D.3
Zaman, M.H.4
-
110
-
-
80055105733
-
Involvement of interleukin-21 in the regulation of colitis-associated colon cancer
-
COI: 1:CAS:528:DC%2BC3MXhsVSru7zF, PID: 21987656
-
Stolfi C, Rizzo A, Franzè E, Rotondi A, Fantini MC, Sarra M, Caruso R, Monteleone I, Sileri P, Franceschilli L, Caprioli F, Ferrero S, MacDonald TT, Pallone F, Monteleone G (2011) Involvement of interleukin-21 in the regulation of colitis-associated colon cancer. J Exp Med 208:2279–2290
-
(2011)
J Exp Med
, vol.208
, pp. 2279-2290
-
-
Stolfi, C.1
Rizzo, A.2
Franzè, E.3
Rotondi, A.4
Fantini, M.C.5
Sarra, M.6
Caruso, R.7
Monteleone, I.8
Sileri, P.9
Franceschilli, L.10
Caprioli, F.11
Ferrero, S.12
MacDonald, T.T.13
Pallone, F.14
Monteleone, G.15
-
111
-
-
55349104462
-
Fibroblasts isolated from common sites of breast cancer metastasis enhance cancer cell growth rates and invasiveness in an interleukin-6-dependent manner
-
COI: 1:CAS:528:DC%2BD1cXhtlSkur3E, PID: 18974155
-
Studebaker AW, Storci G, Werbeck JL, Sansone P, Sasser AK, Tavolari S, Huang T, Chan MW, Marini FC, Rosol TJ, Bonafé M, Hall BM (2008) Fibroblasts isolated from common sites of breast cancer metastasis enhance cancer cell growth rates and invasiveness in an interleukin-6-dependent manner. Cancer Res 68:9087–9095
-
(2008)
Cancer Res
, vol.68
, pp. 9087-9095
-
-
Studebaker, A.W.1
Storci, G.2
Werbeck, J.L.3
Sansone, P.4
Sasser, A.K.5
Tavolari, S.6
Huang, T.7
Chan, M.W.8
Marini, F.C.9
Rosol, T.J.10
Bonafé, M.11
Hall, B.M.12
-
112
-
-
84890500784
-
Targeting blockage of STAT3 in hepatocellular carcinoma cells augments NK cell functions via reverse hepatocellular carcinoma-induced immune suppression
-
COI: 1:CAS:528:DC%2BC3sXhvVyqsrjO, PID: 24107450
-
Sun X, Sui Q, Zhang C, Tian Z, Zhang J (2013) Targeting blockage of STAT3 in hepatocellular carcinoma cells augments NK cell functions via reverse hepatocellular carcinoma-induced immune suppression. Mol Cancer Ther 12:2885–2896
-
(2013)
Mol Cancer Ther
, vol.12
, pp. 2885-2896
-
-
Sun, X.1
Sui, Q.2
Zhang, C.3
Tian, Z.4
Zhang, J.5
-
113
-
-
80053249325
-
Twist1 is up-regulated in gastric cancer-associated fibroblasts with poor clinical outcomes
-
COI: 1:CAS:528:DC%2BC3MXhsVSqtbvP, PID: 21854747
-
Sung CO, Lee KW, Han S, Kim SH (2011) Twist1 is up-regulated in gastric cancer-associated fibroblasts with poor clinical outcomes. Am J Pathol 179:1827–1838
-
(2011)
Am J Pathol
, vol.179
, pp. 1827-1838
-
-
Sung, C.O.1
Lee, K.W.2
Han, S.3
Kim, S.H.4
-
114
-
-
0034046605
-
STAT family of transcription factors in cytokine-mediated biological responses
-
COI: 1:CAS:528:DC%2BD3cXjvFWmtbg%3D, PID: 10817963
-
Takeda K, Akira S (2000) STAT family of transcription factors in cytokine-mediated biological responses. Cytokine Growth Factor Rev 11:199–207
-
(2000)
Cytokine Growth Factor Rev
, vol.11
, pp. 199-207
-
-
Takeda, K.1
Akira, S.2
-
115
-
-
84929353226
-
Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer
-
COI: 1:CAS:528:DC%2BC2MXhtFyhtrvO, PID: 25973915
-
Thakur R, Trivedi R, Rastogi N, Singh M, Mishra DP (2015) Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer. Sci Rep 5:10194
-
(2015)
Sci Rep
, vol.5
, pp. 10194
-
-
Thakur, R.1
Trivedi, R.2
Rastogi, N.3
Singh, M.4
Mishra, D.P.5
-
116
-
-
84926414059
-
Tumor microenvironment: a new treatment target for cancer
-
PID: 25937967
-
Tsai MJ, Chang WA, Huang MS, Kuo PL (2014) Tumor microenvironment: a new treatment target for cancer. ISRN Biochem 2014:351959
-
(2014)
ISRN Biochem
, vol.2014
, pp. 351959
-
-
Tsai, M.J.1
Chang, W.A.2
Huang, M.S.3
Kuo, P.L.4
-
117
-
-
3543055012
-
Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity
-
COI: 1:CAS:528:DC%2BD2cXitFCns74%3D, PID: 15026546
-
Turkson J, Kim JS, Zhang S, Yuan J, Huang M, Glenn M, Haura E, Sebti S, Hamilton AD, Jove R (2004a) Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity. Mol Cancer Ther 3:261–269
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 261-269
-
-
Turkson, J.1
Kim, J.S.2
Zhang, S.3
Yuan, J.4
Huang, M.5
Glenn, M.6
Haura, E.7
Sebti, S.8
Hamilton, A.D.9
Jove, R.10
-
118
-
-
12344328541
-
Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity
-
COI: 1:CAS:528:DC%2BD2MXmtV2q, PID: 15634646
-
Turkson J, Zhang S, Palmer J, Kay H, Stanko J, Mora LB, Sebti S, Yu H, Jove R (2004b) Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity. Mol Cancer Ther 3:1533–1542
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 1533-1542
-
-
Turkson, J.1
Zhang, S.2
Palmer, J.3
Kay, H.4
Stanko, J.5
Mora, L.B.6
Sebti, S.7
Yu, H.8
Jove, R.9
-
119
-
-
25444513779
-
A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells
-
COI: 1:CAS:528:DC%2BD2MXhtVWiurrL, PID: 16046414
-
Turkson J, Zhang S, Mora LB, Burns A, Sebti S, Jove R (2005) A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells. J Biol Chem 280:32979–32988
-
(2005)
J Biol Chem
, vol.280
, pp. 32979-32988
-
-
Turkson, J.1
Zhang, S.2
Mora, L.B.3
Burns, A.4
Sebti, S.5
Jove, R.6
-
120
-
-
60549104746
-
Novel high-throughput screening system for identifying STAT3-SH2 antagonists
-
COI: 1:CAS:528:DC%2BD1MXis1Grsrw%3D, PID: 19285012
-
Uehara Y, Mochizuki M, Matsuno K, Haino T, Asai A (2009) Novel high-throughput screening system for identifying STAT3-SH2 antagonists. Biochem Biophys Res Commun 380:627–631
-
(2009)
Biochem Biophys Res Commun
, vol.380
, pp. 627-631
-
-
Uehara, Y.1
Mochizuki, M.2
Matsuno, K.3
Haino, T.4
Asai, A.5
-
121
-
-
84919684042
-
Mechanisms of Jak/STAT signaling in immunity and disease
-
COI: 1:CAS:528:DC%2BC2cXitFWls7rF, PID: 25527793
-
Villarino AV, Kanno Y, Ferdinand JR, O’Shea JJ (2015) Mechanisms of Jak/STAT signaling in immunity and disease. J Immunol 194:21–27
-
(2015)
J Immunol
, vol.194
, pp. 21-27
-
-
Villarino, A.V.1
Kanno, Y.2
Ferdinand, J.R.3
O’Shea, J.J.4
-
122
-
-
68149170225
-
Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells
-
COI: 1:CAS:528:DC%2BD1MXms1alur4%3D, PID: 19483720
-
Walter M, Liang S, Ghosh S, Hornsby PJ, Li R (2009) Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells. Oncogene 28:2745–2755
-
(2009)
Oncogene
, vol.28
, pp. 2745-2755
-
-
Walter, M.1
Liang, S.2
Ghosh, S.3
Hornsby, P.J.4
Li, R.5
-
123
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
-
COI: 1:CAS:528:DyaK2MXmtFOgs7k%3D, PID: 7539918
-
Wang GL, Jiang BH, Rue EA, Semenza GL (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 92:5510–5514
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 5510-5514
-
-
Wang, G.L.1
Jiang, B.H.2
Rue, E.A.3
Semenza, G.L.4
-
124
-
-
11144357779
-
Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells
-
PID: 14702634
-
Wang T, Niu G, Kortylewski M, Burdelya L, Shain K, Zhang S, Bhattacharya R, Gabrilovich D, Heller R, Coppola D, Dalton W, Jove R, Pardoll D, Yu H (2004) Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nat Med 10:48–54
-
(2004)
Nat Med
, vol.10
, pp. 48-54
-
-
Wang, T.1
Niu, G.2
Kortylewski, M.3
Burdelya, L.4
Shain, K.5
Zhang, S.6
Bhattacharya, R.7
Gabrilovich, D.8
Heller, R.9
Coppola, D.10
Dalton, W.11
Jove, R.12
Pardoll, D.13
Yu, H.14
-
125
-
-
67650495415
-
IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway
-
COI: 1:CAS:528:DC%2BD1MXos1eis7k%3D, PID: 19564351
-
Wang L, Yi T, Kortylewski M, Pardoll DM, Zeng D, Yu H (2009) IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway. J Exp Med 206:1457–1464
-
(2009)
J Exp Med
, vol.206
, pp. 1457-1464
-
-
Wang, L.1
Yi, T.2
Kortylewski, M.3
Pardoll, D.M.4
Zeng, D.5
Yu, H.6
-
126
-
-
84936995048
-
Snail promotes epithelial-mesenchymal transition and invasiveness in human ovarian cancer cells
-
COI: 1:CAS:528:DC%2BC28XnsFers7o%3D, PID: 26221280
-
Wang YL, Zhao XM, Shuai ZF, Li CY, Bai QY, Yu XW, Wen QT (2015) Snail promotes epithelial-mesenchymal transition and invasiveness in human ovarian cancer cells. Int J Clin Exp Med 8:7388–7393
-
(2015)
Int J Clin Exp Med
, vol.8
, pp. 7388-7393
-
-
Wang, Y.L.1
Zhao, X.M.2
Shuai, Z.F.3
Li, C.Y.4
Bai, Q.Y.5
Yu, X.W.6
Wen, Q.T.7
-
127
-
-
33845332311
-
-
Taylor & Francis Group LLC, Garland Science
-
Weinberg RA (2013) The biology of cancer, 2nd edn. Taylor & Francis Group LLC, Garland Science
-
(2013)
The biology of cancer
-
-
Weinberg, R.A.1
-
128
-
-
40349098612
-
Migratory neighbors and distant invaders: tumor-associated niche cells
-
COI: 1:CAS:528:DC%2BD1cXjsVKnt7s%3D, PID: 18316475
-
Wels J, Kaplan RN, Rafii S, Lyden D (2008) Migratory neighbors and distant invaders: tumor-associated niche cells. Genes Dev 22:559–574
-
(2008)
Genes Dev
, vol.22
, pp. 559-574
-
-
Wels, J.1
Kaplan, R.N.2
Rafii, S.3
Lyden, D.4
-
129
-
-
53549102755
-
The tumor microenvironment and its role in promoting tumor growth
-
COI: 1:CAS:528:DC%2BD1cXhtF2msbbK, PID: 18836471
-
Whiteside TL (2008) The tumor microenvironment and its role in promoting tumor growth. Oncogene 27:5904–5912
-
(2008)
Oncogene
, vol.27
, pp. 5904-5912
-
-
Whiteside, T.L.1
-
130
-
-
76049116822
-
Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome
-
COI: 1:CAS:528:DC%2BC3cXitVKhsbg%3D, PID: 20159255
-
Woellner C, Gertz EM, Schäffer AA, Lagos M, Perro M, Glocker EO, Pietrogrande MC, Cossu F, Franco JL, Matamoros N, Pietrucha B, Heropolitańska-Pliszka E, Yeganeh M, Moin M, Español T, Ehl S, Gennery AR, Abinun M, Breborowicz A, Niehues T, Kilic SS, Junker A, Turvey SE, Plebani A, Sánchez B, Garty BZ, Pignata C, Cancrini C, Litzman J, Sanal O, Baumann U, Bacchetta R, Hsu AP, Davis JN, Hammarström L, Davies EG, Eren E, Arkwright PD, Moilanen JS, Viemann D, Khan S, Maródi L, Cant AJ, Freeman AF, Puck JM, Holland SM, Grimbacher B (2010) Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome. J Allergy Clin Immunol 125:424–432
-
(2010)
J Allergy Clin Immunol
, vol.125
, pp. 424-432
-
-
Woellner, C.1
Gertz, E.M.2
Schäffer, A.A.3
Lagos, M.4
Perro, M.5
Glocker, E.O.6
Pietrogrande, M.C.7
Cossu, F.8
Franco, J.L.9
Matamoros, N.10
Pietrucha, B.11
Heropolitańska-Pliszka, E.12
Yeganeh, M.13
Moin, M.14
Español, T.15
Ehl, S.16
Gennery, A.R.17
Abinun, M.18
Breborowicz, A.19
Niehues, T.20
Kilic, S.S.21
Junker, A.22
Turvey, S.E.23
Plebani, A.24
Sánchez, B.25
Garty, B.Z.26
Pignata, C.27
Cancrini, C.28
Litzman, J.29
Sanal, O.30
Baumann, U.31
Bacchetta, R.32
Hsu, A.P.33
Davis, J.N.34
Hammarström, L.35
Davies, E.G.36
Eren, E.37
Arkwright, P.D.38
Moilanen, J.S.39
Viemann, D.40
Khan, S.41
Maródi, L.42
Cant, A.J.43
Freeman, A.F.44
Puck, J.M.45
Holland, S.M.46
Grimbacher, B.47
more..
-
131
-
-
84942551966
-
Signal transducer and activator of transcription 3-mediated CD133 up-regulation contributes to promotion of hepatocellular carcinoma
-
COI: 1:CAS:528:DC%2BC2MXhs1SrtbrE, PID: 26154152
-
Won C, Kim BH, Yi EH, Choi KJ, Kim EK, Jeong JM, Lee JH, Jang JJ, Yoon JH, Jeong WI, Park IC, Kim TW, Bae SS, Factor VM, Ma S, Thorgeirsson SS, Lee YH, Ye SK (2015) Signal transducer and activator of transcription 3-mediated CD133 up-regulation contributes to promotion of hepatocellular carcinoma. Hepatology 62:1160–1173
-
(2015)
Hepatology
, vol.62
, pp. 1160-1173
-
-
Won, C.1
Kim, B.H.2
Yi, E.H.3
Choi, K.J.4
Kim, E.K.5
Jeong, J.M.6
Lee, J.H.7
Jang, J.J.8
Yoon, J.H.9
Jeong, W.I.10
Park, I.C.11
Kim, T.W.12
Bae, S.S.13
Factor, V.M.14
Ma, S.15
Thorgeirsson, S.S.16
Lee, Y.H.17
Ye, S.K.18
-
132
-
-
0347093460
-
Inhibitors of cytokine signal transduction
-
COI: 1:CAS:528:DC%2BD2cXhtV2htw%3D%3D, PID: 14607831
-
Wormald S, Hilton DJ (2004) Inhibitors of cytokine signal transduction. J Biol Chem 279:821–824
-
(2004)
J Biol Chem
, vol.279
, pp. 821-824
-
-
Wormald, S.1
Hilton, D.J.2
-
133
-
-
80053224991
-
Signal transducer and activator of transcription 3 (Stat3C) promotes myeloid-derived suppressor cell expension and immune suppression during lung tumorigenesis
-
COI: 1:CAS:528:DC%2BC3MXhsVSqtbbM, PID: 21864492
-
Wu L, Du H, Li Y, Qu P, Yan C (2011) Signal transducer and activator of transcription 3 (Stat3C) promotes myeloid-derived suppressor cell expension and immune suppression during lung tumorigenesis. Am J Pathol 179:2131–2141
-
(2011)
Am J Pathol
, vol.179
, pp. 2131-2141
-
-
Wu, L.1
Du, H.2
Li, Y.3
Qu, P.4
Yan, C.5
-
134
-
-
84879295096
-
Discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer
-
COI: 1:CAS:528:DC%2BC3sXptVOks7s%3D, PID: 23536726
-
Xu S, Grande F, Garofalo A, Neamati N (2013) Discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer. Mol Cancer Ther 12:937–949
-
(2013)
Mol Cancer Ther
, vol.12
, pp. 937-949
-
-
Xu, S.1
Grande, F.2
Garofalo, A.3
Neamati, N.4
-
136
-
-
61649125595
-
The dysfunction and abnormal signaling pathway of dendritic cells loaded by tumor antigen can be overcome by neutralizing VEGF in multiple myeloma
-
COI: 1:CAS:528:DC%2BD1MXivVWqu7Y%3D, PID: 18922577
-
Yang DH, Park JS, Jin CJ, Kang HK, Nam JH, Rhee JH, Kim YK, Chung SY, Choi SJ, Kim HJ, Chung IJ, Lee JJ (2009) The dysfunction and abnormal signaling pathway of dendritic cells loaded by tumor antigen can be overcome by neutralizing VEGF in multiple myeloma. Leuk Res 33:665–670
-
(2009)
Leuk Res
, vol.33
, pp. 665-670
-
-
Yang, D.H.1
Park, J.S.2
Jin, C.J.3
Kang, H.K.4
Nam, J.H.5
Rhee, J.H.6
Kim, Y.K.7
Chung, S.Y.8
Choi, S.J.9
Kim, H.J.10
Chung, I.J.11
Lee, J.J.12
-
137
-
-
84874291853
-
Tumor-associated macrophages regulate murine breast cancer stem cells through a novel paracrine EGFR/Stat3/Sox-2 signaling pathway
-
COI: 1:CAS:528:DC%2BC3sXjvFOiu74%3D, PID: 23169551
-
Yang J, Liao D, Chen C, Liu Y, Chuang TH, Xiang R, Markowitz D, Reisfeld RA, Luo Y (2013) Tumor-associated macrophages regulate murine breast cancer stem cells through a novel paracrine EGFR/Stat3/Sox-2 signaling pathway. Stem Cells 31:248–258
-
(2013)
Stem Cells
, vol.31
, pp. 248-258
-
-
Yang, J.1
Liao, D.2
Chen, C.3
Liu, Y.4
Chuang, T.H.5
Xiang, R.6
Markowitz, D.7
Reisfeld, R.A.8
Luo, Y.9
-
138
-
-
84923078160
-
The effectiveness of an anti-human IL-6 receptor monoclonal antibodycombined with chemotherapy to target colon cancer stem-like cells
-
PID: 25625841
-
Ying J, Tsujii M, Kondo J, Hayashi Y, Kato M, Akasaka T, Inoue T, Shiraishi E, Inoue T, Hiyama S, Tsujii Y, Maekawa A, Kawai S, Fujinaga T, Araki M, Shinzaki S, Watabe K, Nishida T, Iijima H, Takehara T (2015) The effectiveness of an anti-human IL-6 receptor monoclonal antibodycombined with chemotherapy to target colon cancer stem-like cells. Int J Oncol 46:1551–1559
-
(2015)
Int J Oncol
, vol.46
, pp. 1551-1559
-
-
Ying, J.1
Tsujii, M.2
Kondo, J.3
Hayashi, Y.4
Kato, M.5
Akasaka, T.6
Inoue, T.7
Shiraishi, E.8
Inoue, T.9
Hiyama, S.10
Tsujii, Y.11
Maekawa, A.12
Kawai, S.13
Fujinaga, T.14
Araki, M.15
Shinzaki, S.16
Watabe, K.17
Nishida, T.18
Iijima, H.19
Takehara, T.20
more..
-
139
-
-
1042302005
-
The STATs of cancer–new molecular targets come of age
-
COI: 1:CAS:528:DC%2BD2cXhtlaqtb0%3D, PID: 14964307
-
Yu H, Jove R (2004) The STATs of cancer–new molecular targets come of age. Nat Rev Cancer 4:97–105
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 97-105
-
-
Yu, H.1
Jove, R.2
-
140
-
-
33845865825
-
Crosstalk between cancer and immune cells: role of STAT3 in the tumourmicroenvironment
-
COI: 1:CAS:528:DC%2BD28XhtlCht7fE, PID: 17186030
-
Yu H, Kortylewski M, Pardoll D (2007) Crosstalk between cancer and immune cells: role of STAT3 in the tumourmicroenvironment. Nat Rev Immunol 7:41–51
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 41-51
-
-
Yu, H.1
Kortylewski, M.2
Pardoll, D.3
-
141
-
-
70350500225
-
STATs in cancer inflammation and immunity: a leading role for STAT3
-
COI: 1:CAS:528:DC%2BD1MXhtlSjur%2FP, PID: 19851315
-
Yu H, Pardoll D, Jove R (2009) STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 9:798–809
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 798-809
-
-
Yu, H.1
Pardoll, D.2
Jove, R.3
-
142
-
-
84949294600
-
Multiple regulation pathways and pivotal biological functions of STAT3 in cancer
-
COI: 1:CAS:528:DC%2BC2MXhvFGmsLjJ, PID: 26631279
-
Yuan J, Zhang F, Niu R (2015) Multiple regulation pathways and pivotal biological functions of STAT3 in cancer. Sci Rep 5:17663
-
(2015)
Sci Rep
, vol.5
, pp. 17663
-
-
Yuan, J.1
Zhang, F.2
Niu, R.3
-
143
-
-
79960122931
-
Dual roles of immune cells and their factors in cancer development and progression
-
COI: 1:CAS:528:DC%2BC3MXmsl2lsrg%3D, PID: 21647333
-
Zamarron BF, Chen W (2011) Dual roles of immune cells and their factors in cancer development and progression. Int J Biol Sci 7:651–658
-
(2011)
Int J Biol Sci
, vol.7
, pp. 651-658
-
-
Zamarron, B.F.1
Chen, W.2
-
144
-
-
0034657415
-
The roles of the Drosophia JAK/STAT pathway
-
COI: 1:CAS:528:DC%2BD3cXktVGhtr0%3D, PID: 10851058
-
Zeidler MP, Bach EA, Perrimon N (2000) The roles of the Drosophia JAK/STAT pathway. Oncogene 19:2598–2606
-
(2000)
Oncogene
, vol.19
, pp. 2598-2606
-
-
Zeidler, M.P.1
Bach, E.A.2
Perrimon, N.3
-
145
-
-
84862193781
-
Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts
-
COI: 1:CAS:528:DC%2BC38XptlWjtLo%3D, PID: 22623533
-
Zhang X, Yue P, Page BD, Li T, Zhao W, Namanja AT, Paladino D, Zhao J, Chen Y, Gunning PT, Turkson J (2012) Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts. Proc Natl Acad Sci USA 109:9623–9628
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 9623-9628
-
-
Zhang, X.1
Yue, P.2
Page, B.D.3
Li, T.4
Zhao, W.5
Namanja, A.T.6
Paladino, D.7
Zhao, J.8
Chen, Y.9
Gunning, P.T.10
Turkson, J.11
-
146
-
-
84875458307
-
A novel inhibitor of STAT3 homodimerization selectively suppresses STAT3 activity and malignant transformation
-
COI: 1:CAS:528:DC%2BC3sXktVGisbg%3D, PID: 23322008
-
Zhang X, Sun Y, Pireddu R, Yang H, Urlam MK, Lawrence HR, Guida WC, Lawrence NJ, Sebti SM (2013) A novel inhibitor of STAT3 homodimerization selectively suppresses STAT3 activity and malignant transformation. Cancer Res 73:1922–1933
-
(2013)
Cancer Res
, vol.73
, pp. 1922-1933
-
-
Zhang, X.1
Sun, Y.2
Pireddu, R.3
Yang, H.4
Urlam, M.K.5
Lawrence, H.R.6
Guida, W.C.7
Lawrence, N.J.8
Sebti, S.M.9
-
147
-
-
80052197203
-
Small molecule inhibitors of STAT3 for cancer therapy
-
COI: 1:CAS:528:DC%2BC3MXht1KjsbrJ, PID: 21824090
-
Zhao M, Jiang B, Gao FH (2011) Small molecule inhibitors of STAT3 for cancer therapy. Curr Med Chem 18:4012–4018
-
(2011)
Curr Med Chem
, vol.18
, pp. 4012-4018
-
-
Zhao, M.1
Jiang, B.2
Gao, F.H.3
-
148
-
-
0028349735
-
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
-
COI: 1:CAS:528:DyaK2cXlt1Kktrk%3D, PID: 8140422
-
Zhong Z, Wen Z, Darnell JE Jr (1994) Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 264:95–98
-
(1994)
Science
, vol.264
, pp. 95-98
-
-
Zhong, Z.1
Wen, Z.2
Darnell, J.E.3
-
149
-
-
33748987908
-
Cancer despite immunosurveillance: immunoselection and immunosubversion
-
COI: 1:CAS:528:DC%2BD28XhtVSgurnM, PID: 16977338
-
Zitvogel L, Tesniere A, Kroemer G (2006) Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat Rev Immunol 6:715–727
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 715-727
-
-
Zitvogel, L.1
Tesniere, A.2
Kroemer, G.3
|