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Volumn 42, Issue 3, 2013, Pages 921-928

PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line

Author keywords

Akt; Cancer stem cell; Proliferation; PTEN; Senescence; Stat3

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CD133 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE 13; PROTEIN KINASE B; STAT3 PROTEIN;

EID: 84873695296     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.1765     Document Type: Article
Times cited : (85)

References (35)
  • 2
    • 0032473921 scopus 로고    scopus 로고
    • Analysis of PTEN and the 10q23 region in primary prostate carcinomas
    • Feilotter HE, Nagai MA, Boag AH, Eng C and Mulligan LM: Analysis of PTEN and the 10q23 region in primary prostate carcinomas. Oncogene 16: 1743-1748, 1998. (Pubitemid 28175055)
    • (1998) Oncogene , vol.16 , Issue.13 , pp. 1743-1748
    • Feilotter, H.E.1    Nagai, M.A.2    Boag, A.H.3    Eng, C.4    Mulligan, L.M.5
  • 4
    • 0031001041 scopus 로고    scopus 로고
    • TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor β
    • Li DM and Sun H: TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res 57: 2124-2129, 1997. (Pubitemid 27247025)
    • (1997) Cancer Research , vol.57 , Issue.11 , pp. 2124-2129
    • Li, D.-M.1    Sun, H.2
  • 7
    • 0032577699 scopus 로고    scopus 로고
    • The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
    • DOI 10.1074/jbc.273.22.13375
    • Maehama T and Dixon JE: The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3, 4, 5-trisphosphate. J Biol Chem 273: 13375-13378, 1998. (Pubitemid 28268370)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.22 , pp. 13375-13378
    • Maehama, T.1    Dixon, J.E.2
  • 10
    • 43049128529 scopus 로고    scopus 로고
    • Tenets of PTEN tumor suppression
    • DOI 10.1016/j.cell.2008.04.013, PII S0092867408005047
    • Salmena L, Carracedo A and Pandolfi PP: Tenets of PTEN tumor suppression. Cell 133: 403-414, 2008. (Pubitemid 351622014)
    • (2008) Cell , vol.133 , Issue.3 , pp. 403-414
    • Salmena, L.1    Carracedo, A.2    Pandolfi, P.P.3
  • 12
    • 0034671221 scopus 로고    scopus 로고
    • Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor
    • Georgescu MM, Kirsch KH, Kaloudis P, Yang H, Pavletich NP and Hanafusa H: Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor. Cancer Res 60: 7033-7038, 2000. (Pubitemid 32059181)
    • (2000) Cancer Research , vol.60 , Issue.24 , pp. 7033-7038
    • Georgescu, M.-M.1    Kirsch, K.H.2    Kaloudis, P.3    Yang, H.4    Pavletich, N.P.5    Hanafusa, H.6
  • 13
    • 4644285846 scopus 로고    scopus 로고
    • PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity
    • DOI 10.1038/sj.onc.1207599
    • Gildea JJ, Herlevsen M, Harding MA, Gulding KM, Moskaluk CA, Frierson HF and Theodorescu D: PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity. Oncogene 23: 6788-6797, 2004. (Pubitemid 39280010)
    • (2004) Oncogene , vol.23 , Issue.40 , pp. 6788-6797
    • Gildea, J.J.1    Herlevsen, M.2    Harding, M.A.3    Gulding, K.M.4    Moskaluk, C.A.5    Frierson, H.F.6    Theodorescu, D.7
  • 14
    • 85047698214 scopus 로고    scopus 로고
    • Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity
    • DOI 10.1038/sj/onc/1205296
    • Koul D, Jasser SA, Lu Y, Davies MA, Shen R, Shi Y, Mills GB and Yung WK: Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity. Oncogene 21: 2357-2364, 2002. (Pubitemid 34407295)
    • (2002) Oncogene , vol.21 , Issue.15 , pp. 2357-2364
    • Koul, D.1    Jasser, S.A.2    Lu, Y.3    Davies, M.A.4    Shen, R.5    Shi, Y.6    Mills, G.B.7    Yung, W.K.A.8
  • 15
    • 0033229893 scopus 로고    scopus 로고
    • The PTEN lipid phosphatase domain is not required to inhibit invasion of glioma cells
    • Maier D, Jones G, Li X, Schonthal AH, Gratzl O, Van Meir EG and Merlo A: The PTEN lipid phosphatase domain is not required to inhibit invasion of glioma cells. Cancer Res 59: 5479-5482, 1999. (Pubitemid 29526461)
    • (1999) Cancer Research , vol.59 , Issue.21 , pp. 5479-5482
    • Maier, D.1    Jones, G.2    Li, X.3    Schonthal, A.H.4    Gratzl, O.5    Van Meir, E.G.6    Merlo, A.7
  • 17
    • 0346059618 scopus 로고    scopus 로고
    • Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity
    • Bajenaru ML, Hernandez MR, Perry A, Zhu Y, Parada LF, Garbow JR and Gutmann DH: Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity. Cancer Res 63: 8573-8577, 2003. (Pubitemid 38064027)
    • (2003) Cancer Research , vol.63 , Issue.24 , pp. 8573-8577
    • Bajenaru, M.L.1    Hernandez, M.R.2    Perry, A.3    Zhu, Y.4    Parada, L.F.5    Garbow, J.R.6    Gutmann, D.H.7
  • 18
    • 0035256772 scopus 로고    scopus 로고
    • Gliomagenesis: Genetic alterations and mouse models
    • DOI 10.1038/35052535
    • Holland EC: Gliomagenesis: genetic alterations and mouse models. Nat Rev Genet 2: 120-129, 2001. (Pubitemid 33674003)
    • (2001) Nature Reviews Genetics , vol.2 , Issue.2 , pp. 120-129
    • Holland, E.C.1
  • 19
    • 0036791177 scopus 로고    scopus 로고
    • Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt
    • Uhrbom L, Dai C, Celestino JC, Rosenblum MK, Fuller GN and Holland EC: Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt. Cancer Res 62: 5551-5558, 2002.
    • (2002) Cancer Res , vol.62 , pp. 5551-5558
    • Uhrbom, L.1    Dai, C.2    Celestino, J.C.3    Rosenblum, M.K.4    Fuller, G.N.5    Holland, E.C.6
  • 21
    • 33746397211 scopus 로고    scopus 로고
    • Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex
    • DOI 10.1242/dev.02419
    • Yoshimatsu T, Kawaguchi D, Oishi K, Takeda K, Akira S, Masuyama N and Gotoh Y: Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex. Development 133: 2553-2563, 2006. (Pubitemid 44123404)
    • (2006) Development , vol.133 , Issue.13 , pp. 2553-2563
    • Yoshimatsu, T.1    Kawaguchi, D.2    Oishi, K.3    Takeda, K.4    Akira, S.5    Masuyama, N.6    Gotoh, Y.7
  • 22
    • 0037028249 scopus 로고    scopus 로고
    • Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells
    • DOI 10.1038/sj.onc.1206047
    • Rahaman SO, Harbor PC, Chernova O, Barnett GH, Vogelbaum MA and Haque SJ: Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. Oncogene 21: 8404-8413, 2002. (Pubitemid 36054883)
    • (2002) Oncogene , vol.21 , Issue.55 , pp. 8404-8413
    • Rahaman, S.O.1    Harbor, P.C.2    Chernova, O.3    Barnett, G.H.4    Vogelbaum, M.A.5    Haque, S.J.6
  • 25
    • 48149093106 scopus 로고    scopus 로고
    • MicroRNAs: Regulators of oncogenesis and stemness
    • Papagiannakopoulos T and Kosik KS: MicroRNAs: regulators of oncogenesis and stemness. BMC Med 6: 15, 2008.
    • (2008) BMC Med , vol.6 , pp. 15
    • Papagiannakopoulos, T.1    Kosik, K.S.2
  • 26
    • 0030221263 scopus 로고    scopus 로고
    • Normal and leukemic human stem cells assayed in SCID mice
    • DOI 10.1006/smim.1996.0025
    • Dick JE: Normal and leukemic human stem cells assayed in SCID mice. Semin Immunol 8: 197-206, 1996. (Pubitemid 26315854)
    • (1996) Seminars in Immunology , vol.8 , Issue.4 , pp. 197-206
    • Dick, J.E.1
  • 27
    • 33749515476 scopus 로고    scopus 로고
    • Targeting of CD44 eradicates human acute myeloid leukemic stem cells
    • DOI 10.1038/nm1483, PII NM1483
    • Jin L, Hope KJ, Zhai Q, Smadja-Joffe F and Dick JE: Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat Med 12: 1167-1174, 2006. (Pubitemid 44527352)
    • (2006) Nature Medicine , vol.12 , Issue.10 , pp. 1167-1174
    • Jin, L.1    Hope, K.J.2    Zhai, Q.3    Smadja-Joffe, F.4    Dick, J.E.5
  • 28
    • 5444256238 scopus 로고    scopus 로고
    • Self-renewal and solid tumor stem cells
    • DOI 10.1038/sj.onc.1207947
    • Al-Hajj M and Clarke MF: Self-renewal and solid tumor stem cells. Oncogene 23: 7274-7282, 2004. (Pubitemid 39382161)
    • (2004) Oncogene , vol.23 , Issue.43 REV. ISS. 6 , pp. 7274-7282
    • Al-Hajj, M.1    Clarke, M.F.2
  • 29
    • 35148888629 scopus 로고    scopus 로고
    • Cancer stem cells in radiation resistance
    • DOI 10.1158/0008-5472.CAN-07-0895
    • Rich JN: Cancer stem cells in radiation resistance. Cancer Res 67: 8980-8984, 2007. (Pubitemid 47535877)
    • (2007) Cancer Research , vol.67 , Issue.19 , pp. 8980-8984
    • Rich, J.N.1
  • 31
    • 3543056884 scopus 로고    scopus 로고
    • Analysis of the activation status of Akt, NFκB, and Stat3 in human diffuse gliomas
    • DOI 10.1038/labinvest.3700123
    • Wang H, Zhang W, Huang HJ, Liao WS and Fuller GN: Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas. Lab Invest 84: 941-951, 2004. (Pubitemid 39025029)
    • (2004) Laboratory Investigation , vol.84 , Issue.8 , pp. 941-951
    • Wang, H.1    Wang, H.2    Zhang, W.3    Huang, H.J.4    Liao, W.S.L.5    Fuller, G.N.6
  • 32
    • 0036554816 scopus 로고    scopus 로고
    • Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention
    • Buettner R, Mora LB and Jove R: Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res 8: 945-954, 2002. (Pubitemid 35177340)
    • (2002) Clinical Cancer Research , vol.8 , Issue.4 , pp. 945-954
    • Buettner, R.1    Mora, L.B.2    Jove, R.3
  • 33
    • 23444452377 scopus 로고    scopus 로고
    • Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors
    • DOI 10.1136/jcp.2004.023416
    • Kusaba T, Nakayama T, Yamazumi K, Yakata Y, Yoshizaki A, Nagayasu T and Sekine I: Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors. J Clin Pathol 58: 833-838, 2005. (Pubitemid 41113390)
    • (2005) Journal of Clinical Pathology , vol.58 , Issue.8 , pp. 833-838
    • Kusaba, T.1    Nakayama, T.2    Yamazumi, K.3    Yakata, Y.4    Yoshizaki, A.5    Nagayasu, T.6    Sekine, I.7
  • 34
    • 80053531658 scopus 로고    scopus 로고
    • Regulation of cancer stem cells by cytokine networks: Attacking cancer's inflammatory roots
    • Korkaya H, Liu S and Wicha MS: Regulation of cancer stem cells by cytokine networks: attacking cancer's inflammatory roots. Clin Cancer Res 17: 6125-6129, 2011.
    • (2011) Clin Cancer Res , vol.17 , pp. 6125-6129
    • Korkaya, H.1    Liu, S.2    Wicha, M.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.