IL-6 enriched lung cancer stem-like cell population by inhibition of cell cycle regulators via DNMT1 upregulation

International Journal of Cancer

Volumn 136, Issue 3, 2015, Pages 547-559

  Liu, Chen Chi ^a,b   Lin, Jiun Han ^a   Hsu, Tien Wei ^a   Su, Kelly ^a   Li, Anna Fen Yau ^b   Hsu, Han Shui ^a,b   Hung, Shih Chieh ^a,b,c  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

Author keywords

DNMT1; IL 6 JAK2 STAT3 pathway; Lung cancer stem cell; Proliferation

Indexed keywords

DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; INTERLEUKIN 6; JANUS KINASE 2; PROTEIN P21; PROTEIN P53; STAT3 PROTEIN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1; IL6 PROTEIN, HUMAN; JAK2 PROTEIN, HUMAN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CANCER STEM CELL; CELL CYCLE REGULATION; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; GENE OVEREXPRESSION; LUNG CANCER; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METHYLATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPHEROID CELL; TUMOR GROWTH; TUMOR MICROENVIRONMENT; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CYCLE; HUMAN; LUNG TUMOR; MULTICELLULAR SPHEROID; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; HUMANS; INTERLEUKIN-6; JANUS KINASE 2; LUNG NEOPLASMS; MICE; NEOPLASTIC STEM CELLS; SPHEROIDS, CELLULAR; STAT3 TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84911004173     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.29033     Document Type: Article

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