메뉴 건너뛰기




Volumn 114, Issue 1, 2014, Pages 18-23

Therapeutic targeting of the JAK/STAT pathway

Author keywords

[No Author keywords available]

Indexed keywords

5 CHLORO N2 [1 (5 FLUORO 2 PYRIMIDINYL)ETHYL] N4 (5 METHYL 1H PYRAZOL 3 YL) 2,4 PYRIMIDINEDIAMINE; ADELATINIB; BARICITINIB; FEDRATINIB; JANUS KINASE; JANUS KINASE INHIBITOR; LESTAURTINIB; MOMELOTINIB; PACRITINIB; PRALNACASAN; RUXOLITINIB; STAT PROTEIN; TOFACITINIB;

EID: 84890806562     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/bcpt.12164     Document Type: Review
Times cited : (124)

References (47)
  • 1
    • 82755186811 scopus 로고    scopus 로고
    • Cytokine signaling: birth of a pathway
    • O'Shea JJ, Gadina M, Kanno Y. Cytokine signaling: birth of a pathway. J Immunol 2011;187:5475-8.
    • (2011) J Immunol , vol.187 , pp. 5475-5478
    • O'Shea, J.J.1    Gadina, M.2    Kanno, Y.3
  • 2
    • 0028845212 scopus 로고
    • Cytokine receptor signalling
    • Ihle JN. Cytokine receptor signalling. Nature 1995;377:591-4.
    • (1995) Nature , vol.377 , pp. 591-594
    • Ihle, J.N.1
  • 3
    • 84859992161 scopus 로고    scopus 로고
    • The JAK-STAT pathway at twenty
    • Stark GR, Darnell JE Jr. The JAK-STAT pathway at twenty. Immunity 2012;36:503-14.
    • (2012) Immunity , vol.36 , pp. 503-514
    • Stark, G.R.1    Darnell Jr, J.E.2
  • 6
    • 84872065897 scopus 로고    scopus 로고
    • JAKs and STATs in immunity, immunodeficiency, and cancer
    • O'Shea JJ, Holland SM, Staudt LM. JAKs and STATs in immunity, immunodeficiency, and cancer. N Engl J Med 2013;368:161-70.
    • (2013) N Engl J Med , vol.368 , pp. 161-170
    • O'Shea, J.J.1    Holland, S.M.2    Staudt, L.M.3
  • 7
    • 84859972127 scopus 로고    scopus 로고
    • JAK and STAT signaling molecules in immunoregulation and immune-mediated disease
    • O'Shea JJ, Plenge R. JAK and STAT signaling molecules in immunoregulation and immune-mediated disease. Immunity 2012;36:542-50.
    • (2012) Immunity , vol.36 , pp. 542-550
    • O'Shea, J.J.1    Plenge, R.2
  • 8
    • 0031777526 scopus 로고    scopus 로고
    • Regulation of T helper cell differentiation by STAT molecules
    • Kaplan MH, Grusby MJ. Regulation of T helper cell differentiation by STAT molecules. J Leukoc Biol 1998;64:2-5.
    • (1998) J Leukoc Biol , vol.64 , pp. 2-5
    • Kaplan, M.H.1    Grusby, M.J.2
  • 9
    • 0031919849 scopus 로고    scopus 로고
    • Jaks and STATs: biological implications
    • Leonard WJ, O'Shea JJ. Jaks and STATs: biological implications. Annu Rev Immunol 1998;16:293-322.
    • (1998) Annu Rev Immunol , vol.16 , pp. 293-322
    • Leonard, W.J.1    O'Shea, J.J.2
  • 12
    • 80053654233 scopus 로고    scopus 로고
    • Mutant JAK3 FERMents ATLL
    • Pesu M. Mutant JAK3 FERMents ATLL. Blood 2011;118:3759-60.
    • (2011) Blood , vol.118 , pp. 3759-3760
    • Pesu, M.1
  • 13
    • 80052492285 scopus 로고    scopus 로고
    • The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling
    • Ungureanu D, Wu J, Pekkala T, Niranjan Y, Young C, Jensen ON, et al. The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling. Nat Struct Mol Biol 2011;18:971-6.
    • (2011) Nat Struct Mol Biol , vol.18 , pp. 971-976
    • Ungureanu, D.1    Wu, J.2    Pekkala, T.3    Niranjan, Y.4    Young, C.5    Jensen, O.N.6
  • 15
    • 0028857954 scopus 로고
    • Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development
    • Russell SM, Tayebi N, Nakajima H, Riedy MC, Roberts JL, Aman MJ, et al. Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science 1995;270:797-800.
    • (1995) Science , vol.270 , pp. 797-800
    • Russell, S.M.1    Tayebi, N.2    Nakajima, H.3    Riedy, M.C.4    Roberts, J.L.5    Aman, M.J.6
  • 16
    • 0031876654 scopus 로고    scopus 로고
    • Physiology and function of the erythropoietin receptor
    • Yoshimura A, Misawa H. Physiology and function of the erythropoietin receptor. Curr Opin Hematol 1998;5:171-6.
    • (1998) Curr Opin Hematol , vol.5 , pp. 171-176
    • Yoshimura, A.1    Misawa, H.2
  • 17
    • 84874260872 scopus 로고    scopus 로고
    • Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent
    • Li Z, Gakovic M, Ragimbeau J, Eloranta ML, Ronnblom L, Michel F, et al. Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent. J Immunol 2013;190:2335-44.
    • (2013) J Immunol , vol.190 , pp. 2335-2344
    • Li, Z.1    Gakovic, M.2    Ragimbeau, J.3    Eloranta, M.L.4    Ronnblom, L.5    Michel, F.6
  • 18
    • 0032076183 scopus 로고    scopus 로고
    • Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the jaks in cytokine-induced biologic responses
    • Rodig SJ, Meraz MA, White JM, Lampe PA, Riley JK, Arthur CD, et al. Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the jaks in cytokine-induced biologic responses. Cell 1998;93:373-83.
    • (1998) Cell , vol.93 , pp. 373-383
    • Rodig, S.J.1    Meraz, M.A.2    White, J.M.3    Lampe, P.A.4    Riley, J.K.5    Arthur, C.D.6
  • 19
    • 18244432009 scopus 로고    scopus 로고
    • Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
    • Neubauer H, Cumano A, Muller M, Wu H, Huffstadt U, Pfeffer K. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell 1998;93:397-409.
    • (1998) Cell , vol.93 , pp. 397-409
    • Neubauer, H.1    Cumano, A.2    Muller, M.3    Wu, H.4    Huffstadt, U.5    Pfeffer, K.6
  • 20
    • 0028799457 scopus 로고
    • Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3
    • Thomis DC, Gurniak CB, Tivol E, Sharpe AH, Berg LJ. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 1995;270:794-7.
    • (1995) Science , vol.270 , pp. 794-797
    • Thomis, D.C.1    Gurniak, C.B.2    Tivol, E.3    Sharpe, A.H.4    Berg, L.J.5
  • 22
    • 0029164841 scopus 로고
    • Mutations of jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)
    • Macchi P, Villa A, Giliani S, Sacco MG, Frattini A, Porta F, et al. Mutations of jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 1995;377:65-8.
    • (1995) Nature , vol.377 , pp. 65-68
    • Macchi, P.1    Villa, A.2    Giliani, S.3    Sacco, M.G.4    Frattini, A.5    Porta, F.6
  • 24
    • 33845897463 scopus 로고    scopus 로고
    • Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity
    • Minegishi Y, Saito M, Morio T, Watanabe K, Agematsu K, Tsuchiya S, et al. Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. Immunity 2006;25:745-55.
    • (2006) Immunity , vol.25 , pp. 745-755
    • Minegishi, Y.1    Saito, M.2    Morio, T.3    Watanabe, K.4    Agematsu, K.5    Tsuchiya, S.6
  • 26
    • 24144475028 scopus 로고    scopus 로고
    • Identification of an acquired mutation in Jak2 provides molecular insights into the pathogenesis of myeloproliferative disorders
    • Pesu M, O'Shea J, Hennighausen L, Silvennoinen O. Identification of an acquired mutation in Jak2 provides molecular insights into the pathogenesis of myeloproliferative disorders. Mol Interv 2005;5:211-5.
    • (2005) Mol Interv , vol.5 , pp. 211-215
    • Pesu, M.1    O'Shea, J.2    Hennighausen, L.3    Silvennoinen, O.4
  • 27
    • 20144363192 scopus 로고    scopus 로고
    • Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
    • Baxter EJ, Scott LM, Campbell PJ, East C, Fourouclas N, Swanton S, et al. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 2005;365:1054-61.
    • (2005) Lancet , vol.365 , pp. 1054-1061
    • Baxter, E.J.1    Scott, L.M.2    Campbell, P.J.3    East, C.4    Fourouclas, N.5    Swanton, S.6
  • 29
    • 17844383458 scopus 로고    scopus 로고
    • A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
    • James C, Ugo V, Le Couedic JP, Staerk J, Delhommeau F, Lacout C, et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 2005;434:1144-8.
    • (2005) Nature , vol.434 , pp. 1144-1148
    • James, C.1    Ugo, V.2    Le Couedic, J.P.3    Staerk, J.4    Delhommeau, F.5    Lacout, C.6
  • 31
    • 41449110468 scopus 로고    scopus 로고
    • Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
    • Milner JD, Brenchley JM, Laurence A, Freeman AF, Hill BJ, Elias KM, et al. Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature 2008;452:773-6.
    • (2008) Nature , vol.452 , pp. 773-776
    • Milner, J.D.1    Brenchley, J.M.2    Laurence, A.3    Freeman, A.F.4    Hill, B.J.5    Elias, K.M.6
  • 32
    • 82055163110 scopus 로고    scopus 로고
    • A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory
    • Siegel AM, Heimall J, Freeman AF, Hsu AP, Brittain E, Brenchley JM, et al. A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory. Immunity 2011;35:806-18.
    • (2011) Immunity , vol.35 , pp. 806-818
    • Siegel, A.M.1    Heimall, J.2    Freeman, A.F.3    Hsu, A.P.4    Brittain, E.5    Brenchley, J.M.6
  • 37
    • 84876155664 scopus 로고    scopus 로고
    • STAT activation in malignancies: roles in tumor progression and in the generation of antineoplastic effects of IFNs
    • Wang BX, Platanias LC, Fish EN. STAT activation in malignancies: roles in tumor progression and in the generation of antineoplastic effects of IFNs. J Interferon Cytokine Res 2013;33:181-8.
    • (2013) J Interferon Cytokine Res , vol.33 , pp. 181-188
    • Wang, B.X.1    Platanias, L.C.2    Fish, E.N.3
  • 40
    • 84890803463 scopus 로고    scopus 로고
    • Internet. (last accessed on October 2013).
    • Internet. http://www.jakafi.com (last accessed on October 2013).
  • 43
    • 79551575494 scopus 로고    scopus 로고
    • Janus kinase inhibitors for the treatment of myeloproliferative neoplasias and beyond
    • Quintas-Cardama A, Kantarjian H, Cortes J, Verstovsek S. Janus kinase inhibitors for the treatment of myeloproliferative neoplasias and beyond. Nat Rev Drug Discov 2011;10:127-40.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 127-140
    • Quintas-Cardama, A.1    Kantarjian, H.2    Cortes, J.3    Verstovsek, S.4
  • 46
    • 77955375143 scopus 로고    scopus 로고
    • Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis
    • Meyer DM, Jesson MI, Li X, Elrick MM, Funckes-Shippy CL, Warner JD, et al. Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690, 550, in rat adjuvant-induced arthritis. J Inflamm (Lond) 2010;7:41.
    • (2010) J Inflamm (Lond) , vol.7 , pp. 41
    • Meyer, D.M.1    Jesson, M.I.2    Li, X.3    Elrick, M.M.4    Funckes-Shippy, C.L.5    Warner, J.D.6
  • 47
    • 84890807519 scopus 로고    scopus 로고
    • Internet. (last accessed on October 2013).
    • Internet. http://www.xeljanz.com (last accessed on October 2013).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.