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1
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0034614637
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The hallmarks of cancer
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1 Hanahan, D., Weinberg, R.A., The hallmarks of cancer. Cell 100 (2000), 57–70.
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Cell
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Hanahan, D.1
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2
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The organizing principle: microenvironmental influences in the normal and malignant breast
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2 Bissell, M.J., Radisky, D.C., Rizki, A., Weaver, V.M., Petersen, O.W., The organizing principle: microenvironmental influences in the normal and malignant breast. Differentiation 70 (2002), 537–546.
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Differentiation
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Bissell, M.J.1
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Rizki, A.3
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Petersen, O.W.5
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3
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The tumor microenvironment is a dominant force in multidrug resistance
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3 Correia, A.L., Bissell, M.J., The tumor microenvironment is a dominant force in multidrug resistance. Drug Resist Update 15 (2012), 39–49.
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Drug Resist Update
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Correia, A.L.1
Bissell, M.J.2
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4
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Cancer-associated fibroblasts: recent developments and emerging challenges
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4 Östman, A., Cancer-associated fibroblasts: recent developments and emerging challenges. Semin Cancer Biol 25 (2014), 1–2.
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Semin Cancer Biol
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Östman, A.1
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5
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Paradoxical roles of the immune system during cancer development
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5 de Visser, K.E., Eichten, A., Coussens, L.M., Paradoxical roles of the immune system during cancer development. Nat Rev Cancer 6 (2006), 24–37.
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Nat Rev Cancer
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de Visser, K.E.1
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6
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84922333220
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Remodelling the extracellular matrix in development and disease
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6 Bonnans, C., Chou, J., Werb, Z., Remodelling the extracellular matrix in development and disease. Nat Rev Mol Cell Biol 15 (2014), 786–801.
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Nat Rev Mol Cell Biol
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Bonnans, C.1
Chou, J.2
Werb, Z.3
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7
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Tensional homeostasis and the malignant phenotype
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7 Paszek, M.J., Zahir, N., Johnson, K.R., Lakins, J.N., Rozenberg, G.I., Gefen, A., Reinhart-King, C., Margulies, a., Dembo, S.S., Boettiger, M.D., et al. Tensional homeostasis and the malignant phenotype. Cancer Cell 8 (2005), 241–254.
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Cancer Cell
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Paszek, M.J.1
Zahir, N.2
Johnson, K.R.3
Lakins, J.N.4
Rozenberg, G.I.5
Gefen, A.6
Reinhart-King, C.7
Margulies, A.8
Dembo, S.S.9
Boettiger, M.D.10
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8
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70450222098
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Matrix crosslinking forces tumor progression by enhancing integrin signaling
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8 Levental, K.R., Yu, H., Kass, L., Lakins, J.N., Egeblad, M., Erler, J.T., Fong, S.F.T., Csiszar, K., Giaccia, A., Weninger, W., et al. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell 139 (2009), 891–906.
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Cell
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Levental, K.R.1
Yu, H.2
Kass, L.3
Lakins, J.N.4
Egeblad, M.5
Erler, J.T.6
Fong, S.F.T.7
Csiszar, K.8
Giaccia, A.9
Weninger, W.10
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9
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84915784640
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Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium
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An important step towards separating the effect of ECM properties such as stiffness and composition in tumor progression.
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9• Chaudhuri, O., Koshy, S.T., Branco da Cunha, C., Shin, J.-W., Verbeke, C.S., Allison, K.H., Mooney, D.J., Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium. Nat Mater 13 (2014), 1–35 An important step towards separating the effect of ECM properties such as stiffness and composition in tumor progression.
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Nat Mater
, vol.13
, pp. 1-35
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Chaudhuri, O.1
Koshy, S.T.2
Branco da Cunha, C.3
Shin, J.-W.4
Verbeke, C.S.5
Allison, K.H.6
Mooney, D.J.7
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10
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33746593689
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Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell–matrix adhesion and proteolysis
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10 Zaman, M.H., Trapani, L.M., Sieminski, A.L., MacKellar, D., Gong, H., Kamm, R.D., Wells, A., Lauffenburger, D.A., Matsudaira, P., Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell–matrix adhesion and proteolysis. Proc Natl Acad Sci 103 (2006), 10889–10894.
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Proc Natl Acad Sci
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Zaman, M.H.1
Trapani, L.M.2
Sieminski, A.L.3
MacKellar, D.4
Gong, H.5
Kamm, R.D.6
Wells, A.7
Lauffenburger, D.A.8
Matsudaira, P.9
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11
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Cell movement is guided by the rigidity of the substrate
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11 Lo, C.M., Wang, H.B., Dembo, M., Wang, Y.L., Cell movement is guided by the rigidity of the substrate. Biophys J 79 (2000), 144–152.
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Lo, C.M.1
Wang, H.B.2
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Wang, Y.L.4
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12
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84871997465
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Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain
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12 Raab, M., Swift, J., Dingal, P.C.D.P., Shah, P., Shin, J.W., Discher, D.E., Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain. J Cell Biol 199 (2012), 669–683.
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J Cell Biol
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Raab, M.1
Swift, J.2
Dingal, P.C.D.P.3
Shah, P.4
Shin, J.W.5
Discher, D.E.6
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13
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84891413831
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Topographical guidance of 3D tumor cell migration at an interface of collagen densities
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13 Bordeleau, F., Tang, L.N., Reinhart-King, C., Topographical guidance of 3D tumor cell migration at an interface of collagen densities. Phys Biol, 10, 2013, 065004.
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Phys Biol
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Bordeleau, F.1
Tang, L.N.2
Reinhart-King, C.3
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14
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84901982024
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A peptide functionalized poly(ethylene glycol) (PEG) hydrogel for investigating the influence of biochemical and biophysical matrix properties on tumor cell migration
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This study used peptide functionalized synthetic hydrogels to independently study the effect of various 3D matrix properties on cancer cell migration. The study also revealed the cell migration phenomenon of ‘reverse durotaxis’.
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14•• Singh, S.P., Schwartz, M.P., Lee, J.Y., Fairbanks, B.D., Anseth, K.S., A peptide functionalized poly(ethylene glycol) (PEG) hydrogel for investigating the influence of biochemical and biophysical matrix properties on tumor cell migration. Biomater Sci 2 (2014), 1024–1034 This study used peptide functionalized synthetic hydrogels to independently study the effect of various 3D matrix properties on cancer cell migration. The study also revealed the cell migration phenomenon of ‘reverse durotaxis’.
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(2014)
Biomater Sci
, vol.2
, pp. 1024-1034
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Singh, S.P.1
Schwartz, M.P.2
Lee, J.Y.3
Fairbanks, B.D.4
Anseth, K.S.5
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15
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33846782878
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Collagen reorganization at the tumor–stromal interface facilitates local invasion
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15 Provenzano, P.P., Eliceiri, K.W., Campbell, J.M., Inman, D.R., White, J.G., Keely, P.J., Collagen reorganization at the tumor–stromal interface facilitates local invasion. BMC Med, 4, 2006, 38.
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BMC Med
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Provenzano, P.P.1
Eliceiri, K.W.2
Campbell, J.M.3
Inman, D.R.4
White, J.G.5
Keely, P.J.6
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16
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84914159978
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3D collagen alignment limits protrusions to enhance breast cancer cell persistence
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This work provided novel insights into how stiffness and fiber alignment affects cancer cell migration.
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16•• Riching, K.M., Cox, B.L., Salick, M.R., Pehlke, C., Riching, A.S., Ponik, S.M., Bass, B.R., Crone, W.C., Jiang, Y., Weaver, A.M., et al. 3D collagen alignment limits protrusions to enhance breast cancer cell persistence. Biophys J 107 (2014), 2546–2558 This work provided novel insights into how stiffness and fiber alignment affects cancer cell migration.
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(2014)
Biophys J
, vol.107
, pp. 2546-2558
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Riching, K.M.1
Cox, B.L.2
Salick, M.R.3
Pehlke, C.4
Riching, A.S.5
Ponik, S.M.6
Bass, B.R.7
Crone, W.C.8
Jiang, Y.9
Weaver, A.M.10
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17
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3D traction stresses activate protease-dependent invasion of cancer cells
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17 Aung, A., Seo, Y.N., Lu, S., Wang, Y., Jamora, C., del Álamo, J.C., Varghese, S., 3D traction stresses activate protease-dependent invasion of cancer cells. Biophys J 107 (2014), 2528–2537.
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(2014)
Biophys J
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Aung, A.1
Seo, Y.N.2
Lu, S.3
Wang, Y.4
Jamora, C.5
del Álamo, J.C.6
Varghese, S.7
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18
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0037455576
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Compensation mechanism in tumor cell migration: mesenchymal–amoeboid transition after blocking of pericellular proteolysis
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18 Wolf, K., Mazo, I., Leung, H., Engelke, K., Von Andrian, U.H., Deryugina, E.I., Strongin, A.Y., Bröcker, E.B., Friedl, P., Compensation mechanism in tumor cell migration: mesenchymal–amoeboid transition after blocking of pericellular proteolysis. J Cell Biol 160 (2003), 267–277.
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(2003)
J Cell Biol
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Wolf, K.1
Mazo, I.2
Leung, H.3
Engelke, K.4
Von Andrian, U.H.5
Deryugina, E.I.6
Strongin, A.Y.7
Bröcker, E.B.8
Friedl, P.9
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19
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84943188477
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Three-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusions
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Provides novel insights into the relation between MMP activity, fiber alignment and migratory activity.
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19•• Fraley, S.I., Wu, P., He, L., Feng, Y., Krisnamurthy, R., Longmore, G.D., Wirtz, D., Three-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusions. Sci Rep, 5, 2015, 14580 Provides novel insights into the relation between MMP activity, fiber alignment and migratory activity.
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(2015)
Sci Rep
, vol.5
, pp. 14580
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Fraley, S.I.1
Wu, P.2
He, L.3
Feng, Y.4
Krisnamurthy, R.5
Longmore, G.D.6
Wirtz, D.7
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20
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84903385203
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Cell jamming: collective invasion of mesenchymal tumor cells imposed by tissue confinement
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Investigates how increased collagen concentration can induce a switch from single to collective cell migration.
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20• Haeger, A., Krause, M., Wolf, K., Friedl, P., Cell jamming: collective invasion of mesenchymal tumor cells imposed by tissue confinement. Biochim Biophys Acta Gen Subj 1840 (2014), 2386–2395 Investigates how increased collagen concentration can induce a switch from single to collective cell migration.
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(2014)
Biochim Biophys Acta Gen Subj
, vol.1840
, pp. 2386-2395
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Haeger, A.1
Krause, M.2
Wolf, K.3
Friedl, P.4
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21
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84948782470
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Collective motion of mammalian cell cohorts in 3D
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21 Sharma, Y., Vargas, D.A., Pegoraro, A.F., Lepzelter, D., Weitz, D.A., Zaman, M., Collective motion of mammalian cell cohorts in 3D. Integr Biol, 2015, 10.1039/C5IB00208G.
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(2015)
Integr Biol
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Sharma, Y.1
Vargas, D.A.2
Pegoraro, A.F.3
Lepzelter, D.4
Weitz, D.A.5
Zaman, M.6
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22
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84947737226
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Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments
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Developed a novel synthetic fibrous material with tunable mechanics and user-defined architecture. The work revealed that cells can probe their surroundings through fiber recruitment, a previously undescribed mechanism.
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22•• Baker, B.M., Trappmann, B., Wang, W.Y., Sakar, M.S., Kim, I.L., Shenoy, V.B., Burdick, J.A., Chen, C.S., Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments. Nat Mater, 2015, 10.1038/nmat4444 Developed a novel synthetic fibrous material with tunable mechanics and user-defined architecture. The work revealed that cells can probe their surroundings through fiber recruitment, a previously undescribed mechanism.
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(2015)
Nat Mater
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Baker, B.M.1
Trappmann, B.2
Wang, W.Y.3
Sakar, M.S.4
Kim, I.L.5
Shenoy, V.B.6
Burdick, J.A.7
Chen, C.S.8
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23
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44049090235
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Notch signaling mediates hypoxia-induced tumor cell migration and invasion
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23 Sahlgren, C., Gustafsson, M.V., Jin, S., Poellinger, L., Lendahl, U., Notch signaling mediates hypoxia-induced tumor cell migration and invasion. Proc Natl Acad Sci U S A 105 (2008), 6392–6397.
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Proc Natl Acad Sci U S A
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Sahlgren, C.1
Gustafsson, M.V.2
Jin, S.3
Poellinger, L.4
Lendahl, U.5
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24
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Hypoxia and the extracellular matrix: drivers of tumour metastasis
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24 Gilkes, D.M., Semenza, G.L., Wirtz, D., Hypoxia and the extracellular matrix: drivers of tumour metastasis. Nat Rev Cancer 14 (2014), 430–439.
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Nat Rev Cancer
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Gilkes, D.M.1
Semenza, G.L.2
Wirtz, D.3
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25
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0344442890
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Oxygen tension regulates the expression of a group of procollagen hydroxylases
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25 Hofbauer, K.H., Gess, B., Lohaus, C., Meyer, H.E., Katschinski, D., Kurtz, A., Oxygen tension regulates the expression of a group of procollagen hydroxylases. Eur J Biochem 270 (2003), 4515–4522.
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Eur J Biochem
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Hofbauer, K.H.1
Gess, B.2
Lohaus, C.3
Meyer, H.E.4
Katschinski, D.5
Kurtz, A.6
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26
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79251540221
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Stiffness gradients mimicking in vivo tissue variation regulate mesenchymal stem cell fate
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26 Tse, J.R., Engler, A.J., Stiffness gradients mimicking in vivo tissue variation regulate mesenchymal stem cell fate. PLoS ONE, 6, 2011, e15978.
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PLoS ONE
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Tse, J.R.1
Engler, A.J.2
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27
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84880079914
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Coevolution of solid stress and interstitial fluid pressure in tumors during progression: implications for vascular collapse
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27 Stylianopoulos, T., Martin, J.D., Snuderl, M., Mpekris, F., Jain, S.R., Jain, R.K., Coevolution of solid stress and interstitial fluid pressure in tumors during progression: implications for vascular collapse. Cancer Res 73 (2013), 3833–3841.
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Cancer Res
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Stylianopoulos, T.1
Martin, J.D.2
Snuderl, M.3
Mpekris, F.4
Jain, S.R.5
Jain, R.K.6
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28
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0035417889
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Interstitial fluid pressure predicts survival in patients with cervix cancer independent of clinical prognostic factors and tumor oxygen measurements
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28 Milosevic, M., Fyles, a., Hedley, D., Pintilie, M., Levin, W., Manchul, L., Hill, R., Interstitial fluid pressure predicts survival in patients with cervix cancer independent of clinical prognostic factors and tumor oxygen measurements. Cancer Res 61 (2001), 6400–6405.
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Cancer Res
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Milosevic, M.1
Fyles, A.2
Hedley, D.3
Pintilie, M.4
Levin, W.5
Manchul, L.6
Hill, R.7
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29
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84894380551
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Mechanotransduction of fluid stresses governs 3D cell migration
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Gives new insights into how directed cell migration arises in response to fluid flow, and how this response is mediated through adhesion molecules.
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29•• Polacheck, W.J., German, A.E., Mammoto, A., Ingber, D.E., Kamm, R.D., Mechanotransduction of fluid stresses governs 3D cell migration. Proc Natl Acad Sci U S A 111 (2014), 2447–2452 Gives new insights into how directed cell migration arises in response to fluid flow, and how this response is mediated through adhesion molecules.
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Proc Natl Acad Sci U S A
, vol.111
, pp. 2447-2452
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Polacheck, W.J.1
German, A.E.2
Mammoto, A.3
Ingber, D.E.4
Kamm, R.D.5
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30
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84877946982
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Defining single molecular forces required to activate integrin and notch signaling
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Introduced novel tension gauge tether technique to measure forces required to active integrin and notch signaling.
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30• Wang, X., Ha, T., Defining single molecular forces required to activate integrin and notch signaling. Science 340 (2013), 991–994 Introduced novel tension gauge tether technique to measure forces required to active integrin and notch signaling.
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Science
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, pp. 991-994
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Wang, X.1
Ha, T.2
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31
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84884243072
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Molecular tension sensors report forces generated by single integrin molecules in living cells
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Introduces novel FRET-sensor based measurements of force distributions acting on individual integrin molecules.
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31•• Morimatsu, M., Mekhdjian, A.H., Adhikari, A.S., Dunn, A.R., Molecular tension sensors report forces generated by single integrin molecules in living cells. Nano Lett 13 (2013), 3985–3989 Introduces novel FRET-sensor based measurements of force distributions acting on individual integrin molecules.
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Nano Lett
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Morimatsu, M.1
Mekhdjian, A.H.2
Adhikari, A.S.3
Dunn, A.R.4
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32
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Rigidity sensing and adaptation through regulation of integrin types
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32 Elosegui-Artola, A., Bazellières, E., Allen, M.D., Andreu, I., Oria, R., Sunyer, R., Gomm, J.J., Marshall, J.F., Jones, J.L., Trepat, X., et al. Rigidity sensing and adaptation through regulation of integrin types. Nat Mater 13 (2014), 631–637.
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Nat Mater
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Elosegui-Artola, A.1
Bazellières, E.2
Allen, M.D.3
Andreu, I.4
Oria, R.5
Sunyer, R.6
Gomm, J.J.7
Marshall, J.F.8
Jones, J.L.9
Trepat, X.10
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33
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The cancer glycocalyx mechanically primes integrin-mediated growth and survival
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33 Paszek, M.J., DuFort, C.C., Rossier, O., Bainer, R., Mouw, J.K., Godula, K., Hudak, J.E., Lakins, J.N., Wijekoon, A.C., Cassereau, L., et al. The cancer glycocalyx mechanically primes integrin-mediated growth and survival. Nature 511 (2014), 319–325.
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Nature
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Paszek, M.J.1
DuFort, C.C.2
Rossier, O.3
Bainer, R.4
Mouw, J.K.5
Godula, K.6
Hudak, J.E.7
Lakins, J.N.8
Wijekoon, A.C.9
Cassereau, L.10
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34
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84907053819
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Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate
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Found that ECM stiffness per se can drive malignant transformation and metastasis through vinculin-mediated PI3K signaling.
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34• Rubashkin, M.G., Cassereau, L., Bainer, R., DuFort, C.C., Yui, Y., Ou, G., Paszek, M.J., Davidson, M.W., Chen, Y.-Y., Weaver, V.M., Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate. Cancer Res 74 (2014), 4597–4611 Found that ECM stiffness per se can drive malignant transformation and metastasis through vinculin-mediated PI3K signaling.
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(2014)
Cancer Res
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, pp. 4597-4611
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Rubashkin, M.G.1
Cassereau, L.2
Bainer, R.3
DuFort, C.C.4
Yui, Y.5
Ou, G.6
Paszek, M.J.7
Davidson, M.W.8
Chen, Y.-Y.9
Weaver, V.M.10
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35
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84880642716
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Vinculin–actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth
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35 Thievessen, I., Thompson, P.M., Berlemont, S., Plevock, K.M., Plotnikov, S.V., Zemljic-Harpf, A., Ross, R.S., Davidson, M.W., Danuser, G., Campbell, S.L., et al. Vinculin–actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth. J Cell Biol 202 (2013), 163–177.
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J Cell Biol
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Thievessen, I.1
Thompson, P.M.2
Berlemont, S.3
Plevock, K.M.4
Plotnikov, S.V.5
Zemljic-Harpf, A.6
Ross, R.S.7
Davidson, M.W.8
Danuser, G.9
Campbell, S.L.10
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36
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63049123066
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Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
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36 Polyak, K., Weinberg, R.A., Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 9 (2009), 265–273.
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(2009)
Nat Rev Cancer
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Polyak, K.1
Weinberg, R.A.2
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37
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84878908851
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Computational model to probe cellular mechanics during epithelial–mesenchymal transition
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37 Vargas, D.A., Bates, O., Zaman, M.H., Computational model to probe cellular mechanics during epithelial–mesenchymal transition. Cells Tissues Organs 197 (2013), 435–444.
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Cells Tissues Organs
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Vargas, D.A.1
Bates, O.2
Zaman, M.H.3
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38
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84864506988
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E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch
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38 Borghi, N., Sorokina, M., Shcherbakova, O.G., Weis, W.I., Pruitt, B.L., Nelson, W.J., Dunn, A.R., E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch. Proc Natl Acad Sci, 109, 2012, 19034.
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Proc Natl Acad Sci
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Borghi, N.1
Sorokina, M.2
Shcherbakova, O.G.3
Weis, W.I.4
Pruitt, B.L.5
Nelson, W.J.6
Dunn, A.R.7
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39
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84909592568
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