A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells

Journal of Biological Chemistry

Volumn 280, Issue 38, 2005, Pages 32979-32988

  Turkson, James ^a,c   Zhang, Shumin ^a   Mora, Linda B ^a   Burns, Audrey ^a   Sebti, Said ^a,b   Jove, Richard ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF CENTRAL FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DNA; GENES; PROTEINS; TUMORS;

CANCER THERAPY; MALIGNANT CELLS; MOUSE TUMOR CELLS;

PLATINUM COMPOUNDS;

CYCLIN D1; IS 3295; PLATINUM DERIVATIVE; PROTEIN BCL XL; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER THERAPY; CARCINOGENESIS; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL TRANSFORMATION; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DRUG PROTEIN BINDING; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOSIS INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION;

AGAR; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BROMODEOXYURIDINE; CELL CYCLE; CELL LINE, TUMOR; CELL NUCLEUS; CELL PROLIFERATION; CYCLIN D1; CYTOSOL; DNA; FIBROBLASTS; FLOW CYTOMETRY; G0 PHASE; G1 PHASE; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; KI-67 ANTIGEN; KINETICS; LUCIFERASES; MICE; NEOPLASMS; NIH 3T3 CELLS; OLIGONUCLEOTIDES; ONCOGENE PROTEIN PP60(V-SRC); PIPERAZINES; PLASMIDS; PLATINUM; PLATINUM COMPOUNDS; PROTEIN BINDING; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 25444513779     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M502694200     Document Type: Article

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