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Volumn 5, Issue , 2015, Pages

Multiple regulation pathways and pivotal biological functions of STAT3 in cancer

Author keywords

[No Author keywords available]

Indexed keywords

STAT3 PROTEIN; STAT3 PROTEIN, HUMAN;

EID: 84949294600     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep17663     Document Type: Article
Times cited : (196)

References (105)
  • 1
    • 84872834298 scopus 로고    scopus 로고
    • STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain
    • Timofeeva, O. A. et al. STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain. Proc Natl Acad Sci USA 110, 1267-1272, doi: 10.1073/pnas.1211805110 (2013).
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 1267-1272
    • Timofeeva, O.A.1
  • 2
    • 84878171024 scopus 로고    scopus 로고
    • STAT3 acetylation-induced promoter methylation is associated with downregulation of the ARHI tumor-suppressor gene in ovarian cancer
    • Li, J. et al. STAT3 acetylation-induced promoter methylation is associated with downregulation of the ARHI tumor-suppressor gene in ovarian cancer. Oncol Rep 30, 165-170, doi: 10.3892/or.2013.2414 (2013).
    • (2013) Oncol Rep , vol.30 , pp. 165-170
    • Li, J.1
  • 3
    • 84861215508 scopus 로고    scopus 로고
    • Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation
    • Lee, H. et al. Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation. Proc Natl Acad Sci USA 109, 7765-7769, doi: 10.1073/pnas.1205132109 (2012).
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 7765-7769
    • Lee, H.1
  • 4
    • 84939536062 scopus 로고    scopus 로고
    • Angiotensin II in atrial structural remodeling: The role of Ang II/JAK/STAT3 signaling pathway
    • Zheng, L. et al. Angiotensin II in atrial structural remodeling: the role of Ang II/JAK/STAT3 signaling pathway. Am J Transl Res 7, 1021-1031 (2015).
    • (2015) Am J Transl Res , vol.7 , pp. 1021-1031
    • Zheng, L.1
  • 5
    • 85016349671 scopus 로고    scopus 로고
    • Sphingosine Phosphate Lyase Regulates Murine Embryonic Stem Cell Proliferation and Pluripotency through an S1P/STAT3 Signaling Pathway
    • Smith, G. S., Kumar, A. & Saba, J. D. Sphingosine Phosphate Lyase Regulates Murine Embryonic Stem Cell Proliferation and Pluripotency through an S1P/STAT3 Signaling Pathway. Biomolecules 3, 351-368, doi: 10.3390/biom3030351 (2013).
    • (2013) Biomolecules , vol.3 , pp. 351-368
    • Smith, G.S.1    Kumar, A.2    Saba, J.D.3
  • 6
    • 9444254649 scopus 로고    scopus 로고
    • A GTPase-activating protein binds STAT3 and is required for IL-6-induced STAT3 activation and for differentiation of a leukemic cell line
    • Tonozuka, Y. et al. A GTPase-activating protein binds STAT3 and is required for IL-6-induced STAT3 activation and for differentiation of a leukemic cell line. Blood 104, 3550-3557, doi: 10.1182/blood-2004-03-1066 (2004).
    • (2004) Blood , vol.104 , pp. 3550-3557
    • Tonozuka, Y.1
  • 7
    • 84878992346 scopus 로고    scopus 로고
    • Crystal structure of GTPase-activating domain from human MgcRacGAP
    • Matsuura, A. & Lee, H. H. Crystal structure of GTPase-activating domain from human MgcRacGAP. Biochem Biophys Res Commun 435, 367-372, doi: 10.1016/j.bbrc.2013.04.094 (2013).
    • (2013) Biochem Biophys Res Commun , vol.435 , pp. 367-372
    • Matsuura, A.1    Lee, H.H.2
  • 8
    • 79959344027 scopus 로고    scopus 로고
    • The R(h)oads to Stat3: Stat3 activation by the Rho GTPases
    • Raptis, L., Arulanandam, R., Geletu, M. & Turkson, J. The R(h)oads to Stat3: Stat3 activation by the Rho GTPases. Exp Cell Res 317, 1787-1795, doi: 10.1016/j.yexcr.2011.05.008 (2011).
    • (2011) Exp Cell Res , vol.317 , pp. 1787-1795
    • Raptis, L.1    Arulanandam, R.2    Geletu, M.3    Turkson, J.4
  • 9
    • 84877832024 scopus 로고    scopus 로고
    • Classical cadherins control survival through the gp130/Stat3 axis
    • Geletu, M. et al. Classical cadherins control survival through the gp130/Stat3 axis. Biochim Biophys Acta 1833, 1947-1959, doi: 10.1016/j.bbamcr.2013.03.014 (2013).
    • (2013) Biochim Biophys Acta , vol.1833 , pp. 1947-1959
    • Geletu, M.1
  • 10
    • 84904389334 scopus 로고    scopus 로고
    • TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells
    • Liu, B. S., Cao, Y., Huizinga, T. W., Hafler, D. A. & Toes, R. E. TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells. Eur J Immunol 44, 2121-2129, doi: 10.1002/eji.201344341 (2014).
    • (2014) Eur J Immunol , vol.44 , pp. 2121-2129
    • Liu, B.S.1    Cao, Y.2    Huizinga, T.W.3    Hafler, D.A.4    Toes, R.E.5
  • 11
    • 84885171514 scopus 로고    scopus 로고
    • TLR4 mediates MAPK-STAT3 axis activation in bladder epithelial cells
    • Ying, H. et al. TLR4 mediates MAPK-STAT3 axis activation in bladder epithelial cells. Inflammation 36, 1064-1074, doi: 10.1007/s10753-013-9638-7 (2013).
    • (2013) Inflammation , vol.36 , pp. 1064-1074
    • Ying, H.1
  • 12
    • 84908312087 scopus 로고    scopus 로고
    • A novel protective role for the innate immunity Toll-Like Receptor 3 (TLR3) in the retina via Stat3
    • Patel, A. K. & Hackam, A. S. A novel protective role for the innate immunity Toll-Like Receptor 3 (TLR3) in the retina via Stat3. Mol Cell Neurosci 63, 38-48, doi: 10.1016/j.mcn.2014.09.004 (2014).
    • (2014) Mol Cell Neurosci , vol.63 , pp. 38-48
    • Patel, A.K.1    Hackam, A.S.2
  • 13
    • 84871515161 scopus 로고    scopus 로고
    • Toll-like receptor 3 (TLR3) protects retinal pigmented epithelium (RPE) cells from oxidative stress through a STAT3-dependent mechanism
    • Patel, A. K. & Hackam, A. S. Toll-like receptor 3 (TLR3) protects retinal pigmented epithelium (RPE) cells from oxidative stress through a STAT3-dependent mechanism. Mol Immunol 54, 122-131, doi: 10.1016/j.molimm.2012.11.005 (2013).
    • (2013) Mol Immunol , vol.54 , pp. 122-131
    • Patel, A.K.1    Hackam, A.S.2
  • 14
    • 84867605321 scopus 로고    scopus 로고
    • STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation
    • Tye, H. et al. STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation. Cancer Cell 22, 466-478, doi: 10.1016/j.ccr.2012.08.010 (2012).
    • (2012) Cancer Cell , vol.22 , pp. 466-478
    • Tye, H.1
  • 15
    • 84868627145 scopus 로고    scopus 로고
    • Toll-like receptor 7 regulates pancreatic carcinogenesis in mice and humans
    • Ochi, A. et al. Toll-like receptor 7 regulates pancreatic carcinogenesis in mice and humans. J Clin Invest 122, 4118-4129, doi: 10.1172/JCI63606 (2012).
    • (2012) J Clin Invest , vol.122 , pp. 4118-4129
    • Ochi, A.1
  • 16
    • 65549111372 scopus 로고    scopus 로고
    • Toll-like receptor 9 activation of signal transducer and activator of transcription 3 constrains its agonistbased immunotherapy
    • Kortylewski, M. et al. Toll-like receptor 9 activation of signal transducer and activator of transcription 3 constrains its agonistbased immunotherapy. Cancer Res 69, 2497-2505, doi: 10.1158/0008-5472.CAN-08-3031 (2009).
    • (2009) Cancer Res , vol.69 , pp. 2497-2505
    • Kortylewski, M.1
  • 17
    • 78650849488 scopus 로고    scopus 로고
    • Toll-like receptors in regulatory T cells of patients with head and neck cancer
    • Wild, C. A. et al. Toll-like Receptors in Regulatory T Cells of Patients With Head and Neck Cancer. Arch Otolaryngol Head Neck Surg 136, 1253-1259, doi: 10.1001/archoto.2010.195 (2010).
    • (2010) Arch Otolaryngol Head Neck Surg , vol.136 , pp. 1253-1259
    • Wild, C.A.1
  • 18
    • 84907546700 scopus 로고    scopus 로고
    • TLR9 is critical for glioma stem cell maintenance and targeting
    • Herrmann, A. et al. TLR9 is critical for glioma stem cell maintenance and targeting. Cancer Res 74, 5218-5228, doi: 10.1158/0008-5472.CAN-14-1151 (2014).
    • (2014) Cancer Res , vol.74 , pp. 5218-5228
    • Herrmann, A.1
  • 19
    • 84939161385 scopus 로고    scopus 로고
    • MiR-519d-mediated downregulation of STAT3 suppresses breast cancer progression
    • Deng, X., Zhao, Y. & Wang, B. miR-519d-mediated downregulation of STAT3 suppresses breast cancer progression. Oncol Rep, doi: 10.3892/or.2015.4160 (2015).
    • (2015) Oncol Rep
    • Deng, X.1    Zhao, Y.2    Wang, B.3
  • 20
    • 84876184639 scopus 로고    scopus 로고
    • Decrease expression of microRNA-20a promotes cancer cell proliferation and predicts poor survival of hepatocellular carcinoma
    • Fan, M. Q. et al. Decrease expression of microRNA-20a promotes cancer cell proliferation and predicts poor survival of hepatocellular carcinoma. J Exp Clin Cancer Res 32, 21, doi: 10.1186/1756-9966-32-21 (2013).
    • (2013) J Exp Clin Cancer Res , vol.32 , pp. 21
    • Fan, M.Q.1
  • 21
    • 84897082706 scopus 로고    scopus 로고
    • MicroRNA let-7 downregulates STAT3 phosphorylation in pancreatic cancer cells by increasing SOCS3 expression
    • Patel, K. et al. MicroRNA let-7 downregulates STAT3 phosphorylation in pancreatic cancer cells by increasing SOCS3 expression. Cancer Lett 347, 54-64, doi: 10.1016/j.canlet.2014.01.020 (2014).
    • (2014) Cancer Lett , vol.347 , pp. 54-64
    • Patel, K.1
  • 22
    • 70350778443 scopus 로고    scopus 로고
    • An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation
    • Iliopoulos, D., Hirsch, H. A. & Struhl, K. An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell 139, 693-706, doi: 10.1016/j.cell.2009.10.014 (2009).
    • (2009) Cell , vol.139 , pp. 693-706
    • Iliopoulos, D.1    Hirsch, H.A.2    Struhl, K.3
  • 23
    • 84881303278 scopus 로고    scopus 로고
    • Stat3-coordinated Lin-28-let-7-HMGA2 and miR-200-ZEB1 circuits initiate and maintain oncostatin M-driven epithelial-mesenchymal transition
    • Guo, L. et al. Stat3-coordinated Lin-28-let-7-HMGA2 and miR-200-ZEB1 circuits initiate and maintain oncostatin M-driven epithelial-mesenchymal transition. Oncogene 32, 5272-5282, doi: 10.1038/onc.2012.573 (2013).
    • (2013) Oncogene , vol.32 , pp. 5272-5282
    • Guo, L.1
  • 24
    • 77956141521 scopus 로고    scopus 로고
    • Phosphotyrosine signaling: Evolving a new cellular communication system
    • Lim, W. A. & Pawson, T. Phosphotyrosine signaling: evolving a new cellular communication system. Cell 142, 661-667, doi: 10.1016/j.cell.2010.08.023 (2010).
    • (2010) Cell , vol.142 , pp. 661-667
    • Lim, W.A.1    Pawson, T.2
  • 25
    • 85006233472 scopus 로고    scopus 로고
    • Glucose-6-phosphate dehydrogenase and NADPH oxidase 4 control STAT3 activity in melanoma cells through a pathway involving reactive oxygen species, c-SRC and SHP2
    • Cai, T. et al. Glucose-6-phosphate dehydrogenase and NADPH oxidase 4 control STAT3 activity in melanoma cells through a pathway involving reactive oxygen species, c-SRC and SHP2. Am J Cancer Res 5, 1610-1620 (2015).
    • (2015) Am J Cancer Res , vol.5 , pp. 1610-1620
    • Cai, T.1
  • 26
    • 84906070874 scopus 로고    scopus 로고
    • Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells
    • Furcht, C. M. et al. Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells. J Cell Sci 127, 3555-3567, doi: 10.1242/jcs.150862 (2014).
    • (2014) J Cell Sci , vol.127 , pp. 3555-3567
    • Furcht, C.M.1
  • 27
    • 84874651128 scopus 로고    scopus 로고
    • Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1
    • Gupta, S. C., Phromnoi, K. & Aggarwal, B. B. Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1. Biochem Pharmacol 85, 898-912, doi: 10.1016/j.bcp.2012.12.018 (2013).
    • (2013) Biochem Pharmacol , vol.85 , pp. 898-912
    • Gupta, S.C.1    Phromnoi, K.2    Aggarwal, B.B.3
  • 28
    • 84885336839 scopus 로고    scopus 로고
    • Adiponectin inhibits leptin-induced oncogenic signalling in oesophageal cancer cells by activation of PTP1B
    • Beales, I. L., Garcia-Morales, C., Ogunwobi, O. O. & Mutungi, G. Adiponectin inhibits leptin-induced oncogenic signalling in oesophageal cancer cells by activation of PTP1B. Mol Cell Endocrinol 382, 150-158, doi: 10.1016/j.mce.2013.08.013 (2014).
    • (2014) Mol Cell Endocrinol , vol.382 , pp. 150-158
    • Beales, I.L.1    Garcia-Morales, C.2    Ogunwobi, O.O.3    Mutungi, G.4
  • 29
    • 84890547028 scopus 로고    scopus 로고
    • PIAS3 activates the intrinsic apoptotic pathway in non-small cell lung cancer cells independent of p53 status
    • Dabir, S. et al. PIAS3 activates the intrinsic apoptotic pathway in non-small cell lung cancer cells independent of p53 status. Int J Cancer 134, 1045-1054, doi: 10.1002/ijc.28448 (2014).
    • (2014) Int J Cancer , vol.134 , pp. 1045-1054
    • Dabir, S.1
  • 30
    • 70249146174 scopus 로고    scopus 로고
    • SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway
    • Diao, Y., Wang, X. & Wu, Z. SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway. Mol Cell Biol 29, 5084-5093, doi: 10.1128/MCB.00267-09 (2009).
    • (2009) Mol Cell Biol , vol.29 , pp. 5084-5093
    • Diao, Y.1    Wang, X.2    Wu, Z.3
  • 31
    • 84925642316 scopus 로고    scopus 로고
    • Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel
    • Lee, J. H., Kim, C., Sethi, G. & Ahn, K. S. Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel. Oncotarget 6, 6386-6405 (2015).
    • (2015) Oncotarget , vol.6 , pp. 6386-6405
    • Lee, J.H.1    Kim, C.2    Sethi, G.3    Ahn, K.S.4
  • 32
    • 84905656745 scopus 로고    scopus 로고
    • SOCS proteins in macrophage polarization and function
    • Wilson, H. M. SOCS Proteins in Macrophage Polarization and Function. Front Immunol 5, 357, doi: 10.3389/fimmu.2014.00357 (2014).
    • (2014) Front Immunol , vol.5 , pp. 357
    • Wilson, H.M.1
  • 33
    • 84918768981 scopus 로고    scopus 로고
    • Platelet factor 4 inhibits IL-17/Stat3 pathway via upregulation of SOCS3 expression in melanoma
    • Fang, S. et al. Platelet factor 4 inhibits IL-17/Stat3 pathway via upregulation of SOCS3 expression in melanoma. Inflammation 37, 1744-1750, doi: 10.1007/s10753-014-9903-4 (2014).
    • (2014) Inflammation , vol.37 , pp. 1744-1750
    • Fang, S.1
  • 34
    • 84859992161 scopus 로고    scopus 로고
    • The JAK-STAT pathway at twenty
    • Stark, G. R. & Darnell, J. E. Jr. The JAK-STAT pathway at twenty. Immunity 36, 503-514, doi: 10.1016/j.immuni.2012.03.013 (2012).
    • (2012) Immunity , vol.36 , pp. 503-514
    • Stark, G.R.1    Darnell, J.E.2
  • 35
    • 67349214601 scopus 로고    scopus 로고
    • MTOR mediates human trophoblast invasion through regulation of matrix-remodeling enzymes and is associated with serine phosphorylation of STAT3
    • Busch, S., Renaud, S. J., Schleussner, E., Graham, C. H. & Markert, U. R. mTOR mediates human trophoblast invasion through regulation of matrix-remodeling enzymes and is associated with serine phosphorylation of STAT3. Exp Cell Res 315, 1724-1733, doi: 10.1016/j.yexcr.2009.01.026 (2009).
    • (2009) Exp Cell Res , vol.315 , pp. 1724-1733
    • Busch, S.1    Renaud, S.J.2    Schleussner, E.3    Graham, C.H.4    Markert, U.R.5
  • 36
    • 34247600538 scopus 로고    scopus 로고
    • STAT3 as a central mediator of neoplastic cellular transformation
    • Frank, D. A. STAT3 as a central mediator of neoplastic cellular transformation. Cancer Lett 251, 199-210, doi: 10.1016/j. canlet.2006.10.017 (2007).
    • (2007) Cancer Lett , vol.251 , pp. 199-210
    • Frank, D.A.1
  • 37
    • 20144376594 scopus 로고    scopus 로고
    • STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation
    • Kojima, H. et al. STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation. Proc Natl Acad Sci USA 102, 4524-4529, doi: 10.1073/pnas.0500679102 (2005).
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 4524-4529
    • Kojima, H.1
  • 38
    • 0034658024 scopus 로고    scopus 로고
    • Serine phosphorylation of STATs
    • Decker, T. & Kovarik, P. Serine phosphorylation of STATs. Oncogene 19, 2628-2637, doi: 10.1038/sj.onc.1203481 (2000).
    • (2000) Oncogene , vol.19 , pp. 2628-2637
    • Decker, T.1    Kovarik, P.2
  • 39
    • 0033588229 scopus 로고    scopus 로고
    • Protein Kinase C Associates with and Phosphorylates Stat3 in an Interleukin-6-dependent Manner
    • Jain, N., Zhang, T., Kee, W. H., Li, W. & Cao, X. Protein Kinase C Associates with and Phosphorylates Stat3 in an Interleukin-6-dependent Manner. Journal of Biological Chemistry 274, 24392-24400, doi: 10.1074/jbc.274.34.24392 (1999).
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 24392-24400
    • Jain, N.1    Zhang, T.2    Kee, W.H.3    Li, W.4    Cao, X.5
  • 40
    • 63249092765 scopus 로고    scopus 로고
    • Persistently activated stat3 maintains constitutive NF-κ B activity in tumors
    • Lee, H. et al. Persistently Activated Stat3 Maintains Constitutive NF-κ B Activity in Tumors. Cancer Cell 15, 283-293, doi: 10.1016/j.ccr.2009.02.015 (2009).
    • (2009) Cancer Cell , vol.15 , pp. 283-293
    • Lee, H.1
  • 41
    • 84874893354 scopus 로고    scopus 로고
    • NF-kappaB and STAT3 signaling pathways collaboratively link inflammation to cancer
    • Fan, Y., Mao, R. & Yang, J. NF-kappaB and STAT3 signaling pathways collaboratively link inflammation to cancer. Protein Cell 4, 176-185, doi: 10.1007/s13238-013-2084-3 (2013).
    • (2013) Protein Cell , vol.4 , pp. 176-185
    • Fan, Y.1    Mao, R.2    Yang, J.3
  • 42
    • 84929366176 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate: Driver of NFkappaB and STAT3 persistent activation in chronic intestinal inflammation and colitis-associated cancer
    • Theiss, A. L. Sphingosine-1-phosphate: Driver of NFkappaB and STAT3 persistent activation in chronic intestinal inflammation and colitis-associated cancer. JAKSTAT 2, e24150, doi: 10.4161/jkst.24150 (2013).
    • (2013) JAKSTAT , vol.2
    • Theiss, A.L.1
  • 43
    • 78650859531 scopus 로고    scopus 로고
    • NF-? B and STAT3-key players in liver inflammation and cancer
    • He, G. & Karin, M. NF-? B and STAT3-key players in liver inflammation and cancer. Cell Res 21, 159-168, doi: 10.1038/ cr.2010.183 (2010).
    • (2010) Cell Res , vol.21 , pp. 159-168
    • He, G.1    Karin, M.2
  • 44
    • 84882853540 scopus 로고    scopus 로고
    • JAB1 regulates unphosphorylated STAT3 DNA-binding activity through protein-protein interaction in human colon cancer cells
    • Nishimoto, A. et al. JAB1 regulates unphosphorylated STAT3 DNA-binding activity through protein-protein interaction in human colon cancer cells. Biochem Biophys Res Commun 438, 513-518, doi: 10.1016/j.bbrc.2013.07.105 (2013).
    • (2013) Biochem Biophys Res Commun , vol.438 , pp. 513-518
    • Nishimoto, A.1
  • 45
    • 13444309088 scopus 로고    scopus 로고
    • Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation
    • Yang, J. et al. Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation. Cancer Res 65, 939-947 (2005).
    • (2005) Cancer Res , vol.65 , pp. 939-947
    • Yang, J.1
  • 46
    • 84860014863 scopus 로고    scopus 로고
    • Mechanisms of unphosphorylated STAT3 transcription factor binding to DNA
    • Timofeeva, O. A. et al. Mechanisms of unphosphorylated STAT3 transcription factor binding to DNA. J Biol Chem 287, 14192-14200, doi: 10.1074/jbc.M111.323899 (2012).
    • (2012) J Biol Chem , vol.287 , pp. 14192-14200
    • Timofeeva, O.A.1
  • 47
    • 43149084600 scopus 로고    scopus 로고
    • Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability
    • Shi, S. et al. Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability. Nat Cell Biol 10, 489-496, doi: 10.1038/ncb1713 (2008).
    • (2008) Nat Cell Biol , vol.10 , pp. 489-496
    • Shi, S.1
  • 48
    • 33748308794 scopus 로고    scopus 로고
    • JAK signaling globally counteracts heterochromatic gene silencing
    • Shi, S. et al. JAK signaling globally counteracts heterochromatic gene silencing. Nat Genet 38, 1071-1076, doi: 10.1038/ng1860 (2006).
    • (2006) Nat Genet , vol.38 , pp. 1071-1076
    • Shi, S.1
  • 49
    • 12244251445 scopus 로고    scopus 로고
    • Stat3 dimerization regulated by reversible acetylation of a single lysine residue
    • Yuan, Z. L., Guan, Y. J., Chatterjee, D. & Chin, Y. E. Stat3 dimerization regulated by reversible acetylation of a single lysine residue. Science 307, 269-273, doi: 10.1126/science.1105166 (2005).
    • (2005) Science , vol.307 , pp. 269-273
    • Yuan, Z.L.1    Guan, Y.J.2    Chatterjee, D.3    Chin, Y.E.4
  • 50
    • 15744385061 scopus 로고    scopus 로고
    • Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation
    • Wang, R., Cherukuri, P. & Luo, J. Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation. J Biol Chem 280, 11528-11534, doi: 10.1074/jbc.M413930200 (2005).
    • (2005) J Biol Chem , vol.280 , pp. 11528-11534
    • Wang, R.1    Cherukuri, P.2    Luo, J.3
  • 51
    • 35349017886 scopus 로고    scopus 로고
    • LIF-and IL-6-induced acetylation of STAT3 at Lys-685 through PI3K/Akt activation
    • Ohbayashi, N. et al. LIF-and IL-6-induced acetylation of STAT3 at Lys-685 through PI3K/Akt activation. Biol Pharm Bull 30, 1860-1864 (2007).
    • (2007) Biol Pharm Bull , vol.30 , pp. 1860-1864
    • Ohbayashi, N.1
  • 52
    • 84938915819 scopus 로고    scopus 로고
    • YKL-40 regulated epithelial-mesenchymal transition and migration/invasion enhancement in non-small cell lung cancer
    • Jefri, M., Huang, Y. N., Huang, W. C., Tai, C. S. & Chen, W. L. YKL-40 regulated epithelial-mesenchymal transition and migration/invasion enhancement in non-small cell lung cancer. BMC Cancer 15, 590, doi: 10.1186/s12885-015-1592-3 (2015).
    • (2015) BMC Cancer , vol.15 , pp. 590
    • Jefri, M.1    Huang, Y.N.2    Huang, W.C.3    Tai, C.S.4    Chen, W.L.5
  • 53
    • 84936995048 scopus 로고    scopus 로고
    • Snail promotes epithelial-mesenchymal transition and invasiveness in human ovarian cancer cells
    • Wang, Y. L. et al. Snail promotes epithelial-mesenchymal transition and invasiveness in human ovarian cancer cells. Int J Clin Exp Med 8, 7388-7393 (2015).
    • (2015) Int J Clin Exp Med , vol.8 , pp. 7388-7393
    • Wang, Y.L.1
  • 54
    • 84940532833 scopus 로고    scopus 로고
    • Highmobility group box 1 has a prognostic role and contributes to epithelial mesenchymal transition in human hepatocellular carcinoma
    • Liu, Z. et al. Highmobility group box 1 has a prognostic role and contributes to epithelial mesenchymal transition in human hepatocellular carcinoma. Mol Med Rep, doi: 10.3892/mmr.2015.4182 (2015).
    • (2015) Mol Med Rep
    • Liu, Z.1
  • 55
    • 84940958476 scopus 로고    scopus 로고
    • Adipocytes can induce epithelial-mesenchymal transition in breast cancer cells
    • Lee, Y., Jung, W. H. & Koo, J. S. Adipocytes can induce epithelial-mesenchymal transition in breast cancer cells. Breast Cancer Res Treat, doi: 10.1007/s10549-015-3550-9 (2015).
    • (2015) Breast Cancer Res Treat
    • Lee, Y.1    Jung, W.H.2    Koo, J.S.3
  • 56
    • 84986913574 scopus 로고    scopus 로고
    • S100A4 hypomethylation affects epithelial-mesenchymal transition partially induced by LMP2A in nasopharyngeal carcinoma
    • Lin, Z. et al. S100A4 hypomethylation affects epithelial-mesenchymal transition partially induced by LMP2A in nasopharyngeal carcinoma. Mol Carcinog, doi: 10.1002/mc.22389 (2015).
    • (2015) Mol Carcinog
    • Lin, Z.1
  • 57
    • 84924853087 scopus 로고    scopus 로고
    • STAT3 cooperates with Twist to mediate epithelial-mesenchymal transition in human hepatocellular carcinoma cells
    • Zhang, C., Guo, F., Xu, G., Ma, J. & Shao, F. STAT3 cooperates with Twist to mediate epithelial-mesenchymal transition in human hepatocellular carcinoma cells. Oncol Rep 33, 1872-1882, doi: 10.3892/or.2015.3783 (2015).
    • (2015) Oncol Rep , vol.33 , pp. 1872-1882
    • Zhang, C.1    Guo, F.2    Xu, G.3    Ma, J.4    Shao, F.5
  • 58
    • 84909997554 scopus 로고    scopus 로고
    • N-myc downstream-regulated gene 2 (NDRG2) suppresses the epithelialmesenchymal transition (EMT) in breast cancer cells via STAT3/Snail signaling
    • Kim, M. J., Lim, J., Yang, Y., Lee, M. S. & Lim, J. S. N-myc downstream-regulated gene 2 (NDRG2) suppresses the epithelialmesenchymal transition (EMT) in breast cancer cells via STAT3/Snail signaling. Cancer Lett 354, 33-42, doi: 10.1016/j. canlet.2014.06.023 (2014).
    • (2014) Cancer Lett , vol.354 , pp. 33-42
    • Kim, M.J.1    Lim, J.2    Yang, Y.3    Lee, M.S.4    Lim, J.S.5
  • 59
    • 82155182020 scopus 로고    scopus 로고
    • Stat3 mediates expression of autotaxin in breast cancer
    • Azare, J. et al. Stat3 mediates expression of autotaxin in breast cancer. PLoS One 6, e27851, doi: 10.1371/journal.pone.0027851 (2011).
    • (2011) PLoS One , vol.6
    • Azare, J.1
  • 60
    • 84920640485 scopus 로고    scopus 로고
    • Twist1 is a Key Regulator of Cancer-Associated Fibroblasts
    • Lee, K., Yeo, S., Sung, C. O. & Kim, S. Twist1 Is a Key Regulator of Cancer-Associated Fibroblasts. Cancer Res, doi: 10.1158/0008-5472.CAN-14-0350 (2014).
    • (2014) Cancer Res
    • Lee, K.1    Yeo, S.2    Sung, C.O.3    Kim, S.4
  • 61
    • 84925456959 scopus 로고    scopus 로고
    • Cancer-mediated adipose reversion promotes cancer cell migration via IL-6 and MCP-1
    • Fujisaki, K. et al. Cancer-mediated adipose reversion promotes cancer cell migration via IL-6 and MCP-1. Breast Cancer Res Treat 150, 255-263, doi: 10.1007/s10549-015-3318-2 (2015).
    • (2015) Breast Cancer Res Treat , vol.150 , pp. 255-263
    • Fujisaki, K.1
  • 62
    • 84897533875 scopus 로고    scopus 로고
    • A novel strategy for inducing the antitumor effects of triterpenoid compounds: Blocking the protumoral functions of tumor-associated macrophages via STAT3 inhibition
    • Fujiwara, Y., Takeya, M. & Komohara, Y. A novel strategy for inducing the antitumor effects of triterpenoid compounds: blocking the protumoral functions of tumor-associated macrophages via STAT3 inhibition. Biomed Res Int 2014, 348539, doi: 10.1155/2014/348539 (2014).
    • (2014) Biomed Res Int , vol.2014 , pp. 348539
    • Fujiwara, Y.1    Takeya, M.2    Komohara, Y.3
  • 63
    • 28644445445 scopus 로고    scopus 로고
    • Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
    • Kortylewski, M. et al. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med 11, 1314-1321, doi: 10.1038/nm1325 (2005).
    • (2005) Nat Med , vol.11 , pp. 1314-1321
    • Kortylewski, M.1
  • 64
    • 80053224991 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 (Stat3C) promotes myeloid-derived suppressor cell expansion and immune suppression during lung tumorigenesis
    • Wu, L., Du, H., Li, Y., Qu, P. & Yan, C. Signal transducer and activator of transcription 3 (Stat3C) promotes myeloid-derived suppressor cell expansion and immune suppression during lung tumorigenesis. Am J Pathol 179, 2131-2141, doi: 10.1016/j. ajpath.2011.06.028 (2011).
    • (2011) Am J Pathol , vol.179 , pp. 2131-2141
    • Wu, L.1    Du, H.2    Li, Y.3    Qu, P.4    Yan, C.5
  • 65
    • 84921395983 scopus 로고    scopus 로고
    • Exosomal Hsp70 mediates immunosuppressive activity of the myeloid-derived suppressor cells via phosphorylation of Stat3
    • Diao, J. et al. Exosomal Hsp70 mediates immunosuppressive activity of the myeloid-derived suppressor cells via phosphorylation of Stat3. Med Oncol 32, 453, doi: 10.1007/s12032-014-0453-2 (2015).
    • (2015) Med Oncol , vol.32 , pp. 453
    • Diao, J.1
  • 66
    • 84890500784 scopus 로고    scopus 로고
    • Targeting blockage of STAT3 in hepatocellular carcinoma cells augments NK cell functions via reverse hepatocellular carcinoma-induced immune suppression
    • Sun, X., Sui, Q., Zhang, C., Tian, Z. & Zhang, J. Targeting blockage of STAT3 in hepatocellular carcinoma cells augments NK cell functions via reverse hepatocellular carcinoma-induced immune suppression. Mol Cancer Ther 12, 2885-2896, doi: 10.1158/1535-7163.MCT-12-1087 (2013).
    • (2013) Mol Cancer Ther , vol.12 , pp. 2885-2896
    • Sun, X.1    Sui, Q.2    Zhang, C.3    Tian, Z.4    Zhang, J.5
  • 67
    • 84939152514 scopus 로고    scopus 로고
    • Characterization of STAT3 expression, signaling and inhibition in feline oral squamous cell carcinoma
    • Brown, M. E. et al. Characterization of STAT3 expression, signaling and inhibition in feline oral squamous cell carcinoma. BMC Vet Res 11, 206, doi: 10.1186/s12917-015-0505-7 (2015).
    • (2015) BMC Vet Res , vol.11 , pp. 206
    • Brown, M.E.1
  • 68
    • 84952874601 scopus 로고    scopus 로고
    • Cardamonin induces apoptosis by suppressing STAT3 signaling pathway in glioblastoma stem cells
    • Wu, N. et al. Cardamonin induces apoptosis by suppressing STAT3 signaling pathway in glioblastoma stem cells. Tumour Biol, doi: 10.1007/s13277-015-3673-y (2015).
    • (2015) Tumour Biol
    • Wu, N.1
  • 69
    • 84928251816 scopus 로고    scopus 로고
    • Expression of signal transducer and activator of transcription 3 and its phosphorylated form is significantly upregulated in patients with papillary thyroid cancer
    • Yan, L. I. et al. Expression of signal transducer and activator of transcription 3 and its phosphorylated form is significantly upregulated in patients with papillary thyroid cancer. Exp Ther Med 9, 2195-2201, doi: 10.3892/etm.2015.2409 (2015).
    • (2015) Exp Ther Med , vol.9 , pp. 2195-2201
    • Yan, L.I.1
  • 70
    • 84884812874 scopus 로고    scopus 로고
    • Antiangiogenic effects of ganetespib in colorectal cancer mediated through inhibition of HIF-1alpha and STAT-3
    • Nagaraju, G. P. et al. Antiangiogenic effects of ganetespib in colorectal cancer mediated through inhibition of HIF-1alpha and STAT-3. Angiogenesis 16, 903-917, doi: 10.1007/s10456-013-9364-7 (2013).
    • (2013) Angiogenesis , vol.16 , pp. 903-917
    • Nagaraju, G.P.1
  • 71
    • 84936118178 scopus 로고    scopus 로고
    • LIF signaling in stem cells and development
    • Onishi, K. & Zandstra, P. W. LIF signaling in stem cells and development. Development 142, 2230-2236, doi: 10.1242/dev.117598 (2015).
    • (2015) Development , vol.142 , pp. 2230-2236
    • Onishi, K.1    Zandstra, P.W.2
  • 72
    • 84921521224 scopus 로고    scopus 로고
    • The differential activation of intracellular signaling pathways confers the permissiveness of embryonic stem cell derivation from different mouse strains
    • Ohtsuka, S. & Niwa, H. The differential activation of intracellular signaling pathways confers the permissiveness of embryonic stem cell derivation from different mouse strains. Development 142, 431-437, doi: 10.1242/dev.112375 (2015).
    • (2015) Development , vol.142 , pp. 431-437
    • Ohtsuka, S.1    Niwa, H.2
  • 73
    • 84929359290 scopus 로고    scopus 로고
    • Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency
    • Chen, H. et al. Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency. Nat Commun 6, 7095, doi: 10.1038/ncomms8095 (2015).
    • (2015) Nat Commun , vol.6 , pp. 7095
    • Chen, H.1
  • 74
    • 84901014050 scopus 로고    scopus 로고
    • Targeted Disruption of the JAK2/STAT3 Pathway in Combination with Systemic Administration of Paclitaxel Inhibits the Priming of Ovarian Cancer Stem Cells Leading to a Reduced Tumor Burden
    • Abubaker, K. et al. Targeted Disruption of the JAK2/STAT3 Pathway in Combination with Systemic Administration of Paclitaxel Inhibits the Priming of Ovarian Cancer Stem Cells Leading to a Reduced Tumor Burden. Front Oncol 4, doi: 10.3389/ fonc.2014.00075 (2014).
    • (2014) Front Oncol , vol.4
    • Abubaker, K.1
  • 75
    • 84939826013 scopus 로고    scopus 로고
    • Comparative study of the effects of PEGylated interferonalpha2a versus 5-fluorouracil on cancer stem cells in a rat model of hepatocellular carcinoma
    • Motawi, T. K., El-Boghdady, N. A., El-Sayed, A. M. & Helmy, H. S. Comparative study of the effects of PEGylated interferonalpha2a versus 5-fluorouracil on cancer stem cells in a rat model of hepatocellular carcinoma. Tumour Biol, doi: 10.1007/ s13277-015-3920-2 (2015).
    • (2015) Tumour Biol
    • Motawi, T.K.1    El-Boghdady, N.A.2    El-Sayed, A.M.3    Helmy, H.S.4
  • 76
    • 84929353226 scopus 로고    scopus 로고
    • Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer
    • Thakur, R., Trivedi, R., Rastogi, N., Singh, M. & Mishra, D. P. Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer. Sci Rep 5, 10194, doi: 10.1038/srep10194 (2015).
    • (2015) Sci Rep , vol.5 , pp. 10194
    • Thakur, R.1    Trivedi, R.2    Rastogi, N.3    Singh, M.4    Mishra, D.P.5
  • 77
    • 84923078160 scopus 로고    scopus 로고
    • The effectiveness of an anti-human IL-6 receptor monoclonal antibody combined with chemotherapy to target colon cancer stem-like cells
    • Ying, J. et al. The effectiveness of an anti-human IL-6 receptor monoclonal antibody combined with chemotherapy to target colon cancer stem-like cells. Int J Oncol 46, 1551-1559, doi: 10.3892/ijo.2015.2851 (2015).
    • (2015) Int J Oncol , vol.46 , pp. 1551-1559
    • Ying, J.1
  • 78
    • 84873695296 scopus 로고    scopus 로고
    • PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line
    • Song, J. PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line. Int J Oncol, doi: 10.3892/ijo.2013.1765 (2013).
    • (2013) Int J Oncol
    • Song, J.1
  • 79
    • 84911004173 scopus 로고    scopus 로고
    • IL-6 enriched lung cancer stem-like cell population by inhibition of cell cycle regulatorsviaDNMT1 upregulation
    • Liu, C.-C. et al. IL-6 enriched lung cancer stem-like cell population by inhibition of cell cycle regulatorsviaDNMT1 upregulation. International Journal of Cancer, n/a-n/a, doi: 10.1002/ijc.29033 (2014).
    • (2014) International Journal of Cancer, N/a-n/a
    • Liu, C.-C.1
  • 80
    • 84894284619 scopus 로고    scopus 로고
    • Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling
    • Schroeder, A. et al. Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling. Cancer Res 74, 1227-1237, doi: 10.1158/0008-5472.CAN-13-0594 (2014).
    • (2014) Cancer Res , vol.74 , pp. 1227-1237
    • Schroeder, A.1
  • 81
    • 84983095158 scopus 로고    scopus 로고
    • Bcl3 bridges LIF-STAT3 to Oct4 signaling in the maintenance of naive pluripotency
    • Chen, C. Y. et al. Bcl3 Bridges LIF-STAT3 to Oct4 Signaling in the Maintenance of Naive Pluripotency. Stem Cells, doi: 10.1002/ stem.2201 (2015).
    • (2015) Stem Cells
    • Chen, C.Y.1
  • 82
    • 84881383785 scopus 로고    scopus 로고
    • Tanshinone IIA inhibits breast cancer stem cells growth in vitro and in vivo through attenuation of IL-6/STAT3/ NF-kB signaling pathways
    • Lin, C. et al. Tanshinone IIA inhibits breast cancer stem cells growth in vitro and in vivo through attenuation of IL-6/STAT3/ NF-kB signaling pathways. J Cell Biochem 114, 2061-2070, doi: 10.1002/jcb.24553 (2013).
    • (2013) J Cell Biochem , vol.114 , pp. 2061-2070
    • Lin, C.1
  • 83
    • 80053531658 scopus 로고    scopus 로고
    • Regulation of cancer stem cells by cytokine networks: Attacking cancer's inflammatory roots
    • Korkaya, H., Liu, S. & Wicha, M. S. Regulation of Cancer Stem Cells by Cytokine Networks: Attacking Cancer's Inflammatory Roots. Clinical Cancer Research 17, 6125-6129, doi: 10.1158/1078-0432.ccr-10-2743 (2011).
    • (2011) Clinical Cancer Research , vol.17 , pp. 6125-6129
    • Korkaya, H.1    Liu, S.2    Wicha, M.S.3
  • 84
    • 84883682803 scopus 로고    scopus 로고
    • Constitutive Activation of Signal Transducer and Activator of Transcription 3 (STAT3) and Nuclear Factor B Signaling in Glioblastoma Cancer Stem Cells Regulates the Notch Pathway
    • Garner, J. M. et al. Constitutive Activation of Signal Transducer and Activator of Transcription 3 (STAT3) and Nuclear Factor B Signaling in Glioblastoma Cancer Stem Cells Regulates the Notch Pathway. Journal of Biological Chemistry 288, 26167-26176, doi: 10.1074/jbc.M113.477950 (2013).
    • (2013) Journal of Biological Chemistry , vol.288 , pp. 26167-26176
    • Garner, J.M.1
  • 85
    • 84890540571 scopus 로고    scopus 로고
    • The noninflammatory role of high mobility group box 1/Toll-like receptor 2 axis in the self-renewal of mammary cancer stem cells
    • Conti, L. et al. The noninflammatory role of high mobility group box 1/Toll-like receptor 2 axis in the self-renewal of mammary cancer stem cells. FASEB J 27, 4731-4744, doi: 10.1096/fj.13-230201 (2013).
    • (2013) FASEB J , vol.27 , pp. 4731-4744
    • Conti, L.1
  • 86
    • 84919499625 scopus 로고    scopus 로고
    • MiR-1181 inhibits stem cell-like phenotypes and suppresses SOX2 and STAT3 in human pancreatic cancer
    • Jiang, J. et al. MiR-1181 inhibits stem cell-like phenotypes and suppresses SOX2 and STAT3 in human pancreatic cancer. Cancer Lett 356, 962-970, doi: 10.1016/j.canlet.2014.11.007 (2015).
    • (2015) Cancer Lett , vol.356 , pp. 962-970
    • Jiang, J.1
  • 87
    • 84895756231 scopus 로고    scopus 로고
    • RhoC regulates cancer stem cells in head and neck squamous cell carcinoma by overexpressing IL-6 and phosphorylation of STAT3
    • Hoque, M. O., Islam, M., Sharma, S. & Teknos, T. N. RhoC Regulates Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma by Overexpressing IL-6 and Phosphorylation of STAT3. PLoS One 9, e88527, doi: 10.1371/journal.pone.0088527 (2014).
    • (2014) PLoS One , vol.9
    • Hoque, M.O.1    Islam, M.2    Sharma, S.3    Teknos, T.N.4
  • 88
    • 84874291853 scopus 로고    scopus 로고
    • Tumor-associated macrophages regulate murine breast cancer stem cells through a novel paracrine EGFR/ Stat3/Sox-2 signaling pathway
    • Yang, J. et al. Tumor-Associated Macrophages Regulate Murine Breast Cancer Stem Cells Through a Novel Paracrine EGFR/ Stat3/Sox-2 Signaling Pathway. Stem Cells 31, 248-258, doi: 10.1002/stem.1281 (2013).
    • (2013) Stem Cells , vol.31 , pp. 248-258
    • Yang, J.1
  • 89
    • 80555127351 scopus 로고    scopus 로고
    • A humanized anti-IL-6 antibody (ALD518) in non-small cell lung cancer
    • Bayliss, T. J., Smith, J. T., Schuster, M., Dragnev, K. H. & Rigas, J. R. A humanized anti-IL-6 antibody (ALD518) in non-small cell lung cancer. Expert Opin Biol Ther 11, 1663-1668, doi: 10.1517/14712598.2011.627850 (2011).
    • (2011) Expert Opin Biol Ther , vol.11 , pp. 1663-1668
    • Bayliss, T.J.1    Smith, J.T.2    Schuster, M.3    Dragnev, K.H.4    Rigas, J.R.5
  • 90
    • 84926304367 scopus 로고    scopus 로고
    • Inhibitor of signal transducer and activator of transcription 3 (STAT3) suppresses ovarian cancer growth, migration and invasion and enhances the effect of cisplatin in vitro
    • Tang, Y. J. et al. Inhibitor of signal transducer and activator of transcription 3 (STAT3) suppresses ovarian cancer growth, migration and invasion and enhances the effect of cisplatin in vitro. Genet Mol Res 14, 2450-2460, doi: 10.4238/2015.March.30.3 (2015).
    • (2015) Genet Mol Res , vol.14 , pp. 2450-2460
    • Tang, Y.J.1
  • 91
    • 84922440337 scopus 로고    scopus 로고
    • A novel small molecular STAT3 inhibitor, LY5, inhibits cell viability, cell migration, and angiogenesis in medulloblastoma cells
    • Xiao, H. et al. A novel small molecular STAT3 inhibitor, LY5, inhibits cell viability, cell migration, and angiogenesis in medulloblastoma cells. J Biol Chem 290, 3418-3429, doi: 10.1074/jbc.M114.616748 (2015).
    • (2015) J Biol Chem , vol.290 , pp. 3418-3429
    • Xiao, H.1
  • 92
    • 84929514550 scopus 로고    scopus 로고
    • Hitting the right spot: Mechanism of action of OPB-31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3)
    • Brambilla, L. et al. Hitting the right spot: Mechanism of action of OPB-31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3). Mol Oncol 9, 1194-1206, doi: 10.1016/j.molonc.2015.02.012 (2015).
    • (2015) Mol Oncol , vol.9 , pp. 1194-1206
    • Brambilla, L.1
  • 93
    • 84888424589 scopus 로고    scopus 로고
    • A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases
    • Hayakawa, F. et al. A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases. Blood Cancer J 3, e166, doi: 10.1038/bcj.2013.63 (2013).
    • (2013) Blood Cancer J , vol.3 , pp. e166
    • Hayakawa, F.1
  • 94
    • 84878432714 scopus 로고    scopus 로고
    • OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells
    • Kim, M. J. et al. OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells. Cancer Lett 335, 145-152, doi: 10.1016/j.canlet.2013.02.010 (2013).
    • (2013) Cancer Lett , vol.335 , pp. 145-152
    • Kim, M.J.1
  • 95
    • 84924934348 scopus 로고    scopus 로고
    • Silibinin inhibits proliferation, induces apoptosis and causes cell cycle arrest in human gastric cancer MGC803 cells via STAT3 pathway inhibition
    • Wang, Y. X., Cai, H., Jiang, G., Zhou, T. B. & Wu, H. Silibinin inhibits proliferation, induces apoptosis and causes cell cycle arrest in human gastric cancer MGC803 cells via STAT3 pathway inhibition. Asian Pac J Cancer Prev 15, 6791-6798 (2014).
    • (2014) Asian Pac J Cancer Prev , vol.15 , pp. 6791-6798
    • Wang, Y.X.1    Cai, H.2    Jiang, G.3    Zhou, T.B.4    Wu, H.5
  • 96
    • 84907291514 scopus 로고    scopus 로고
    • Induction of fibronectin in response to epidermal growth factor is suppressed by silibinin through the inhibition of STAT3 in triple negative breast cancer cells
    • Kim, S. et al. Induction of fibronectin in response to epidermal growth factor is suppressed by silibinin through the inhibition of STAT3 in triple negative breast cancer cells. Oncol Rep 32, 2230-2236, doi: 10.3892/or.2014.3450 (2014).
    • (2014) Oncol Rep , vol.32 , pp. 2230-2236
    • Kim, S.1
  • 97
    • 34547829030 scopus 로고    scopus 로고
    • Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells
    • Agarwal, C., Tyagi, A., Kaur, M. & Agarwal, R. Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells. Carcinogenesis 28, 1463-1470, doi: 10.1093/carcin/bgm042 (2007).
    • (2007) Carcinogenesis , vol.28 , pp. 1463-1470
    • Agarwal, C.1    Tyagi, A.2    Kaur, M.3    Agarwal, R.4
  • 98
    • 84937228085 scopus 로고    scopus 로고
    • Silibinin and STAT3: A natural way of targeting transcription factors for cancer therapy
    • Bosch-Barrera, J. & Menendez, J. A. Silibinin and STAT3: A natural way of targeting transcription factors for cancer therapy. Cancer Treat Rev 41, 540-546, doi: 10.1016/j.ctrv.2015.04.008 (2015).
    • (2015) Cancer Treat Rev , vol.41 , pp. 540-546
    • Bosch-Barrera, J.1    Menendez, J.A.2
  • 99
    • 85018193045 scopus 로고    scopus 로고
    • Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinibresistant lung cancer cells
    • Cao, W. et al. Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinibresistant lung cancer cells. Sci Rep 5, 8477, doi: 10.1038/srep08477 (2015).
    • (2015) Sci Rep , vol.5 , pp. 8477
    • Cao, W.1
  • 100
    • 84866254673 scopus 로고    scopus 로고
    • First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: Implications for cancer therapy
    • Sen, M. et al. First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy. Cancer Discov 2, 694-705, doi: 10.1158/2159-8290.CD-12-0191 (2012).
    • (2012) Cancer Discov , vol.2 , pp. 694-705
    • Sen, M.1
  • 101
    • 33644983005 scopus 로고    scopus 로고
    • Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: A potential novel therapy for head and neck cancer
    • Jing, N. et al. Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer. Mol Cancer Ther 5, 279-286, doi: 10.1158/1535-7163.mct-05-0302 (2006).
    • (2006) Mol Cancer Ther , vol.5 , pp. 279-286
    • Jing, N.1
  • 102
    • 34548576919 scopus 로고    scopus 로고
    • Inhibition of Stat3 activation and tumor growth suppression of non-small cell lung cancer by G-quartet oligonucleotides
    • Weerasinghe, P. et al. Inhibition of Stat3 activation and tumor growth suppression of non-small cell lung cancer by G-quartet oligonucleotides. Int J Oncol 31, 129-136 (2007).
    • (2007) Int J Oncol , vol.31 , pp. 129-136
    • Weerasinghe, P.1
  • 103
    • 80054057846 scopus 로고    scopus 로고
    • Combined treatment targeting HIF-1alpha and Stat3 is a potent strategy for prostate cancer therapy
    • Reddy, K. R., Guan, Y., Qin, G., Zhou, Z. & Jing, N. Combined treatment targeting HIF-1alpha and Stat3 is a potent strategy for prostate cancer therapy. Prostate 71, 1796-1809, doi: 10.1002/pros.21397 (2011).
    • (2011) Prostate , vol.71 , pp. 1796-1809
    • Reddy, K.R.1    Guan, Y.2    Qin, G.3    Zhou, Z.4    Jing, N.5
  • 104
    • 84898785162 scopus 로고    scopus 로고
    • Design and in Vitro Evaluation of Layer by Layer siRNA Nanovectors Targeting Breast Tumor Initiating Cells
    • Cheng, J. Q. et al. Design and In Vitro Evaluation of Layer by Layer siRNA Nanovectors Targeting Breast Tumor Initiating Cells. PLoS One 9, e91986, doi: 10.1371/journal.pone.0091986 (2014).
    • (2014) PLoS One , vol.9
    • Cheng, J.Q.1
  • 105
    • 84933497700 scopus 로고    scopus 로고
    • A new strategy in the treatment of chemoresistant lung adenocarcinoma via specific siRNA transfection of SRF, E2F1, Survivin, HIF and STAT3
    • Stoleriu, M. G. et al. A new strategy in the treatment of chemoresistant lung adenocarcinoma via specific siRNA transfection of SRF, E2F1, Survivin, HIF and STAT3. Eur J Cardiothorac Surg 46, 877-886, doi: 10.1093/ejcts/ezu087 (2014).
    • (2014) Eur J Cardiothorac Surg , vol.46 , pp. 877-886
    • Stoleriu, M.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.