메뉴 건너뛰기




Volumn 2016, Issue , 2016, Pages

Cancer stem cell quiescence and plasticity as major challenges in cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ANTIGEN; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2;

EID: 84978765993     PISSN: None     EISSN: 16879678     Source Type: Journal    
DOI: 10.1155/2016/1740936     Document Type: Review
Times cited : (305)

References (166)
  • 1
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • D. Bonnet and J. E. Dick, "Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell, " Nature Medicine, vol. 3, no. 7, pp. 730-737, 1997.
    • (1997) Nature Medicine , vol.3 , Issue.7 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 2
    • 69449096005 scopus 로고    scopus 로고
    • Heterogeneity in cancer: Cancer stem cells versus clonal evolution
    • M. Shackleton, E. Quintana, E. R. Fearon, and S. J. Morrison, "Heterogeneity in cancer: cancer stem cells versus clonal evolution, " Cell, vol. 138, no. 5, pp. 822-829, 2009.
    • (2009) Cell , vol.138 , Issue.5 , pp. 822-829
    • Shackleton, M.1    Quintana, E.2    Fearon, E.R.3    Morrison, S.J.4
  • 3
    • 84924656152 scopus 로고    scopus 로고
    • Cancer stem cell: Fundamental experimental pathological concepts and updates
    • F. Islam, B. Qiao, R. A. Smith, V. Gopalan, and A. K.-Y. Lam, "Cancer stem cell: fundamental experimental pathological concepts and updates, " Experimental and Molecular Pathology, vol. 98, no. 2, pp. 184-191, 2015.
    • (2015) Experimental and Molecular Pathology , vol.98 , Issue.2 , pp. 184-191
    • Islam, F.1    Qiao, B.2    Smith, R.A.3    Gopalan, V.4    Lam, A.K.-Y.5
  • 4
    • 78751676408 scopus 로고    scopus 로고
    • Cells of origin in cancer
    • J. E. Visvader, "Cells of origin in cancer, " Nature, vol. 469, no. 7330, pp. 314-322, 2011.
    • (2011) Nature , vol.469 , Issue.7330 , pp. 314-322
    • Visvader, J.E.1
  • 5
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions
    • J. E. Visvader and G. J. Lindeman, "Cancer stem cells in solid tumours: accumulating evidence and unresolved questions, " Nature Reviews Cancer, vol. 8, no. 10, pp. 755-768, 2008.
    • (2008) Nature Reviews Cancer , vol.8 , Issue.10 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 7
    • 84879983245 scopus 로고    scopus 로고
    • XPoisedchromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity
    • C. L. Chaffer, N. D. Marjanovic, T. Lee, et al., "XPoisedchromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity, " Cell, vol. 154, no. 1, pp. X61-74, 2013.
    • (2013) Cell , vol.154 , Issue.1 , pp. X61-74
    • Chaffer, C.L.1    Marjanovic, N.D.2    Lee, T.3
  • 9
    • 84930761557 scopus 로고    scopus 로고
    • Cancer stem cells-the current status of an old concept: Literature review and clinical approaches
    • article 66
    • L. Fulawka, P. Donizy, and A. Halon, "Cancer stem cells-the current status of an old concept: literature review and clinical approaches, " Biological Research, vol. 47, no. 1, article 66, 2014.
    • (2014) Biological Research , vol.47 , Issue.1
    • Fulawka, L.1    Donizy, P.2    Halon, A.3
  • 11
    • 35848955428 scopus 로고    scopus 로고
    • ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    • C. Ginestier, M. H. Hur, E. Charafe-Jauffret, et al., "ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome, " Cell Stem Cell, vol. 1, no. 5, pp. 555-567, 2007.
    • (2007) Cell Stem Cell , vol.1 , Issue.5 , pp. 555-567
    • Ginestier, C.1    Hur, M.H.2    Charafe-Jauffret, E.3
  • 12
    • 4944250781 scopus 로고    scopus 로고
    • Isolation and characterization of tumorigenic, stem-like neural precursors fromhuman glioblastoma
    • R. Galli, E. Binda, U. Orfanelli, et al., "Isolation and characterization of tumorigenic, stem-like neural precursors fromhuman glioblastoma, " Cancer Research, vol. 64, no. 19, pp. 7011-7021, 2004.
    • (2004) Cancer Research , vol.64 , Issue.19 , pp. 7011-7021
    • Galli, R.1    Binda, E.2    Orfanelli, U.3
  • 14
    • 0141842674 scopus 로고    scopus 로고
    • Identification of a cancer stem cell in human brain tumors
    • S. K. Singh, I. D. Clarke, M. Terasaki, et al., "Identification of a cancer stem cell in human brain tumors, " Cancer Research, vol. 63, no. 18, pp. 5821-5828, 2003.
    • (2003) Cancer Research , vol.63 , Issue.18 , pp. 5821-5828
    • Singh, S.K.1    Clarke, I.D.2    Terasaki, M.3
  • 15
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • S. K. Singh, C. Hawkins, I. D. Clarke, et al., "Identification of human brain tumour initiating cells, " Nature, vol. 432, no. 7015, pp. 396-401, 2004.
    • (2004) Nature , vol.432 , Issue.7015 , pp. 396-401
    • Singh, S.K.1    Hawkins, C.2    Clarke, I.D.3
  • 16
    • 11244293572 scopus 로고    scopus 로고
    • Isolation of cancer stem cells from adult glioblastoma multiforme
    • X. Yuan, J. Curtin, Y. Xiong, et al., "Isolation of cancer stem cells from adult glioblastoma multiforme, " Oncogene, vol. 23, no. 58, pp. 9392-9400, 2004.
    • (2004) Oncogene , vol.23 , Issue.58 , pp. 9392-9400
    • Yuan, X.1    Curtin, J.2    Xiong, Y.3
  • 17
    • 34548455927 scopus 로고    scopus 로고
    • Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    • P. C. Hermann, S. L. Huber, T. Herrler, et al., "Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer, " Cell Stem Cell, vol. 1, no. 3, pp. 313-323, 2007.
    • (2007) Cell Stem Cell , vol.1 , Issue.3 , pp. 313-323
    • Hermann, P.C.1    Huber, S.L.2    Herrler, T.3
  • 18
    • 33847052127 scopus 로고    scopus 로고
    • Identification of pancreatic cancer stem cells
    • C. Li, D. G. Heidt, P. Dalerba, et al., "Identification of pancreatic cancer stem cells, " Cancer Research, vol. 67, no. 3, pp. 1030-1037, 2007.
    • (2007) Cancer Research , vol.67 , Issue.3 , pp. 1030-1037
    • Li, C.1    Heidt, D.G.2    Dalerba, P.3
  • 20
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • C. A. O'Brien, A. Pollett, S. Gallinger, and J. E. Dick, "A human colon cancer cell capable of initiating tumour growth in immunodeficient mice, " Nature, vol. 445, no. 7123, pp. 106-110, 2007.
    • (2007) Nature , vol.445 , Issue.7123 , pp. 106-110
    • O'Brien, C.A.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 21
    • 33846095137 scopus 로고    scopus 로고
    • Identification and expansion of human colon-cancer-initiating cells
    • L. Ricci-Vitiani, D. G. Lombardi, E. Pilozzi, et al., "Identification and expansion of human colon-cancer-initiating cells, " Nature, vol. 445, no. 7123, pp. 111-115, 2007.
    • (2007) Nature , vol.445 , Issue.7123 , pp. 111-115
    • Ricci-Vitiani, L.1    Lombardi, D.G.2    Pilozzi, E.3
  • 23
    • 38549139140 scopus 로고    scopus 로고
    • Significance of CD90+ cancer stem cells in human liver cancer
    • Z. F. Yang, D. W. Ho, M. N. Ng, et al., "Significance of CD90+ cancer stem cells in human liver cancer, " Cancer Cell, vol. 13, no. 2, pp. 153-166, 2008.
    • (2008) Cancer Cell , vol.13 , Issue.2 , pp. 153-166
    • Yang, Z.F.1    Ho, D.W.2    Ng, M.N.3
  • 24
    • 39449088496 scopus 로고    scopus 로고
    • Identification and expansion of the tumorigenic lung cancer stem cell population
    • A. Eramo, F. Lotti, G. Sette, et al., "Identification and expansion of the tumorigenic lung cancer stem cell population, " Cell Death and Differentiation, vol. 15, no. 3, pp. 504-514, 2008.
    • (2008) Cell Death and Differentiation , vol.15 , Issue.3 , pp. 504-514
    • Eramo, A.1    Lotti, F.2    Sette, G.3
  • 25
    • 20444397431 scopus 로고    scopus 로고
    • Identification of bronchioalveolar stem cells in normal lung and lung cancer
    • C. F. Bender Kim, E. L. Jackson, A. E. Woolfenden, et al., "Identification of bronchioalveolar stem cells in normal lung and lung cancer, " Cell, vol. 121, no. 6, pp. 823-835, 2005.
    • (2005) Cell , vol.121 , Issue.6 , pp. 823-835
    • Bender Kim, C.F.1    Jackson, E.L.2    Woolfenden, A.E.3
  • 26
    • 28244472369 scopus 로고    scopus 로고
    • Prospective identification of tumorigenic prostate cancer stem cells
    • A. T. Collins, P. A. Berry, C. Hyde, M. J. Stower, and N. J. Maitland, "Prospective identification of tumorigenic prostate cancer stem cells, " Cancer Research, vol. 65, no. 23, pp. 10946-10951, 2005.
    • (2005) Cancer Research , vol.65 , Issue.23 , pp. 10946-10951
    • Collins, A.T.1    Berry, P.A.2    Hyde, C.3    Stower, M.J.4    Maitland, N.J.5
  • 27
    • 69549114870 scopus 로고    scopus 로고
    • Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells
    • K. S. Chan, I. Espinosa, M. Chao, et al., "Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells, " Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 33, pp. 14016-14021, 2009.
    • (2009) Proceedings of the National Academy of Sciences of the United States of America , vol.106 , Issue.33 , pp. 14016-14021
    • Chan, K.S.1    Espinosa, I.2    Chao, M.3
  • 29
    • 49249091523 scopus 로고    scopus 로고
    • Identification and characterization of ovarian cancer-initiating cells from primary human tumors
    • S. Zhang, C. Balch, M. W. Chan, et al., "Identification and characterization of ovarian cancer-initiating cells from primary human tumors, " Cancer Research, vol. 68, no. 11, pp. 4311-4320, 2008.
    • (2008) Cancer Research , vol.68 , Issue.11 , pp. 4311-4320
    • Zhang, S.1    Balch, C.2    Chan, M.W.3
  • 30
    • 27144557960 scopus 로고    scopus 로고
    • A tumorigenic subpopulation with stem cell properties in melanomas
    • D. Fang, T. K. Nguyen, K. Leishear, et al., "A tumorigenic subpopulation with stem cell properties in melanomas, " Cancer Research, vol. 65, no. 20, pp. 9328-9337, 2005.
    • (2005) Cancer Research , vol.65 , Issue.20 , pp. 9328-9337
    • Fang, D.1    Nguyen, T.K.2    Leishear, K.3
  • 32
    • 38349165576 scopus 로고    scopus 로고
    • Identification of cells initiating human melanomas
    • T. Schatton, G. F. Murphy, N. Y. Frank, et al., "Identification of cells initiating human melanomas, " Nature, vol. 451, no. 7176, pp. 345-349, 2008.
    • (2008) Nature , vol.451 , Issue.7176 , pp. 345-349
    • Schatton, T.1    Murphy, G.F.2    Frank, N.Y.3
  • 33
    • 84879659043 scopus 로고    scopus 로고
    • Sphere-forming cell subsets with cancer stem cell properties in human musculoskeletal sarcomas
    • M. Salerno, S. Avnet, G. Bonuccelli, et al., "Sphere-forming cell subsets with cancer stem cell properties in human musculoskeletal sarcomas, " International Journal of Oncology, vol. 43, no. 1, pp. 95-102, 2013.
    • (2013) International Journal of Oncology , vol.43 , Issue.1 , pp. 95-102
    • Salerno, M.1    Avnet, S.2    Bonuccelli, G.3
  • 34
    • 0028091194 scopus 로고
    • A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
    • T. Lapidot, C. Sirard, J. Vormoor, et al., "A cell initiating human acute myeloid leukaemia after transplantation into SCID mice, " Nature, vol. 367, no. 6464, pp. 645-648, 1994.
    • (1994) Nature , vol.367 , Issue.6464 , pp. 645-648
    • Lapidot, T.1    Sirard, C.2    Vormoor, J.3
  • 35
    • 58249095085 scopus 로고    scopus 로고
    • Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells
    • T. Baba, P. A. Convery, N. Matsumura, et al., "Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells, " Oncogene, vol. 28, no. 2, pp. 209-218, 2009.
    • (2009) Oncogene , vol.28 , Issue.2 , pp. 209-218
    • Baba, T.1    Convery, P.A.2    Matsumura, N.3
  • 36
    • 33847639310 scopus 로고    scopus 로고
    • Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential
    • E. Monzani, F. Facchetti, E. Galmozzi, et al., "Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential, " European Journal of Cancer, vol. 43, no. 5, pp. 935-946, 2007.
    • (2007) European Journal of Cancer , vol.43 , Issue.5 , pp. 935-946
    • Monzani, E.1    Facchetti, F.2    Galmozzi, E.3
  • 37
    • 84858792036 scopus 로고    scopus 로고
    • Flow cytometry in cancer stem cell analysis and separation
    • B. Greve, R. Kelsch, K. Spaniol, H. T. Eich, and M. Gotte, "Flow cytometry in cancer stem cell analysis and separation, " Cytometry Part A, vol. 81, no. 4, pp. 284-293, 2012.
    • (2012) Cytometry Part A , vol.81 , Issue.4 , pp. 284-293
    • Greve, B.1    Kelsch, R.2    Spaniol, K.3    Eich, H.T.4    Gotte, M.5
  • 38
    • 84961942167 scopus 로고    scopus 로고
    • Chemotherapy targeting cancer stem cells
    • H. Liu, L. Lv, and K. Yang, "Chemotherapy targeting cancer stem cells, " American Journal of Cancer Research, vol. 5, no. 3, pp. 880-893, 2015.
    • (2015) American Journal of Cancer Research , vol.5 , Issue.3 , pp. 880-893
    • Liu, H.1    Lv, L.2    Yang, K.3
  • 39
    • 84876489727 scopus 로고    scopus 로고
    • Cancer stem cells: The challenges ahead
    • J. P. Medema, "Cancer stem cells: the challenges ahead, " Nature Cell Biology, vol. 15, no. 4, pp. 338-344, 2013.
    • (2013) Nature Cell Biology , vol.15 , Issue.4 , pp. 338-344
    • Medema, J.P.1
  • 41
    • 84884232859 scopus 로고    scopus 로고
    • Pluripotency transcription factors and cancer stem cells: Small genes make a big difference
    • A. Liu, X. Yu, and S. Liu, "Pluripotency transcription factors and cancer stem cells: small genes make a big difference, " Chinese Journal of Cancer, vol. 32, no. 9, pp. 483-487, 2013.
    • (2013) Chinese Journal of Cancer , vol.32 , Issue.9 , pp. 483-487
    • Liu, A.1    Yu, X.2    Liu, S.3
  • 42
    • 84960858868 scopus 로고    scopus 로고
    • Identification and validation of housekeeping genes for gene expression analysis of cancer stem cells
    • Article IDe0149481
    • S. Lemma, S. Avnet, M. Salerno, T. Chano, N. Baldini, and J. S. Castresana, "Identification and validation of housekeeping genes for gene expression analysis of cancer stem cells, " PLoS ONE, vol. 11, no. 2, Article IDe0149481, 2016.
    • (2016) PLoS ONE , vol.11 , Issue.2
    • Lemma, S.1    Avnet, S.2    Salerno, M.3    Chano, T.4    Baldini, N.5    Castresana, J.S.6
  • 43
    • 84899752025 scopus 로고    scopus 로고
    • Comparative expression study of the endo-G protein coupled receptor (GPCR) repertoire in human glioblastoma cancer stem-like cells, U87-MG cells and non malignant cells of neural origin unveils new potential therapeutic targets
    • Article ID e91519
    • M. Feve, J.-M. Saliou, M. Zeniou, et al., "Comparative expression study of the endo-G protein coupled receptor (GPCR) repertoire in human glioblastoma cancer stem-like cells, U87-MG cells and non malignant cells of neural origin unveils new potential therapeutic targets, " PLoS ONE, vol. 9, no. 3, Article ID e91519, 2014.
    • (2014) PLoS ONE , vol.9 , Issue.3
    • Feve, M.1    Saliou, J.-M.2    Zeniou, M.3
  • 44
    • 84943195160 scopus 로고    scopus 로고
    • Chemical library screening and structure-function relationship studies identify bisacodyl as a potent and selective cytotoxic agent towards quiescent human glioblastoma tumor stem-like cells
    • Article IDe0134793
    • M. Zeniou, M. Feve, S. Mameri, et al., "Chemical library screening and structure-function relationship studies identify bisacodyl as a potent and selective cytotoxic agent towards quiescent human glioblastoma tumor stem-like cells, " PLoS ONE, vol. 10, no. 8, Article IDe0134793, 2015.
    • (2015) PLoS ONE , vol.10 , Issue.8
    • Zeniou, M.1    Feve, M.2    Mameri, S.3
  • 45
    • 79952370202 scopus 로고    scopus 로고
    • The cancer stem cell: Premises, promises and challenges
    • H. Clevers, "The cancer stem cell: premises, promises and challenges, " Nature Medicine, vol. 17, no. 3, pp. 313-319, 2011.
    • (2011) Nature Medicine , vol.17 , Issue.3 , pp. 313-319
    • Clevers, H.1
  • 46
    • 84863309089 scopus 로고    scopus 로고
    • The quest for self-identity: Not all cancer stem cells are the same
    • A. B. Hjelmeland and J. N. Rich, "The quest for self-identity: not all cancer stem cells are the same, " Clinical Cancer Research, vol. 18, no. 13, pp. 3495-3498, 2012.
    • (2012) Clinical Cancer Research , vol.18 , Issue.13 , pp. 3495-3498
    • Hjelmeland, A.B.1    Rich, J.N.2
  • 47
    • 84954554493 scopus 로고    scopus 로고
    • Optimized stem cell detection using the DyeCycle-triggered side population phenotype
    • Article ID 1652389, 14 pages
    • M. Boesch, D. Wolf, and S. Sopper, "Optimized stem cell detection using the DyeCycle-triggered side population phenotype, " Stem Cells International, vol. 2016, Article ID 1652389, 14 pages, 2016.
    • (2016) Stem Cells International , vol.2016
    • Boesch, M.1    Wolf, D.2    Sopper, S.3
  • 48
    • 79551602468 scopus 로고    scopus 로고
    • Critical appraisal of the side population assay in stem cell and cancer stem cell research
    • A. Golebiewska, N. H. C. Brons, R. Bjerkvig, and S. P. Niclou, "Critical appraisal of the side population assay in stem cell and cancer stem cell research, " Cell Stem Cell, vol. 8, no. 2, pp. 136-147, 2011.
    • (2011) Cell Stem Cell , vol.8 , Issue.2 , pp. 136-147
    • Golebiewska, A.1    Brons, N.H.C.2    Bjerkvig, R.3    Niclou, S.P.4
  • 49
    • 84888985799 scopus 로고    scopus 로고
    • Side population cells as prototype of chemoresistant, tumorinitiating cells
    • Article ID 517237, 8 pages
    • V. Richard, M. G. Nair, T. R. Santhosh Kumar, and M. R. Pillai, "Side population cells as prototype of chemoresistant, tumorinitiating cells, " BioMed Research International, vol. 2013, Article ID 517237, 8 pages, 2013.
    • (2013) BioMed Research International , vol.2013
    • Richard, V.1    Nair, M.G.2    Santhosh Kumar, T.R.3    Pillai, M.R.4
  • 50
    • 84981763580 scopus 로고    scopus 로고
    • Cancer stem cells: A metastasizing menace!
    • S. Bandhavkar, "Cancer stem cells: a metastasizing menace!, " Cancer Medicine, vol. 5, no. 4, pp. 649-655, 2016.
    • (2016) Cancer Medicine , vol.5 , Issue.4 , pp. 649-655
    • Bandhavkar, S.1
  • 51
    • 84989360957 scopus 로고    scopus 로고
    • Targeting self-renewal pathways in cancer stem cells: Clinical implications for cancer therapy
    • article e177
    • A. Borah, S. Raveendran, A. Rochani, T. Maekawa, and D. S. Kumar, "Targeting self-renewal pathways in cancer stem cells: clinical implications for cancer therapy, " Oncogenesis, vol. 4, no. 11, article e177, 2015.
    • (2015) Oncogenesis , vol.4 , Issue.11
    • Borah, A.1    Raveendran, S.2    Rochani, A.3    Maekawa, T.4    Kumar, D.S.5
  • 52
    • 34748837360 scopus 로고    scopus 로고
    • Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis
    • M. Katoh, "Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis, " StemCell Reviews, vol. 3, no. 1, pp. 30-38, 2007.
    • (2007) StemCell Reviews , vol.3 , Issue.1 , pp. 30-38
    • Katoh, M.1
  • 54
    • 84938209433 scopus 로고    scopus 로고
    • Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: Clinical update
    • N. Takebe, L. Miele, P. J. Harris, et al., "Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update, " Nature Reviews Clinical Oncology, vol. 12, no. 8, pp. 445-464, 2015.
    • (2015) Nature Reviews Clinical Oncology , vol.12 , Issue.8 , pp. 445-464
    • Takebe, N.1    Miele, L.2    Harris, P.J.3
  • 55
    • 84867116494 scopus 로고    scopus 로고
    • Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3K/AKT pathway
    • B. Ramaswamy, Y. Lu, K.-Y. Teng, et al., "Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3K/AKT pathway, " Cancer Research, vol. 72, no. 19, pp. 5048-5059, 2012.
    • (2012) Cancer Research , vol.72 , Issue.19 , pp. 5048-5059
    • Ramaswamy, B.1    Lu, Y.2    Teng, K.-Y.3
  • 56
    • 70350496540 scopus 로고    scopus 로고
    • Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma
    • R. L. Yauch, G. J. P. Dijkgraaf, B. Alicke, et al., "Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma, " Science, vol. 326, no. 5952, pp. 572-574, 2009.
    • (2009) Science , vol.326 , Issue.5952 , pp. 572-574
    • Yauch, R.L.1    Dijkgraaf, G.J.P.2    Alicke, B.3
  • 57
    • 85014088728 scopus 로고    scopus 로고
    • Targeting gliomainitiating cells in GBM: ABTC-0904, a randomized phase 0/II study targeting the Sonic Hedgehog-signaling pathway
    • abstract 2026 Proceedings of the 2014 ASCO Annual Meeting
    • A. E. Sloan, C. J. Nock, X. B. Ye, et al., "Targeting gliomainitiating cells in GBM: ABTC-0904, a randomized phase 0/II study targeting the SonicHedgehog-signaling pathway, " Journal of Clinical Oncology, vol. 32, abstract 2026, 2014, Proceedings of the 2014 ASCO Annual Meeting.
    • (2014) Journal of Clinical Oncology , vol.32
    • Sloan, A.E.1    Nock, C.J.2    Ye, X.B.3
  • 58
    • 84980010120 scopus 로고    scopus 로고
    • The BCL2 family: Key mediators of the apoptotic response to targeted anticancer therapeutics
    • A. N. Hata, J. A. Engelman, and A. C. Faber, "The BCL2 family: key mediators of the apoptotic response to targeted anticancer therapeutics, " Cancer Discovery, vol. 5, no. 5, pp. 475-487, 2015.
    • (2015) Cancer Discovery , vol.5 , Issue.5 , pp. 475-487
    • Hata, A.N.1    Engelman, J.A.2    Faber, A.C.3
  • 59
    • 65649086790 scopus 로고    scopus 로고
    • Stem-cell-like glioma cells are resistant to TRAIL/Apo2L and exhibit down-regulation of caspase-8 by promoter methylation
    • D. Capper, T. Gaiser, C. Hartmann, et al., "Stem-cell-like glioma cells are resistant to TRAIL/Apo2L and exhibit down-regulation of caspase-8 by promoter methylation, " Acta Neuropathologica, vol. 117, no. 4, pp. 445-456, 2009.
    • (2009) Acta Neuropathologica , vol.117 , Issue.4 , pp. 445-456
    • Capper, D.1    Gaiser, T.2    Hartmann, C.3
  • 60
    • 46549084099 scopus 로고    scopus 로고
    • Comparison between cells and cancer stem-like cells isolated from glioblastoma and astrocytoma on expression of anti-apoptotic and multidrug resistance-associated protein genes
    • F. Jin, L. Zhao, H.-Y. Zhao, et al., "Comparison between cells and cancer stem-like cells isolated from glioblastoma and astrocytoma on expression of anti-apoptotic and multidrug resistance-associated protein genes, " Neuroscience, vol. 154, no. 2, pp. 541-550, 2008.
    • (2008) Neuroscience , vol.154 , Issue.2 , pp. 541-550
    • Jin, F.1    Zhao, L.2    Zhao, H.-Y.3
  • 61
    • 84859847164 scopus 로고    scopus 로고
    • Emerging insights into themolecular and cellular basis of glioblastoma
    • G. P. Dunn, M. L. Rinne, J. Wykosky, et al., "Emerging insights into themolecular and cellular basis of glioblastoma, "Genes and Development, vol. 26, no. 8, pp. 756-784, 2012.
    • (2012) Genes and Development , vol.26 , Issue.8 , pp. 756-784
    • Dunn, G.P.1    Rinne, M.L.2    Wykosky, J.3
  • 62
    • 35949002429 scopus 로고    scopus 로고
    • Malignant astrocytic glioma: Genetics, biology, and paths to treatment
    • F. B. Furnari, T. Fenton, R. M. Bachoo, et al., "Malignant astrocytic glioma: genetics, biology, and paths to treatment, " Genes & Development, vol. 21, no. 21, pp. 2683-2710, 2007.
    • (2007) Genes & Development , vol.21 , Issue.21 , pp. 2683-2710
    • Furnari, F.B.1    Fenton, T.2    Bachoo, R.M.3
  • 63
    • 56149097601 scopus 로고    scopus 로고
    • Apoptosisbased treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins
    • K. E. Tagscherer, A. Fassl, B. Campos, et al., "Apoptosisbased treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins, " Oncogene, vol. 27, no. 52, pp. 6646-6656, 2008.
    • (2008) Oncogene , vol.27 , Issue.52 , pp. 6646-6656
    • Tagscherer, K.E.1    Fassl, A.2    Campos, B.3
  • 64
    • 80052662217 scopus 로고    scopus 로고
    • Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL
    • article R88
    • L. Piggott, N. Omidvar, S. Marti Perez, R. French, M. Eberl, and R. W. Clarkson, "Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL, " Breast Cancer Research, vol. 13, no. 5, article R88, 2011.
    • (2011) Breast Cancer Research , vol.13 , Issue.5
    • Piggott, L.1    Omidvar, N.2    Marti Perez, S.3    French, R.4    Eberl, M.5    Clarkson, R.W.6
  • 65
    • 83355166283 scopus 로고    scopus 로고
    • Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using microRNA145 with cationic polyurethaneshort branch PEI
    • Y.-P. Yang, Y. Chien, G.-Y. Chiou, et al., "Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using microRNA145 with cationic polyurethaneshort branch PEI, " Biomaterials, vol. 33, no. 5, pp. 1462-1476, 2012.
    • (2012) Biomaterials , vol.33 , Issue.5 , pp. 1462-1476
    • Yang, Y.-P.1    Chien, Y.2    Chiou, G.-Y.3
  • 66
    • 84956950067 scopus 로고    scopus 로고
    • DNA damage responses in cancer stem cells: Implications for cancer therapeutic strategies
    • Q. E. Wang, "DNA damage responses in cancer stem cells: implications for cancer therapeutic strategies, " World Journal of Biological Chemistry, vol. 6, no. 3, pp. 57-64, 2015.
    • (2015) World Journal of Biological Chemistry , vol.6 , Issue.3 , pp. 57-64
    • Wang, Q.E.1
  • 67
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • S. Bao, Q. Wu, R. E. McLendon, et al., "Glioma stem cells promote radioresistance by preferential activation of the DNA damage response, " Nature, vol. 444, no. 7120, pp. 756-760, 2006.
    • (2006) Nature , vol.444 , Issue.7120 , pp. 756-760
    • Bao, S.1    Wu, Q.2    McLendon, R.E.3
  • 68
    • 84865635727 scopus 로고    scopus 로고
    • Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition
    • V. A. Venkatesha, L. A. Parsels, J. D. Parsels, et al., "Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition, " Neoplasia, vol. 14, no. 6, pp. 519-525, 2012.
    • (2012) Neoplasia , vol.14 , Issue.6 , pp. 519-525
    • Venkatesha, V.A.1    Parsels, L.A.2    Parsels, J.D.3
  • 69
    • 77955381770 scopus 로고    scopus 로고
    • BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery
    • S. Facchino, M. Abdouh, W. Chatoo, and G. Bernier, "BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery, " Journal of Neuroscience, vol. 30, no. 30, pp. 10096-10111, 2010.
    • (2010) Journal of Neuroscience , vol.30 , Issue.30 , pp. 10096-10111
    • Facchino, S.1    Abdouh, M.2    Chatoo, W.3    Bernier, G.4
  • 70
    • 76749158386 scopus 로고    scopus 로고
    • Inhibition of tumorigenicity and enhancement of radiochemosensitivity in head and neck squamous cell cancer-derived ALDH1-positive cells by knockdown of Bmi-1
    • Y.-C. Chen, C.-J. Chang, H.-S. Hsu, et al., "Inhibition of tumorigenicity and enhancement of radiochemosensitivity in head and neck squamous cell cancer-derived ALDH1-positive cells by knockdown of Bmi-1, " Oral Oncology, vol. 46, no. 3, pp. 158-165, 2010.
    • (2010) Oral Oncology , vol.46 , Issue.3 , pp. 158-165
    • Chen, Y.-C.1    Chang, C.-J.2    Hsu, H.-S.3
  • 71
    • 33845671339 scopus 로고    scopus 로고
    • Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma
    • article 67
    • G. Liu, X. Yuan, Z. Zeng, et al., "Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma, " Molecular Cancer, vol. 5, article 67, 2006.
    • (2006) Molecular Cancer , vol.5
    • Liu, G.1    Yuan, X.2    Zeng, Z.3
  • 72
    • 79959834028 scopus 로고    scopus 로고
    • Increased expression of DNA repair genes in invasive human pancreatic cancer cells
    • L. A. Mathews, S. M. Cabarcas, E. M. Hurt, X. Zhang, E. M. Jaffee, and W. L. Farrar, "Increased expression of DNA repair genes in invasive human pancreatic cancer cells, " Pancreas, vol. 40, no. 5, pp. 730-739, 2011.
    • (2011) Pancreas , vol.40 , Issue.5 , pp. 730-739
    • Mathews, L.A.1    Cabarcas, S.M.2    Hurt, E.M.3    Zhang, X.4    Jaffee, E.M.5    Farrar, W.L.6
  • 73
    • 84941178104 scopus 로고    scopus 로고
    • Mammary stem cells and tumor-initiating cells are more resistant to apoptosis and exhibit increased DNA repair activity in response to DNA damage
    • C.-H. Chang, M. Zhang, K. Rajapakshe, et al., "Mammary stem cells and tumor-initiating cells are more resistant to apoptosis and exhibit increased DNA repair activity in response to DNA damage, " Stem Cell Reports, vol. 5, no. 3, pp. 378-391, 2015.
    • (2015) Stem Cell Reports , vol.5 , Issue.3 , pp. 378-391
    • Chang, C.-H.1    Zhang, M.2    Rajapakshe, K.3
  • 74
    • 84925593582 scopus 로고    scopus 로고
    • Reactive oxygen species-mediated therapeutic response and resistance in glioblastoma
    • Article ID e1601
    • E. Singer, J. Judkins, N. Salomonis, et al., "Reactive oxygen species-mediated therapeutic response and resistance in glioblastoma, " Cell Death and Disease, vol. 6, no. 1, Article ID e1601, 2015.
    • (2015) Cell Death and Disease , vol.6 , Issue.1
    • Singer, E.1    Judkins, J.2    Salomonis, N.3
  • 75
    • 84961989544 scopus 로고    scopus 로고
    • Cancer stem cells and signaling pathways in radioresistance
    • L. Chang, P. Graham, J. Hao, et al., "Cancer stem cells and signaling pathways in radioresistance, " Oncotarget, vol. 7, no. 10, pp. 11002-11017, 2016.
    • (2016) Oncotarget , vol.7 , Issue.10 , pp. 11002-11017
    • Chang, L.1    Graham, P.2    Hao, J.3
  • 77
    • 84959210717 scopus 로고    scopus 로고
    • The metastatic potential and chemoresistance of human pancreatic cancer stem cells
    • Article ID e0148807
    • V. J. Bhagwandin, J. M. Bishop, W. E. Wright, and J. W. Shay, "The metastatic potential and chemoresistance of human pancreatic cancer stem cells, " PLoS ONE, vol. 11, no. 2, Article ID e0148807, 2016.
    • (2016) PLoS ONE , vol.11 , Issue.2
    • Bhagwandin, V.J.1    Bishop, J.M.2    Wright, W.E.3    Shay, J.W.4
  • 78
    • 33745924696 scopus 로고    scopus 로고
    • Side population purified from hepatocellular carcinoma cells harbors cancer stem celllike properties
    • T. Chiba, K. Kita, Y.-W. Zheng, et al., "Side population purified from hepatocellular carcinoma cells harbors cancer stem celllike properties, " Hepatology, vol. 44, no. 1, pp. 240-251, 2006.
    • (2006) Hepatology , vol.44 , Issue.1 , pp. 240-251
    • Chiba, T.1    Kita, K.2    Zheng, Y.-W.3
  • 79
    • 84927635947 scopus 로고    scopus 로고
    • Isolation and characterization of cancer stem cells from medulloblastoma
    • J. Liu, N. Chi, J. Y. Zhang, W. Zhu, Y. S. Bian, and H. G. Chen, "Isolation and characterization of cancer stem cells from medulloblastoma, " Genetics andMolecular Research, vol. 14, no. 2, pp. 3355-3361, 2015.
    • (2015) Genetics and Molecular Research , vol.14 , Issue.2 , pp. 3355-3361
    • Liu, J.1    Chi, N.2    Zhang, J.Y.3    Zhu, W.4    Bian, Y.S.5    Chen, H.G.6
  • 80
    • 84918791885 scopus 로고    scopus 로고
    • Multiple drug resistance due to resistance to stem cells and stem cell treatment progress in cancer
    • C. Di and Y. Zhao, "Multiple drug resistance due to resistance to stem cells and stem cell treatment progress in cancer, " Experimental and Therapeutic Medicine, vol. 9, no. 2, pp. 289-293, 2015.
    • (2015) Experimental and Therapeutic Medicine , vol.9 , Issue.2 , pp. 289-293
    • Di, C.1    Zhao, Y.2
  • 82
    • 84930719130 scopus 로고    scopus 로고
    • Development of fourth generation ABC inhibitors from natural products: A novel approach to overcome cancer multidrug resistance
    • S. Karthikeyan and S. L. Hoti, "Development of fourth generation ABC inhibitors from natural products: a novel approach to overcome cancer multidrug resistance, " Anti-Cancer Agents in Medicinal Chemistry, vol. 15, no. 5, pp. 605-615, 2015.
    • (2015) Anti-Cancer Agents in Medicinal Chemistry , vol.15 , Issue.5 , pp. 605-615
    • Karthikeyan, S.1    Hoti, S.L.2
  • 83
    • 84903768676 scopus 로고    scopus 로고
    • Tackling the cancer stem cells-what challenges do they pose?
    • D. R. Pattabiraman and R. A. Weinberg, "Tackling the cancer stem cells-what challenges do they pose?" Nature Reviews Drug Discovery, vol. 13, no. 7, pp. 497-512, 2014.
    • (2014) Nature Reviews Drug Discovery , vol.13 , Issue.7 , pp. 497-512
    • Pattabiraman, D.R.1    Weinberg, R.A.2
  • 84
    • 33845610993 scopus 로고    scopus 로고
    • Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells
    • S. G. M. Piccirillo, B. A. Reynolds, N. Zanetti, et al., "Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells, " Nature, vol. 444, no. 7120, pp. 761-765, 2006.
    • (2006) Nature , vol.444 , Issue.7120 , pp. 761-765
    • Piccirillo, S.G.M.1    Reynolds, B.A.2    Zanetti, N.3
  • 85
    • 37349067098 scopus 로고    scopus 로고
    • Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells
    • J. Lee, M. J. Son, K. Woolard, et al., "Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells, " Cancer Cell, vol. 13, no. 1, pp. 69-80, 2008.
    • (2008) Cancer Cell , vol.13 , Issue.1 , pp. 69-80
    • Lee, J.1    Son, M.J.2    Woolard, K.3
  • 86
    • 84945570659 scopus 로고    scopus 로고
    • Aberrantmesenchymal differentiation of glioma stem-like cells: Implications for therapeutic targeting
    • V. Balasubramaniyan, B. Vaillant, S. Wang, et al., "Aberrantmesenchymal differentiation of glioma stem-like cells: implications for therapeutic targeting, " Oncotarget, vol. 6, no. 31, pp. 31007-31017, 2015.
    • (2015) Oncotarget , vol.6 , Issue.31 , pp. 31007-31017
    • Balasubramaniyan, V.1    Vaillant, B.2    Wang, S.3
  • 87
    • 84878240136 scopus 로고    scopus 로고
    • Molecular regulation of stem cell quiescence
    • T. H. Cheung and T. A. Rando, "Molecular regulation of stem cell quiescence, " Nature Reviews Molecular Cell Biology, vol. 14, no. 6, pp. 329-340, 2013.
    • (2013) Nature Reviews Molecular Cell Biology , vol.14 , Issue.6 , pp. 329-340
    • Cheung, T.H.1    Rando, T.A.2
  • 88
    • 84882709882 scopus 로고    scopus 로고
    • Epigenomic enhancer annotation reveals a key role for NFIX in neural stem cell quiescence
    • B. Martynoga, J. L. Mateo, B. Zhou, et al., "Epigenomic enhancer annotation reveals a key role for NFIX in neural stem cell quiescence, " Genes and Development, vol. 27, no. 16, pp. 1769-1786, 2013.
    • (2013) Genes and Development , vol.27 , Issue.16 , pp. 1769-1786
    • Martynoga, B.1    Mateo, J.L.2    Zhou, B.3
  • 89
    • 70350497348 scopus 로고    scopus 로고
    • FoxOs cooperatively regulate diverse pathways governing neural stemcell homeostasis
    • J.-H. Paik, Z. Ding, R. Narurkar, et al., "FoxOs cooperatively regulate diverse pathways governing neural stemcell homeostasis, " Cell Stem Cell, vol. 5, no. 5, pp. 540-553, 2009.
    • (2009) Cell Stem Cell , vol.5 , Issue.5 , pp. 540-553
    • Paik, J.-H.1    Ding, Z.2    Narurkar, R.3
  • 91
    • 84926667072 scopus 로고    scopus 로고
    • Tumor dormancy: Potential therapeutic target in tumor recurrence and metastasis prevention
    • article 29
    • S. H. Wang and S. Lin, "Tumor dormancy: potential therapeutic target in tumor recurrence and metastasis prevention, " Experimental Hematology & Oncology, vol. 2, no. 1, article 29, 2013.
    • (2013) Experimental Hematology & Oncology , vol.2 , Issue.1
    • Wang, S.H.1    Lin, S.2
  • 92
    • 84906937205 scopus 로고    scopus 로고
    • Mechanisms of disseminated cancer cell dormancy: An awakening field
    • M. S. Sosa, P. Bragado, and J. A. Aguirre-Ghiso, "Mechanisms of disseminated cancer cell dormancy: an awakening field, " Nature Reviews Cancer, vol. 14, no. 9, pp. 611-622, 2014.
    • (2014) Nature Reviews Cancer , vol.14 , Issue.9 , pp. 611-622
    • Sosa, M.S.1    Bragado, P.2    Aguirre-Ghiso, J.A.3
  • 93
    • 71849108136 scopus 로고    scopus 로고
    • Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma
    • J. L. Dembinski and S. Krauss, "Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma, " Clinical and Experimental Metastasis, vol. 26, no. 7, pp. 611-623, 2009.
    • (2009) Clinical and Experimental Metastasis , vol.26 , Issue.7 , pp. 611-623
    • Dembinski, J.L.1    Krauss, S.2
  • 94
    • 73149110562 scopus 로고    scopus 로고
    • Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content
    • S. Pece, D. Tosoni, S. Confalonieri, et al., "Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content, " Cell, vol. 140, no. 1, pp. 62-73, 2010.
    • (2010) Cell , vol.140 , Issue.1 , pp. 62-73
    • Pece, S.1    Tosoni, D.2    Confalonieri, S.3
  • 95
    • 77956388547 scopus 로고    scopus 로고
    • CD13 is a therapeutic target in human liver cancer stem cells
    • N. Haraguchi, H. Ishii, K. Mimori, et al., "CD13 is a therapeutic target in human liver cancer stem cells, "The Journal of Clinical Investigation, vol. 120, no. 9, pp. 3326-3339, 2010.
    • (2010) The Journal of Clinical Investigation , vol.120 , Issue.9 , pp. 3326-3339
    • Haraguchi, N.1    Ishii, H.2    Mimori, K.3
  • 96
    • 77952502408 scopus 로고    scopus 로고
    • A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth
    • A. Roesch, M. Fukunaga-Kalabis, E. C. Schmidt, et al., "A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth, " Cell, vol. 141, no. 4, pp. 583-594, 2010.
    • (2010) Cell , vol.141 , Issue.4 , pp. 583-594
    • Roesch, A.1    Fukunaga-Kalabis, M.2    Schmidt, E.C.3
  • 97
    • 77952240931 scopus 로고    scopus 로고
    • CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells
    • M.-Q. Gao, Y.-P. Choi, S. Kang, J. H. Youn, and N.-H. Cho, "CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells, " Oncogene, vol. 29, no. 18, pp. 2672-2680, 2010.
    • (2010) Oncogene , vol.29 , Issue.18 , pp. 2672-2680
    • Gao, M.-Q.1    Choi, Y.-P.2    Kang, S.3    Youn, J.H.4    Cho, N.-H.5
  • 98
    • 84919638312 scopus 로고    scopus 로고
    • CD133-positive cancer stem cells from Colo205 human colon adenocarcinoma cell line show resistance to chemotherapy and display a specific metabolomic profile
    • Z. Vincent, K. Urakami, K. Maruyama, K. Yamaguchi, and M. Kusuhara, "CD133-positive cancer stem cells from Colo205 human colon adenocarcinoma cell line show resistance to chemotherapy and display a specific metabolomic profile, " Genes & Cancer, vol. 5, no. 7-8, pp. 250-260, 2014.
    • (2014) Genes & Cancer , vol.5 , Issue.7-8 , pp. 250-260
    • Vincent, Z.1    Urakami, K.2    Maruyama, K.3    Yamaguchi, K.4    Kusuhara, M.5
  • 99
    • 79957472391 scopus 로고    scopus 로고
    • Evidence for labelretaining tumour-initiating cells in human glioblastoma
    • L. P. Deleyrolle, A. Harding, K. Cato, et al., "Evidence for labelretaining tumour-initiating cells in human glioblastoma, " Brain, vol. 134, no. 5, pp. 1331-1343, 2011.
    • (2011) Brain , vol.134 , Issue.5 , pp. 1331-1343
    • Deleyrolle, L.P.1    Harding, A.2    Cato, K.3
  • 100
    • 84865203983 scopus 로고    scopus 로고
    • A restricted cell population propagates glioblastoma growth after chemotherapy
    • J. Chen, Y. Li, T.-S. Yu, et al., "A restricted cell population propagates glioblastoma growth after chemotherapy, " Nature, vol. 488, no. 7412, pp. 522-526, 2012.
    • (2012) Nature , vol.488 , Issue.7412 , pp. 522-526
    • Chen, J.1    Li, Y.2    Yu, T.-S.3
  • 101
    • 84902668801 scopus 로고    scopus 로고
    • Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
    • A. P. Patel, I. Tirosh, J. J. Trombetta, et al., "Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma, " Science, vol. 344, no. 6190, pp. 1396-1401, 2014.
    • (2014) Science , vol.344 , Issue.6190 , pp. 1396-1401
    • Patel, A.P.1    Tirosh, I.2    Trombetta, J.J.3
  • 102
    • 84958230967 scopus 로고    scopus 로고
    • Histological characterization of the tumorigenic Peri-Necrotic Niche harboring quiescent stem-like tumor cells in glioblastoma
    • Article ID e0147366
    • A. Ishii, T. Kimura, H. Sadahiro, et al., "Histological characterization of the tumorigenic Peri-Necrotic Niche harboring quiescent stem-like tumor cells in glioblastoma, " PLoSONE, vol. 11, no. 1, Article ID e0147366, 2016.
    • (2016) PLoSONE , vol.11 , Issue.1
    • Ishii, A.1    Kimura, T.2    Sadahiro, H.3
  • 103
    • 84876422526 scopus 로고    scopus 로고
    • Ablation of Fbxw7 eliminates leukemiainitiating cells by preventing quiescence
    • S. Takeishi, A. Matsumoto, I. Onoyama, K. Naka, A. Hirao, and K. I. Nakayama, "Ablation of Fbxw7 eliminates leukemiainitiating cells by preventing quiescence, " Cancer Cell, vol. 23, no. 3, pp. 347-361, 2013.
    • (2013) Cancer Cell , vol.23 , Issue.3 , pp. 347-361
    • Takeishi, S.1    Matsumoto, A.2    Onoyama, I.3    Naka, K.4    Hirao, A.5    Nakayama, K.I.6
  • 104
    • 77749317560 scopus 로고    scopus 로고
    • Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML
    • Y. Saito, N. Uchida, S. Tanaka, et al., "Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML, " Nature Biotechnology, vol. 28, no. 3, pp. 275-280, 2010.
    • (2010) Nature Biotechnology , vol.28 , Issue.3 , pp. 275-280
    • Saito, Y.1    Uchida, N.2    Tanaka, S.3
  • 105
    • 67651003108 scopus 로고    scopus 로고
    • Computational identification of a p38 SAPK-regulated transcription factor network required for tumor cell quiescence
    • A. P. Adam, A. George, D. Schewe, et al., "Computational identification of a p38 SAPK-regulated transcription factor network required for tumor cell quiescence, " Cancer Research, vol. 69, no. 14, pp. 5664-5672, 2009.
    • (2009) Cancer Research , vol.69 , Issue.14 , pp. 5664-5672
    • Adam, A.P.1    George, A.2    Schewe, D.3
  • 106
    • 84887219089 scopus 로고    scopus 로고
    • TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling
    • P. Bragado, Y. Estrada, F. Parikh, et al., "TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling, " Nature Cell Biology, vol. 15, no. 11, pp. 1351-1361, 2013.
    • (2013) Nature Cell Biology , vol.15 , Issue.11 , pp. 1351-1361
    • Bragado, P.1    Estrada, Y.2    Parikh, F.3
  • 107
    • 84862917865 scopus 로고    scopus 로고
    • Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stemlike cells in bone
    • A. Kobayashi, H. Okuda, F. Xing, et al., "Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stemlike cells in bone, " The Journal of Experimental Medicine, vol. 208, no. 13, pp. 2641-2655, 2011.
    • (2011) The Journal of Experimental Medicine , vol.208 , Issue.13 , pp. 2641-2655
    • Kobayashi, A.1    Okuda, H.2    Xing, F.3
  • 109
    • 84957800593 scopus 로고    scopus 로고
    • The epigenetics of tumour initiation: Cancer stem cells and their chromatin
    • A. Avgustinova and S. A. Benitah, "The epigenetics of tumour initiation: cancer stem cells and their chromatin, " Current Opinion in Genetics & Development, vol. 36, pp. 8-15, 2016.
    • (2016) Current Opinion in Genetics & Development , vol.36 , pp. 8-15
    • Avgustinova, A.1    Benitah, S.A.2
  • 110
    • 84930043885 scopus 로고    scopus 로고
    • Non-genetic cancer cell plasticity and therapy-induced stemness in tumour relapse: What does not kill me strengthens me
    • A. O. Pisco and S. Huang, "Non-genetic cancer cell plasticity and therapy-induced stemness in tumour relapse: what does not kill me strengthens me, " British Journal of Cancer, vol. 112, no. 11, pp. 1725-1732, 2015.
    • (2015) British Journal of Cancer , vol.112 , Issue.11 , pp. 1725-1732
    • Pisco, A.O.1    Huang, S.2
  • 111
    • 78249250559 scopus 로고    scopus 로고
    • Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized
    • E. Quintana, M. Shackleton, H. R. Foster, et al., "Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized, " Cancer Cell, vol. 18, no. 5, pp. 510-523, 2010.
    • (2010) Cancer Cell , vol.18 , Issue.5 , pp. 510-523
    • Quintana, E.1    Shackleton, M.2    Foster, H.R.3
  • 112
    • 84899524502 scopus 로고    scopus 로고
    • Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells
    • M. L. Suva, E. Rheinbay, S. M. Gillespie, et al., "Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells, " Cell, vol. 157, no. 3, pp. 580-594, 2014.
    • (2014) Cell , vol.157 , Issue.3 , pp. 580-594
    • Suva, M.L.1    Rheinbay, E.2    Gillespie, S.M.3
  • 113
    • 84904035128 scopus 로고    scopus 로고
    • Induction of cancer stem cell properties in colon cancer cells by defined factors
    • Article ID e101735
    • N. Oshima, Y. Yamada, S. Nagayama, et al., "Induction of cancer stem cell properties in colon cancer cells by defined factors, " PLoS ONE, vol. 9, no. 7, Article ID e101735, 2014.
    • (2014) PLoS ONE , vol.9 , Issue.7
    • Oshima, N.1    Yamada, Y.2    Nagayama, S.3
  • 114
    • 84884368877 scopus 로고    scopus 로고
    • Influence of tumour microenvironment heterogeneity on therapeutic response
    • M. R. Junttila and F. J. de Sauvage, "Influence of tumour microenvironment heterogeneity on therapeutic response, " Nature, vol. 501, no. 7467, pp. 346-354, 2013.
    • (2013) Nature , vol.501 , Issue.7467 , pp. 346-354
    • Junttila, M.R.1    De Sauvage, F.J.2
  • 115
    • 84944028806 scopus 로고    scopus 로고
    • Cancer microenvironment: What can we learn from the stem cell niche
    • L. Lacina, J. Plzak, O. Kodet, et al., "Cancer microenvironment: what can we learn from the stem cell niche, " International Journal of Molecular Sciences, vol. 16, no. 10, pp. 24094-24110, 2015.
    • (2015) International Journal of Molecular Sciences , vol.16 , Issue.10 , pp. 24094-24110
    • Lacina, L.1    Plzak, J.2    Kodet, O.3
  • 116
    • 84924249260 scopus 로고    scopus 로고
    • Thecancer stem cell niche: How essential is the niche in regulating stemness of tumor cells?
    • V. Plaks, N. Kong, and Z. Werb, "Thecancer stem cell niche: how essential is the niche in regulating stemness of tumor cells?" Cell Stem Cell, vol. 16, no. 3, pp. 225-238, 2015.
    • (2015) Cell Stem Cell , vol.16 , Issue.3 , pp. 225-238
    • Plaks, V.1    Kong, N.2    Werb, Z.3
  • 117
    • 77953722864 scopus 로고    scopus 로고
    • The difficulty of targeting cancer stem cell niches
    • M. A. LaBarge, "The difficulty of targeting cancer stem cell niches, " Clinical Cancer Research, vol. 16, no. 12, pp. 3121-3129, 2010.
    • (2010) Clinical Cancer Research , vol.16 , Issue.12 , pp. 3121-3129
    • LaBarge, M.A.1
  • 118
    • 84858188758 scopus 로고    scopus 로고
    • Matricellular proteins: A sticky affair with cancers
    • Article ID 351089, 17 pages
    • H. C. Chong, C. K. Tan, R.-L. Huang, and N. S. Tan, "Matricellular proteins: a sticky affair with cancers, " Journal of Oncology, vol. 2012, Article ID 351089, 17 pages, 2012.
    • (2012) Journal of Oncology , vol.2012
    • Chong, H.C.1    Tan, C.K.2    Huang, R.-L.3    Tan, N.S.4
  • 119
    • 84859949610 scopus 로고    scopus 로고
    • The extracellular matrix: A dynamic niche in cancer progression
    • P. Lu, V. M. Weaver, and Z. Werb, "The extracellular matrix: a dynamic niche in cancer progression, " The Journal of Cell Biology, vol. 196, no. 4, pp. 395-406, 2012.
    • (2012) The Journal of Cell Biology , vol.196 , Issue.4 , pp. 395-406
    • Lu, P.1    Weaver, V.M.2    Werb, Z.3
  • 120
    • 84880795993 scopus 로고    scopus 로고
    • Role of the extracellularmatrix in regulating stem cell fate
    • F. M. Watt and W. T. S. Huck, "Role of the extracellularmatrix in regulating stem cell fate, "Nature ReviewsMolecular Cell Biology, vol. 14, no. 8, pp. 467-473, 2013.
    • (2013) Nature Reviews Molecular Cell Biology , vol.14 , Issue.8 , pp. 467-473
    • Watt, F.M.1    Huck, W.T.S.2
  • 121
    • 84941951078 scopus 로고    scopus 로고
    • Microenvironmental modulation of decorin and lumican in temozolomide-resistant glioblastoma and neuroblastoma cancer stem-like cells
    • Article ID e0134111
    • C. Farace, J. A. Oliver, C. Melguizo, et al., "Microenvironmental modulation of decorin and lumican in temozolomide-resistant glioblastoma and neuroblastoma cancer stem-like cells, " PLoS ONE, vol. 10, no. 7, Article ID e0134111, 2015.
    • (2015) PLoS ONE , vol.10 , Issue.7
    • Farace, C.1    Oliver, J.A.2    Melguizo, C.3
  • 122
    • 84939514262 scopus 로고    scopus 로고
    • Endothelial cells induce cancer stem cell features in differentiated glioblastoma cells via bFGF
    • article 157
    • E. Fessler, T. Borovski, and J. P. Medema, "Endothelial cells induce cancer stem cell features in differentiated glioblastoma cells via bFGF, " Molecular Cancer, vol. 14, article 157, 2015.
    • (2015) Molecular Cancer , vol.14
    • Fessler, E.1    Borovski, T.2    Medema, J.P.3
  • 123
    • 77956178360 scopus 로고    scopus 로고
    • EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer
    • A. Singh and J. Settleman, "EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer, " Oncogene, vol. 29, no. 34, pp. 4741-4751, 2010.
    • (2010) Oncogene , vol.29 , Issue.34 , pp. 4741-4751
    • Singh, A.1    Settleman, J.2
  • 124
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • J. P. Thiery and J. P. Sleeman, "Complex networks orchestrate epithelial-mesenchymal transitions, " Nature Reviews Molecular Cell Biology, vol. 7, no. 2, pp. 131-142, 2006.
    • (2006) Nature Reviews Molecular Cell Biology , vol.7 , Issue.2 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 125
    • 84954411415 scopus 로고    scopus 로고
    • Cancer stem cell plasticity drives therapeutic resistance
    • M. R. Doherty, J. M. Smigiel, D. J. Junk, and M. W. Jackson, "Cancer stem cell plasticity drives therapeutic resistance, " Cancers (Basel), vol. 8, no. 1, p. 8, 2016.
    • (2016) Cancers (Basel) , vol.8 , Issue.1 , pp. 8
    • Doherty, M.R.1    Smigiel, J.M.2    Junk, D.J.3    Jackson, M.W.4
  • 126
    • 43049165453 scopus 로고    scopus 로고
    • The epithelialmesenchymal transition generates cells with properties of stem cells
    • S. A. Mani, W. Guo, M.-J. Liao, et al., "The epithelialmesenchymal transition generates cells with properties of stem cells, " Cell, vol. 133, no. 4, pp. 704-715, 2008.
    • (2008) Cell , vol.133 , Issue.4 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.-J.3
  • 127
    • 84929645752 scopus 로고    scopus 로고
    • EMT, CTCs and CSCs in tumor relapse and drug-resistance
    • A. Mitra, L. Mishra, and S. Li, "EMT, CTCs and CSCs in tumor relapse and drug-resistance, " Oncotarget, vol. 6, no. 13, pp. 10697-10711, 2015.
    • (2015) Oncotarget , vol.6 , Issue.13 , pp. 10697-10711
    • Mitra, A.1    Mishra, L.2    Li, S.3
  • 128
    • 84958899570 scopus 로고    scopus 로고
    • Conversion to stem-cell state in response to microenvironmental cues is regulated by balance between epithelial and mesenchymal features in lung cancer cells
    • F. Andriani, G. Bertolini, F. Facchinetti, et al., "Conversion to stem-cell state in response to microenvironmental cues is regulated by balance between epithelial and mesenchymal features in lung cancer cells, " Molecular Oncology, vol. 10, no. 2, pp. 253-271, 2016.
    • (2016) Molecular Oncology , vol.10 , Issue.2 , pp. 253-271
    • Andriani, F.1    Bertolini, G.2    Facchinetti, F.3
  • 129
    • 84900459331 scopus 로고    scopus 로고
    • IL-22+CD4+ Tcellspromote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L
    • I. Kryczek, Y. Lin, N. Nagarsheth, et al., "IL-22+CD4+ Tcellspromote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L, " Immunity, vol. 40, no. 5, pp. 772-784, 2014.
    • (2014) Immunity , vol.40 , Issue.5 , pp. 772-784
    • Kryczek, I.1    Lin, Y.2    Nagarsheth, N.3
  • 130
    • 66149131111 scopus 로고    scopus 로고
    • Immuneinduced epithelial to mesenchymal transition in vivo generates breast cancer stem cells
    • M. Santisteban, J. M. Reiman, M. K. Asiedu, et al., "Immuneinduced epithelial to mesenchymal transition in vivo generates breast cancer stem cells, " Cancer Research, vol. 69, no. 7, pp. 2887-2895, 2009.
    • (2009) Cancer Research , vol.69 , Issue.7 , pp. 2887-2895
    • Santisteban, M.1    Reiman, J.M.2    Asiedu, M.K.3
  • 131
    • 84860431671 scopus 로고    scopus 로고
    • Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells
    • S. Hamada, A. Masamune, T. Takikawa, et al., "Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells, " Biochemical and Biophysical Research Communications, vol. 421, no. 2, pp. 349-354, 2012.
    • (2012) Biochemical and Biophysical Research Communications , vol.421 , Issue.2 , pp. 349-354
    • Hamada, S.1    Masamune, A.2    Takikawa, T.3
  • 132
    • 84860342715 scopus 로고    scopus 로고
    • Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness
    • E. Lonardo, J. Frias-Aldeguer, P. C. Hermann, and C. Heeschen, "Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness, " Cell Cycle, vol. 11, no. 7, pp. 1282-1290, 2012.
    • (2012) Cell Cycle , vol.11 , Issue.7 , pp. 1282-1290
    • Lonardo, E.1    Frias-Aldeguer, J.2    Hermann, P.C.3    Heeschen, C.4
  • 133
    • 84999106863 scopus 로고    scopus 로고
    • Registered report: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
    • Article ID e07301
    • J. Evans, A. Essex, H. Xin, N. Amitai, L. Brinton, and E. Griner, "Registered report:Wnt activity defines colon cancer stem cells and is regulated by the microenvironment, " eLife, vol. 4, Article ID e07301, 2015.
    • (2015) ELife , vol.4
    • Evans, J.1    Essex, A.2    Xin, H.3    Amitai, N.4    Brinton, L.5    Griner, E.6
  • 134
    • 77951975325 scopus 로고    scopus 로고
    • Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
    • L. Vermeulen, F. De Sousa E Melo, M. van der Heijden, et al., "Wnt activity defines colon cancer stem cells and is regulated by the microenvironment, " Nature Cell Biology, vol. 12, no. 5, pp. 468-476, 2010.
    • (2010) Nature Cell Biology , vol.12 , Issue.5 , pp. 468-476
    • Vermeulen, L.1    De Sousa Melo, E.F.2    Heijden Van Der, M.3
  • 135
    • 57149142495 scopus 로고    scopus 로고
    • The impact of O2 availability on human cancer
    • J. A. Bertout, S. A. Patel, and M. C. Simon, "The impact of O2 availability on human cancer, " Nature Reviews Cancer, vol. 8, no. 12, pp. 967-975, 2008.
    • (2008) Nature Reviews Cancer , vol.8 , Issue.12 , pp. 967-975
    • Bertout, J.A.1    Patel, S.A.2    Simon, M.C.3
  • 136
    • 50149097983 scopus 로고    scopus 로고
    • Hypoxia, HIF1 and glucose metabolism in the solid tumour
    • N. C. Denko, "Hypoxia, HIF1 and glucose metabolism in the solid tumour, " Nature Reviews Cancer, vol. 8, no. 9, pp. 705-713, 2008.
    • (2008) Nature Reviews Cancer , vol.8 , Issue.9 , pp. 705-713
    • Denko, N.C.1
  • 138
    • 84881539307 scopus 로고    scopus 로고
    • HIF expression and the role of hypoxic microenvironments within primary tumours as protective sites driving cancer stem cell renewal and metastatic progression
    • B. Philip, K. Ito, R. Moreno-Sanchez, and S. J. Ralph, "HIF expression and the role of hypoxic microenvironments within primary tumours as protective sites driving cancer stem cell renewal and metastatic progression, " Carcinogenesis, vol. 34, no. 8, pp. 1699-1707, 2013.
    • (2013) Carcinogenesis , vol.34 , Issue.8 , pp. 1699-1707
    • Philip, B.1    Ito, K.2    Moreno-Sanchez, R.3    Ralph, S.J.4
  • 140
    • 68349133231 scopus 로고    scopus 로고
    • Hypoxic tumor microenvironment and cancer cell differentiation
    • Y. Kim, Q. Lin, P. M. Glazer, and Z. Yun, "Hypoxic tumor microenvironment and cancer cell differentiation, " Current Molecular Medicine, vol. 9, no. 4, pp. 425-434, 2009.
    • (2009) Current Molecular Medicine , vol.9 , Issue.4 , pp. 425-434
    • Kim, Y.1    Lin, Q.2    Glazer, P.M.3    Yun, Z.4
  • 141
    • 79959908506 scopus 로고    scopus 로고
    • HIF induces human embryonic stem cell markers in cancer cells
    • J. Mathieu, Z. Zhang, W. Zhou, et al., "HIF induces human embryonic stem cell markers in cancer cells, " Cancer Research, vol. 71, no. 13, pp. 4640-4652, 2011.
    • (2011) Cancer Research , vol.71 , Issue.13 , pp. 4640-4652
    • Mathieu, J.1    Zhang, Z.2    Zhou, W.3
  • 142
    • 70350225829 scopus 로고    scopus 로고
    • The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype
    • J. M. Heddleston, Z. Li, R. E. McLendon, A. B. Hjelmeland, and J. N. Rich, "The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype, " Cell Cycle, vol. 8, no. 20, pp. 3274-3284, 2009.
    • (2009) Cell Cycle , vol.8 , Issue.20 , pp. 3274-3284
    • Heddleston, J.M.1    Li, Z.2    McLendon, R.E.3    Hjelmeland, A.B.4    Rich, J.N.5
  • 143
    • 65749106405 scopus 로고    scopus 로고
    • Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
    • Z. Li, S. Bao, Q. Wu, et al., "Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells, " Cancer Cell, vol. 15, no. 6, pp. 501-513, 2009.
    • (2009) Cancer Cell , vol.15 , Issue.6 , pp. 501-513
    • Li, Z.1    Bao, S.2    Wu, Q.3
  • 144
    • 0037380791 scopus 로고    scopus 로고
    • Hypoxia promotes a dedifferentiated phenotype in ductal breast carcinoma in situ
    • K. Helczynska, A. Kronblad, A. Jogi, et al., "Hypoxia promotes a dedifferentiated phenotype in ductal breast carcinoma in situ, " Cancer Research, vol. 63, no. 7, pp. 1441-1444, 2003.
    • (2003) Cancer Research , vol.63 , Issue.7 , pp. 1441-1444
    • Helczynska, K.1    Kronblad, A.2    Jogi, A.3
  • 145
    • 78149243774 scopus 로고    scopus 로고
    • Identification of a stem-like cell population by exposing metastatic breast cancer cell lines to repetitive cycles of hypoxia and reoxygenation
    • article R94
    • E. Louie, S. Nik, J.-S. Chen, et al., "Identification of a stem-like cell population by exposing metastatic breast cancer cell lines to repetitive cycles of hypoxia and reoxygenation, " Breast Cancer Research, vol. 12, no. 6, article R94, 2010.
    • (2010) Breast Cancer Research , vol.12 , Issue.6
    • Louie, E.1    Nik, S.2    Chen, J.-S.3
  • 146
    • 54249151684 scopus 로고    scopus 로고
    • Hypoxia enhances tumor stemness by increasing the invasive and tumorigenic side population fraction
    • B. Das, R. Tsuchida, D. Malkin, G. Koren, S. Baruchel, and H. Yeger, "Hypoxia enhances tumor stemness by increasing the invasive and tumorigenic side population fraction, " STEM CELLS, vol. 26, no. 7, pp. 1818-1830, 2008.
    • (2008) STEM CELLS , vol.26 , Issue.7 , pp. 1818-1830
    • Das, B.1    Tsuchida, R.2    Malkin, D.3    Koren, G.4    Baruchel, S.5    Yeger, H.6
  • 147
    • 36148995870 scopus 로고    scopus 로고
    • Influence of oxygen tension on CD133 phenotype in human glioma cell cultures
    • N. Platet, S. Y. Liu, M. E. Atifi, et al., "Influence of oxygen tension on CD133 phenotype in human glioma cell cultures, " Cancer Letters, vol. 258, no. 2, pp. 286-290, 2007.
    • (2007) Cancer Letters , vol.258 , Issue.2 , pp. 286-290
    • Platet, N.1    Liu, S.Y.2    Atifi, M.E.3
  • 149
    • 84923289688 scopus 로고    scopus 로고
    • Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER
    • article 5203
    • T. van den Beucken, E. Koch, K. Chu, et al., "Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER, " Nature Communications, vol. 5, article 5203, 2014.
    • (2014) Nature Communications , vol.5
    • Van Den Beucken, T.1    Koch, E.2    Chu, K.3
  • 150
    • 84944040597 scopus 로고    scopus 로고
    • Hypoxia induces epithelial-mesenchymal transition in follicular thyroid cancer: Involvement of regulation of twist by hypoxia inducible factor-1α
    • Y. J. Yang, H. J. Na, M. J. Suh, et al., "Hypoxia induces epithelial-mesenchymal transition in follicular thyroid cancer: involvement of regulation of twist by hypoxia inducible factor-1α, " Yonsei Medical Journal, vol. 56, no. 6, pp. 1503-1514, 2015.
    • (2015) Yonsei Medical Journal , vol.56 , Issue.6 , pp. 1503-1514
    • Yang, Y.J.1    Na, H.J.2    Suh, M.J.3
  • 151
    • 84957109989 scopus 로고    scopus 로고
    • Hypoxic microenvironment induces EMT and upgrades stem-like properties of gastric cancer cells
    • J. Guo, B. Wang, Z. Fu, J. Wei, and W. Lu, "Hypoxic microenvironment induces EMT and upgrades stem-like properties of gastric cancer cells, " Technology in Cancer Research & Treatment, vol. 15, no. 1, pp. 60-68, 2016.
    • (2016) Technology in Cancer Research & Treatment , vol.15 , Issue.1 , pp. 60-68
    • Guo, J.1    Wang, B.2    Fu, Z.3    Wei, J.4    Lu, W.5
  • 153
    • 77953935500 scopus 로고    scopus 로고
    • Tumour hypoxia induces a metabolic shift causing acidosis: A common feature in cancer
    • J. Chiche, M. C. Brahimi-Horn, and J. Pouyssegur, "Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer, " Journal of Cellular and Molecular Medicine, vol. 14, no. 4, pp. 771-794, 2010.
    • (2010) Journal of Cellular and Molecular Medicine , vol.14 , Issue.4 , pp. 771-794
    • Chiche, J.1    Brahimi-Horn, M.C.2    Pouyssegur, J.3
  • 154
    • 79954423356 scopus 로고    scopus 로고
    • Acidic stress promotes a glioma stem cell phenotype
    • A. B. Hjelmeland, Q. Wu, J. M. Heddleston, et al., "Acidic stress promotes a glioma stem cell phenotype, " Cell Death and Differentiation, vol. 18, no. 5, pp. 829-840, 2011.
    • (2011) Cell Death and Differentiation , vol.18 , Issue.5 , pp. 829-840
    • Hjelmeland, A.B.1    Wu, Q.2    Heddleston, J.M.3
  • 155
    • 84859036222 scopus 로고    scopus 로고
    • Radiation-induced reprogramming of breast cancer cells
    • C. Lagadec, E. Vlashi, L. Della Donna, C. Dekmezian, and F. Pajonk, "Radiation-induced reprogramming of breast cancer cells, " STEM CELLS, vol. 30, no. 5, pp. 833-844, 2012.
    • (2012) STEM CELLS , vol.30 , Issue.5 , pp. 833-844
    • Lagadec, C.1    Vlashi, E.2    Della Donna, L.3    Dekmezian, C.4    Pajonk, F.5
  • 156
    • 84900456376 scopus 로고    scopus 로고
    • Cisplatin inducesBmi and enhances the stem cell fraction in head and neck cancer
    • C. Nor, Z. C. Zhang, K. A. Warner, et al., "Cisplatin inducesBmi and enhances the stem cell fraction in head and neck cancer, " Neoplasia, vol. 16, no. 2, pp. 137-146, 2014.
    • (2014) Neoplasia , vol.16 , Issue.2 , pp. 137-146
    • Nor, C.1    Zhang, Z.C.2    Warner, K.A.3
  • 157
    • 84878959237 scopus 로고    scopus 로고
    • Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells
    • A. Roesch, A. Vultur, I. Bogeski, et al., "Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells, " Cancer Cell, vol. 23, no. 6, pp. 811-825, 2013.
    • (2013) Cancer Cell , vol.23 , Issue.6 , pp. 811-825
    • Roesch, A.1    Vultur, A.2    Bogeski, I.3
  • 158
    • 84951754044 scopus 로고    scopus 로고
    • 5-Fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits
    • C. Denise, P. Paoli, M. Calvani, et al., "5-Fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits, " Oncotarget, vol. 6, no. 39, pp. 41706-41721, 2015.
    • (2015) Oncotarget , vol.6 , Issue.39 , pp. 41706-41721
    • Denise, C.1    Paoli, P.2    Calvani, M.3
  • 159
    • 84885352426 scopus 로고    scopus 로고
    • Origins of metastatic traits
    • S. Vanharanta and J. Massague, "Origins of metastatic traits, " Cancer Cell, vol. 24, no. 4, pp. 410-421, 2013.
    • (2013) Cancer Cell , vol.24 , Issue.4 , pp. 410-421
    • Vanharanta, S.1    Massague, J.2
  • 160
    • 84887421660 scopus 로고    scopus 로고
    • Tumormetastasis:moving new biological insights into the clinic
    • L. Wan, K. Pantel, and Y. Kang, "Tumormetastasis:moving new biological insights into the clinic, " Nature Medicine, vol. 19, no. 11, pp. 1450-1464, 2013.
    • (2013) Nature Medicine , vol.19 , Issue.11 , pp. 1450-1464
    • Wan, L.1    Pantel, K.2    Kang, Y.3
  • 161
    • 84948714131 scopus 로고    scopus 로고
    • Clinical andmolecular complexity of breast cancer metastases
    • S. Kimbung, N. Loman, and I. Hedenfalk, "Clinical andmolecular complexity of breast cancer metastases, " Seminars in Cancer Biology, vol. 35, pp. 85-95, 2015.
    • (2015) Seminars in Cancer Biology , vol.35 , pp. 85-95
    • Kimbung, S.1    Loman, N.2    Hedenfalk, I.3
  • 162
    • 84880270290 scopus 로고    scopus 로고
    • Identification of a population of blood circulating tumor cells frombreast cancer patients that initiates metastasis in a xenograft assay
    • I. Baccelli, A. Schneeweiss, S. Riethdorf, et al., "Identification of a population of blood circulating tumor cells frombreast cancer patients that initiates metastasis in a xenograft assay, " Nature Biotechnology, vol. 31, no. 6, pp. 539-544, 2013.
    • (2013) Nature Biotechnology , vol.31 , Issue.6 , pp. 539-544
    • Baccelli, I.1    Schneeweiss, A.2    Riethdorf, S.3
  • 163
    • 84880059674 scopus 로고    scopus 로고
    • Cancer stem-like cell marker CD44 promotes bone metastases by enhancing tumorigenicity, cell motility, and hyaluronan production
    • T. Hiraga, S. Ito, and H. Nakamura, "Cancer stem-like cell marker CD44 promotes bone metastases by enhancing tumorigenicity, cell motility, and hyaluronan production, " Cancer Research, vol. 73, no. 13, pp. 4112-4122, 2013.
    • (2013) Cancer Research , vol.73 , Issue.13 , pp. 4112-4122
    • Hiraga, T.1    Ito, S.2    Nakamura, H.3
  • 164
    • 77953789724 scopus 로고    scopus 로고
    • High aldehyde dehydrogenase activity identifies tumor-initiating and metastasis-initiating cells in human prostate cancer
    • C. van den Hoogen, G. van der Horst, H. Cheung, et al., "High aldehyde dehydrogenase activity identifies tumor-initiating and metastasis-initiating cells in human prostate cancer, " Cancer Research, vol. 70, no. 12, pp. 5163-5173, 2010.
    • (2010) Cancer Research , vol.70 , Issue.12 , pp. 5163-5173
    • Van Den Hoogen, C.1    Van Der Horst, G.2    Cheung, H.3
  • 165
    • 84943143136 scopus 로고    scopus 로고
    • Single-cell analysis reveals a stem-cell program in humanmetastatic breast cancer cells
    • D. A. Lawson, N. R. Bhakta, K. Kessenbrock, et al., "Single-cell analysis reveals a stem-cell program in humanmetastatic breast cancer cells, " Nature, vol. 526, no. 7571, pp. 131-135, 2015.
    • (2015) Nature , vol.526 , Issue.7571 , pp. 131-135
    • Lawson, D.A.1    Bhakta, N.R.2    Kessenbrock, K.3
  • 166
    • 84855425160 scopus 로고    scopus 로고
    • Interactions between cancer stem cells and their niche govern metastatic colonization
    • I. Malanchi, A. Santamaria-Martinez, E. Susanto, et al., "Interactions between cancer stem cells and their niche govern metastatic colonization, " Nature, vol. 481, no. 7379, pp. 85-91, 2012.
    • (2012) Nature , vol.481 , Issue.7379 , pp. 85-91
    • Malanchi, I.1    Santamaria-Martinez, A.2    Susanto, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.