Pluripotency transcription factors and cancer stem cells: Small genes make a big difference

Chinese Journal of Cancer

Volumn 32, Issue 9, 2013, Pages 483-487

  Liu, Anfei ^a   Yu, Xiya ^a   Liu, Shanrong ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Cancer stem cell; Isoforms; NANOG; OCT4; SOX2

Indexed keywords

ALDEHYDE DEHYDROGENASE; ANTINEOPLASTIC AGENT; BREAST CANCER RESISTANCE PROTEIN; CD133 ANTIGEN; HERMES ANTIGEN; OCTAMER TRANSCRIPTION FACTOR 4; SOMATOMEDIN C RECEPTOR; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2;

APOPTOSIS; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER STEM CELL; CARCINOGENESIS; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; DOWN REGULATION; ECTODERM; EMBRYONIC STEM CELL; ENZYME ACTIVITY; GENE OVEREXPRESSION; HUMAN; LUNG CANCER; MOUTH SQUAMOUS CELL CARCINOMA; NANOG GENE; OCT4 GENE; ONCOGENE; PROSTATE CANCER; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECTUM CANCER; REVIEW; SIGNAL TRANSDUCTION; SOX2 GENE; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALS; EMBRYONIC STEM CELLS; HOMEODOMAIN PROTEINS; HUMANS; NEOPLASMS; NEOPLASTIC STEM CELLS; OCTAMER TRANSCRIPTION FACTOR-3; SIGNAL TRANSDUCTION; SOXB1 TRANSCRIPTION FACTORS;

EID: 84884232859     PISSN: 1000467X     EISSN: 1944446X     Source Type: Journal    
DOI: 10.5732/cjc.012.10282     Document Type: Review

References (42)

1. Clarke M, Dick J, Dirks P, et al. Cancer stem cells-perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res, 2006,66:9339-9344.
2. Chen J, Li Y, Yu TS, et al. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature, 2012,488:522-526.
3. + stem cell activity in mouse intestinal adenomas. Science, 2012,337:730-735.
4. Driessens G, Beck B, Caauwe A, et al. Defining the mode of tumour growth by clonal analysis. Nature, 2012,488:527-530.
5. Bernstein A. Cancer stem cells: the centrality of translational research to cancer control. CMAJ, 2007,176:29-30.
6. Singh SK, Clarke ID, Terasaki M, et al. Identification of a cancer stem cell in human brain tumors. Cancer Res, 2003,63:5821-5828.
7. Al-Hajj M, Wicha MS, Benito-Hernandez A, et al. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A, 2003,100:3983-3988.
8. O'Brien CA, Pollett A, Gallinger S, et al. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature, 2007,445:106-110.
9. Zhang S, Balch C, Chan MW, et al. Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Res, 2008,68:4311-4320.
10. Chiou SH, Yu CC, Huang CY, et al. Positive correlations of Oct 4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma. Clin Cancer Res, 2008,14:4085-4095.
11. Maitland NJ, Collins AT. Prostate cancer stem cells: a new target for therapy. J Clin Oncol, 2008,26:2862-2870.
12. Schatton T, Murphy GF, Frank NY, et al. Identification of cells initiating human melanomas. Nature, 2008,451:345-349.
13. Zhang J, Wang X, Li M, et al. NANOGP8 is a retrogene expressed in cancers. FEBS J, 2006,273:1723-1730.
14. Wang X, Dai J. Concise review: isoforms of OCT4 contribute to the confusing diversity in stem cell biology. Stem Cells, 2010,28:885-893.
15. Chen X, Xu H, Yuan P, et al. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell, 2008,133:1106-1117.
16. Ben-Porath I, Thomson MW, Carey VJ, et al. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet, 2008,40:499-507.
17. Feske S. Calcium signalling in lymphocyte activation and disease. Nat Rev Immunol, 2007,7:690-702.
18. Gu G, Yuan J, Wills M, et al. Prostate cancer cells with stem cell characteristics reconstitute the original human tumor in vivo. Cancer Res, 2007,67:4807-4815.
19. Atlasi Y, Mowla SJ, Ziaee SA, et al. Oct-4, an embryonic stem cell marker, is highly expressed in bladder cancer. Int J Cancer, 2007,120:1598-1602.
20. Ezeh UI, Turek PJ, Reijo RA, et al. Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma. Cancer, 2005,104:2255-2265.
21. Boyer LA, Lee TI, Cole MF, et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell, 2005,122:947-956.
22. Hart AH, Hartley L, Ibrahim M, et al. Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human. Dev Dyn, 2004,230:187-198.
23. Mirza AM, Gysin S, Malek N, et al. Cooperative regulation of the cell division cycle by the protein kinases RAF and AKT. Mol Cell Biol, 2004,24:10868-10881.
24. Takeda J, Seino S, Bell GI. Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. Nucleic Acids Res, 1992,20:4613-4620.
25. Shan J, Shen J, Liu L, et al. Nanog regulates self-renewal of cancer stem cells through the insulin-like growth factor pathway in human hepatocellular carcinoma. Hepatology, 2012,56:1004-1014.
26. Jeter CR, Liu B, Liu X, et al. Nanog promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation. Oncogene, 2011,30:3833-3845.
27. Mak VC, Siu MK, Wong OG, et al. Dysregulated stemnessrelated genes in gynecological malignancies. Histol Histopathol, 2012,27:1121-1130.
28. Gao Y, Wang X, Han J, et al. The novel OCT4 spliced variant OCT4B1 can generate three protein isoforms by alternative splicing into OCT4B. J Genet Genomics, 2010,37:461-465.
29. Lee J, Kim HK, Rho JY, et al. The human OCT-4 isoforms differ in their ability to confer self-renewal. J Biol Chem, 2006,281:33554-33565.
30. Mueller T, Luetzkendorf J, Nerger K, et al. Analysis of OCT4 expression in an extended panel of human tumor cell lines from multiple entities and in human mesenchymal stem cells. Cell Mol Life Sci, 2009,66:495-503.
31. Eberle I, Pless B, Braun M, et al. Transcriptional properties of human NANOG1 and NANOG2 in acute leukemic cells. Nucleic Acids Res, 2010,38:5384-5395.
32. Ambady S, Malcuit C, Kashpur O, et al. Expression of NANOG and NANOGP8 in a variety of undifferentiated and differentiated human cells. Int J Dev Biol, 2010,54:1743-1754.
33. Jeter CR, Badeaux M, Choy G, et al. Functional evidence that the self-renewal gene NANOG regulates human tumor development. Stem Cells, 2009,27:993-1005.
34. Rodda DJ, Chew JL, Lim LH, et al. Transcriptional regulation of nanog by OCT4 and SOX2. J Biol Chem, 2005,280:24731-24737.
35. Cheng L. Establishing a germ cell origin for metastatic tumors using OCT4 immunohistochemistry. Cancer, 2004,101:2006-2010.
36. Meng HM, Zheng P, Wang XY, et al. Overexpression of nanog predicts tumor progression and poor prognosis in colorectal cancer. Cancer Biol Ther, 2010,9.
37. Zhang J, Wang X, Chen B, et al. The human pluripotency gene NANOG/NANOGP8 is expressed in gastric cancer and associated with tumor development. Oncol Lett, 2010,1:457-463.
38. Jia X, Li X, Xu Y, et al. SOX2 promotes tumorigenesis and increases the anti-apoptotic property of human prostate cancer cell. J Mol Cell Biol, 2011,3:230-238.
39. Lu Y, Futtner C, Rock JR, et al. Evidence that SOX2 overexpression is oncogenic in the lung. PLoS One, 2010,5:e11022.
40. Saigusa S, Tanaka K, Toiyama Y, et al. Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy. Ann Surg Oncol, 2009,16:3488-3498.
41. Bao S, Wu Q, McLendon RE, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature, 2006,444:756-760.
42. Orkin SH, Hochedlinger K. Chromatin connections to pluripotency and cellular reprogramming. Cell, 2011,145:835-850.