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Volumn 5, Issue 4, 2016, Pages 649-655

Cancer stem cells: A metastasizing menace!

Author keywords

Cancer stem cells; Drug resistance; Signaling pathways; Therapeutic potential

Indexed keywords

ALDEHYDE DEHYDROGENASE; ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; CABOZANTINIB; CELL MARKER; CISPLATIN; DIETHYLAMINOBENZALDEHYDE; DOCETAXEL; FLUOROURACIL; GEMCITABINE; METFORMIN; MICRORNA; NOTCH RECEPTOR; PROTEIN P53; RETINOIC ACID; SALINOMYCIN; SONIC HEDGEHOG PROTEIN; SURVIVIN; UNCLASSIFIED DRUG; VORINOSTAT; WNT PROTEIN; BIOLOGICAL MARKER;

EID: 84981763580     PISSN: None     EISSN: 20457634     Source Type: Journal    
DOI: 10.1002/cam4.629     Document Type: Review
Times cited : (29)

References (42)
  • 1
    • 84862818281 scopus 로고    scopus 로고
    • Can lung cancer stem cells be targeted for therapies?
    • Wu, X., H. Chen, and X. Wang . 2012. Can lung cancer stem cells be targeted for therapies?. Cancer Treat. Rev. 38:580-588.
    • (2012) Cancer Treat. Rev. , vol.38 , pp. 580-588
    • Wu, X.1    Chen, H.2    Wang, X.3
  • 2
    • 13244298130 scopus 로고    scopus 로고
    • Self-renewal and solid-tumor stem cells
    • Clarke, M. F. 2005. Self-renewal and solid-tumor stem cells. Biol. Blood Marrow Transplant. 11:14-16.
    • (2005) Biol. Blood Marrow Transplant. , vol.11 , pp. 14-16
    • Clarke, M.F.1
  • 3
    • 33750313208 scopus 로고    scopus 로고
    • Cancer stem cells-perspectives on current status and future directions: AACR workshop on cancer stem cells
    • Clarke, M. F., J. E. Dick, P. B. Dirks, C. J. Eaves, C. H. Jamieson, D. L. Jones, et al. 2006. Cancer stem cells-perspectives on current status and future directions: AACR workshop on cancer stem cells. Cancer Res. 66:9339-9344.
    • (2006) Cancer Res. , vol.66 , pp. 9339-9344
    • Clarke, M.F.1    Dick, J.E.2    Dirks, P.B.3    Eaves, C.J.4    Jamieson, C.5    Jones, D.L.6
  • 4
    • 58149380742 scopus 로고    scopus 로고
    • Stem cell concepts renew cancer research
    • Dick, J. E. 2008. Stem cell concepts renew cancer research. Blood 112:4793-4807.
    • (2008) Blood , vol.112 , pp. 4793-4807
    • Dick, J.E.1
  • 5
    • 84907848243 scopus 로고    scopus 로고
    • Cancer stem cells: therapeutic implications and perspectives in cancer therapy
    • Han, L., S. Shi, T. Gong, Z. Zang, and X. Sun . 2013. Cancer stem cells: therapeutic implications and perspectives in cancer therapy. Sci. Direct 3:65-75.
    • (2013) Sci. Direct , vol.3 , pp. 65-75
    • Han, L.1    Shi, S.2    Gong, T.3    Zang, Z.4    Sun, X.5
  • 6
    • 85019512906 scopus 로고    scopus 로고
    • Understanding the biological functions and therapeutic potentials of stem cells and cancer stem cells: where are we?
    • Kumar, D., S. Shankar, and R. K. Srivastava . 2014. Understanding the biological functions and therapeutic potentials of stem cells and cancer stem cells: where are we?. J. Cancer Stem Cell Res. 2:e1002.
    • (2014) J. Cancer Stem Cell Res. , vol.2 , pp. e1002
    • Kumar, D.1    Shankar, S.2    Srivastava, R.K.3
  • 7
    • 65949106349 scopus 로고    scopus 로고
    • Genomic instability en route to and from cancer stem cells
    • Li, L., L. Borodyansky, and Y. Yang . 2009. Genomic instability en route to and from cancer stem cells. Cell Cycle 8:1000-1002.
    • (2009) Cell Cycle , vol.8 , pp. 1000-1002
    • Li, L.1    Borodyansky, L.2    Yang, Y.3
  • 8
    • 84944446395 scopus 로고    scopus 로고
    • Cancer stem cells and autophagy: facts and perspectives
    • Hamaï, A., P. Codogno, and M. Mehrpour . 2014. Cancer stem cells and autophagy: facts and perspectives. J. Cancer Stem Cell Res. 2:e1005.
    • (2014) J. Cancer Stem Cell Res. , vol.2 , pp. e1005
    • Hamaï, A.1    Codogno, P.2    Mehrpour, M.3
  • 9
    • 84978257762 scopus 로고    scopus 로고
    • A review on the biology of cancer stem cells
    • Atena, M., A. Mohammad Reza, and G. Mehran . 2014. A review on the biology of cancer stem cells. Sci. Res. 4:83-89.
    • (2014) Sci. Res. , vol.4 , pp. 83-89
    • Atena, M.1    Mohammad Reza, A.2    Mehran, G.3
  • 10
    • 84876489727 scopus 로고    scopus 로고
    • Cancer stem cells: the challenges ahead
    • Paul Medema J. 2013. Cancer stem cells: the challenges ahead. Nat. Cell Biol. 15:338-344. doi:10.1038/ncb2717
    • (2013) Nat. Cell Biol. , vol.15 , pp. 338-344
    • Paul Medema, J.1
  • 11
    • 84863100269 scopus 로고    scopus 로고
    • Characterization of sphere-forming cells with stem-like properties from the small cell lung cancer cell line H446
    • Qiu, X., Z. Wang, Y. Li, Y. Miao, Y. Ren, and Y Lua . 2012. Characterization of sphere-forming cells with stem-like properties from the small cell lung cancer cell line H446. Cancer Lett. 323:161-170.
    • (2012) Cancer Lett. , vol.323 , pp. 161-170
    • Qiu, X.1    Wang, Z.2    Li, Y.3    Miao, Y.4    Ren, Y.5    Lua, Y.6
  • 12
    • 79955679188 scopus 로고    scopus 로고
    • Eyes wide open: a critical review of sphere-formation as an assay for stem cells
    • Pastrana, Erika, Violeta Silva-Vargas, and Fiona Doetsch . 2011. Eyes wide open: a critical review of sphere-formation as an assay for stem cells. Cell Stem Cell 8:486-498.
    • (2011) Cell Stem Cell , vol.8 , pp. 486-498
    • Pastrana, E.1    Silva-Vargas, V.2    Doetsch, F.3
  • 13
    • 79958716191 scopus 로고    scopus 로고
    • ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma
    • Kim, M. P., J. B. Fleming, H. Wang, J. L. Abbruzzese, W. Choi, S. Kopetz, et al. 2011. ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma. PLoS ONE 6:e20636.
    • (2011) PLoS ONE , vol.6 , pp. e20636
    • Kim, M.P.1    Fleming, J.B.2    Wang, H.3    Abbruzzese, J.L.4    Choi, W.5    Kopetz, S.6
  • 16
    • 84884237412 scopus 로고    scopus 로고
    • Human pancreatic cancer contains a side population expressing cancer stem cell-associated and prognostic genes
    • Van den Broeck, A., H. Vankelecom, D. W. Van, L. Gremeaux, J. Wouters, and J. Allemeersch, et al. 2013. Human pancreatic cancer contains a side population expressing cancer stem cell-associated and prognostic genes. PLoS ONE 8:e73968.
    • (2013) PLoS ONE , vol.8 , pp. e73968
    • Van den Broeck, A.1    Vankelecom, H.2    Van, D.W.3    Gremeaux, L.4    Wouters, J.5    Allemeersch, J.6
  • 17
    • 34548417118 scopus 로고    scopus 로고
    • Limiting Factors in murine hematopoietic stem cell assays
    • Purton, L. E., and D. T. Scadden . 2007. Limiting Factors in murine hematopoietic stem cell assays. Cell Stem Cell 1:263.
    • (2007) Cell Stem Cell , vol.1 , pp. 263
    • Purton, L.E.1    Scadden, D.T.2
  • 18
    • 22844440427 scopus 로고    scopus 로고
    • Identification of hundreds of conserved and nonconserved human microRNAs
    • Bentwich, I., A. Avniel, Y. Karov, R. Aharonov, S. Gilad, O. Barad, et al. 2005. Identification of hundreds of conserved and nonconserved human microRNAs. Nat. Genet. 37:766-770.
    • (2005) Nat. Genet. , vol.37 , pp. 766-770
    • Bentwich, I.1    Avniel, A.2    Karov, Y.3    Aharonov, R.4    Gilad, S.5    Barad, O.6
  • 19
    • 70350778443 scopus 로고    scopus 로고
    • An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation
    • Iliopoulos, D., H. A. Hirsch, and K. Struhl . 2009. An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell 139:693-706.
    • (2009) Cell , vol.139 , pp. 693-706
    • Iliopoulos, D.1    Hirsch, H.A.2    Struhl, K.3
  • 20
    • 18744396337 scopus 로고    scopus 로고
    • Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
    • Calin, G. A., C. D. Dumitru, M. Shimizu, R. Bichi, S. Zupo, E. Noch, et al. 2002. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc. Natl. Acad. Sci. USA 99:15524-15529.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 15524-15529
    • Calin, G.A.1    Dumitru, C.D.2    Shimizu, M.3    Bichi, R.4    Zupo, S.5    Noch, E.6
  • 22
    • 70349320158 scopus 로고    scopus 로고
    • Causes and consequences of microRNA dysregulation in cancer
    • Croce, C. M. 2009. Causes and consequences of microRNA dysregulation in cancer. Nat. Rev. Genet. 10:704-714.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 704-714
    • Croce, C.M.1
  • 23
    • 0037212983 scopus 로고    scopus 로고
    • Hedgehog signaling in pancreas development
    • Hebrok, M. 2003. Hedgehog signaling in pancreas development. Mech. Dev. 120:45-57.
    • (2003) Mech. Dev. , vol.120 , pp. 45-57
    • Hebrok, M.1
  • 24
    • 58149174376 scopus 로고    scopus 로고
    • Exploitation of the notch signaling pathway as a novel target for cancer therapy
    • Wang, Z. W., Y. W. Li, S. Banerjee, and F. H. Sarkar . 2008. Exploitation of the notch signaling pathway as a novel target for cancer therapy. Anticancer Res. 28:3621-3630.
    • (2008) Anticancer Res. , vol.28 , pp. 3621-3630
    • Wang, Z.W.1    Li, Y.W.2    Banerjee, S.3    Sarkar, F.H.4
  • 26
    • 42549164807 scopus 로고    scopus 로고
    • Wnt signalling and its impact on development and cancer
    • Klaus, A., and W. Birchmeier 2008. Wnt signalling and its impact on development and cancer. Nat. Rev. Cancer 8:387-398.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 387-398
    • Klaus, A.1    Birchmeier, W.2
  • 27
    • 76349104842 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling regulates cancer stem cells in lung cancer A549 cells
    • Teng, Y., X. Wang, Y. Wang, and D. Ma . 2010. Wnt/beta-catenin signaling regulates cancer stem cells in lung cancer A549 cells. Biochem. Biophys. Res. Commun. 392:373-379.
    • (2010) Biochem. Biophys. Res. Commun. , vol.392 , pp. 373-379
    • Teng, Y.1    Wang, X.2    Wang, Y.3    Ma, D.4
  • 28
    • 36048963331 scopus 로고    scopus 로고
    • Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance
    • Zhou, J., J. Wulfkuhle, H. Zhang, P. Gu, Y. Yang, J. Deng, et al. 2007. Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. Proc. Natl. Acad. Sci. USA 104:16158-16163.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 16158-16163
    • Zhou, J.1    Wulfkuhle, J.2    Zhang, H.3    Gu, P.4    Yang, Y.5    Deng, J.6
  • 29
    • 84923225259 scopus 로고    scopus 로고
    • Tumor heterogeneity and cancer stem cell paradigm: updates in concept, controversies and clinical relevance
    • Singh, A. K., R. K. Arya, S. Maheshwari, A. Singh, S. Meena, P. Pandey, et al. 2014. Tumor heterogeneity and cancer stem cell paradigm: updates in concept, controversies and clinical relevance. Int. J. Cancer 136:1991-2000.
    • (2014) Int. J. Cancer , vol.136 , pp. 1991-2000
    • Singh, A.K.1    Arya, R.K.2    Maheshwari, S.3    Singh, A.4    Meena, S.5    Pandey, P.6
  • 30
    • 80555145216 scopus 로고    scopus 로고
    • Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms
    • Singh, B.N., J. Fu, R. K. Srivastava, and S. Shankar . 2011. Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms. PLoS ONE 6:27-30.
    • (2011) PLoS ONE , vol.6 , pp. 27-30
    • Singh, B.N.1    Fu, J.2    Srivastava, R.K.3    Shankar, S.4
  • 31
    • 75349105363 scopus 로고    scopus 로고
    • NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts
    • Fan, X., L. Khaki, T.S. Zhu, M.E. Soules, C.E. Talsma, N. Gul, et al. 2010. NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem Cells 28:5-16.
    • (2010) Stem Cells , vol.28 , pp. 5-16
    • Fan, X.1    Khaki, L.2    Zhu, T.S.3    Soules, M.E.4    Talsma, C.E.5    Gul, N.6
  • 32
    • 84855344803 scopus 로고    scopus 로고
    • Gamma-secretase inhibitors target tumor-initiating cells in a mouse model of ERBB2 breast cancer
    • Kondratyev, M., A. Kreso, R. M. Hallett, A. Girgis-Gabardo, M. E. Barcelon, D. Llieva, et al. 2012. Gamma-secretase inhibitors target tumor-initiating cells in a mouse model of ERBB2 breast cancer. Oncogene 31:93-103.
    • (2012) Oncogene , vol.31 , pp. 93-103
    • Kondratyev, M.1    Kreso, A.2    Hallett, R.M.3    Girgis-Gabardo, A.4    Barcelon, M.E.5    Llieva, D.6
  • 33
    • 84891355130 scopus 로고    scopus 로고
    • Ursolic acid inhibits the growth of colon cancer-initiating cells by targeting STAT3
    • Wang, W., C. Zhao, D. Jou, J. Lu, C. Zhang, L. Lin, et al. 2013. Ursolic acid inhibits the growth of colon cancer-initiating cells by targeting STAT3. Anticancer Res. 33:4279-4284.
    • (2013) Anticancer Res. , vol.33 , pp. 4279-4284
    • Wang, W.1    Zhao, C.2    Jou, D.3    Lu, J.4    Zhang, C.5    Lin, L.6
  • 34
    • 84885742331 scopus 로고    scopus 로고
    • Metformin targets the metabolic achilles heel of human pancreatic cancer stem cells
    • Lonardo, E., M. Cioffi, P. Sancho, Y. Sanchez-Ripoll, S. M. Trabulo, J. Dorado, et al. 2013. Metformin targets the metabolic achilles heel of human pancreatic cancer stem cells. PLoS ONE 8:e76518.
    • (2013) PLoS ONE , vol.8 , pp. e76518
    • Lonardo, E.1    Cioffi, M.2    Sancho, P.3    Sanchez-Ripoll, Y.4    Trabulo, S.M.5    Dorado, J.6
  • 35
    • 84871395763 scopus 로고    scopus 로고
    • Salinomycin as a drug for targeting human cancer stem cells
    • Naujokat, C., and R. Steinhart . 2012. Salinomycin as a drug for targeting human cancer stem cells. J. Biomed. Biotechnol. 2012:9506-9558.
    • (2012) J. Biomed. Biotechnol. , vol.2012 , pp. 9506-9558
    • Naujokat, C.1    Steinhart, R.2
  • 36
    • 84879372540 scopus 로고    scopus 로고
    • The novel c-Met inhibitor cabozantinib overcomes gemcitabine resistance and stem cell signaling in pancreatic cancer
    • Hage, C., V. Rausch, N. Giese, T. Giese, F. Schönsiegel, S. Labsch, et al. 2013. The novel c-Met inhibitor cabozantinib overcomes gemcitabine resistance and stem cell signaling in pancreatic cancer. Cell Death Dis. 4:e627.
    • (2013) Cell Death Dis. , vol.4 , pp. e627
    • Hage, C.1    Rausch, V.2    Giese, N.3    Giese, T.4    Schönsiegel, F.5    Labsch, S.6
  • 38
    • 33847296106 scopus 로고    scopus 로고
    • Targeted therapy for cancer stem cells: the patched pathway and ABC transporters
    • Lou, H., and M. Dean . 2007. Targeted therapy for cancer stem cells: the patched pathway and ABC transporters. Oncogene 26:1357-1360.
    • (2007) Oncogene , vol.26 , pp. 1357-1360
    • Lou, H.1    Dean, M.2
  • 39
    • 33748329381 scopus 로고    scopus 로고
    • Small interfering RNA targeting epidermal growth factor receptor enhances chemosensitivity to cisplatin, 5-fluorouracil and docetaxel in head and neck squamous cell carcinoma
    • Nozawa, H., T. Tadakuma, T. Ono, M. Sato, S. Hiroi, K. Masumoto, et al. 2006. Small interfering RNA targeting epidermal growth factor receptor enhances chemosensitivity to cisplatin, 5-fluorouracil and docetaxel in head and neck squamous cell carcinoma. Cancer Sci. 97: 1115-1124.
    • (2006) Cancer Sci. , vol.97 , pp. 1115-1124
    • Nozawa, H.1    Tadakuma, T.2    Ono, T.3    Sato, M.4    Hiroi, S.5    Masumoto, K.6
  • 41
    • 25144459486 scopus 로고    scopus 로고
    • Antisense-mediated downregulation of antiapoptotic proteins induces apoptosis and sensitises head and neck squamous cell carcinoma cells to chemotherapy
    • Sharma, H., S. Sen, L. M. L. Mraiggiò, and N. Singh . 2005. Antisense-mediated downregulation of antiapoptotic proteins induces apoptosis and sensitises head and neck squamous cell carcinoma cells to chemotherapy. Cancer Biol. Ther. 4:720-727.
    • (2005) Cancer Biol. Ther. , vol.4 , pp. 720-727
    • Sharma, H.1    Sen, S.2    Mraiggiò, L.M.L.3    Singh, N.4
  • 42
    • 0037015071 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin
    • Butler, L. M., X. Zhou, W.S. Xu, H.I. Scher, R.A. Rifkind, P.A. Marks, et al. 2002. The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin. PNAS 99:11700-11705.
    • (2002) PNAS , vol.99 , pp. 11700-11705
    • Butler, L.M.1    Zhou, X.2    Xu, W.S.3    Scher, H.I.4    Rifkind, R.A.5    Marks, P.A.6


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