New (E)-1-alkyl-1H-benzo[d]imidazol-2-yl)methylene)indolin-2-ones: Synthesis, in vitro cytotoxicity evaluation and apoptosis inducing studies

European Journal of Medicinal Chemistry

Volumn 122, Issue , 2016, Pages 584-600

  Sharma, Pankaj ^a   Thummuri, Dinesh ^a   Reddy, T Srinivasa ^b   Senwar, Kishna Ram ^a   Naidu, V G M ^a   Srinivasulu, Gannoju ^a   Bharghava, Suresh K ^b   Shankaraiah, Nagula ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b RMIT UNIVERSITY   (Australia)

Author keywords

3 Alkenyl indolin 2 one; Anticancer; Apoptosis; Benzimidazole; Knoevenagel condensation

Indexed keywords

1 ALKYL 1H BENZO[DEXTRO]IMIDAZOL 2 YL)METHYLENE]INDOLIN 2 ONE; 3 [(1 ETHYL 1H BENZO[DEXTRO]IMIDAZOL 2 YL)METHYLENE] 5 METHYLINDOLIN 2 ONE; 3 [(1 ETHYL 1H BENZO[DEXTRO]IMIDAZOL 2 YL)METHYLENE] 5 NITROINDOLIN 2 ONE; 3 [(1 ETHYL 1H BENZO[DEXTRO]IMIDAZOL 2 YL)METHYLENE]INDOLIN 2 ONE; 3 [(1 ETHYL 1H BENZO[DEXTRO]IMIDAZOL2 YL)METHYLENE] 5 FLUOROINDOLIN 2 ONE; 3 [(1 ETHYL 5 METHYL 1H BENZO[DEXTRO]IMIDAZOL 2 YL)METHYLENE] 5 FLUOROINDOLIN 2 ONE; 3 [(1 ETHYL 5 METHYL 1H BENZO[DEXTRO]IMIDAZOL 2 YL)METHYLENE]INDOLIN 2 ONE; 3 [(1 ISOPROPYL 1H BENZO[DEXTRO]IMIDAZOL 2 YL)METHYLENE] 5 METHYLINDOLIN 2 ONE; 3 [(1 ISOPROPYL 1H BENZO[DEXTRO]IMIDAZOL 2 YL)METHYLENE]INDOLIN 2 ONE; 3 [(1 METHYL 1H BENZO[DEXTRO]IMIDAZOL 2 YL)METHYLENE] 5 NITROINDOLIN 2 ONE; 3 [(1 METHYL 1H BENZO[DEXTRO]IMIDAZOL 2 YL)METHYLENE]INDOLIN 2 ONE; 3 [(1,5 DIMETHYL 1H BENZO[DEXTRO]IMIDAZOL 2 YL)METHYLENE]INDOLIN 2 ONE; 5 BROMO 3 [(1 ETHYL 1H BENZO[DEXTRO]IMIDAZOL 2 YL)METHYLENE]INDOLIN 2 ONE; 5 BROMO 3 [(1 METHYL 1H BENZO[DEXTRO]IMIDAZOL 2 YL)METHYLENE]INDOLIN 2 ONE; 5 BROMO 3 [(1,5 DIMETHYL 1H BENZO[DEXTRO]IMIDAZOL 2 YL)METHYLENE]INDOLIN 2 ONE; 5 BROMO3 [(1 ISOPROPYL 1H BENZO[DEXTRO]IMIDAZOL 2 YL)METHYLENE]INDOLIN 2 ONE; 5 CHLORO 3 [(1 ETHYL 1H BENZO[DEXTRO]IMIDAZOL 2 YL)METHYLENE]INDOLIN 2 ONE; 5 CHLORO 3 [(1 ETHYL 5 METHYL 1H BENZO[DEXTRO]IMIDAZOL 2 YL)METHYLENE]INDOLIN 2 ONE; 5 CHLORO 3 [(1 ISOPROPYL 1H BENZO[DEXTRO]IMIDAZOL 2 YL)METHYLENE]INDOLIN 2 ONE; 5 CHLORO 3 [(1 METHYL 1H BENZO[DEXTRO]IMIDAZOL 2 YL)METHYLENE]INDOLIN 2 ONE; 5 CHLORO 3 [(1,5 DIMETHYL 1H BENZO[DEXTRO]IMIDAZOL 2 YL)METHYLENE]INDOLIN 2 ONE; 5 FLUORO 3 [(1 ISOPROPYL 1H BENZO[DEXTRO]IMIDAZOL 2 YL)METHYLENE]INDOLIN 2 ONE; 5 FLUORO 3 [(1 METHYL 1H BENZO[DEXTRO]IMIDAZOL 2 YL)METHYLENE]INDOLIN 2 ONE; 5 METHYL 3 [(1 METHYL 1H BENZO[DEXTRO]IMIDAZOL 2 YL)METHYLENE]INDOLIN 2 ONE; ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; CASPASE 3; F ACTIN; SUNITINIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; ACTIN; INDOLE DERIVATIVE; INDOLIN-2-ONE; SUPEROXIDE;

4T1 CELL LINE; A549 CELL LINE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER CELL LINE; BT 549 CELL LINE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CYCLE G1 PHASE; CELL MIGRATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; DU 145 CELL LINE; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; GASTRIC CANCER CELL LINE; HGC CELL LINE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; MCF 7 CELL LINE; MDA MB 231 CEL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; PC 3 CELL LINE; PROSTATE CANCER CELL LINE; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; WESTERN BLOTTING; CELL CYCLE; CELL MOTION; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; METABOLISM; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; SYNTHESIS; TUMOR CELL LINE;

ACTINS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLES; MEMBRANE POTENTIAL, MITOCHONDRIAL; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; SUPEROXIDES;

EID: 84978529182     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2016.07.019     Document Type: Article

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