Anticancer effect of celastrol on human triple negative breast cancer: Possible involvement of oxidative stress, mitochondrial dysfunction, apoptosis and PI3K/Akt pathways

Experimental and Molecular Pathology

Volumn 98, Issue 3, 2015, Pages 313-327

  Shrivastava, Shweta ^a   Jeengar, Manish Kumar ^a   Reddy, V Sudhakar ^b   Reddy, G Bhanuprakash ^b   Naidu, V G M ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b NATIONAL INSTITUTE OF NUTRITION   (India)

Author keywords

Apoptosis; Celastrol; Mitochondrial dysfunction; Oxidative stress; PI3K Akt; TNBC

Indexed keywords

2 AMINO 8 [4 (2 HYDROXYETHOXY)CYCLOHEXYL] 6 (6 METHOXY 3 PYRIDINYL) 4 METHYLPYRIDO[2,3 D]PYRIMIDIN 7(8H) ONE; CASPASE 3; CELASTROL; DNA; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; S6 KINASE; TRIPTERINE; TRITERPENE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING ASSAY; BREAST CANCER CELL LINE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA FRAGMENTATION; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRIPLE NEGATIVE BREAST CANCER; UPREGULATION; WESTERN BLOTTING; BREAST TUMOR; CELL SURVIVAL; DRUG EFFECTS; MCF 7 CELL LINE; METABOLISM; MITOCHONDRION;

APOPTOSIS; BREAST NEOPLASMS; CELL SURVIVAL; MCF-7 CELLS; MITOCHONDRIA; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRITERPENES;

EID: 84926296864     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2015.03.031     Document Type: Article

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