Withaferin a-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Hahm, Eun Ryeong ^a,b   Moura, Michelle B ^a,b   Kelley, Eric E ^a   van Houten, Bennett ^a,b   Shiva, Sruti ^a   Singh, Shivendra V ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; DNA FRAGMENT; PROTEIN BAK; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; UBIQUINOL CYTOCHROME C REDUCTASE; WITHAFERIN A; ADENOSINE TRIPHOSPHATE; PROTECTIVE AGENT; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; SUPEROXIDE DISMUTASE; WITHANOLIDE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; OXIDATIVE PHOSPHORYLATION; PROTEIN EXPRESSION; ANIMAL; BREAST TUMOR; CHEMISTRY; DRUG EFFECT; DRUG RESISTANCE; DRUG SCREENING; ENZYMOLOGY; FEMALE; METABOLISM; MOUSE; PATHOLOGY; TUMOR CELL LINE;

WITHANIA SOMNIFERA;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BREAST NEOPLASMS; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; ELECTRON TRANSPORT COMPLEX III; FEMALE; HUMANS; MICE; OXIDATIVE PHOSPHORYLATION; PROTECTIVE AGENTS; REACTIVE OXYGEN SPECIES; RHO GTP-BINDING PROTEINS; SUPEROXIDE DISMUTASE; WITHANOLIDES;

EID: 80051512168     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023354     Document Type: Article

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