DNA-binding affinity and anticancer activity of β-carboline-chalcone conjugates as potential DNA intercalators: Molecular modelling and synthesis

Bioorganic Chemistry

Volumn 59, Issue , 2015, Pages 130-139

  Shankaraiah, Nagula ^a   Siraj, K P ^a   Nekkanti, Shalini ^a   Srinivasulu, Vunnam ^b   Sharma, Pankaj ^a   Senwar, Kishna Ram ^a   Sathish, Manda ^b   Vishnuvardhan, M V P S ^b   Ramakrishna, Sistla ^b   Jadala, Chetna ^a,b   Nagesh, Narayana ^c   Kamal, Ahmed ^b  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^c CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

Anticancer activity; Chalcone; Claisen Schmidt condensation; DNA binding ability; Molecular modelling; Carboline

Indexed keywords

1 (3,4,5 TRIMETHOXYPHENYL) 3 [1 (3,4 DIMETHOXYPHENYL) 9H PYRIDO[3,4 B]INDOL 3 YL]PROP 2 EN 1 ONE; 1 (3,4,5 TRIMETHOXYPHENYL) 3 [1 (3,4,5 TRIMETHOXYPHENYL) 9H PYRIDO[3,4 B]INDOL 3 YL]PROP 2 EN 1 ONE; 1 (4 AMINOPHENYL) 3 [1 (3,4 DIMETHOXYPHENYL) 9H PYRIDO[3,4 B]INDOL 3 YL]PROP 2 EN 1 ONE; 1 (4 AMINOPHENYL) 3 [1 (3,4,5 TRIMETHOXYPHENYL) 9H PYRIDO[3,4 B]INDOL 3 YL]PROP 2 EN 1 ONE; 1 (4 AMINOPHENYL) 3 [1 (4 FLUORO 3 METHOXYPHENYL)INDOL 3 YL]PROP 2 EN 1 ONE; 1 (4 AMINOPHENYL) 3 [1 (4 FLUOROPHENYL) 9H PYRIDO[3,4 B]INDOL 3 YL]PROP 2 EN 1 ONE; 1 (4 FLUOROPHENYL) 3 [1 (3,4 DIMETHOXYPHENYL) 9H PYRIDO[3,4 B]INDOL 3 YL]PROP 2 EN 1 ONE; 1 (4 FLUOROPHENYL) 3 [1 (4 FLUOROPHENYL) 9H PYRIDO[3,4 B]INDOL 3 YL]PROP 2 EN 1 ONE; 1 (4 FLUROPHENYL) 3 [1 (3,4,5 TRIMETHOXYPHENYL) 9H PYRIDO[3,4 B]INDOL 3 YL]PROP 2 EN 1 ONE; 1 (4 HYDROXYPHENYL) 3 [1 (3,4,5 TRIMETHOXYPHENYL) 9H PYRIDO[3,4 B]INDOL 3 YL]PROP 2 EN 1 ONE; 1 (4 METHOXYPHENYL) 3 [1 (3,4,5 TRIMETHOXYPHENYL) 9H PYRIDO[3,4 B]INDOL 3 YL]PROP 2 EN 1 ONE; 3 [1 (3,4 DIMETHOXYPHENYL) 9H PYRIDO[3,4 B]INDOL 3YL] 1 (4 NITROPHENYL)PROP 2 EN 1 ONE; 3 [1 (3,4,5 TRIMETHOXYPHENYL) 9H PYRIDO[3,4 B]INDOL 3 YL] 1 (4 NITROPHENYL)PROP 2 EN 1 ONE; 3 [1 (4 FLUORO 3 METHOXYPHENYL) 9H PYRIDO[3,4 B]INDOL 3 YL) 1 (4 NITROPHENYL)PROP 2 EN 1 ONE; 3 [1 (4 FLUORO 3 METHOXYPHENYL) 9H PYRIDO[3,4 B]INDOL 3 YL] 1 (3,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 3 [1 (4 FLUORO 3 METHOXYPHENYL) 9H PYRIDO[3,4 B]INDOL 3 YL] 1 (4 FLUOROPHENYL)PROP 2 EN 1 ONE; 3 [1 (4 FLUORO 3 METHOXYPHENYL) 9H PYRIDO[3,4 B]INDOL 3 YL] 1 (4 METHOXYPHENYL)PROP 1 EN 1 ONE; 3 [1 (4 FLUOROPHENYL) 9H PYRIDO[3,4 B]INDOL 3 YL] 1 (3,4,5 TRIMRTHOXY PHENYL)PROP 2 EN 1 ONE; 3 [1 (4 FLUOROPHENYL) 9H PYRIDO[3,4 B]INDOL 3 YL] 1 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 3 [1 (4 FLUOROPHENYL) 9H PYRIDO[3,4 B]INDOL 3 YL] 1 (4 NITROPHENYL)PROP 2 EN 1 ONE; ANTINEOPLASTIC AGENT; BETA CARBOLINE CHALCONE DERIVATIVE; BETA CARBOLINE DERIVATIVE; CHALCONE DERIVATIVE; DNA; DOXORUBICIN; INTERCALATING AGENT; UNCLASSIFIED DRUG; CARBOLINE DERIVATIVE; CHALCONE;

A549 CELL LINE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CERVICAL CANCER CELL LINE; CLINICAL EFFECTIVENESS; CLINICAL EVALUATION; COLON CANCER; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DNA DENATURATION; DRUG CONJUGATION; DRUG DESIGN; DRUG DNA INTERACTION; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; FLUORESCENCE IMAGING; HELA CELL LINE; HUMAN; HUMAN CELL; HYDROGEN BOND; IC50; IN VITRO STUDY; INTERCALATION COMPLEX; MOLECULAR BIOLOGY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; PHARMACOPHORE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TITRIMETRY; VISCOMETRY; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; METABOLISM; NEOPLASMS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CARBOLINES; CELL LINE, TUMOR; CELL PROLIFERATION; CHALCONE; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INTERCALATING AGENTS; MODELS, MOLECULAR; NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84924758104     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2015.02.007     Document Type: Article

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