Analogue-based design, synthesis and biological evaluation of 3-substituted-(methylenehydrazono)indolin-2-ones as anticancer agents

European Journal of Medicinal Chemistry

Volumn 78, Issue , 2014, Pages 275-280

  Dweedar, Haytham E ^a   Mahrous, Hoda ^a   Ibrahim, Hany S ^b   Abdel Aziz, Hatem A ^c,d  

^a UNIVERSITY OF SADAT CITY   (Egypt)

^b Egyptian Russian University   (Egypt)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

^d NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Analogue based design; Cancer; Human breast cell line MCF 7; Indoline 2,3 dione hydrazones; Molecular docking

Indexed keywords

3 [(FURAN 2 YLMETHYLENE)HYDRAZONO] 5 METHYLINDOLIN 2 ONE; 3 [(FURAN 2 YLMETHYLENE)HYDRAZONO]INDOLIN 2 ONE; 3 [(THIOPHEN 2 YLMETHYLENE)HYDRAZONO]INDOLIN 2 ONE; 3 [[( 1H PYRROL 2 YL)METHYLENE]HYDRAZONO] 5 CHLOROINDOLIN 2 ONE; 3 [[( 1H PYRROL 2 YL)METHYLENE]HYDRAZONO] 5 FLUOROINDOLIN 2 ONE; 3 [[( 1H PYRROL 2 YL)METHYLENE]HYDRAZONO] 5 METHYLINDOLIN 2 ONE; 3 [[( 1H PYRROL 2 YL)METHYLENE]HYDRAZONO]INDOLIN 2 ONE; 5 CHLORO 3 [(FURAN 2 YLMETHYLENE)HYDRAZONO]INDOLIN 2 ONE; 5 CHLORO 3 [(THIOPHEN 2 YLMETHYLENE)HYDRAZONO]INDOLIN 2 ONE; 5 FLUORO 3 [(FURAN 2 YLMETHYLENE)HYDRAZONO]INDOLIN 2 ONE; 5 FLUORO 3 [(THIOPHEN 2 YLMETHYLENE)HYDRAZONO]INDOLIN 2 ONE; 5 METHYL 3 [(THIOPHEN 2 YLMETHYLENE)HYDRAZONO]INDOLIN 2 ONE; ALDEHYDE DERIVATIVE; ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE 2; DOXORUBICIN; GLYCOGEN SYNTHASE KINASE 3BETA; HYDRAZINE; HYDRAZONE DERIVATIVE; UNCLASSIFIED DRUG; INDOLE DERIVATIVE; INDOLIN-2-ONE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; SUBSTITUTION REACTION; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; MCF 7 CELL LINE; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL CULTURE;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; HYDRAZONES; INDOLES; MCF-7 CELLS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84897438796     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.03.058     Document Type: Article

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