Design, synthesis and biological evaluation of novel 4-thiazolidinones containing indolin-2-one moiety as potential antitumor agent

European Journal of Medicinal Chemistry

Volumn 46, Issue 8, 2011, Pages 3509-3518

  Wang, Shuobing ^a   Zhao, Yanfang ^a   Zhang, Guogang ^a   Lv, Yingxiang ^a   Zhang, Ning ^a   Gong, Ping ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

4 thiazolidinone; Cytotoxic activities; Indolin 2 one; Synthesis

Indexed keywords

3 [3 [2 (DIMETHYLAMINO)ETHYL] 5 [2,4 DIFLUOROBENZYLIDENE] 4 OXO 2 THIAZOLIDINYLIDENE] 6 FLUOROINDOLIN 2 ONE; 3 [3 [2 (DIMETHYLAMINO)ETHYL] 5 [2,4 DIMETHOXYBENZYLIDENE] 4 OXO 2 THIAZOLIDINYLIDENE] 5 CHLOROINDOLIN 2 ONE; 3 [3 [2 (DIMETHYLAMINO)ETHYL] 5 [2,4 DIMETHOXYBENZYLIDENE] 4 OXO 2 THIAZOLIDINYLIDENE] 6 FLUOROINDOLIN 2 ONE; 3 [3 [2 (DIMETHYLAMINO)ETHYL] 5 [2,5 DIMETHOXYBENZYLIDENE] 4 OXO 2 THIAZOLIDINYLIDENE] 6 FLUOROINDOLIN 2 ONE; 3 [3 [2 (DIMETHYLAMINO)ETHYL] 5 [2,5 DIMETHOXYBENZYLIDENE] 4 OXO 2 THIAZOLIDINYLIDENE]INDOLIN 2 ONE; 3 [3 [2 (DIMETHYLAMINO)ETHYL] 5 [3,4 DIFLOUROBENZYLIDENE] 4 OXO 2 THIAZOLIDINYLIDENE] 5 METHYLINDOLIN 2 ONE; 3 [3 [2 (DIMETHYLAMINO)ETHYL] 5 [3,4 DIFLUOROBENZYLIDENE] 4 OXO 2 THIAZOLIDINYLIDENE] 5 FLUOROINDOLIN 2 ONE; 3 [3 [2 (DIMETHYLAMINO)ETHYL] 5 [3,4 METHOXYBENZYLIDENE] 4 OXO 2 THIAZOLIDINYLIDENE] 6 FLUOROINDOLIN 2 ONE; 3 [3 [2 (DIMETHYLAMINO)ETHYL] 5 [4 HYDROXYBENZYLIDENE] 4 OXO 2 THIAZOLIDINYLIDENE] 5 BROMOINDOLIN 2 ONE; 3 [3 [2 (DIMETHYLAMINO)ETHYL] 5 [4 HYDROXYBENZYLIDENE] 4 OXO 2 THIAZOLIDINYLIDENE] 5 CHLOROINDOLIN 2 ONE; 3 [3 [2 (DIMETHYLAMINO)ETHYL] 5 [4 HYDROXYBENZYLIDENE] 4 OXO 2 THIAZOLIDINYLIDENE] 5 FLUOROINDOLIN 2 ONE; 3 [3 [2 (DIMETHYLAMINO)ETHYL] 5 [4 HYDROXYBENZYLIDENE] 4 OXO 2 THIAZOLIDINYLIDENE] 5 METHYLINDOLIN 2 ONE; 3 [3 [2 (DIMETHYLAMINO)ETHYL] 5 [4 HYDROXYBENZYLIDENE] 4 OXO 2 THIAZOLIDINYLIDENE] 6 FLUOROINDOLIN 2 ONE; 3 [3 [2 (DIMETHYLAMINO)ETHYL] 5 [4 HYDROXYBENZYLIDENE] 4 OXO 2 THIAZOLIDINYLIDENE]INDOLIN 2 ONE; 3 [3 [2 (DIMETHYLAMINO)ETHYL] 5 [4 METHOXYBENZYLIDENE] 4 OXO 2 THIAZOLIDINYLIDENE] 6 FLUOROINDOLIN 2 ONE; 3 [3 [2 (DIMETHYLAMINO)ETHYL] 5 [[BENZO[D][1,3]DIOXOL 5 YL]METHYLENE] 4 OXO 2 THIAZOLIDINYLIDENE] 5 FLUOROINDOLIN 2 ONE; 3 [3 [2 (DIMETHYLAMINO)ETHYL] 5 [[BENZO[D][1,3]DIOXOL 5 YL]METHYLENE] 4 OXO 2 THIAZOLIDINYLIDENE] 6 FLUOROINDOLIN 2 ONE; 3 [3 [2 (DIMETHYLAMINO)ETHYL] 5 [[BENZO[D][1,3]DIOXOL 5 YL]METHYLENE] 4 OXO 2 THIAZOLIDINYLIDENE]INDOLIN 2 ONE; 3 [3 [2 (DIMETHYLAMINO)ETHYL] 5 [[BENZO[D][1,3]DIOXOL 5 YL]METHYLENE] 4 OXO 2 THIAZOLIDINYLIDENE]METHYLINDOLIN 2 ONE; 3 [3 [2 (DIMETHYLAMINO)PROPYL] 5 [[BENZO[D][1,3]DIOXOL 5 YL]METHYLENE] 4 OXO 2 THIAZOLIDINYLIDENE] 5 CHLOROINDOLIN 2 ONE; 3 [3 [2 (DIMETHYLAMINO)PROPYL] 5 [[BENZO[D][1,3]DIOXOL 5 YL]METHYLENE] 4 OXO 2 THIAZOLIDINYLIDENE] 5 FLUOROINDOLIN 2 ONE; 3 [3 [2 (DIMETHYLAMINO)PROPYL] 5 [[BENZO[D][1,3]DIOXOL 5 YL]METHYLENE] 4 OXO 2 THIAZOLIDINYLIDENE] 6 FLUOROINDOLIN 2 ONE; 3 [3 [2 (DIMETHYLAMINO)PROPYL] 5 [[BENZO[D][1,3]DIOXOL 5 YL]METHYLENE] 4 OXO 2 THIAZOLIDINYLIDENE]FLUOROINDOLIN 2 ONE; 3 [3 [2 (DIMETHYLAMINO)PROPYL] 5 [[BENZO[D][1,3]DIOXOL 5 YL]METHYLENE] 4 OXO 2 THIAZOLIDINYLIDENE]INDOLIN 2 ONE; 3 [3 [2 (DIMETHYLAMINO)PROPYL] 5 [[BENZO[D][1,3]DIOXOL 5 YL]METHYLENE] 4 OXO 2 THIAZOLIDINYLIDENE]METHYLINDOLIN 2 ONE; 4 THIAZOLIDINONE DERIVATIVE; ANTINEOPLASTIC AGENT; INDOLIN 2 ONE; SUNITINIB; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; FIBROBLASTS; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; LIVER NEOPLASMS; LUNG NEOPLASMS; PYRROLES; THIAZOLIDINES;

EID: 79958296582     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.05.017     Document Type: Article

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