Synthesis of 2-aryl-1,2,4-oxadiazolo-benzimidazoles: Tubulin polymerization inhibitors and apoptosis inducing agents

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 15, 2015, Pages 4608-4623

  Kamal, Ahmed ^a,b   Reddy, T Srinivasa ^a,b   Vishnuvardhan, M V P S ^a   Nimbarte, Vijaykumar D ^a,b   Subba Rao, A V ^a   Srinivasulu, Vunnam ^a   Shankaraiah, Nagula ^b  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

1,2,4 Oxadiazole; Apoptosis; Benzimidazole; Cytotoxicity; Molecular docking; Tubulin polymerization

Indexed keywords

2 ARYL 1,2,4 OXADIAZOLO BENZIMIDAZOLE DERIVATIVE; 3 [4 (1H BENZO[D]IMIDAZOL 2 YL)PHENYL] 5 (3,4,5 TRIMETHOXYPHENYL) 1,2,4 OXADIAZOLE; 3 [4 (1H BENZO[D]IMIDAZOL 2 YL)PHENYL] 5 (4 CHLOROPHENYL) 1,2,4 OXADIAZOLE; 3 [4 (1H BENZO[D]IMIDAZOL 2 YL)PHENYL] 5 (4 FLUOROPHENYL) 1,2,4 OXADIAZOLE; 3 [4 (1H BENZO[D]IMIDAZOL 2 YL)PHENYL] 5 (4 METHOXYPHENYL) 1,2,4 OXADIAZOLE; 3 [4 (1H BENZO[D]IMIDAZOL 2 YL)PHENYL] 5 4 TOLYL 1,2,4 OXADIAZOLE; 3 [4 (1H BENZO[D]IMIDAZOL 2 YL)PHENYL] 5 PHENYL 1,2,4 OXADIAZOLE; 3 [4 (5 CHLORO 1H BENZO[D]IMIDAZOL 2 YL)PHENYL] 5 (3,4,5 TRIMETHOXYPHENYL) 1,2,4 OXADIAZOLE; 3 [4 (5 CHLORO 1H BENZO[D]IMIDAZOL 2 YL)PHENYL] 5 (4 CHLOROPHENYL) 1,2,4 OXADIAZOLE; 3 [4 (5 CHLORO 1H BENZO[D]IMIDAZOL 2 YL)PHENYL] 5 (4 FLUOROPHENYL) 1,2,4 OXADIAZOLE; 3 [4 (5 CHLORO 1H BENZO[D]IMIDAZOL 2 YL)PHENYL] 5 (4 METHOXYPHENYL) 1,2,4 OXADIAZOLE; 3 [4 (5 CHLORO 1H BENZO[D]IMIDAZOL 2 YL)PHENYL] 5 4 TOLYL 1,2,4 OXADIAZOLE; 3 [4 (5 CHLORO 1H BENZO[D]IMIDAZOL 2 YL)PHENYL] 5 PHENYL 1,2,4 OXADIAZOLE; 3 [4 (5 FLUORO 1H BENZO[D]IMIDAZOL 2 YL)PHENYL] 5 (3,4,5 TRIMETHOXYPHENYL) 1,2,4 OXADIAZOLE; 3 [4 (5 FLUORO 1H BENZO[D]IMIDAZOL 2 YL)PHENYL] 5 (4 FLUOROPHENYL) 1,2,4 OXADIAZOLE; 3 [4 (5 FLUORO 1H BENZO[D]IMIDAZOL 2 YL)PHENYL] 5 (4 METHOXYPHENYL) 1,2,4 OXADIAZOLE; 3 [4 (5 FLUORO 1H BENZO[D]IMIDAZOL 2 YL)PHENYL] 5 4 TOLYL 1,2,4 OXADIAZOLE; 3 [4 (5 FLUORO 1H BENZO[D]IMIDAZOL 2 YL)PHENYL] 5 PHENYL 1,2,4 OXADIAZOLE; 3 [4 (5 METHOXY 1H BENZO[D]IMIDAZOL 2 YL)PHENYL] 5 (3,4,5 TRIMETHOXYPHENYL) 1,2,4 OXADIAZOLE; 3 [4 (5 METHOXY 1H BENZO[D]IMIDAZOL 2 YL)PHENYL] 5 (4 METHOXYPHENYL) 1,2,4 OXADIAZOLE; 3 [4 (5 METHOXY 1H BENZO[D]IMIDAZOL 2 YL)PHENYL] 5 4 TOLYL 1,2,4 OXADIAZOLE; 3 [4 (5 METHOXY 1H BENZO[D]IMIDAZOL 2 YL)PHENYL] 5 PHENYL 1,2,4 OXADIAZOLE; 5 (4 CHLOROPHENYL) 3 [4 (5 FLUORO 1H BENZO[D]IMIDAZOL 2 YL)PHENYL] 1,2,4 OXADIAZOLE; 5 (4 CHLOROPHENYL) 3 [4 (5 METHOXY 1H BENZO[D]IMIDAZOL 2 YL)PHENYL] 1,2,4 OXADIAZOLE; 5 (4 FLUOROPHENYL) 3 [4 (5 METHOXY 1H BENZO[D]IMIDAZOL 2 YL)PHENYL] 1,2,4 OXADIAZOLE; ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; NOCODAZOLE; TUBULIN; UNCLASSIFIED DRUG; LIPOCORTIN 5; PROPIDIUM IODIDE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BINDING SITE; CANCER CELL LINE; CELL MEMBRANE DEPOLARIZATION; CHROMATIN CONDENSATION; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG SYNTHESIS; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; MITOCHONDRIAL MEMBRANE; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DRUG EFFECTS; MITOCHONDRIAL MEMBRANE POTENTIAL; POLYMERIZATION; SYNTHESIS;

ANNEXIN A5; APOPTOSIS; BENZIMIDAZOLES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MOLECULAR DOCKING SIMULATION; POLYMERIZATION; PROPIDIUM;

EID: 84937978703     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.05.060     Document Type: Article

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