Design and synthesis of new benzimidazole-carbazole conjugates for the stabilization of human telomeric DNA, telomerase inhibition, and their selective action on cancer cells

Journal of Medicinal Chemistry

Volumn 57, Issue 16, 2014, Pages 6973-6988

  Maji, Basudeb ^a   Kumar, Krishan ^a   Kaulage, Mangesh ^a   Muniyappa, K ^a   Bhattacharya, Santanu ^a,b  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BENZIMIDAZOLE; BENZIMIDAZOLE DERIVATIVE; CARBAZOLE; CARBAZOLE DERIVATIVE; ENZYME INHIBITOR; GUANINE QUADRUPLEX; LIGAND; TELOMERASE;

ANTAGONISTS AND INHIBITORS; CELL DEATH; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; DRUG DESIGN; DRUG EFFECTS; DRUG SCREENING; GENETICS; HUMAN; IC50; METABOLISM; MOLECULAR DYNAMICS; NEOPLASMS; PATHOLOGY; PROCEDURES; SPECTROFLUOROMETRY; SYNTHESIS; TELOMERE; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; CARBAZOLES; CELL DEATH; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; CIRCULAR DICHROISM; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; G-QUADRUPLEXES; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; NEOPLASMS; SPECTROMETRY, FLUORESCENCE; TELOMERASE; TELOMERE;

EID: 84906874905     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500427n     Document Type: Article

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