Piperlongumine, an alkaloid causes inhibition of PI3 K/Akt/mTOR signaling axis to induce caspase-dependent apoptosis in human triple-negative breast cancer cells

Apoptosis

Volumn 19, Issue 7, 2014, Pages 1148-1164

  Shrivastava, Shweta ^a   Kulkarni, Prasad ^b   Thummuri, Dinesh ^a   Jeengar, Manish Kumar ^a   Naidu, V G M ^a   Alvala, Mallika ^a   Redddy, G Bhanuprakash ^c   Ramakrishna, Sistla ^b  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^c NATIONAL INSTITUTE OF NUTRITION   (India)

Author keywords

Apoptosis; Human triple negative breast cancer; PI3 K Akt mTOR dual inhibitor; Piperlongumine

Indexed keywords

ALKALOID DERIVATIVE; CASPASE; CYCLIN D1; CYTOCHROME C; ENZYME INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; PF 04691502; PHOSPHATIDYLINOSITOL 3 KINASE; PIPERLONGUMINE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P53; S6 KINASE; UNCLASSIFIED DRUG; 1,3 DIOXOLANE DERIVATIVE; ALKALOID; MTOR PROTEIN, HUMAN; PIPERLONGUMININE; REACTIVE OXYGEN METABOLITE; TARGET OF RAPAMYCIN KINASE;

APOPTOSIS; ARTICLE; BREAST CANCER CELL LINE; CANCER INHIBITION; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG EFFECT; ENZYME INHIBITION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; INSULIN TREATMENT; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRIPLE NEGATIVE BREAST CANCER; CELL CYCLE CHECKPOINT; DNA FRAGMENTATION; DRUG EFFECTS; FEMALE; GENETICS; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ALKALOIDS; APOPTOSIS; CASPASES; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; DIOXOLANES; DNA FRAGMENTATION; FEMALE; HUMANS; MOLECULAR DOCKING SIMULATION; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRIPLE NEGATIVE BREAST NEOPLASMS;

EID: 84902550498     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-014-0991-2     Document Type: Article

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