Synthesis and anticancer activity of oxindole derived imidazo[1,5-a] pyrazines

European Journal of Medicinal Chemistry

Volumn 46, Issue 6, 2011, Pages 2427-2435

  Kamal, Ahmed ^a   Ramakrishna, G ^a   Raju, P ^a   Rao, A V Subba ^a   Viswanath, A ^a   Nayak, V Lakshma ^a   Ramakrishna, Sistla ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Annexin V FITC; Anticancer activity; Apoptosis; Cell cycle arrest; DNA fragmentation; G0 G1; Hoechst staining; Imidazo 1,5 a pyrazines

Indexed keywords

3 (2 FLUOROPHENYL)IMIDAZO[1,5 A]PYRIDINE; 3 (2 FLUOROPHENYL)IMIDAZO[1,5 A]PYRIDINE 1 CARBALDEHYDE; 3 (3 FLUOROPHENYL)IMIDAZO[1,5 A]PYRIDINE; 3 (3 FLUOROPHENYL)IMIDAZO[1,5 A]PYRIDINE 1 CARBALDEHYDE; 3 (3,4 DIMETHOXYPHENYL)IMIDAZO[1,5 A]PYRIDINE; 3 (3,4 DIMETHOXYPHENYL)IMIDAZO[1,5 A]PYRIDINE 1 CARBALDEHYDE; 3 (3,4,5 TRIMETHOXYPHENYL)IMIDAZO[1,5 A]PYRIDINE; 3 (3,4,5 TRIMETHOXYPHENYL)IMIDAZO[1,5 A]PYRIDINE 1 CARBALDEHYDE; 3 (4 FLUOROPHENYL)IMIDAZO[1,5 A]PYRIDINE; 3 (4 FLUOROPHENYL)IMIDAZO[1,5 A]PYRIDINE 1 CARBALDEHYDE; 3 (4 METHOXYPHENYL)IMIDAZO[1,5 A]PYRIDINE; 3 (4 METHOXYPHENYL)IMIDAZO[1,5 A]PYRIDINE 1 CARBALDEHYDE; 3 (4 METHYLPHENYL)IMIDAZO[1,5 A]PYRIDINE; 3 (4 METHYLPHENYL)IMIDAZO[1,5 A]PYRIDINE 1 CARBALDEHYDE; 3 1 [3 (4 METHYLPHENYL)IMIDAZO[1,5 A]PYRIDIN 1 YL]METHYLIDENE 2 INDOLINONE; 3 [1 (3 PHENYLIMIDAZO[1,5 A]PYRIDIN 1 YL)METHYLIDENE] 2 INDOLINONE; 3 PHENYLIMIDAZO[1,5 A]PYRIDINE; 3 PHENYLIMIDAZO[1,5 A]PYRIDINE 1 CARBALDEHYDE; ANTINEOPLASTIC AGENT; IMIDAZOPYRAZINE DERIVATIVE; INDOLE DERIVATIVE; N1 (2 PYRIDYLMETHYL) 2 FLUOROBENZAMIDE; N1 (2 PYRIDYLMETHYL) 3 FLUOROBENZAMIDE; N1 (2 PYRIDYLMETHYL) 3,4 DIMETHOXYBENZAMIDE; N1 (2 PYRIDYLMETHYL) 3,4,5 TRIMETHOXYBENZAMIDE; N1 (2 PYRIDYLMETHYL) 4 FLUOROBENZAMIDE; N1 (2 PYRIDYLMETHYL) 4 METHOXYBENZAMIDE; N1 (2 PYRIDYLMETHYL) 4 METHYLBENZAMIDE; N1 (2 PYRIDYLMETHYL)BENZAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CENTRAL NERVOUS SYSTEM TUMOR; COLON CANCER; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LEUKEMIA; LUNG CANCER; MELANOMA; OVARY CANCER; PROSTATE CANCER; PROTON NUCLEAR MAGNETIC RESONANCE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; IMIDAZOLES; INDOLES; MOLECULAR STRUCTURE; PYRAZINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 79955612412     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.03.027     Document Type: Article

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