Synthesis of (Z)-1-(1,3-diphenyl-1 H -pyrazol-4-yl)-3-(phenylamino)prop-2-en-1-one derivatives as potential anticancer and apoptosis inducing agents

European Journal of Medicinal Chemistry

Volumn 117, Issue , 2016, Pages 157-166

  Reddy, T Srinivasa ^a,b   Reddy, V Ganga ^a   Kulhari, Hitesh ^a,b   Shukla, Ravi ^b   Kamal, Ahmed ^a   Bansal, Vipul ^b  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b RMIT UNIVERSITY   (Australia)

Author keywords

Anti cancer activity; Apoptosis; Cell cycle; Pyrazole

Indexed keywords

1 (1,3 DIPHENYL 1H PYRAZOL 4 YL) 3 (PHENYLAMINO) PROP 2 EN 1 ONE DERIVATIVE; 1 (1,3 DIPHENYL 1H PYRAZOL 4 YL) 3 [(3,4,5 TRIMETHOXYPHENYL)AMINO] PROP 2 EN 1 ONE; 1 (1,3 DIPHENYL 1H PYRAZOL 4 YL) 3 [(4 FLUOROPHENYL)AMINO] PROP 2 EN 1 ONE; 1 (1,3 DIPHENYL 1H PYRAZOL 4 YL) 3 [(4 HYDROXYPHENYL)AMINO] PROP 2 EN 1 ONE; 1 (1,3 DIPHENYL 1H PYRAZOL 4 YL) 3 [(4 METHOXYPHENYL)AMINO] PROP 2 EN 1 ONE; 1 (1,3 DIPHENYL 1H PYRAZOL 4 YL) 3 [[4 (TRIFLUOROMETHYL)PHENYL]AMINO] PROP 2 EN 1 ONE; 1 [1 PHENYL 3 (3,4,5 TRIMETHOXYPHENYL) 1H PYRAZOL 4 YL] 3 [[4 (TRIFLUOROMETHYL)PHENYL]AMINO]PROP 2 EN 1 ONE; 1 [3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 3 [(3,4,5 TRIMETHOXYPHENYL)AMINO]PROP 2 EN 1 ONE; 1 [3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 3 [(4 CHLORPHENYL)AMINO]PROP 2 EN 1 ONE; 1 [3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 3 [(4 FLUOROPHENYL)AMINO]PROP 2 EN 1 ONE; 1 [3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 3 [(4 HYDROXYPHENYL)AMINO]PROP 2 EN 1 ONE; 1 [3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 3 [(4 METHOXYPHENYL)AMINO]PROP 2 EN 1 ONE; 1 [3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 3 [[4 (TRIFLUOROMETHYL)PHENYL]AMINO]PROP 2 EN 1 ONE; 1 [3 (4 FLUOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 3 [(3,4,5 TRIMETHOXYPHENYL)AMINO]PROP 2 EN 1 ONE; 1 [3 (4 FLUOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 3 [(4 FLUOROPHENYL)AMINO]PROP 2 EN 1 ONE; 1 [3 (4 FLUOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 3 [(4 HYDROXYPHENYL)AMINO]PROP 2 EN 1 ONE; 1 [3 (4 FLUOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 3 [(4 METHOXYPHENYL)AMINO]PROP 2 EN 1 ONE; 1 [3 (4 FLUOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 3 [[4 (TRIFLUOROMETHYL)PHENYL]AMINO]PROP 2 EN 1 ONE; 1 [3 (4 METHOXYPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 3 [(3,4,5 TRIMETHOXYPHENYL)AMINO]PROP 2 EN 1 ONE; 1 [3 (4 METHOXYPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 3 [(4 METHOXYPHENYL)AMINO]PROP 2 EN 1 ONE; 3 [(4 CHLOROPHENYL)AMINO] 1 (1,3 DIPHENYL 1H PYRAZOL 4 YL PROP 2 EN 1 ONE; 3 [(4 CHLOROPHENYL)AMINO] 1 [3 (4 FLUOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] PROP 2 EN 1 ONE; 3 [(4 FLUOROPHENYL)AMINO] 1 [1 PHENYL (3,4,5 TRIMETHOXYPHENYL) 1H PYRAZOL 4 YL] PROP 2 EN 1 ONE; 3 [(4 HYDROXYPHENYL)AMINO] 1 [1 PHENYL (3,4,5 TRIMETHOXYPHENYL) 1H PYRAZOL 4 YL] PROP 2 EN 1 ONE; 3 [(4 HYDROXYPHENYL)AMINO] 1 [3 (4 METHOXYPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] PROP 2 EN 1 ONE; 3 [(4 METHOXYPHENYL)AMINO] 1 [1 PHENYL (3,4,5 TRIMETHOXYPHENYL) 1H PYRAZOL 4 YL] PROP 2 EN 1 ONE; ANTINEOPLASTIC AGENT; FLUOROURACIL; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; REACTIVE OXYGEN METABOLITE;

ACTIN POLYMERIZATION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BRAIN CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CYCLE G1 PHASE; COLON CANCER; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; ELECTRON TRANSPORT; ELECTROSPRAY MASS SPECTROMETRY; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; LUNG CANCER; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; PROSTATE CANCER; PROTON NUCLEAR MAGNETIC RESONANCE; A-549 CELL LINE; CELL MOTION; DRUG EFFECTS; DRUG SCREENING; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

A549 CELLS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL MOVEMENT; DRUG SCREENING ASSAYS, ANTITUMOR; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; PYRAZOLES; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84963804488     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2016.03.051     Document Type: Article

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