Synthesis and biological evaluation of 5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one structural derivatives as anti-cancer and apoptosis inducing agents

European Journal of Medicinal Chemistry

Volumn 108, Issue , 2016, Pages 674-686

  Praveen Kumar, Chintakunta ^a,b   Reddy, T Srinivasa ^a   Mainkar, Prathama S ^b   Bansal, Vipul ^a   Shukla, Ravi ^a   Chandrasekhar, Srivari ^b   Hügel, Helmut M ^a  

^a RMIT UNIVERSITY   (Australia)

^b INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Anti cancer activity; Apoptosis; Dibenzodiazepinones; Triazoles

Indexed keywords

10 (PROP 2 YN 1 YL) 5,10 DIHYDRO 11H DIBENZO[B,E] [1,4]DIAZEPIN 11 ONE; 10 [(1 BENZYL 1H 1,2,3 TRIAZOL 4 YL)METHYL] 5,10 DIHYDRO 11H DIBENZO[B,E] [1,4]DIAZEPIN 11 ONE; 10 [[1 (2 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 5,10 DIHYDRO 11H DIBENZO[B,E][1,4]DIAZEPIN 11 ONE; 10 [[1 (3 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 5,10 DIHYDRO 11H DIBENZO[B,E][1,4]DIAZEPIN 11 ONE; 10 [[1 (3 NITROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 5,10 DIHYDRO 11H DIBENZO[B,E][1,4]DIAZEPIN 11 ONE; 10 [[1 (3,4,5 TRIMETHOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 5,10 DIHYDRO 11H DIBENZO[B,E][1,4]DIAZEPIN 11 ONE; 10 [[1 (4 CHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 5,10 DIHYDRO 11H DIBENZO[B,E][1,4]DIAZEPIN 11 ONE; 10 [[1 (4 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 5,10 DIHYDRO 11H DIBENZO[B,E][1,4]DIAZEPIN 11 ONE; 10 [[1 (4 NITROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 5,10 DIHYDRO 11H DIBENZO[B,E][1,4]DIAZEPIN 11 ONE; 10 [[1 (BENZO[D][1,3]DIOXOL 4 YLMETHYL] 1H 1,2,3 TRIAZOL 4 YL]METHYL] 5,10 DIHYDRO 11H DIBENZO[B,E][1,4]DIAZEPIN 11 ONE; 10 [[1 [2 (TRIFLUOROMETHOXY)BENZYL] 1H 1,2,3 TRIAZOL 4 YL]METHYL] 5,10 DIHYDRO 11H DIBENZO[B,E][1,4]DIAZEPIN 11 ONE; 5,10 DIHYDRO 11H DIBENZO[B,E][1,4]DIAZEPIN 11 ONE; ANTINEOPLASTIC AGENT; BENZODIAZEPINE DERIVATIVE; FLUOROURACIL; REACTIVE OXYGEN METABOLITE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; 5,10-DIHYDRO-11H-DIBENZO(B,E)(1,4)DIAZEPIN-11-ONE; AZEPINE DERIVATIVE;

A549 CELL LINE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; BREAST CANCER CELL LINE; CANCER INHIBITION; CELL PROLIFERATION; CLINICAL EVALUATION; CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC50; MITOCHONDRIAL MEMBRANE POTENTIAL; STAINING; CELL CYCLE; CELL MOTION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL CULTURE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; AZEPINES; CELL CYCLE; CELL MOVEMENT; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MOLECULAR STRUCTURE; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84952642394     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.12.007     Document Type: Article

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