메뉴 건너뛰기




Volumn 222, Issue 1, 2017, Pages 89-100

Toll-like receptor stimulation in cancer: A pro- and anti-tumor double-edged sword

Author keywords

Anti tumoral effect; Immune cells; Pro tumoral effect; TLR; TLR signaling; Tumor cells

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CYCLIN B1; DEFOSLIMOD; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; HEAT SHOCK PROTEIN; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; MYC PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PICIBANIL; PROTEIN P16; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 11; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TRANSFORMING GROWTH FACTOR BETA; UNINDEXED DRUG; VASCULOTROPIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

EID: 84977579665     PISSN: 01712985     EISSN: 18783279     Source Type: Journal    
DOI: 10.1016/j.imbio.2016.06.009     Document Type: Review
Times cited : (170)

References (151)
  • 1
    • 77953469710 scopus 로고    scopus 로고
    • Toll-like receptor agonists in cancer therapy
    • Adams, S., Toll-like receptor agonists in cancer therapy. Immunotherapy 1 (2009), 949–964.
    • (2009) Immunotherapy , vol.1 , pp. 949-964
    • Adams, S.1
  • 2
    • 84892784488 scopus 로고    scopus 로고
    • Silencing of TLR4 increases tumor progression and lung metastasis in a murine model of breast cancer
    • Ahmed, A., Wang, J.H., Redmond, H.P., Silencing of TLR4 increases tumor progression and lung metastasis in a murine model of breast cancer. Ann. Surg. Oncol. 20:Suppl. 3 (2013), S389–S396.
    • (2013) Ann. Surg. Oncol. , vol.20 , pp. S389-S396
    • Ahmed, A.1    Wang, J.H.2    Redmond, H.P.3
  • 3
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira, S., Uematsu, S., Takeuchi, O., Pathogen recognition and innate immunity. Cell 124 (2006), 783–801.
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 5
    • 84922391749 scopus 로고    scopus 로고
    • Imiquimod inhibits melanoma development by promoting pDC cytotoxic functions and impeding tumor vascularization
    • Aspord, C., Tramcourt, L., Leloup, C., Molens, J.-P., Leccia, M.-T., Charles, J., Plumas, J., Imiquimod inhibits melanoma development by promoting pDC cytotoxic functions and impeding tumor vascularization. J. Invest. Dermatol. 134 (2014), 2551–2561.
    • (2014) J. Invest. Dermatol. , vol.134 , pp. 2551-2561
    • Aspord, C.1    Tramcourt, L.2    Leloup, C.3    Molens, J.-P.4    Leccia, M.-T.5    Charles, J.6    Plumas, J.7
  • 6
    • 4644335311 scopus 로고    scopus 로고
    • Cancer: an inflammatory link
    • Balkwill, F., Coussens, L.M., Cancer: an inflammatory link. Nature 431 (2004), 405–406.
    • (2004) Nature , vol.431 , pp. 405-406
    • Balkwill, F.1    Coussens, L.M.2
  • 7
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: back to Virchow?
    • Balkwill, F., Mantovani, A., Inflammation and cancer: back to Virchow?. Lancet Lond. Engl. 357 (2001), 539–545.
    • (2001) Lancet Lond. Engl. , vol.357 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 9
    • 84868101247 scopus 로고    scopus 로고
    • Roles of Toll-like receptors in cancer: a double-edged sword for defense and offense
    • Basith, S., Manavalan, B., Yoo, T.H., Kim, S.G., Choi, S., Roles of Toll-like receptors in cancer: a double-edged sword for defense and offense. Arch. Pharm. Res. 35 (2012), 1297–1316.
    • (2012) Arch. Pharm. Res. , vol.35 , pp. 1297-1316
    • Basith, S.1    Manavalan, B.2    Yoo, T.H.3    Kim, S.G.4    Choi, S.5
  • 11
    • 0036839577 scopus 로고    scopus 로고
    • Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses
    • Beg, A.A., Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses. Trends Immunol. 23 (2002), 509–512.
    • (2002) Trends Immunol. , vol.23 , pp. 509-512
    • Beg, A.A.1
  • 12
    • 84890125832 scopus 로고    scopus 로고
    • Expression of TLR9 in tumor-infiltrating mononuclear cells enhances angiogenesis and is associated with a worse survival in lung cancer
    • Belmont, L., Rabbe, N., Antoine, M., Cathelin, D., Guignabert, C., Kurie, J., Cadranel, J., Wislez, M., Expression of TLR9 in tumor-infiltrating mononuclear cells enhances angiogenesis and is associated with a worse survival in lung cancer. Int. J. Cancer J. Int. Cancer 134 (2014), 765–777.
    • (2014) Int. J. Cancer J. Int. Cancer , vol.134 , pp. 765-777
    • Belmont, L.1    Rabbe, N.2    Antoine, M.3    Cathelin, D.4    Guignabert, C.5    Kurie, J.6    Cadranel, J.7    Wislez, M.8
  • 14
    • 33845951211 scopus 로고    scopus 로고
    • DAMPs, PAMPs and alarmins: all we need to know about danger
    • Bianchi, M.E., DAMPs, PAMPs and alarmins: all we need to know about danger. J. Leukoc. Biol. 81 (2007), 1–5.
    • (2007) J. Leukoc. Biol. , vol.81 , pp. 1-5
    • Bianchi, M.E.1
  • 17
    • 79953320415 scopus 로고    scopus 로고
    • Activation of Toll-like receptor 5 on breast cancer cells by flagellin suppresses cell proliferation and tumor growth
    • Cai, Z., Sanchez, A., Shi, Z., Zhang, T., Liu, M., Zhang, D., Activation of Toll-like receptor 5 on breast cancer cells by flagellin suppresses cell proliferation and tumor growth. Cancer Res. 71 (2011), 2466–2475.
    • (2011) Cancer Res. , vol.71 , pp. 2466-2475
    • Cai, Z.1    Sanchez, A.2    Shi, Z.3    Zhang, T.4    Liu, M.5    Zhang, D.6
  • 21
    • 33846211375 scopus 로고    scopus 로고
    • Inflammation, cancer and chemoresistance: taking advantage of the Toll-like receptor signaling pathway
    • Chen, R., Alvero, A.B., Silasi, D.-A., Mor, G., Inflammation, cancer and chemoresistance: taking advantage of the Toll-like receptor signaling pathway. Am. J. Reprod. Immunol. N. Y. 198:57 (2007), 93–107.
    • (2007) Am. J. Reprod. Immunol. N. Y. , vol.198 , Issue.57 , pp. 93-107
    • Chen, R.1    Alvero, A.B.2    Silasi, D.-A.3    Mor, G.4
  • 25
    • 33846993355 scopus 로고    scopus 로고
    • The in vivo antitumoral effects of lipopolysaccharide against glioblastoma multiforme are mediated in part by Toll-like receptor 4
    • (discussion 381)
    • Chicoine, M.R., Zahner, M., Won, E.K., Kalra, R.R., Kitamura, T., Perry, A., Higashikubo, R., The in vivo antitumoral effects of lipopolysaccharide against glioblastoma multiforme are mediated in part by Toll-like receptor 4. Neurosurgery 60 (2007), 372–380 (discussion 381).
    • (2007) Neurosurgery , vol.60 , pp. 372-380
    • Chicoine, M.R.1    Zahner, M.2    Won, E.K.3    Kalra, R.R.4    Kitamura, T.5    Perry, A.6    Higashikubo, R.7
  • 26
    • 77950787070 scopus 로고    scopus 로고
    • Toll-like receptor 3-mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance
    • Chin, A.I., Miyahira, A.K., Covarrubias, A., Teague, J., Guo, B., Dempsey, P.W., Cheng, G., Toll-like receptor 3-mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance. Cancer Res. 70 (2010), 2595–2603.
    • (2010) Cancer Res. , vol.70 , pp. 2595-2603
    • Chin, A.I.1    Miyahira, A.K.2    Covarrubias, A.3    Teague, J.4    Guo, B.5    Dempsey, P.W.6    Cheng, G.7
  • 27
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens, L.M., Werb, Z., Inflammation and cancer. Nature 420 (2002), 860–867.
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 28
    • 19444386768 scopus 로고    scopus 로고
    • Antitumour effect of OM-174 and cyclophosphamide on murine B16 melanoma in different experimental conditions
    • D'Agostini, C., Pica, F., Febbraro, G., Grelli, S., Chiavaroli, C., Garaci, E., Antitumour effect of OM-174 and cyclophosphamide on murine B16 melanoma in different experimental conditions. Int. Immunopharmacol. 5 (2005), 1205–1212.
    • (2005) Int. Immunopharmacol. , vol.5 , pp. 1205-1212
    • D'Agostini, C.1    Pica, F.2    Febbraro, G.3    Grelli, S.4    Chiavaroli, C.5    Garaci, E.6
  • 29
    • 84954525988 scopus 로고    scopus 로고
    • Dual roles of TLR7 in the lung cancer microenvironment
    • Dajon, M., Iribarren, K., Cremer, I., Dual roles of TLR7 in the lung cancer microenvironment. Oncoimmunology, 4, 2015, e991615.
    • (2015) Oncoimmunology , vol.4 , pp. e991615
    • Dajon, M.1    Iribarren, K.2    Cremer, I.3
  • 31
  • 32
    • 0037396989 scopus 로고    scopus 로고
    • Coordinated tumor immunity
    • Dranoff, G., Coordinated tumor immunity. J. Clin. Invest. 111 (2003), 1116–1118.
    • (2003) J. Clin. Invest. , vol.111 , pp. 1116-1118
    • Dranoff, G.1
  • 35
    • 33749003484 scopus 로고    scopus 로고
    • Stimulation of TLR9 with CpG ODN enhances apoptosis of glioma and prolongs the survival of mice with experimental brain tumors
    • El Andaloussi, A., Sonabend, A.M., Han, Y., Lesniak, M.S., Stimulation of TLR9 with CpG ODN enhances apoptosis of glioma and prolongs the survival of mice with experimental brain tumors. Glia 54 (2006), 526–535.
    • (2006) Glia , vol.54 , pp. 526-535
    • El Andaloussi, A.1    Sonabend, A.M.2    Han, Y.3    Lesniak, M.S.4
  • 36
    • 84929583365 scopus 로고    scopus 로고
    • Targeting Toll-like receptor 2 inhibits growth of head and neck squamous cell carcinoma
    • Farnebo, L., Shahangian, A., Lee, Y., Shin, J.H., Scheeren, F.A., Sunwoo, J.B., Targeting Toll-like receptor 2 inhibits growth of head and neck squamous cell carcinoma. Oncotarget 6 (2015), 9897–9907.
    • (2015) Oncotarget , vol.6 , pp. 9897-9907
    • Farnebo, L.1    Shahangian, A.2    Lee, Y.3    Shin, J.H.4    Scheeren, F.A.5    Sunwoo, J.B.6
  • 39
    • 84858800620 scopus 로고    scopus 로고
    • The immune contexture in human tumours: impact on clinical outcome
    • Fridman, W.H., Pagès, F., Sautès-Fridman, C., Galon, J., The immune contexture in human tumours: impact on clinical outcome. Nat. Rev. Cancer 12 (2012), 298–306.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 298-306
    • Fridman, W.H.1    Pagès, F.2    Sautès-Fridman, C.3    Galon, J.4
  • 43
    • 84997611267 scopus 로고    scopus 로고
    • Immune modulating effects of cyclophosphamide and treatment with tumor lysate/CpG synergize to eliminate murine neuroblastoma
    • Gershan, J.A., Barr, K.M., Weber, J.J., Jing, W., Johnson, B.D., Immune modulating effects of cyclophosphamide and treatment with tumor lysate/CpG synergize to eliminate murine neuroblastoma. J. Immunother. Cancer, 3, 2015, 24.
    • (2015) J. Immunother. Cancer , vol.3 , pp. 24
    • Gershan, J.A.1    Barr, K.M.2    Weber, J.J.3    Jing, W.4    Johnson, B.D.5
  • 45
    • 4043088499 scopus 로고    scopus 로고
    • IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • Greten, F.R., Eckmann, L., Greten, T.F., Park, J.M., Li, Z.-W., Egan, L.J., Kagnoff, M.F., Karin, M., IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118 (2004), 285–296.
    • (2004) Cell , vol.118 , pp. 285-296
    • Greten, F.R.1    Eckmann, L.2    Greten, T.F.3    Park, J.M.4    Li, Z.-W.5    Egan, L.J.6    Kagnoff, M.F.7    Karin, M.8
  • 46
    • 77957196909 scopus 로고    scopus 로고
    • Toll-like receptor (TLR) 7 and TLR8 expression on CD133+ cells in colorectal cancer points to a specific role for inflammation-induced TLRs in tumourigenesis and tumour progression
    • Grimm, M., Kim, M., Rosenwald, A., Heemann, U., Germer, C.-T., Waaga-Gasser, A.M., Gasser, M., Toll-like receptor (TLR) 7 and TLR8 expression on CD133+ cells in colorectal cancer points to a specific role for inflammation-induced TLRs in tumourigenesis and tumour progression. Eur. J. Cancer Oxf. Engl. 1990:46 (2010), 2849–2857.
    • (2010) Eur. J. Cancer Oxf. Engl. , vol.1990 , Issue.46 , pp. 2849-2857
    • Grimm, M.1    Kim, M.2    Rosenwald, A.3    Heemann, U.4    Germer, C.-T.5    Waaga-Gasser, A.M.6    Gasser, M.7
  • 48
    • 84940063312 scopus 로고    scopus 로고
    • The influence of TLR4 agonist lipopolysaccharides on hepatocellular carcinoma cells and the feasibility of its application in treating liver cancer
    • Gu, J., Sun, R., Shen, S., Yu, Z., The influence of TLR4 agonist lipopolysaccharides on hepatocellular carcinoma cells and the feasibility of its application in treating liver cancer. OncoTargets Ther. 8 (2015), 2215–2225.
    • (2015) OncoTargets Ther. , vol.8 , pp. 2215-2225
    • Gu, J.1    Sun, R.2    Shen, S.3    Yu, Z.4
  • 49
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D., Weinberg, R.A., The hallmarks of cancer. Cell 100 (2000), 57–70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 50
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan, D., Weinberg, R.A., Hallmarks of cancer: the next generation. Cell 144 (2011), 646–674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 51
    • 20044368019 scopus 로고    scopus 로고
    • Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88
    • Hasan, U., Chaffois, C., Gaillard, C., Saulnier, V., Merck, E., Tancredi, S., Guiet, C., Brière, F., Vlach, J., Lebecque, S., et al. Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88. J. Immunol. Baltim. Md 1950:174 (2005), 2942–2950.
    • (2005) J. Immunol. Baltim. Md , vol.1950 , Issue.174 , pp. 2942-2950
    • Hasan, U.1    Chaffois, C.2    Gaillard, C.3    Saulnier, V.4    Merck, E.5    Tancredi, S.6    Guiet, C.7    Brière, F.8    Vlach, J.9    Lebecque, S.10
  • 53
    • 33947179887 scopus 로고    scopus 로고
    • TLR4 signaling promotes immune escape of human lung cancer cells by inducing immunosuppressive cytokines and apoptosis resistance
    • He, W., Liu, Q., Wang, L., Chen, W., Li, N., Cao, X., TLR4 signaling promotes immune escape of human lung cancer cells by inducing immunosuppressive cytokines and apoptosis resistance. Mol. Immunol. 44 (2007), 2850–2859.
    • (2007) Mol. Immunol. , vol.44 , pp. 2850-2859
    • He, W.1    Liu, Q.2    Wang, L.3    Chen, W.4    Li, N.5    Cao, X.6
  • 54
    • 0346366980 scopus 로고    scopus 로고
    • Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2
    • Hertz, C.J., Wu, Q., Porter, E.M., Zhang, Y.J., Weismüller, K.-H., Godowski, P.J., Ganz, T., Randell, S.H., Modlin, R.L., Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2. J. Immunol. Baltim. Md 1950:171 (2003), 6820–6826.
    • (2003) J. Immunol. Baltim. Md , vol.1950 , Issue.171 , pp. 6820-6826
    • Hertz, C.J.1    Wu, Q.2    Porter, E.M.3    Zhang, Y.J.4    Weismüller, K.-H.5    Godowski, P.J.6    Ganz, T.7    Randell, S.H.8    Modlin, R.L.9
  • 56
    • 20444500241 scopus 로고    scopus 로고
    • Mammalian Toll-like receptors: to immunity and beyond
    • Hopkins, P.A., Sriskandan, S., Mammalian Toll-like receptors: to immunity and beyond. Clin. Exp. Immunol. 140 (2005), 395–407.
    • (2005) Clin. Exp. Immunol. , vol.140 , pp. 395-407
    • Hopkins, P.A.1    Sriskandan, S.2
  • 57
    • 0142157000 scopus 로고    scopus 로고
    • Intracellular recognition of lipopolysaccharide by Toll-like receptor 4 in intestinal epithelial cells
    • Hornef, M.W., Normark, B.H., Vandewalle, A., Normark, S., Intracellular recognition of lipopolysaccharide by Toll-like receptor 4 in intestinal epithelial cells. J. Exp. Med. 198 (2003), 1225–1235.
    • (2003) J. Exp. Med. , vol.198 , pp. 1225-1235
    • Hornef, M.W.1    Normark, B.H.2    Vandewalle, A.3    Normark, S.4
  • 58
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of Toll-like receptor 1–10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Hornung, V., Rothenfusser, S., Britsch, S., Krug, A., Jahrsdörfer, B., Giese, T., Endres, S., Hartmann, G., Quantitative expression of Toll-like receptor 1–10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol. Baltim. Md 1950:168 (2002), 4531–4537.
    • (2002) J. Immunol. Baltim. Md , vol.1950 , Issue.168 , pp. 4531-4537
    • Hornung, V.1    Rothenfusser, S.2    Britsch, S.3    Krug, A.4    Jahrsdörfer, B.5    Giese, T.6    Endres, S.7    Hartmann, G.8
  • 61
  • 62
    • 84894080015 scopus 로고    scopus 로고
    • Toll receptor agonist therapy of skin cancer and cutaneous T-cell lymphoma
    • Huen, A.O., Rook, A.H., Toll receptor agonist therapy of skin cancer and cutaneous T-cell lymphoma. Curr. Opin. Oncol. 26 (2014), 237–244.
    • (2014) Curr. Opin. Oncol. , vol.26 , pp. 237-244
    • Huen, A.O.1    Rook, A.H.2
  • 63
    • 84913612246 scopus 로고    scopus 로고
    • Role of Toll-like receptors in cervical, endometrial and ovarian cancers: a review
    • Husseinzadeh, N., Davenport, S.M., Role of Toll-like receptors in cervical, endometrial and ovarian cancers: a review. Gynecol. Oncol. 135 (2014), 359–363.
    • (2014) Gynecol. Oncol. , vol.135 , pp. 359-363
    • Husseinzadeh, N.1    Davenport, S.M.2
  • 65
    • 84929024875 scopus 로고    scopus 로고
    • TLR4 activation by lipopolysaccharide confers survival advantage to growth factor deprived prostate cancer cells
    • Jain, S., Suklabaidya, S., Das, B., Raghav, S.K., Batra, S.K., Senapati, S., TLR4 activation by lipopolysaccharide confers survival advantage to growth factor deprived prostate cancer cells. The Prostate 75 (2015), 1020–1033.
    • (2015) The Prostate , vol.75 , pp. 1020-1033
    • Jain, S.1    Suklabaidya, S.2    Das, B.3    Raghav, S.K.4    Batra, S.K.5    Senapati, S.6
  • 67
    • 33744465220 scopus 로고    scopus 로고
    • Pathogen-associated molecular patterns are growth and survival factors for human myeloma cells through Toll-like receptors
    • Jego, G., Bataille, R., Geffroy-Luseau, A., Descamps, G., Pellat-Deceunynck, C., Pathogen-associated molecular patterns are growth and survival factors for human myeloma cells through Toll-like receptors. Leukemia 20 (2006), 1130–1137.
    • (2006) Leukemia , vol.20 , pp. 1130-1137
    • Jego, G.1    Bataille, R.2    Geffroy-Luseau, A.3    Descamps, G.4    Pellat-Deceunynck, C.5
  • 68
    • 39449118809 scopus 로고    scopus 로고
    • Poly I:C enhances cycloheximide-induced apoptosis of tumor cells through TLR3 pathway
    • Jiang, Q., Wei, H., Tian, Z., Poly I:C enhances cycloheximide-induced apoptosis of tumor cells through TLR3 pathway. BMC Cancer, 8, 2008, 12.
    • (2008) BMC Cancer , vol.8 , pp. 12
    • Jiang, Q.1    Wei, H.2    Tian, Z.3
  • 70
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-kappaB in cancer development and progression
    • Karin, M., Nuclear factor-kappaB in cancer development and progression. Nature 441 (2006), 431–436.
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 71
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
    • Kawai, T., Akira, S., The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11 (2010), 373–384.
    • (2010) Nat. Immunol. , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 75
    • 84898010578 scopus 로고    scopus 로고
    • A flagellin-derived Toll-like receptor 5 agonist stimulates cytotoxic lymphocyte-mediated tumor immunity
    • Leigh, N.D., Bian, G., Ding, X., Liu, H., Aygun-Sunar, S., Burdelya, L.G., Gudkov, A.V., Cao, X., A flagellin-derived Toll-like receptor 5 agonist stimulates cytotoxic lymphocyte-mediated tumor immunity. PLoS One, 9, 2014, e85587.
    • (2014) PLoS One , vol.9 , pp. e85587
    • Leigh, N.D.1    Bian, G.2    Ding, X.3    Liu, H.4    Aygun-Sunar, S.5    Burdelya, L.G.6    Gudkov, A.V.7    Cao, X.8
  • 76
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    • Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J.M., Hoffmann, J.A., The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86 (1996), 973–983.
    • (1996) Cell , vol.86 , pp. 973-983
    • Lemaitre, B.1    Nicolas, E.2    Michaut, L.3    Reichhart, J.M.4    Hoffmann, J.A.5
  • 77
    • 84930646349 scopus 로고    scopus 로고
    • TLR2 limits development of hepatocellular carcinoma by reducing IL18-mediated immunosuppression
    • Li, S., Sun, R., Chen, Y., Wei, H., Tian, Z., TLR2 limits development of hepatocellular carcinoma by reducing IL18-mediated immunosuppression. Cancer Res. 75 (2015), 986–995.
    • (2015) Cancer Res. , vol.75 , pp. 986-995
    • Li, S.1    Sun, R.2    Chen, Y.3    Wei, H.4    Tian, Z.5
  • 78
    • 84940031281 scopus 로고    scopus 로고
    • Microenvironmental interleukin-6 suppresses Toll-like receptor signaling in human leukemia cells through miR-17/19A
    • Li, Y., Shi, Y., McCaw, L., Li, Y.-J., Zhu, F., Gorczynski, R., Duncan, G.S., Yang, B., Ben-David, Y., Spaner, D.E., Microenvironmental interleukin-6 suppresses Toll-like receptor signaling in human leukemia cells through miR-17/19A. Blood 126 (2015), 766–778.
    • (2015) Blood , vol.126 , pp. 766-778
    • Li, Y.1    Shi, Y.2    McCaw, L.3    Li, Y.-J.4    Zhu, F.5    Gorczynski, R.6    Duncan, G.S.7    Yang, B.8    Ben-David, Y.9    Spaner, D.E.10
  • 79
    • 84872125408 scopus 로고    scopus 로고
    • Loss of immunity-supported senescence enhances susceptibility to hepatocellular carcinogenesis and progression in Toll-like receptor 2-deficient mice
    • Lin, H., Yan, J., Wang, Z., Hua, F., Yu, J., Sun, W., Li, K., Liu, H., Yang, H., Lv, Q., et al. Loss of immunity-supported senescence enhances susceptibility to hepatocellular carcinogenesis and progression in Toll-like receptor 2-deficient mice. Hepatol. Baltim. Md 57 (2013), 171–182.
    • (2013) Hepatol. Baltim. Md , vol.57 , pp. 171-182
    • Lin, H.1    Yan, J.2    Wang, Z.3    Hua, F.4    Yu, J.5    Sun, W.6    Li, K.7    Liu, H.8    Yang, H.9    Lv, Q.10
  • 80
    • 84931562356 scopus 로고    scopus 로고
    • Hypoxia induced HMGB1 and mitochondrial DNA interactions mediate tumor growth in hepatocellular carcinoma through Toll-like receptor 9
    • Liu, Y., Yan, W., Tohme, S., Chen, M., Fu, Y., Tian, D., Lotze, M., Tang, D., Tsung, A., Hypoxia induced HMGB1 and mitochondrial DNA interactions mediate tumor growth in hepatocellular carcinoma through Toll-like receptor 9. J. Hepatol. 63 (2015), 114–121.
    • (2015) J. Hepatol. , vol.63 , pp. 114-121
    • Liu, Y.1    Yan, W.2    Tohme, S.3    Chen, M.4    Fu, Y.5    Tian, D.6    Lotze, M.7    Tang, D.8    Tsung, A.9
  • 81
    • 0018676793 scopus 로고
    • A fate map for the larval epidermis of Drosophila melanogaster: localized cuticle defects following irradiation of the blastoderm with an ultraviolet laser microbeam
    • Lohs-Schardin, M., Cremer, C., Nüsslein-Volhard, C., A fate map for the larval epidermis of Drosophila melanogaster: localized cuticle defects following irradiation of the blastoderm with an ultraviolet laser microbeam. Dev. Biol. 73 (1979), 239–255.
    • (1979) Dev. Biol. , vol.73 , pp. 239-255
    • Lohs-Schardin, M.1    Cremer, C.2    Nüsslein-Volhard, C.3
  • 83
    • 84941236551 scopus 로고    scopus 로고
    • Regulation of migration and invasion by Toll-like receptor-9 signaling network in prostate cancer
    • Luo, Y., Jiang, Q.-W., Wu, J.-Y., Qiu, J.-G., Zhang, W.-J., Mei, X.-L., Shi, Z., Di, J.-M., Regulation of migration and invasion by Toll-like receptor-9 signaling network in prostate cancer. Oncotarget 6 (2015), 22564–22574.
    • (2015) Oncotarget , vol.6 , pp. 22564-22574
    • Luo, Y.1    Jiang, Q.-W.2    Wu, J.-Y.3    Qiu, J.-G.4    Zhang, W.-J.5    Mei, X.-L.6    Shi, Z.7    Di, J.-M.8
  • 84
    • 84909994701 scopus 로고    scopus 로고
    • Prognostic value of myeloid differentiation primary response 88 and Toll-like receptor 4 in breast cancer patients
    • Ma, F.-J., Liu, Z.-B., Hu, X., Ling, H., Li, S., Wu, J., Shao, Z.-M., Prognostic value of myeloid differentiation primary response 88 and Toll-like receptor 4 in breast cancer patients. PLoS One, 9, 2014, e111639.
    • (2014) PLoS One , vol.9 , pp. e111639
    • Ma, F.-J.1    Liu, Z.-B.2    Hu, X.3    Ling, H.4    Li, S.5    Wu, J.6    Shao, Z.-M.7
  • 85
    • 85015818790 scopus 로고    scopus 로고
    • Should a Toll-like receptor 4 (TLR-4) agonist or antagonist be designed to treat cancer? TLR-4: its expression and effects in the ten most common cancers
    • Mai, C.W., Kang, Y.B., Pichika, M.R., Should a Toll-like receptor 4 (TLR-4) agonist or antagonist be designed to treat cancer? TLR-4: its expression and effects in the ten most common cancers. OncoTargets Ther. 6 (2013), 1573–1587.
    • (2013) OncoTargets Ther. , vol.6 , pp. 1573-1587
    • Mai, C.W.1    Kang, Y.B.2    Pichika, M.R.3
  • 86
    • 0037064536 scopus 로고    scopus 로고
    • Summary and comparison of the signaling mechanisms of the toll/interleukin-1 receptor family
    • Martin, M.U., Wesche, H., Summary and comparison of the signaling mechanisms of the toll/interleukin-1 receptor family. Biochim. Biophys. Acta 1592 (2002), 265–280.
    • (2002) Biochim. Biophys. Acta , vol.1592 , pp. 265-280
    • Martin, M.U.1    Wesche, H.2
  • 87
    • 84922697043 scopus 로고    scopus 로고
    • Pam2 lipopeptides systemically increase myeloid-derived suppressor cells through TLR2 signaling
    • Maruyama, A., Shime, H., Takeda, Y., Azuma, M., Matsumoto, M., Seya, T., Pam2 lipopeptides systemically increase myeloid-derived suppressor cells through TLR2 signaling. Biochem. Biophys. Res. Commun. 457 (2015), 445–450.
    • (2015) Biochem. Biophys. Res. Commun. , vol.457 , pp. 445-450
    • Maruyama, A.1    Shime, H.2    Takeda, Y.3    Azuma, M.4    Matsumoto, M.5    Seya, T.6
  • 88
    • 67649818408 scopus 로고    scopus 로고
    • Functionally active Toll-like receptor 3 on human primary and metastatic cancer cells
    • Matijevic, T., Marjanovic, M., Pavelic, J., Functionally active Toll-like receptor 3 on human primary and metastatic cancer cells. Scand. J. Immunol. 70 (2009), 18–24.
    • (2009) Scand. J. Immunol. , vol.70 , pp. 18-24
    • Matijevic, T.1    Marjanovic, M.2    Pavelic, J.3
  • 89
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • Medzhitov, R., Preston-Hurlburt, P., Janeway, C.A., A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388 (1997), 394–397.
    • (1997) Nature , vol.388 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway, C.A.3
  • 91
    • 33645889669 scopus 로고    scopus 로고
    • Melanoma cell lines are responsive in vitro to lipopolysaccharide and express TLR-4
    • Molteni, M., Marabella, D., Orlandi, C., Rossetti, C., Melanoma cell lines are responsive in vitro to lipopolysaccharide and express TLR-4. Cancer Lett. 235 (2006), 75–83.
    • (2006) Cancer Lett. , vol.235 , pp. 75-83
    • Molteni, M.1    Marabella, D.2    Orlandi, C.3    Rossetti, C.4
  • 93
    • 84905653969 scopus 로고    scopus 로고
    • Toll-like receptors in ovarian cancer as targets for immunotherapies
    • Muccioli, M., Benencia, F., Toll-like receptors in ovarian cancer as targets for immunotherapies. Front. Immunol., 5, 2014, 341.
    • (2014) Front. Immunol. , vol.5 , pp. 341
    • Muccioli, M.1    Benencia, F.2
  • 98
    • 77953014773 scopus 로고    scopus 로고
    • Toll-like receptor 3 signaling induces apoptosis in human head and neck cancer via survivin associated pathway
    • Nomi, N., Kodama, S., Suzuki, M., Toll-like receptor 3 signaling induces apoptosis in human head and neck cancer via survivin associated pathway. Oncol. Rep. 24 (2010), 225–231.
    • (2010) Oncol. Rep. , vol.24 , pp. 225-231
    • Nomi, N.1    Kodama, S.2    Suzuki, M.3
  • 103
    • 33745077384 scopus 로고    scopus 로고
    • Immunobiology of Toll-like receptors: emerging trends
    • Pandey, S., Agrawal, D.K., Immunobiology of Toll-like receptors: emerging trends. Immunol. Cell Biol. 84 (2006), 333–341.
    • (2006) Immunol. Cell Biol. , vol.84 , pp. 333-341
    • Pandey, S.1    Agrawal, D.K.2
  • 104
    • 49349103910 scopus 로고    scopus 로고
    • Toll-like receptor 3 triggers apoptosis of human prostate cancer cells through a PKC-alpha-dependent mechanism
    • Paone, A., Starace, D., Galli, R., Padula, F., De Cesaris, P., Filippini, A., Ziparo, E., Riccioli, A., Toll-like receptor 3 triggers apoptosis of human prostate cancer cells through a PKC-alpha-dependent mechanism. Carcinogenesis 29 (2008), 1334–1342.
    • (2008) Carcinogenesis , vol.29 , pp. 1334-1342
    • Paone, A.1    Starace, D.2    Galli, R.3    Padula, F.4    De Cesaris, P.5    Filippini, A.6    Ziparo, E.7    Riccioli, A.8
  • 105
    • 79251565525 scopus 로고    scopus 로고
    • Toll-like receptor 5 activation promotes migration and invasion of salivary gland adenocarcinoma
    • Park, J.-H., Yoon, H.-E., Kim, D.-J., Kim, S.-A., Ahn, S.-G., Yoon, J.-H., Toll-like receptor 5 activation promotes migration and invasion of salivary gland adenocarcinoma. J. Oral Pathol. Med. 40 (2011), 187–193.
    • (2011) J. Oral Pathol. Med. , vol.40 , pp. 187-193
    • Park, J.-H.1    Yoon, H.-E.2    Kim, D.-J.3    Kim, S.-A.4    Ahn, S.-G.5    Yoon, J.-H.6
  • 106
    • 77955383770 scopus 로고    scopus 로고
    • DAMPening inflammation by modulating TLR signalling
    • Piccinini, A.M., Midwood, K.S., DAMPening inflammation by modulating TLR signalling. Mediators Inflamm., 2010, 2010.
    • (2010) Mediators Inflamm. , vol.2010
    • Piccinini, A.M.1    Midwood, K.S.2
  • 109
    • 84903884741 scopus 로고    scopus 로고
    • The yin and yang of toll-like receptors in cancer
    • Pradere, J.-P., Dapito, D.H., Schwabe, R.F., The yin and yang of toll-like receptors in cancer. Oncogene 33 (2014), 3485–3495.
    • (2014) Oncogene , vol.33 , pp. 3485-3495
    • Pradere, J.-P.1    Dapito, D.H.2    Schwabe, R.F.3
  • 110
    • 48549106083 scopus 로고    scopus 로고
    • Toll-like receptor 5 engagement modulates tumor development and growth in a mouse xenograft model of human colon cancer
    • Rhee, S.H., Im, E., Pothoulakis, C., Toll-like receptor 5 engagement modulates tumor development and growth in a mouse xenograft model of human colon cancer. Gastroenterology 135 (2008), 518–528.
    • (2008) Gastroenterology , vol.135 , pp. 518-528
    • Rhee, S.H.1    Im, E.2    Pothoulakis, C.3
  • 114
    • 34547665101 scopus 로고    scopus 로고
    • Toll-like receptor 3 expressed by melanoma cells as a target for therapy?
    • Salaun, B., Lebecque, S., Matikainen, S., Rimoldi, D., Romero, P., Toll-like receptor 3 expressed by melanoma cells as a target for therapy?. Clin. Cancer Res. 13 (2007), 4565–4574.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 4565-4574
    • Salaun, B.1    Lebecque, S.2    Matikainen, S.3    Rimoldi, D.4    Romero, P.5
  • 115
  • 117
    • 20144373185 scopus 로고    scopus 로고
    • Toll-like receptors TLR4, TLR5 and TLR9 on gastric carcinoma cells: an implication for interaction with Helicobacter pylori
    • Schmausser, B., Andrulis, M., Endrich, S., Müller-Hermelink, H.-K., Eck, M., Toll-like receptors TLR4, TLR5 and TLR9 on gastric carcinoma cells: an implication for interaction with Helicobacter pylori. Int. J. Med. Microbiol. IJMM 295 (2005), 179–185.
    • (2005) Int. J. Med. Microbiol. IJMM , vol.295 , pp. 179-185
    • Schmausser, B.1    Andrulis, M.2    Endrich, S.3    Müller-Hermelink, H.-K.4    Eck, M.5
  • 118
    • 0035953308 scopus 로고    scopus 로고
    • IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity
    • Shankaran, V., Ikeda, H., Bruce, A.T., White, J.M., Swanson, P.E., Old, L.J., Schreiber, R.D., IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 410 (2001), 1107–1111.
    • (2001) Nature , vol.410 , pp. 1107-1111
    • Shankaran, V.1    Ikeda, H.2    Bruce, A.T.3    White, J.M.4    Swanson, P.E.5    Old, L.J.6    Schreiber, R.D.7
  • 119
    • 84922392512 scopus 로고    scopus 로고
    • Suppression of Toll-like receptor 2 expression inhibits the bioactivity of human hepatocellular carcinoma
    • Shi, W., Su, L., Li, Q., Sun, L., Lv, J., Li, J., Cheng, B., Suppression of Toll-like receptor 2 expression inhibits the bioactivity of human hepatocellular carcinoma. Tumour Biol. 35 (2014), 9627–9637.
    • (2014) Tumour Biol. , vol.35 , pp. 9627-9637
    • Shi, W.1    Su, L.2    Li, Q.3    Sun, L.4    Lv, J.5    Li, J.6    Cheng, B.7
  • 124
    • 74249084935 scopus 로고    scopus 로고
    • A phase I/II trial of TLR-7 agonist immunotherapy in chronic lymphocytic leukemia
    • Spaner, D.E., Shi, Y., White, D., Shaha, S., He, L., Masellis, A., Wong, K., Gorczynski, R., A phase I/II trial of TLR-7 agonist immunotherapy in chronic lymphocytic leukemia. Leukemia 24 (2010), 222–226.
    • (2010) Leukemia , vol.24 , pp. 222-226
    • Spaner, D.E.1    Shi, Y.2    White, D.3    Shaha, S.4    He, L.5    Masellis, A.6    Wong, K.7    Gorczynski, R.8
  • 126
    • 66149140644 scopus 로고    scopus 로고
    • Triggering of Toll-like receptor 4 expressed on human head and neck squamous cell carcinoma promotes tumor development and protects the tumor from immune attack
    • Szczepanski, M.J., Czystowska, M., Szajnik, M., Harasymczuk, M., Boyiadzis, M., Kruk-Zagajewska, A., Szyfter, W., Zeromski, J., Whiteside, T.L., Triggering of Toll-like receptor 4 expressed on human head and neck squamous cell carcinoma promotes tumor development and protects the tumor from immune attack. Cancer Res. 69 (2009), 3105–3113.
    • (2009) Cancer Res. , vol.69 , pp. 3105-3113
    • Szczepanski, M.J.1    Czystowska, M.2    Szajnik, M.3    Harasymczuk, M.4    Boyiadzis, M.5    Kruk-Zagajewska, A.6    Szyfter, W.7    Zeromski, J.8    Whiteside, T.L.9
  • 129
    • 84859401430 scopus 로고    scopus 로고
    • Cancer and inflammation: an old intuition with rapidly evolving new concepts
    • Trinchieri, G., Cancer and inflammation: an old intuition with rapidly evolving new concepts. Annu. Rev. Immunol. 30 (2012), 677–706.
    • (2012) Annu. Rev. Immunol. , vol.30 , pp. 677-706
    • Trinchieri, G.1
  • 132
    • 28544449709 scopus 로고    scopus 로고
    • Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8
    • Vollmer, J., Tluk, S., Schmitz, C., Hamm, S., Jurk, M., Forsbach, A., Akira, S., Kelly, K.M., Reeves, W.H., Bauer, S., et al. Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8. J. Exp. Med. 202 (2005), 1575–1585.
    • (2005) J. Exp. Med. , vol.202 , pp. 1575-1585
    • Vollmer, J.1    Tluk, S.2    Schmitz, C.3    Hamm, S.4    Jurk, M.5    Forsbach, A.6    Akira, S.7    Kelly, K.M.8    Reeves, W.H.9    Bauer, S.10
  • 133
    • 77955288686 scopus 로고    scopus 로고
    • TLR9 expression in glioma tissues correlated to glioma progression and the prognosis of GBM patients
    • Wang, C., Cao, S., Yan, Y., Ying, Q., Jiang, T., Xu, K., Wu, A., TLR9 expression in glioma tissues correlated to glioma progression and the prognosis of GBM patients. BMC Cancer, 10, 2010, 415.
    • (2010) BMC Cancer , vol.10 , pp. 415
    • Wang, C.1    Cao, S.2    Yan, Y.3    Ying, Q.4    Jiang, T.5    Xu, K.6    Wu, A.7
  • 134
    • 77949904945 scopus 로고    scopus 로고
    • Circulating toll-like receptor (TLR) 2, TLR4, and regulatory T cells in patients with chronic hepatitis C: APMIS acta pathol
    • Wang, J.-P., Zhang, Y., Wei, X., Li, J., Nan, X.-P., Yu, H.-T., Li, Y., Wang, P.-Z., Bai, X.-F., Circulating toll-like receptor (TLR) 2, TLR4, and regulatory T cells in patients with chronic hepatitis C: APMIS acta pathol. Microbiol. Immunol. Scand. 118 (2010), 261–270.
    • (2010) Microbiol. Immunol. Scand. , vol.118 , pp. 261-270
    • Wang, J.-P.1    Zhang, Y.2    Wei, X.3    Li, J.4    Nan, X.-P.5    Yu, H.-T.6    Li, Y.7    Wang, P.-Z.8    Bai, X.-F.9
  • 135
    • 84876737303 scopus 로고    scopus 로고
    • Toll-like receptor 4 activity protects against hepatocellular tumorigenesis and progression by regulating expression of DNA repair protein Ku70 in mice
    • Wang, Z., Yan, J., Lin, H., Hua, F., Wang, X., Liu, H., Lv, X., Yu, J., Mi, S., Wang, J., et al. Toll-like receptor 4 activity protects against hepatocellular tumorigenesis and progression by regulating expression of DNA repair protein Ku70 in mice. Hepatol. Baltim. Md 57 (2013), 1869–1881.
    • (2013) Hepatol. Baltim. Md , vol.57 , pp. 1869-1881
    • Wang, Z.1    Yan, J.2    Lin, H.3    Hua, F.4    Wang, X.5    Liu, H.6    Lv, X.7    Yu, J.8    Mi, S.9    Wang, J.10
  • 136
    • 58949103657 scopus 로고    scopus 로고
    • Toll-like receptor 2 mediates invasion via activating NF-kappaB in MDA-MB-231 breast cancer cells
    • Xie, W., Wang, Y., Huang, Y., Yang, H., Wang, J., Hu, Z., Toll-like receptor 2 mediates invasion via activating NF-kappaB in MDA-MB-231 breast cancer cells. Biochem. Biophys. Res. Commun. 379 (2009), 1027–1032.
    • (2009) Biochem. Biophys. Res. Commun. , vol.379 , pp. 1027-1032
    • Xie, W.1    Wang, Y.2    Huang, Y.3    Yang, H.4    Wang, J.5    Hu, Z.6
  • 137
    • 84883426762 scopus 로고    scopus 로고
    • Inhibitory effect of dsRNA TLR3 agonist in a rat hepatocellular carcinoma model
    • Xu, Y.-Y., Chen, L., Zhou, J.-M., Wu, Y.-Y., Zhu, Y.-Y., Inhibitory effect of dsRNA TLR3 agonist in a rat hepatocellular carcinoma model. Mol. Med. Rep. 8 (2013), 1037–1042.
    • (2013) Mol. Med. Rep. , vol.8 , pp. 1037-1042
    • Xu, Y.-Y.1    Chen, L.2    Zhou, J.-M.3    Wu, Y.-Y.4    Zhu, Y.-Y.5
  • 138
    • 84887066948 scopus 로고    scopus 로고
    • A synthetic dsRNA, as a TLR3 pathwaysynergist, combined with sorafenib suppresses HCC in vitro and in vivo
    • Xu, Y.-Y., Chen, L., Wang, G.-L., Zhou, J.-M., Zhang, Y.-X., Wei, Y.-Z., Zhu, Y.-Y., Qin, J., A synthetic dsRNA, as a TLR3 pathwaysynergist, combined with sorafenib suppresses HCC in vitro and in vivo. BMC Cancer, 13, 2013, 527.
    • (2013) BMC Cancer , vol.13 , pp. 527
    • Xu, Y.-Y.1    Chen, L.2    Wang, G.-L.3    Zhou, J.-M.4    Zhang, Y.-X.5    Wei, Y.-Z.6    Zhu, Y.-Y.7    Qin, J.8
  • 139
    • 77954336273 scopus 로고    scopus 로고
    • Reduced expression of Toll-like receptor 4 inhibits human breast cancer cells proliferation and inflammatory cytokines secretion
    • Yang, H., Zhou, H., Feng, P., Zhou, X., Wen, H., Xie, X., Shen, H., Zhu, X., Reduced expression of Toll-like receptor 4 inhibits human breast cancer cells proliferation and inflammatory cytokines secretion. J. Exp. Clin. Cancer Res. CR, 29, 2010, 92.
    • (2010) J. Exp. Clin. Cancer Res. CR , vol.29 , pp. 92
    • Yang, H.1    Zhou, H.2    Feng, P.3    Zhou, X.4    Wen, H.5    Xie, X.6    Shen, H.7    Zhu, X.8
  • 140
    • 84907816018 scopus 로고    scopus 로고
    • Toll-like receptor 4 prompts human breast cancer cells invasiveness via lipopolysaccharide stimulation and is overexpressed in patients with lymph node metastasis
    • Yang, H., Wang, B., Wang, T., Xu, L., He, C., Wen, H., Yan, J., Su, H., Zhu, X., Toll-like receptor 4 prompts human breast cancer cells invasiveness via lipopolysaccharide stimulation and is overexpressed in patients with lymph node metastasis. PLoS One, 9, 2014, e109980.
    • (2014) PLoS One , vol.9 , pp. e109980
    • Yang, H.1    Wang, B.2    Wang, T.3    Xu, L.4    He, C.5    Wen, H.6    Yan, J.7    Su, H.8    Zhu, X.9
  • 141
    • 84905641569 scopus 로고    scopus 로고
    • Multiple roles of Toll-like receptor 4 in colorectal cancer
    • Yesudhas, D., Gosu, V., Anwar, M.A., Choi, S., Multiple roles of Toll-like receptor 4 in colorectal cancer. Front. Immunol., 5, 2014, 334.
    • (2014) Front. Immunol. , vol.5 , pp. 334
    • Yesudhas, D.1    Gosu, V.2    Anwar, M.A.3    Choi, S.4
  • 142
    • 58149195681 scopus 로고    scopus 로고
    • Dual topology of functional Toll-like receptor 3 expression in human hepatocellular carcinoma: differential signaling mechanisms of TLR3-induced NF-kappaB activation and apoptosis
    • Yoneda, K., Sugimoto, K., Shiraki, K., Tanaka, J., Beppu, T., Fuke, H., Yamamoto, N., Masuya, M., Horie, R., Uchida, K., et al. Dual topology of functional Toll-like receptor 3 expression in human hepatocellular carcinoma: differential signaling mechanisms of TLR3-induced NF-kappaB activation and apoptosis. Int. J. Oncol. 33 (2008), 929–936.
    • (2008) Int. J. Oncol. , vol.33 , pp. 929-936
    • Yoneda, K.1    Sugimoto, K.2    Shiraki, K.3    Tanaka, J.4    Beppu, T.5    Fuke, H.6    Yamamoto, N.7    Masuya, M.8    Horie, R.9    Uchida, K.10
  • 143
    • 39049104004 scopus 로고    scopus 로고
    • Protective role of Toll-like receptor 4 during the initiation stage of cutaneous chemical carcinogenesis
    • Yusuf, N., Nasti, T.H., Long, J.A., Naseemuddin, M., Lucas, A.P., Xu, H., Elmets, C.A., Protective role of Toll-like receptor 4 during the initiation stage of cutaneous chemical carcinogenesis. Cancer Res. 68 (2008), 615–622.
    • (2008) Cancer Res. , vol.68 , pp. 615-622
    • Yusuf, N.1    Nasti, T.H.2    Long, J.A.3    Naseemuddin, M.4    Lucas, A.P.5    Xu, H.6    Elmets, C.A.7
  • 145
    • 77954259621 scopus 로고    scopus 로고
    • Expression and significance of TLR4 and HIF-1alpha in pancreatic ductal adenocarcinoma
    • Zhang, J.-J., Wu, H.-S., Wang, L., Tian, Y., Zhang, J.-H., Wu, H.-L., Expression and significance of TLR4 and HIF-1alpha in pancreatic ductal adenocarcinoma. World J. Gastroenterol. WJG 16 (2010), 2881–2888.
    • (2010) World J. Gastroenterol. WJG , vol.16 , pp. 2881-2888
    • Zhang, J.-J.1    Wu, H.-S.2    Wang, L.3    Tian, Y.4    Zhang, J.-H.5    Wu, H.-L.6
  • 146
    • 79951822508 scopus 로고    scopus 로고
    • TLR1/TLR2 agonist induces tumor regression by reciprocal modulation of effector and regulatory T cells
    • Zhang, Y., Luo, F., Cai, Y., Liu, N., Wang, L., Xu, D., Chu, Y., TLR1/TLR2 agonist induces tumor regression by reciprocal modulation of effector and regulatory T cells. J. Immunol. Baltim. Md 1950:186 (2011), 1963–1969.
    • (2011) J. Immunol. Baltim. Md , vol.1950 , Issue.186 , pp. 1963-1969
    • Zhang, Y.1    Luo, F.2    Cai, Y.3    Liu, N.4    Wang, L.5    Xu, D.6    Chu, Y.7
  • 147
    • 84898670689 scopus 로고    scopus 로고
    • Functional expression of TLR9 in esophageal cancer
    • Zhang, Y., Wang, Q., Ma, A., Li, Y., Li, R., Wang, Y., Functional expression of TLR9 in esophageal cancer. Oncol. Rep. 31 (2014), 2298–2304.
    • (2014) Oncol. Rep. , vol.31 , pp. 2298-2304
    • Zhang, Y.1    Wang, Q.2    Ma, A.3    Li, Y.4    Li, R.5    Wang, Y.6
  • 148
    • 84874004337 scopus 로고    scopus 로고
    • Toll-like receptor 5 agonist inhibition of growth of A549 lung cancer cells in vivo in a Myd88 dependent manner
    • Zhou, S.-X., Li, F.-S., Qiao, Y.-L., Zhang, X.-Q., Wang, Z.-D., Toll-like receptor 5 agonist inhibition of growth of A549 lung cancer cells in vivo in a Myd88 dependent manner. Asian Pac. J. Cancer Prev. APJCP 13 (2012), 2807–2812.
    • (2012) Asian Pac. J. Cancer Prev. APJCP , vol.13 , pp. 2807-2812
    • Zhou, S.-X.1    Li, F.-S.2    Qiao, Y.-L.3    Zhang, X.-Q.4    Wang, Z.-D.5
  • 149
    • 84899493278 scopus 로고    scopus 로고
    • High expression of Toll-like receptor 5 correlates with better prognosis in non-small-cell lung cancer: an anti-tumor effect of TLR5 signaling in non-small cell lung cancer
    • Zhou, H., Chen, J., Hu, J., Luo, Y., Li, F., Xiao, L., Zhong, M., High expression of Toll-like receptor 5 correlates with better prognosis in non-small-cell lung cancer: an anti-tumor effect of TLR5 signaling in non-small cell lung cancer. J. Cancer Res. Clin. Oncol. 140 (2014), 633–643.
    • (2014) J. Cancer Res. Clin. Oncol. , vol.140 , pp. 633-643
    • Zhou, H.1    Chen, J.2    Hu, J.3    Luo, Y.4    Li, F.5    Xiao, L.6    Zhong, M.7
  • 150
    • 84945293359 scopus 로고    scopus 로고
    • TLR7/8 agonists promote NK-DC cross-talk to enhance NK cell anti-tumor effects in hepatocellular carcinoma
    • Zhou, Z., Yu, X., Zhang, J., Tian, Z., Zhang, C., TLR7/8 agonists promote NK-DC cross-talk to enhance NK cell anti-tumor effects in hepatocellular carcinoma. Cancer Lett. 369 (2015), 298–306.
    • (2015) Cancer Lett. , vol.369 , pp. 298-306
    • Zhou, Z.1    Yu, X.2    Zhang, J.3    Tian, Z.4    Zhang, C.5
  • 151
    • 84925016356 scopus 로고    scopus 로고
    • Local administration of a novel Toll-like receptor 7 agonist in combination with doxorubicin induces durable tumouricidal effects in a murine model of T cell lymphoma
    • Zhu, J., He, S., Du, J., Wang, Z., Li, W., Chen, X., Jiang, W., Zheng, D., Jin, G., Local administration of a novel Toll-like receptor 7 agonist in combination with doxorubicin induces durable tumouricidal effects in a murine model of T cell lymphoma. J. Hematol. Oncol., 8, 2015, 21.
    • (2015) J. Hematol. Oncol. , vol.8 , pp. 21
    • Zhu, J.1    He, S.2    Du, J.3    Wang, Z.4    Li, W.5    Chen, X.6    Jiang, W.7    Zheng, D.8    Jin, G.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.