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Volumn 57, Issue 1, 2013, Pages 171-182

Loss of immunity-supported senescence enhances susceptibility to hepatocellular carcinogenesis and progression in Toll-like receptor 2-deficient mice

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; CXCL2 CHEMOKINE; DIETHYLNITROSAMINE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P62; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA;

EID: 84872125408     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.25991     Document Type: Article
Times cited : (94)

References (37)
  • 1
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    • El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007; 132: 2557-2576.
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 2
    • 84867212593 scopus 로고    scopus 로고
    • Chronic inflammation, immune escape and oncogenesis in the liver: a unique neighborhood for novel intersections
    • Epub ahead of print].
    • Stauffer JK, Scarzello AJ, Jiang Q, Wiltrout RH. Chronic inflammation, immune escape and oncogenesis in the liver: a unique neighborhood for novel intersections. HEPATOLOGY 2012 [Epub ahead of print].
    • (2012) HEPATOLOGY
    • Stauffer, J.K.1    Scarzello, A.J.2    Jiang, Q.3    Wiltrout, R.H.4
  • 3
    • 21244472975 scopus 로고    scopus 로고
    • IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    • Maeda S, Kamata H, Luo JL, Leffert H, Karin M. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 2005; 121: 977-990.
    • (2005) Cell , vol.121 , pp. 977-990
    • Maeda, S.1    Kamata, H.2    Luo, J.L.3    Leffert, H.4    Karin, M.5
  • 4
    • 33747040825 scopus 로고    scopus 로고
    • Pattern recognition receptors: a contemporary view on liver diseases
    • Szabo G, Dolganiuc A, Mandrekar P. Pattern recognition receptors: a contemporary view on liver diseases. HEPATOLOGY 2006; 44: 287-298.
    • (2006) HEPATOLOGY , vol.44 , pp. 287-298
    • Szabo, G.1    Dolganiuc, A.2    Mandrekar, P.3
  • 5
    • 37849035627 scopus 로고    scopus 로고
    • TLR signaling by tumor and immune cells: a double-edged sword
    • Huang B, Zhao J, Unkeless JC, Feng ZH, Xiong H. TLR signaling by tumor and immune cells: a double-edged sword. Oncogene 2008; 27: 218-224.
    • (2008) Oncogene , vol.27 , pp. 218-224
    • Huang, B.1    Zhao, J.2    Unkeless, J.C.3    Feng, Z.H.4    Xiong, H.5
  • 6
    • 77950275185 scopus 로고    scopus 로고
    • Toll-like receptors: cost or benefit for cancer?
    • Matijevic T, Pavelic J. Toll-like receptors: cost or benefit for cancer? Curr Pharm Des 2010; 16: 1081-1090.
    • (2010) Curr Pharm Des , vol.16 , pp. 1081-1090
    • Matijevic, T.1    Pavelic, J.2
  • 7
    • 77957948007 scopus 로고    scopus 로고
    • Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents
    • Yu LX, Yan HX, Liu Q, Yang W, Wu HP, Dong W, et al. Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents. HEPATOLOGY 2010; 52: 1322-1333.
    • (2010) HEPATOLOGY , vol.52 , pp. 1322-1333
    • Yu, L.X.1    Yan, H.X.2    Liu, Q.3    Yang, W.4    Wu, H.P.5    Dong, W.6
  • 8
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 2007; 317: 121-124.
    • (2007) Science , vol.317 , pp. 121-124
    • Naugler, W.E.1    Sakurai, T.2    Kim, S.3    Maeda, S.4    Kim, K.5    Elsharkawy, A.M.6
  • 9
    • 77958532945 scopus 로고    scopus 로고
    • Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress
    • Seimon TA, Nadolski MJ, Liao X, Magallon J, Nguyen M, Feric NT, et al. Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress. Cell Metab 2010; 12: 467-482.
    • (2010) Cell Metab , vol.12 , pp. 467-482
    • Seimon, T.A.1    Nadolski, M.J.2    Liao, X.3    Magallon, J.4    Nguyen, M.5    Feric, N.T.6
  • 10
    • 47149105036 scopus 로고    scopus 로고
    • Toll-like receptors and adaptor molecules in liver disease: update
    • Seki E, Brenner DA. Toll-like receptors and adaptor molecules in liver disease: update. HEPATOLOGY 2008; 48: 322-335.
    • (2008) HEPATOLOGY , vol.48 , pp. 322-335
    • Seki, E.1    Brenner, D.A.2
  • 12
    • 68349130145 scopus 로고    scopus 로고
    • Blocking TLR2 activity attenuates pulmonary metastases of tumor
    • Yang HZ, Cui B, Liu HZ, Mi S, Yan J, Yan HM, et al. Blocking TLR2 activity attenuates pulmonary metastases of tumor. PLoS One 2009; 4: e6520.
    • (2009) PLoS One , vol.4
    • Yang, H.Z.1    Cui, B.2    Liu, H.Z.3    Mi, S.4    Yan, J.5    Yan, H.M.6
  • 13
    • 77958610178 scopus 로고    scopus 로고
    • Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer
    • Lowe EL, Crother T, Rabizadeh S, Hu B, Wang H, Chen S, et al. Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer. PLoS One 2010; 5: e13027.
    • (2010) PLoS One , vol.5
    • Lowe, E.L.1    Crother, T.2    Rabizadeh, S.3    Hu, B.4    Wang, H.5    Chen, S.6
  • 14
  • 15
    • 33746032571 scopus 로고    scopus 로고
    • Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation
    • Sakurai T, Maeda S, Chang L, Karin M. Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc Natl Acad Sci U S A 2006; 103: 10544-10551.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 10544-10551
    • Sakurai, T.1    Maeda, S.2    Chang, L.3    Karin, M.4
  • 16
    • 77649265091 scopus 로고    scopus 로고
    • The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
    • Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, et al. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol 2010; 12: 213-223.
    • (2010) Nat Cell Biol , vol.12 , pp. 213-223
    • Komatsu, M.1    Kurokawa, H.2    Waguri, S.3    Taguchi, K.4    Kobayashi, A.5    Ichimura, Y.6
  • 17
    • 83455230751 scopus 로고    scopus 로고
    • TLR4 activity is required in the resolution of pulmonary inflammation and fibrosis after acute and chronic lung injury
    • Yang HZ, Wang JP, Mi S, Liu HZ, Cui B, Yan HM, et al. TLR4 activity is required in the resolution of pulmonary inflammation and fibrosis after acute and chronic lung injury. Am J Pathol 2012; 180: 275-292.
    • (2012) Am J Pathol , vol.180 , pp. 275-292
    • Yang, H.Z.1    Wang, J.P.2    Mi, S.3    Liu, H.Z.4    Cui, B.5    Yan, H.M.6
  • 18
    • 79953315567 scopus 로고    scopus 로고
    • Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis
    • Kennedy AL, Morton JP, Manoharan I, Nelson DM, Jamieson NB, Pawlikowski JS, et al. Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis. Mol Cell 2011; 42: 36-49.
    • (2011) Mol Cell , vol.42 , pp. 36-49
    • Kennedy, A.L.1    Morton, J.P.2    Manoharan, I.3    Nelson, D.M.4    Jamieson, N.B.5    Pawlikowski, J.S.6
  • 19
    • 37049019073 scopus 로고    scopus 로고
    • Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo
    • Kang JS, Wanibuchi H, Morimura K, Gonzalez FJ, Fukushima S. Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo. Cancer Res 2007; 67: 11141-11146.
    • (2007) Cancer Res , vol.67 , pp. 11141-11146
    • Kang, J.S.1    Wanibuchi, H.2    Morimura, K.3    Gonzalez, F.J.4    Fukushima, S.5
  • 20
    • 81855169964 scopus 로고    scopus 로고
    • Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
    • Kang TW, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, et al. Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature 2011; 479: 547-51.
    • (2011) Nature , vol.479 , pp. 547-551
    • Kang, T.W.1    Yevsa, T.2    Woller, N.3    Hoenicke, L.4    Wuestefeld, T.5    Dauch, D.6
  • 22
    • 34548186667 scopus 로고    scopus 로고
    • Cellular senescence: when bad things happen to good cells
    • Campisi J, d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 2007; 8: 729-740.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 729-740
    • Campisi, J.1    d'Adda di Fagagna, F.2
  • 23
    • 66449099090 scopus 로고    scopus 로고
    • Autophagy suppresses tumorigenesis through elimination of p62
    • Mathew R, Karp CM, Beaudoin B, Vuong N, Chen G, Chen HY, et al. Autophagy suppresses tumorigenesis through elimination of p62. Cell 2009; 137: 1062-1075.
    • (2009) Cell , vol.137 , pp. 1062-1075
    • Mathew, R.1    Karp, C.M.2    Beaudoin, B.3    Vuong, N.4    Chen, G.5    Chen, H.Y.6
  • 25
    • 75749122303 scopus 로고    scopus 로고
    • Methods in mammalian autophagy research
    • Mizushima N, Yoshimori T, Levine B. Methods in mammalian autophagy research. Cell 2010; 140: 313-326.
    • (2010) Cell , vol.140 , pp. 313-326
    • Mizushima, N.1    Yoshimori, T.2    Levine, B.3
  • 27
    • 79959535966 scopus 로고    scopus 로고
    • Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated mitogen-activated protein kinase
    • Nakagawa H, Hirata Y, Takeda K, Hayakawa Y, Sato T, Kinoshita H, et al. Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated mitogen-activated protein kinase. HEPATOLOGY 2011; 54: 185-195.
    • (2011) HEPATOLOGY , vol.54 , pp. 185-195
    • Nakagawa, H.1    Hirata, Y.2    Takeda, K.3    Hayakawa, Y.4    Sato, T.5    Kinoshita, H.6
  • 28
    • 79955017452 scopus 로고    scopus 로고
    • p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype
    • Freund A, Patil CK, Campisi J. p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype. EMBO J 2011; 30: 1536-1548.
    • (2011) EMBO J , vol.30 , pp. 1536-1548
    • Freund, A.1    Patil, C.K.2    Campisi, J.3
  • 29
    • 33846846493 scopus 로고    scopus 로고
    • A radical role for p38 MAPK in tumor initiation
    • Kennedy NJ, Cellurale C, Davis RJ. A radical role for p38 MAPK in tumor initiation. Cancer Cell. 2007; 11: 101-3.
    • (2007) Cancer Cell , vol.11 , pp. 101-103
    • Kennedy, N.J.1    Cellurale, C.2    Davis, R.J.3
  • 30
    • 59049088856 scopus 로고    scopus 로고
    • Interferon-gamma induces cellular senescence through p53-dependent DNA damage signaling in human endothelial cells
    • Kim KS, Kang K, Seu YB, Baek SH, Kim JR. Interferon-gamma induces cellular senescence through p53-dependent DNA damage signaling in human endothelial cells. Mech Ageing Dev 2009; 130: 179-188.
    • (2009) Mech Ageing Dev , vol.130 , pp. 179-188
    • Kim, K.S.1    Kang, K.2    Seu, Y.B.3    Baek, S.H.4    Kim, J.R.5
  • 31
    • 33845420396 scopus 로고    scopus 로고
    • The role of cytokines in hepatocellular carcinoma
    • Budhu A, Wang XW. The role of cytokines in hepatocellular carcinoma. J Leukoc Biol 2006; 80: 1197-1213.
    • (2006) J Leukoc Biol , vol.80 , pp. 1197-1213
    • Budhu, A.1    Wang, X.W.2
  • 32
    • 80052731707 scopus 로고    scopus 로고
    • Timing is critical for an effective anti-metastatic immunotherapy: the decisive role of IFNgamma/STAT1-mediated activation of autophagy
    • Yan J, Wang ZY, Yang HZ, Liu HZ, Mi S, Lv XX, et al. Timing is critical for an effective anti-metastatic immunotherapy: the decisive role of IFNgamma/STAT1-mediated activation of autophagy. PLoS One 2011; 6: e24705.
    • (2011) PLoS One , vol.6
    • Yan, J.1    Wang, Z.Y.2    Yang, H.Z.3    Liu, H.Z.4    Mi, S.5    Lv, X.X.6
  • 33
    • 77952105389 scopus 로고    scopus 로고
    • Inflammatory networks during cellular senescence: causes and consequences
    • Freund A, Orjalo AV, Desprez PY, Campisi J. Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med 2010; 16: 238-246.
    • (2010) Trends Mol Med , vol.16 , pp. 238-246
    • Freund, A.1    Orjalo, A.V.2    Desprez, P.Y.3    Campisi, J.4
  • 34
    • 74549167737 scopus 로고    scopus 로고
    • Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
    • Park EJ, Lee JH, Yu GY, He G, Ali SR, Holzer RG, et al. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 2010; 140: 197-208.
    • (2010) Cell , vol.140 , pp. 197-208
    • Park, E.J.1    Lee, J.H.2    Yu, G.Y.3    He, G.4    Ali, S.R.5    Holzer, R.G.6
  • 35
    • 69449102284 scopus 로고    scopus 로고
    • Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors
    • Fukata M, Hernandez Y, Conduah D, Cohen J, Chen A, Breglio K, et al. Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors. Inflamm Bowel Dis 2009; 15: 997-1006.
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 997-1006
    • Fukata, M.1    Hernandez, Y.2    Conduah, D.3    Cohen, J.4    Chen, A.5    Breglio, K.6
  • 36
    • 66449114033 scopus 로고    scopus 로고
    • p62 at the crossroads of autophagy, apoptosis, and cancer
    • Moscat J, Diaz-Meco MT. p62 at the crossroads of autophagy, apoptosis, and cancer. Cell 2009; 137: 1001-1004.
    • (2009) Cell , vol.137 , pp. 1001-1004
    • Moscat, J.1    Diaz-Meco, M.T.2
  • 37
    • 79958830077 scopus 로고    scopus 로고
    • Interferon-{gamma} inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T cell apoptosis
    • Tu S, Quante M, Bhagat G, Takaishi S, Cui G, Yang XD, et al. Interferon-{gamma} inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T cell apoptosis. Cancer Res 2011; 71: 4247-4259.
    • (2011) Cancer Res , vol.71 , pp. 4247-4259
    • Tu, S.1    Quante, M.2    Bhagat, G.3    Takaishi, S.4    Cui, G.5    Yang, X.D.6


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