Hypoxia induced HMGB1 and mitochondrial DNA interactions mediate tumor growth in hepatocellular carcinoma through Toll-like receptor 9

Journal of Hepatology

Volumn 63, Issue 1, 2015, Pages 114-121

  Liu, Yao ^a,b   Yan, Wei ^a,c   Tohme, Samer ^a   Chen, Man ^a   Fu, Yu ^c   Tian, Dean ^c   Lotze, Michael ^a   Tang, Daolin ^a   Tsung, Allan ^a  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b GANNAN MEDICAL UNIVERSITY   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

DAMPs; Hepatocellular carcinoma; HMGB1; Hypoxia; Liver; Mitochondrial DNA

Indexed keywords

HIGH MOBILITY GROUP B1 PROTEIN; MITOCHONDRIAL DNA; SHORT HAIRPIN RNA; TOLL LIKE RECEPTOR 9; DNA; HMGB1 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CANCER CELL; CANCER GROWTH; CELL NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN TISSUE; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DNA INTERACTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; EXPERIMENTAL LIVER NEOPLASM; FLOW CYTOMETRY; GENETICS; LIVER TUMOR; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DNA, MITOCHONDRIAL; DNA, NEOPLASM; FLOW CYTOMETRY; HMGB1 PROTEIN; HUMANS; HYPOXIA; LIVER NEOPLASMS; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE; MICE, INBRED C57BL; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84931562356     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2015.02.009     Document Type: Article

References (38)

1. M. Sherman Hepatocellular carcinoma: epidemiology, surveillance, and diagnosis Semin Liver Dis 30 2010 3 16
2. H.B. El-Serag, and K.L. Rudolph Hepatocellular carcinoma: epidemiology and molecular carcinogenesis Gastroenterology 132 2007 2557 2576
3. A. Mantovani, P. Allavena, A. Sica, and F. Balkwill Cancer-related inflammation Nature 454 2008 436 444
4. G.P. Sims, D.C. Rowe, S.T. Rietdijk, R. Herbst, and A.J. Coyle HMGB1 and RAGE in inflammation and cancer Annu Rev Immunol 28 2010 367 388
5. D. Tang, R. Kang, H.J. Zeh 3rd, and M.T. Lotze High-mobility group box 1 and cancer Biochim Biophys Acta 1799 2010 131 140
6. W. Yan, Y. Chang, X. Liang, J.S. Cardinal, H. Huang, and S.H. Thorne High mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases Hepatology 55 2012 1863 1875
7. J. Tian, A.M. Avalos, S.Y. Mao, B. Chen, K. Senthil, and H. Wu Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE Nat Immunol 8 2007 487 496
8. H. Yanai, T. Ban, Z. Wang, M.K. Choi, T. Kawamura, and H. Negishi HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses Nature 462 2009 99 103
9. K. Takeda, T. Kaisho, and S. Akira Toll-like receptors Annu Rev Immunol 21 2003 335 376
10. S. Akira, S. Uematsu, and O. Takeuchi Pathogen recognition and innate immunity Cell 124 2006 783 801
11. H. Yanai, T. Ban, and T. Taniguchi High-mobility group box family of proteins: ligand and sensor for innate immunity Trends Immunol 33 2012 633 640
12. Q. Zhang, M. Raoof, Y. Chen, Y. Sumi, T. Sursal, and W. Junger Circulating mitochondrial DAMPs cause inflammatory responses to injury Nature 464 2010 104 107
13. D.V. Krysko, P. Agostinis, O. Krysko, A.D. Garg, C. Bachert, and B.N. Lambrecht Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation Trends Immunol 32 2011 157 164
14. M. Yu Generation, function and diagnostic value of mitochondrial DNA copy number alterations in human cancers Life Sci 89 2011 65 71
15. S.J. Lee, S.W. Ryter, J.F. Xu, K. Nakahira, H.P. Kim, and A.M. Choi Carbon monoxide activates autophagy via mitochondrial reactive oxygen species formation Am J Respir Cell Mol Biol 45 2011 867 873
16. M.C. Tal, M. Sasai, H.K. Lee, B. Yordy, G.S. Shadel, and A. Iwasaki Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling Proc Natl Acad Sci U S A 106 2009 2770 2775
17. K. Nakahira, J.A. Haspel, V.A. Rathinam, S.J. Lee, T. Dolinay, and H.C. Lam Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome Nat Immunol 12 2011 222 230
18. J. Gao, Y. Chen, K.C. Wu, J. Liu, Y.Q. Zhao, and Y.L. Pan RUNX3 directly interacts with intracellular domain of Notch1 and suppresses Notch signaling in hepatocellular carcinoma cells Exp Cell Res 316 2010 149 157
19. H. Huang, J. Evankovich, W. Yan, G. Nace, L. Zhang, and M. Ross Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice Hepatology 54 2011 999 1008
20. T. Ren, L. Xu, S. Jiao, Y. Wang, Y. Cai, and Y. Liang TLR9 signaling promotes tumor progression of human lung cancer cell in vivo Pathol Oncol Res 15 2009 623 630
21. J. Tanaka, K. Sugimoto, K. Shiraki, M. Tameda, S. Kusagawa, and K. Nojiri Functional cell surface expression of toll-like receptor 9 promotes cell proliferation and survival in human hepatocellular carcinomas Int J Oncol 37 2010 805 814
22. R.O. Poyton, K.A. Ball, and P.R. Castello Mitochondrial generation of free radicals and hypoxic signaling Trends Endocrinol Metab 20 2009 332 340
23. N. Li, K. Ragheb, G. Lawler, J. Sturgis, B. Rajwa, and J.A. Melendez Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production J Biol Chem 278 2003 8516 8525
24. E. Latz, A. Schoenemeyer, A. Visintin, K.A. Fitzgerald, B.G. Monks, and C.F. Knetter TLR9 signals after translocating from the ER to CpG DNA in the lysosome Nat Immunol 5 2004 190 198
25. A.S. Dhillon, S. Hagan, O. Rath, and W. Kolch MAP kinase signalling pathways in cancer Oncogene 26 2007 3279 3290
26. C. Bubici, S. Papa, C.G. Pham, F. Zazzeroni, and G. Franzoso NF-kappaB and JNK: an intricate affair Cell Cycle 3 2004 1524 1529
27. N. Voorzanger, R. Touitou, E. Garcia, H.J. Delecluse, F. Rousset, and I. Joab Interleukin (IL)-10 and IL-6 are produced in vivo by non-Hodgkin's lymphoma cells and act as cooperative growth factors Cancer Res 56 1996 5499 5505
28. C. Gao, A. Kozlowska, S. Nechaev, H. Li, Q. Zhang, and D.M. Hossain TLR9 signaling in the tumor microenvironment initiates cancer recurrence after radiotherapy Cancer Res 73 2013 7211 7221
29. E.C. Finger, and A.J. Giaccia Hypoxia, inflammation, and the tumor microenvironment in metastatic disease Cancer Metastasis Rev 29 2010 285 293
30. K. Ruan, G. Song, and G. Ouyang Role of hypoxia in the hallmarks of human cancer J Cell Biochem 107 2009 1053 1062
31. R. Kang, Q. Zhang, H.J. Zeh 3rd, M.T. Lotze, and D. Tang HMGB1 in cancer: good, bad, or both? Clin Cancer Res 19 2013 4046 4057
32. S.S. Lange, and K.M. Vasquez HMGB1: the jack-of-all-trades protein is a master DNA repair mechanic Mol Carcinog 48 2009 571 580
33. Y. Jiao, H.C. Wang, and S.J. Fan Growth suppression and radiosensitivity increase by HMGB1 in breast cancer Acta Pharmacol Sin 28 2007 1957 1967
34. W. Yan, Y. Chang, X. Liang, J.S. Cardinal, H. Huang, and S.H. Thorne High-mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases Hepatology 55 2012 1863 1875
35. T. Kawai, and S. Akira The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors Nat Immunol 11 2010 373 384
36. S. Ivanov, A.M. Dragoi, X. Wang, C. Dallacosta, J. Louten, and G. Musco A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA Blood 110 2007 1970 1981
37. S. Tohme, D.A. Geller, J.S. Cardinal, H.W. Chen, V. Packiam, and S. Reddy Radiofrequency ablation compared to resection in early-stage hepatocellular carcinoma HPB 15 2013 210 217
38. W. Jarnagin, W.C. Chapman, S. Curley, M. D'Angelica, C. Rosen, and E. Dixon Surgical treatment of hepatocellular carcinoma: expert consensus statement HPB 12 2010 302 310