메뉴 건너뛰기




Volumn 24, Issue 1, 2010, Pages 222-226

A phase I/II trial of TLR-7 agonist immunotherapy in chronic lymphocytic leukemia

Author keywords

[No Author keywords available]

Indexed keywords

CHLORAMBUCIL; COMPOUND 852A; CYCLOPHOSPHAMIDE; CYTOKINE; DOXORUBICIN; FLUDARABINE; IMMUNOGLOBULIN; IMMUNOMODULATING AGENT; PREDNISONE; RITUXIMAB; TOLL LIKE RECEPTOR 7 AGONIST; UNCLASSIFIED DRUG; VINCRISTINE;

EID: 74249084935     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2009.195     Document Type: Letter
Times cited : (40)

References (9)
  • 3
    • 37849010503 scopus 로고    scopus 로고
    • Obstacles to effective Toll-like receptor agonist therapy for hematologic malignancies
    • Spaner DE, Foley R, Galipeau J, Bramson J. Obstacles to effective Toll-like receptor agonist therapy for hematologic malignancies. Oncogene 2008; 27: 208-217.
    • (2008) Oncogene , vol.27 , pp. 208-217
    • Spaner, D.E.1    Foley, R.2    Galipeau, J.3    Bramson, J.4
  • 4
    • 33847702017 scopus 로고    scopus 로고
    • TLR-7 tolerizes malignant B cells and enhances killing by cytotoxic agents
    • Shi Y, White D, He L, Miller RL, Spaner DE. TLR-7 tolerizes malignant B cells and enhances killing by cytotoxic agents. Cancer Res 2007; 67: 1823-1831.
    • (2007) Cancer Res , vol.67 , pp. 1823-1831
    • Shi, Y.1    White, D.2    He, L.3    Miller, R.L.4    Spaner, D.E.5
  • 5
    • 33845542139 scopus 로고    scopus 로고
    • TLR agonists in the treatment of CLL
    • Spaner DE, Masellis A. TLR agonists in the treatment of CLL. Leukemia 2007; 21: 53-60.
    • (2007) Leukemia , vol.21 , pp. 53-60
    • Spaner, D.E.1    Masellis, A.2
  • 6
    • 38949100471 scopus 로고    scopus 로고
    • An exploratory study of systemic administration of the TLR-7 agonist 852A in patients with refractory metastatic melanoma
    • Dummer R, Hauschild A, Becker JC, Grob JJ, Schadendorf D, Tebbs V et al. An exploratory study of systemic administration of the TLR-7 agonist 852A in patients with refractory metastatic melanoma. Clin Cancer Res 2008; 14: 856-864.
    • (2008) Clin Cancer Res , vol.14 , pp. 856-864
    • Dummer, R.1    Hauschild, A.2    Becker, J.C.3    Grob, J.J.4    Schadendorf, D.5    Tebbs, V.6
  • 7
    • 37249041922 scopus 로고    scopus 로고
    • First in human phase i trial of 852A, a novel systemic TLR-7 agonist, to activate innate immune responses in patients with advanced cancer
    • Dudek AZ, Yunis C, Harrison LI, Kumar S, Hawkinson R, Cooley S et al. First in human phase I trial of 852A, a novel systemic TLR-7 agonist, to activate innate immune responses in patients with advanced cancer. Clin Cancer Res 2007; 13: 7119-7125.
    • (2007) Clin Cancer Res , vol.13 , pp. 7119-7125
    • Dudek, A.Z.1    Yunis, C.2    Harrison, L.I.3    Kumar, S.4    Hawkinson, R.5    Cooley, S.6
  • 8
    • 0025910992 scopus 로고
    • Comparison of chlorambucil and prednisone versus cyclophos-phamide, vincristine, and prednisone as initial treatment for CLL
    • Raphael B, Andersen JW, Silber R, Oken M, Moore D, Bennett J et al. Comparison of chlorambucil and prednisone versus cyclophos-phamide, vincristine, and prednisone as initial treatment for CLL. J Clin Oncol 1991; 9: 770-776.
    • (1991) J Clin Oncol , vol.9 , pp. 770-776
    • Raphael, B.1    Andersen, J.W.2    Silber, R.3    Oken, M.4    Moore, D.5    Bennett, J.6
  • 9
    • 33644847257 scopus 로고    scopus 로고
    • Sensitization of IL-2 signaling through TLR-7 enhances B lymphoma cell immunogenicity
    • Tomic J, White D, Shi Y, Mena J, Hammond C, He L et al. Sensitization of IL-2 signaling through TLR-7 enhances B lymphoma cell immunogenicity. J Immunol 2006; 176: 3830-3839.
    • (2006) J Immunol , vol.176 , pp. 3830-3839
    • Tomic, J.1    White, D.2    Shi, Y.3    Mena, J.4    Hammond, C.5    He, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.