메뉴 건너뛰기




Volumn 122, Issue 11, 2012, Pages 4118-4129

Toll-like receptor 7 regulates pancreatic carcinogenesis in mice and humans

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN B1; CYCLIN D1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MYC PROTEIN; NOTCH RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P16; PROTEIN P21; PROTEIN P27; PROTEIN P53; STAT3 PROTEIN; TOLL LIKE RECEPTOR 7; TRANSFORMING GROWTH FACTOR BETA;

EID: 84868627145     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI63606     Document Type: Article
Times cited : (165)

References (72)
  • 1
    • 77952546646 scopus 로고    scopus 로고
    • Postresection survival outcomes of pancreatic cancer according to demographic factors and socio-economic status
    • Kuhn Y, Koscielny A, Glowka T, Hirner A, Kalff JC, Standop J. Postresection survival outcomes of pancreatic cancer according to demographic factors and socio-economic status. Eur J Surg Oncol. 2010;36(5):496-500.
    • (2010) Eur J Surg Oncol , vol.36 , Issue.5 , pp. 496-500
    • Kuhn, Y.1    Koscielny, A.2    Glowka, T.3    Hirner, A.4    Kalff, J.C.5    Standop, J.6
  • 2
    • 34648852355 scopus 로고    scopus 로고
    • Pancreatic cancer-associated stroma production
    • DOI 10.1016/j.amjsurg.2007.05.004, PII S0002961007003480
    • Korc M. Pancreatic cancer-associated stroma production. Am J Surg. 2007;194(4 suppl):S84-S86. (Pubitemid 47454597)
    • (2007) American Journal of Surgery , vol.194 , Issue.4 SUPPL.
    • Korc, M.1
  • 3
    • 0346157370 scopus 로고    scopus 로고
    • Tumor-Stroma Interaction of Human Pancreatic Cancer: Acquired Resistance to Anticancer Drugs and Proliferation Regulation Is Dependent on Extracellular Matrix Proteins
    • DOI 10.1097/00006676-200401000-00006
    • Miyamoto H, Murakami T, Tsuchida K, Sugino H, Miyake H, Tashiro S. Tumor-stroma interaction of human pancreatic cancer: acquired resistance to anticancer drugs and proliferation regulation is dependent on extracellular matrix proteins. Pancreas. 2004;28(1):38-44. (Pubitemid 38032243)
    • (2004) Pancreas , vol.28 , Issue.1 , pp. 38-44
    • Miyamoto, H.1    Murakami, T.2    Tsuchida, K.3    Sugino, H.4    Miyake, H.5    Tashiro, S.6
  • 4
    • 0037899253 scopus 로고    scopus 로고
    • Role of tissue stroma in cancer cell invasion
    • DOI 10.1002/path.1398
    • De Wever O, Mareel M. Role of tissue stroma in cancer cell invasion. J Pathol. 2003;200(4):429-447. (Pubitemid 36818244)
    • (2003) Journal of Pathology , vol.200 , Issue.4 , pp. 429-447
    • De Wever, O.1    Mareel, M.2
  • 5
    • 27944469616 scopus 로고    scopus 로고
    • Growth factor-induced shedding of syndecan-1 confers glypican-1 dependence on mitogenic responses of cancer cells
    • DOI 10.1083/jcb.200508010
    • Ding K, Lopez-Burks M, Sanchez-Duran JA, Korc M, Lander AD. Growth factor-induced shedding of syndecan-1 confers glypican-1 dependence on mitogenic responses of cancer cells. J Cell Biol. 2005;171(4):729-738. (Pubitemid 41668731)
    • (2005) Journal of Cell Biology , vol.171 , Issue.4 , pp. 729-738
    • Ding, K.1    Lopez-Burks, M.2    Sanchez-Duran, J.A.3    Korc, M.4    Lander, A.D.5
  • 6
    • 0032213027 scopus 로고    scopus 로고
    • The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer
    • Kleeff J, et al. The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer. J Clin Invest. 1998;102(9):1662-1673. (Pubitemid 28516251)
    • (1998) Journal of Clinical Investigation , vol.102 , Issue.9 , pp. 1662-1673
    • Kleeff, J.1    Ishiwata, T.2    Kumbasar, A.3    Friess, H.4    Buchler, M.W.5    Lander, A.D.6    Korc, M.7
  • 8
    • 79955828776 scopus 로고    scopus 로고
    • Stromal biology and therapy in pancreatic cancer
    • Neesse A, et al. Stromal biology and therapy in pancreatic cancer. Gut. 2011;60(6):861-868.
    • (2011) Gut , vol.60 , Issue.6 , pp. 861-868
    • Neesse, A.1
  • 9
    • 37849035627 scopus 로고    scopus 로고
    • TLR signaling by tumor and immune cells: A double-edged sword
    • Huang B, Zhao J, Unkeless JC, Feng ZH, Xiong H. TLR signaling by tumor and immune cells: a double-edged sword. Oncogene. 2008;27(2):218-224.
    • (2008) Oncogene , vol.27 , Issue.2 , pp. 218-224
    • Huang, B.1    Zhao, J.2    Unkeless, J.C.3    Feng, Z.H.4    Xiong, H.5
  • 12
    • 33749152085 scopus 로고    scopus 로고
    • Toll-like receptors: From the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity
    • DOI 10.1016/j.bcp.2006.07.010, PII S0006295206004278
    • Doyle SL, O'Neill LA. Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity. Biochem Pharmacol. 2006;72(9):1102-1113. (Pubitemid 44468394)
    • (2006) Biochemical Pharmacology , vol.72 , Issue.9 SPEC. ISS. , pp. 1102-1113
    • Doyle, S.L.1    O'Neill, L.A.J.2
  • 13
    • 34249677845 scopus 로고    scopus 로고
    • Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
    • DOI 10.1038/nm1589, PII NM1589
    • Kanzler H, Barrat FJ, Hessel EM, Coffman RL. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat Med. 2007;13(5):552-559. (Pubitemid 46830615)
    • (2007) Nature Medicine , vol.13 , Issue.5 , pp. 552-559
    • Kanzler, H.1    Barrat, F.J.2    Hessel, E.M.3    Coffman, R.L.4
  • 14
    • 33847020899 scopus 로고    scopus 로고
    • Isolation of Mouse Pancreatic Ductal Progenitor Cells Expressing CD133 and c-Met by Flow Cytometric Cell Sorting
    • DOI 10.1053/j.gastro.2006.11.027, PII S0016508506024826
    • Oshima Y, Suzuki A, Kawashimo K, Ishikawa M, Ohkohchi N, Taniguchi H. Isolation of mouse pancreatic ductal progenitor cells expressing CD133 and c-Met by flow cytometric cell sorting. Gastroenterology. 2007;132(2):720-732. (Pubitemid 46274661)
    • (2007) Gastroenterology , vol.132 , Issue.2 , pp. 720-732
    • Oshima, Y.1    Suzuki, A.2    Kawashimo, K.3    Ishikawa, M.4    Ohkohchi, N.5    Taniguchi, H.6
  • 15
    • 41049106901 scopus 로고    scopus 로고
    • Murine CD146 is widely expressed on endothelial cells and is recognized by the monoclonal antibody ME-9F1
    • Schrage A, et al. Murine CD146 is widely expressed on endothelial cells and is recognized by the monoclonal antibody ME-9F1. Histochem Cell Biol. 2008;129(4):441-451.
    • (2008) Histochem Cell Biol , vol.129 , Issue.4 , pp. 441-451
    • Schrage, A.1
  • 16
    • 36148968456 scopus 로고    scopus 로고
    • RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells
    • DOI 10.1093/carcin/bgm159
    • Chow JY, Quach KT, Cabrera BL, Cabral JA, Beck SE, Carethers JM. RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells. Carcinogenesis. 2007;28(11):2321-2327. (Pubitemid 350111590)
    • (2007) Carcinogenesis , vol.28 , Issue.11 , pp. 2321-2327
    • Chow, J.Y.C.1    Quach, K.T.2    Cabrera, B.L.3    Cabral, J.A.4    Beck, S.E.5    Carethers, J.M.6
  • 17
    • 77956911099 scopus 로고    scopus 로고
    • In hepatic fibrosis, liver sinusoidal endothelial cells acquire enhanced immunogenicity
    • Connolly MK, et al. In hepatic fibrosis, liver sinusoidal endothelial cells acquire enhanced immunogenicity. J Immunol. 2010;185(4):2200-2208.
    • (2010) J Immunol , vol.185 , Issue.4 , pp. 2200-2208
    • Connolly, M.K.1
  • 18
    • 79953761842 scopus 로고    scopus 로고
    • Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression
    • Fukuda A, et al. Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression. Cancer Cell. 2011;19(4):441-455.
    • (2011) Cancer Cell , vol.19 , Issue.4 , pp. 441-455
    • Fukuda, A.1
  • 19
    • 79953756112 scopus 로고    scopus 로고
    • Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer
    • Lesina M, et al. Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Cancer Cell. 2011;19(4):456-469.
    • (2011) Cancer Cell , vol.19 , Issue.4 , pp. 456-469
    • Lesina, M.1
  • 20
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer. 2009;9(11):798-809.
    • (2009) Nat Rev Cancer , vol.9 , Issue.11 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 21
    • 64049085356 scopus 로고    scopus 로고
    • Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras
    • Carriere C, Young AL, Gunn JR, Longnecker DS, Korc M. Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras. Biochem Biophys Res Commun. 2009;382(3):561-565.
    • (2009) Biochem Biophys Res Commun , vol.382 , Issue.3 , pp. 561-565
    • Carriere, C.1    Young, A.L.2    Gunn, J.R.3    Longnecker, D.S.4    Korc, M.5
  • 22
    • 78650315462 scopus 로고    scopus 로고
    • Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9
    • Guiducci C, et al. Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9. J Exp Med. 2010;207(13):2931-2942.
    • (2010) J Exp Med , vol.207 , Issue.13 , pp. 2931-2942
    • Guiducci, C.1
  • 23
    • 33845998896 scopus 로고    scopus 로고
    • The pancreatic stellate cell: A star on the rise in pancreatic diseases
    • DOI 10.1172/JCI30082
    • Omary MB, Lugea A, Lowe AW, Pandol SJ. The pancreatic stellate cell: a star on the rise in pancreatic diseases. J Clin Invest. 2007;117(1):50-59. (Pubitemid 46048449)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.1 , pp. 50-59
    • Omary, M.B.1    Lugea, A.2    Lowe, A.W.3    Pandol, S.J.4
  • 24
    • 57749116315 scopus 로고    scopus 로고
    • Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia
    • De La OJ, et al. Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. Proc Natl Acad Sci U S A. 2008;105(48):18907- 18912.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.48 , pp. 18907-18912
    • De La, O.J.1
  • 25
    • 79960385475 scopus 로고    scopus 로고
    • Notch signaling activated by replication stress-induced expression of midkine drives epithelial-mesenchymal transition and chemoresistance in pancreatic cancer
    • Gungor C, et al. Notch signaling activated by replication stress-induced expression of midkine drives epithelial-mesenchymal transition and chemoresistance in pancreatic cancer. Cancer Res. 2011;71(14):5009-5019.
    • (2011) Cancer Res , vol.71 , Issue.14 , pp. 5009-5019
    • Gungor, C.1
  • 26
    • 55349128861 scopus 로고    scopus 로고
    • Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways
    • Hu X, et al. Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways. Immunity. 2008;29(5):691-703.
    • (2008) Immunity , vol.29 , Issue.5 , pp. 691-703
    • Hu, X.1
  • 27
    • 84055217307 scopus 로고    scopus 로고
    • Crosstalk between the canonical NF-kappaB and Notch signaling pathways inhibits Ppargamma expression and promotes pancreatic cancer progression in mice
    • Maniati E, et al. Crosstalk between the canonical NF-kappaB and Notch signaling pathways inhibits Ppargamma expression and promotes pancreatic cancer progression in mice. J Clin Invest. 2011;121(12):4685-4699.
    • (2011) J Clin Invest , vol.121 , Issue.12 , pp. 4685-4699
    • Maniati, E.1
  • 28
    • 37549037911 scopus 로고    scopus 로고
    • Off the beaten pathway: The complex cross talk between Notch and NF-kappaB
    • Osipo C, Golde TE, Osborne BA, Miele LA. Off the beaten pathway: the complex cross talk between Notch and NF-kappaB. Lab Invest. 2008;88(1):11-17.
    • (2008) Lab Invest , vol.88 , Issue.1 , pp. 11-17
    • Osipo, C.1    Golde, T.E.2    Osborne, B.A.3    Miele, L.A.4
  • 29
    • 77956925475 scopus 로고    scopus 로고
    • PTEN loss accelerates KrasG12D-induced pancreatic cancer development
    • Hill R, et al. PTEN loss accelerates KrasG12D-induced pancreatic cancer development. Cancer Res. 2010;70(18):7114-7124.
    • (2010) Cancer Res , vol.70 , Issue.18 , pp. 7114-7124
    • Hill, R.1
  • 31
    • 0035011374 scopus 로고    scopus 로고
    • Copy number of cancer genes predict tumor grade and survival of pancreatic cancer patients
    • Nagy A, et al. Copy number of cancer genes predict tumor grade and survival of pancreatic cancer patients. Anticancer Res. 2001;21(2B):1321-1325.
    • (2001) Anticancer Res , vol.21 , Issue.2 , pp. 1321-1325
    • Nagy, A.1
  • 34
    • 80052127297 scopus 로고    scopus 로고
    • Deletion of Rb accelerates pancreatic carcinogenesis by oncogenic Kras and impairs senescence in premalignant lesions
    • Carriere C, et al. Deletion of Rb accelerates pancreatic carcinogenesis by oncogenic Kras and impairs senescence in premalignant lesions. Gastroenterology. 2011;141(3):1091-1101.
    • (2011) Gastroenterology , vol.141 , Issue.3 , pp. 1091-1101
    • Carriere, C.1
  • 36
    • 33751569391 scopus 로고    scopus 로고
    • Tumor-stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c-Met pathway
    • DOI 10.1002/ijc.22178
    • Ide T, et al. Tumor-stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c-Met pathway. Int J Cancer. 2006;119(12):2750-2759. (Pubitemid 44846225)
    • (2006) International Journal of Cancer , vol.119 , Issue.12 , pp. 2750-2759
    • Ide, T.1    Kitajima, Y.2    Miyoshi, A.3    Ohtsuka, T.4    Mitsuno, M.5    Ohtaka, K.6    Koga, Y.7    Miyazaki, K.8
  • 38
    • 80051531363 scopus 로고    scopus 로고
    • Notch signaling: Simplicity in design, versatility in function
    • Andersson ER, Sandberg R, Lendahl U. Notch signaling: simplicity in design, versatility in function. Development. 2011;138(17):3593-3612.
    • (2011) Development , vol.138 , Issue.17 , pp. 3593-3612
    • Andersson, E.R.1    Sandberg, R.2    Lendahl, U.3
  • 39
    • 33645755382 scopus 로고    scopus 로고
    • TLR3 can directly trigger apoptosis in human cancer cells
    • Salaun B, Coste I, Rissoan MC, Lebecque SJ, Renno T. TLR3 can directly trigger apoptosis in human cancer cells. J Immunol. 2006;176(8):4894-4901.
    • (2006) J Immunol , vol.176 , Issue.8 , pp. 4894-4901
    • Salaun, B.1    Coste, I.2    Rissoan, M.C.3    Lebecque, S.J.4    Renno, T.5
  • 41
    • 33845542139 scopus 로고    scopus 로고
    • Toll-like receptor agonists in the treatment of chronic lymphocytic leukemia
    • DOI 10.1038/sj.leu.2404456, PII 2404456
    • Spaner DE, Masellis A. Toll-like receptor agonists in the treatment of chronic lymphocytic leukemia. Leukemia. 2007;21(1):53-60. (Pubitemid 44921834)
    • (2007) Leukemia , vol.21 , Issue.1 , pp. 53-60
    • Spaner, D.E.1    Masellis, A.2
  • 44
    • 37849008154 scopus 로고    scopus 로고
    • Radiation therapy and Toll-like receptor signaling: Implications for the treatment of cancer
    • Roses RE, Xu M, Koski GK, Czerniecki BJ. Radiation therapy and Toll-like receptor signaling: implications for the treatment of cancer. Oncogene. 2008;27(2):200-207.
    • (2008) Oncogene , vol.27 , Issue.2 , pp. 200-207
    • Roses, R.E.1    Xu, M.2    Koski, G.K.3    Czerniecki, B.J.4
  • 45
    • 37849014248 scopus 로고    scopus 로고
    • Toll-like receptors and immune regulation: Implications for cancer therapy
    • Wang RF, Miyahara Y, Wang HY. Toll-like receptors and immune regulation: implications for cancer therapy. Oncogene. 2008;27(2):181-189.
    • (2008) Oncogene , vol.27 , Issue.2 , pp. 181-189
    • Wang, R.F.1    Miyahara, Y.2    Wang, H.Y.3
  • 47
    • 77954514970 scopus 로고    scopus 로고
    • Treatment failure of a TLR-7 agonist occurs due to self-regulation of acute inflammation and can be overcome by IL-10 blockade
    • Lu H, et al. Treatment failure of a TLR-7 agonist occurs due to self-regulation of acute inflammation and can be overcome by IL-10 blockade. J Immunol. 2010;184(9):5360-5367.
    • (2010) J Immunol , vol.184 , Issue.9 , pp. 5360-5367
    • Lu, H.1
  • 48
    • 37849033136 scopus 로고    scopus 로고
    • Role of Toll-like receptors in gastrointestinal malignancies
    • Fukata M, Abreu MT. Role of Toll-like receptors in gastrointestinal malignancies. Oncogene. 2008;27(2):234-243.
    • (2008) Oncogene , vol.27 , Issue.2 , pp. 234-243
    • Fukata, M.1    Abreu, M.T.2
  • 49
    • 36549082403 scopus 로고    scopus 로고
    • Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors
    • Fukata M, et al. Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors. Gastroenterology. 2007;133(6):1869-1881.
    • (2007) Gastroenterology , vol.133 , Issue.6 , pp. 1869-1881
    • Fukata, M.1
  • 52
    • 77957196909 scopus 로고    scopus 로고
    • Toll-like receptor (TLR) 7 and TLR8 expression on CD133+ cells in colorectal cancer points to a specific role for inflammation-induced TLRs in tumourigenesis and tumour progression
    • Grimm M, et al. Toll-like receptor (TLR) 7 and TLR8 expression on CD133+ cells in colorectal cancer points to a specific role for inflammation-induced TLRs in tumourigenesis and tumour progression. Eur J Cancer. 2010;46(15):2849-2857.
    • (2010) Eur J Cancer , vol.46 , Issue.15 , pp. 2849-2857
    • Grimm, M.1
  • 53
    • 77951196379 scopus 로고    scopus 로고
    • Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance
    • Cherfils-Vicini J, et al. Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance. J Clin Invest. 2010;120(4):1285-1297.
    • (2010) J Clin Invest , vol.120 , Issue.4 , pp. 1285-1297
    • Cherfils-Vicini, J.1
  • 55
    • 70350664389 scopus 로고    scopus 로고
    • Cancer cells expressing toll-like receptors and the tumor microenvironment
    • Sato Y, Goto Y, Narita N, Hoon DS. Cancer cells expressing toll-like receptors and the tumor microenvironment. Cancer Microenviron. 2009;2(suppl 1):205-214.
    • (2009) Cancer Microenviron , vol.2 , Issue.SUPPL. 1 , pp. 205-214
    • Sato, Y.1    Goto, Y.2    Narita, N.3    Hoon, D.S.4
  • 56
    • 78649263282 scopus 로고    scopus 로고
    • The redox protein HMGB1 regulates cell death and survival in cancer treatment
    • Tang D, Loze MT, Zeh HJ, Kang R. The redox protein HMGB1 regulates cell death and survival in cancer treatment. Autophagy. 2010;6(8):1181-1183.
    • (2010) Autophagy , vol.6 , Issue.8 , pp. 1181-1183
    • Tang, D.1    Loze, M.T.2    Zeh, H.J.3    Kang, R.4
  • 58
    • 18944393984 scopus 로고    scopus 로고
    • TT virus infection and pancreatic cancer: Relationship or accidental coexistence
    • Tomasiewicz K, Modrzewska R, Lyczak A, Krawczuk G. TT virus infection and pancreatic cancer: relationship or accidental coexistence. World J Gastroenterol. 2005;11(18):2847-2849. (Pubitemid 40704264)
    • (2005) World Journal of Gastroenterology , vol.11 , Issue.18 , pp. 2847-2849
    • Tomasiewicz, K.1    Modrzewska, R.2    Lyczak, A.3    Krawczuk, G.4
  • 59
    • 53749101443 scopus 로고    scopus 로고
    • Association between hepatitis B virus and pancreatic cancer
    • Hassan MM, et al. Association between hepatitis B virus and pancreatic cancer. J Clin Oncol. 2008;26(28):4557-4562.
    • (2008) J Clin Oncol , vol.26 , Issue.28 , pp. 4557-4562
    • Hassan, M.M.1
  • 60
    • 0030931156 scopus 로고    scopus 로고
    • Hepatitis C and hepatocellular carcinoma
    • Di Bisceglie AM. Hepatitis C and hepatocellular carcinoma. Hepatology. 1997;26(3 suppl 1):34S-38S. (Pubitemid 27388069)
    • (1997) Hepatology , vol.26 , Issue.3 SUPPL.
    • Di, B.A.M.1
  • 61
    • 0028950183 scopus 로고
    • HCV-associated liver cancer without cirrhosis
    • De Mitri MS, et al. HCV-associated liver cancer without cirrhosis. Lancet. 1995;345(8947):413-415.
    • (1995) Lancet , vol.345 , Issue.8947 , pp. 413-415
    • De Mitri, M.S.1
  • 62
    • 58949095678 scopus 로고    scopus 로고
    • Risk of hepatobiliary and pancreatic cancers after hepatitis C virus infection: A population-based study of U.S. veterans
    • El-Serag HB, et al. Risk of hepatobiliary and pancreatic cancers after hepatitis C virus infection: A population-based study of U.S. veterans. Hepatology. 2009;49(1):116-123.
    • (2009) Hepatology , vol.49 , Issue.1 , pp. 116-123
    • El-Serag, H.B.1
  • 65
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • Olive KP, et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science. 2009;324(5933):1457-1461.
    • (2009) Science , vol.324 , Issue.5933 , pp. 1457-1461
    • Olive, K.P.1
  • 67
    • 80054857694 scopus 로고    scopus 로고
    • Dendritic cells promote pancreatic viability in mice with acute pancreatitis
    • Bedrosian AS, et al. Dendritic cells promote pancreatic viability in mice with acute pancreatitis. Gastroenterology. 2011;141(5):1915-1926.
    • (2011) Gastroenterology , vol.141 , Issue.5 , pp. 1915-1926
    • Bedrosian, A.S.1
  • 68
    • 70449355084 scopus 로고    scopus 로고
    • In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha
    • Connolly MK, et al. In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha. J Clin Invest. 2009;119(11):3213-3225.
    • (2009) J Clin Invest , vol.119 , Issue.11 , pp. 3213-3225
    • Connolly, M.K.1
  • 69
    • 77950561247 scopus 로고    scopus 로고
    • Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumor
    • Connolly MK, et al. Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumor. J Leukoc Biol. 2010;87(4):713-725.
    • (2010) J Leukoc Biol , vol.87 , Issue.4 , pp. 713-725
    • Connolly, M.K.1
  • 70
    • 84862147254 scopus 로고    scopus 로고
    • Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia
    • Pylayeva-Gupta Y, Lee KE, Hajdu CH, Miller G, Bar-Sagi D. Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia. Cancer Cell. 2012;21(6):836-847.
    • (2012) Cancer Cell , vol.21 , Issue.6 , pp. 836-847
    • Pylayeva-Gupta, Y.1    Lee, K.E.2    Hajdu, C.H.3    Miller, G.4    Bar-Sagi, D.5
  • 71
    • 33744542791 scopus 로고    scopus 로고
    • Pancreatic Duct Epithelial Cell Isolation and Cultivation in Two-Dimensional and Three-Dimensional Culture Systems
    • DOI 10.1016/S0076-6879(05)07055-2, PII S0076687905070552, Regulators and Effectors of Small GTPases: Ras Family
    • Agbunag C, Lee KE, Buontempo S, Bar-Sagi D. Pancreatic duct epithelial cell isolation and cultivation in two-dimensional and three-dimensional culture systems. Methods Enzymol. 2006;407:703-710. (Pubitemid 43815987)
    • (2005) Methods in Enzymology , vol.407 , pp. 703-710
    • Agbunag, C.1    Lee, K.E.2    Buontempo, S.3    Bar-Sagi, D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.