-
1
-
-
33846319348
-
The innate signaling of dangers and the dangers of innate signaling
-
DOI 10.1038/ni1420, PII NI1420
-
Sansonetti PJ. The innate signaling of dangers and the dangers of innate signaling. Nat Immunol 2006;7:1237-42 (Pubitemid 46111240)
-
(2006)
Nature Immunology
, vol.7
, Issue.12
, pp. 1237-1242
-
-
Sansonetti, P.J.1
-
2
-
-
32944464648
-
Pathogen recognition and innate immunity
-
DOI 10.1016/j.cell.2006.02.015, PII S0092867406001905
-
Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 2006;124:783-801 (Pubitemid 43261452)
-
(2006)
Cell
, vol.124
, Issue.4
, pp. 783-801
-
-
Akira, S.1
Uematsu, S.2
Takeuchi, O.3
-
3
-
-
33750574752
-
TLR signaling pathways: Opportunities for activation and blockade in pursuit of therapy
-
DOI 10.2174/138161206778743466
-
Hoebe K, Jiang Z, Georgel P, et al. TLR signaling pathways: opportunities for activation and blockade in pursuit of therapy. Curr Pharm Des 2006;12:4123-34 (Pubitemid 44669741)
-
(2006)
Current Pharmaceutical Design
, vol.12
, Issue.32
, pp. 4123-4134
-
-
Hoebe, K.1
Jiang, Z.2
Georgel, P.3
Tabeta, K.4
Janssen, E.5
Du, X.6
Beutler, B.7
-
4
-
-
0030831210
-
A human homologue of the Drosophila toll protein signals activation of adaptive immunity
-
DOI 10.1038/41131
-
Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997;388:394-7 (Pubitemid 27334820)
-
(1997)
Nature
, vol.388
, Issue.6640
, pp. 394-397
-
-
Medzhitov, R.1
Preston-Hurlburt, P.2
Janeway Jr., C.A.3
-
5
-
-
0032170215
-
Genetic and physical mapping of the Lps locus: Identification of the toll-4 receptor as a candidate gene in the critical region
-
DOI 10.1006/bcmd.1998.0201
-
Poltorak A, Smirnova I, He X, et al. Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region. Blood Cells Mol Dis 1998;24:340-55 (Pubitemid 28524834)
-
(1998)
Blood Cells, Molecules, and Diseases
, vol.24
, Issue.3
, pp. 340-355
-
-
Poltorak, A.1
Smirnova, I.2
He, X.3
Liu, M.-Y.4
Van Huffel, C.5
Birdwell, D.6
Alejos, E.7
Silva, M.8
Du, X.9
Thompson, P.10
Chan, E.K.L.11
Ledesma, J.12
Roe, B.13
Clifton, S.14
Vogel, S.N.15
Beutler, B.16
-
6
-
-
0031905311
-
A family of human receptors structurally related to Drosophila Toll
-
DOI 10.1073/pnas.95.2.588
-
Rock FL, Hardiman G, Timans JC, et al. A family of human receptors structurally related to Drosophila Toll. Proc Natl Acad Sci USA 1998;95:588-93 (Pubitemid 28083787)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.2
, pp. 588-593
-
-
Rock, F.L.1
Hardiman, G.2
Timans, J.C.3
Kastelein, R.A.4
Bazan, J.F.5
-
7
-
-
22144452520
-
The evolution of vertebrate Toll-like receptors
-
DOI 10.1073/pnas.0502272102
-
Roach JC, Glusman G, Rowen L, et al. The evolution of vertebrate Toll-like receptors. Proc Natl Acad Sci USA 2005;102:9577-82 (Pubitemid 40981723)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.27
, pp. 9577-9582
-
-
Roach, J.C.1
Glusman, G.2
Rowen, L.3
Kaur, A.4
Purcell, M.K.5
Smith, K.D.6
Hood, L.E.7
Aderem, A.8
-
8
-
-
33750980112
-
Genomic insights into the immune system of the sea urchin
-
DOI 10.1126/science.1134301
-
Rast JP, Smith LC, Loza-Coll M, et al. Genomic insights into the immune system of the sea urchin. Science 2006;314:952-6 (Pubitemid 44749931)
-
(2006)
Science
, vol.314
, Issue.5801
, pp. 952-956
-
-
Rast, J.P.1
Smith, L.C.2
Loza-Coll, M.3
Hibino, T.4
Litman, G.W.5
-
9
-
-
77951260924
-
The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors
-
Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 2010;11:373-84
-
(2010)
Nat Immunol
, vol.11
, pp. 373-84
-
-
Kawai, T.1
Akira, S.2
-
10
-
-
0037505362
-
The Toll-IL-1 receptor adaptor family grows to five members
-
O?Neill LA, Fitzgerald KA, Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends Immunol 2003;24:286-90
-
(2003)
Trends Immunol
, vol.24
, pp. 286-90
-
-
Oneill, L.A.1
Fitzgerald, K.A.2
Bowie, A.G.3
-
11
-
-
33750369226
-
Toll-like receptors in systemic autoimmune disease
-
DOI 10.1038/nri1957, PII NRI1957
-
Marshak-Rothstein A. Toll-like receptors in systemic autoimmune disease. Nat Rev Immunol 2006;6:823-35 (Pubitemid 44631651)
-
(2006)
Nature Reviews Immunology
, vol.6
, Issue.11
, pp. 823-835
-
-
Marshak-Rothstein, A.1
-
13
-
-
67349182481
-
The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
-
Park BS, Song DH, Kim HM, et al. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature 2009;458:1191-5
-
(2009)
Nature
, vol.458
, pp. 1191-5
-
-
Park, B.S.1
Song, D.H.2
Kim, H.M.3
-
14
-
-
42349090335
-
Structural basis of toll-like receptor 3 signaling with double-stranded RNA
-
DOI 10.1126/science.1155406
-
Liu L, Botos I, Wang Y, et al. Structural basis of toll-like receptor 3 signaling with double-stranded RNA. Science 2008;320:379-81 (Pubitemid 351555661)
-
(2008)
Science
, vol.320
, Issue.5874
, pp. 379-381
-
-
Liu, L.1
Botos, I.2
Wang, Y.3
Leonard, J.N.4
Shiloach, J.5
Segal, D.M.6
Davies, D.R.7
-
15
-
-
34548608447
-
Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide
-
DOI 10.1016/j.cell.2007.09.008, PII S009286740701152X
-
Jin MS, Kim SE, Heo JY, et al. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 2007;130:1071-82 (Pubitemid 47410281)
-
(2007)
Cell
, vol.130
, Issue.6
, pp. 1071-1082
-
-
Jin, M.S.1
Kim, S.E.2
Heo, J.Y.3
Lee, M.E.4
Kim, H.M.5
Paik, S.-G.6
Lee, H.7
Lee, J.-O.8
-
16
-
-
34548844720
-
Toll-like receptor signal transduction
-
Krishnan J, Selvarajoo K, Tsuchiya M, et al. Toll-like receptor signal transduction. Exp Mol Med 2007;39:421-38 (Pubitemid 47443856)
-
(2007)
Experimental and Molecular Medicine
, vol.39
, Issue.4
, pp. 421-438
-
-
Krishnan, J.1
Selvarajoo, K.2
Tsuchiya, M.3
Lee, G.4
Choi, S.5
-
17
-
-
59249095900
-
Characterization of bovine Toll-like receptor 8: Ligand specificity, signaling essential sites and dimerization
-
Zhu J, Brownlie R, Liu Q, et al. Characterization of bovine Toll-like receptor 8: ligand specificity, signaling essential sites and dimerization. Mol Immunol 2009;46:978-90
-
(2009)
Mol Immunol
, vol.46
, pp. 978-90
-
-
Zhu, J.1
Brownlie, R.2
Liu, Q.3
-
18
-
-
7444250116
-
Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling
-
DOI 10.1073/pnas.0406933101
-
Honda K, Yanai H, Mizutani T, et al. Role of a transductional- transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proc Natl Acad Sci USA 2004;101:15416-21 (Pubitemid 39441556)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.43
, pp. 15416-15421
-
-
Honda, K.1
Yanai, H.2
Mizutani, T.3
Negishi, H.4
Shimada, N.5
Suzuki, N.6
Ohba, Y.7
Takaoka, A.8
Yeh, W.-C.9
Taniguchi, T.10
-
19
-
-
5444274514
-
Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
-
DOI 10.1038/ni1118
-
Kawai T, Sato S, Ishii KJ, et al. Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol 2004;5:1061-8 (Pubitemid 41057726)
-
(2004)
Nature Immunology
, vol.5
, Issue.10
, pp. 1061-1068
-
-
Kawai, T.1
Sato, S.2
Ishii, K.J.3
Coban, C.4
Hemmi, H.5
Yamamoto, M.6
Terai, K.7
Matsuda, M.8
Inoue, J.-I.9
Uematsu, S.10
Takeuchi, O.11
Akira, S.12
-
20
-
-
33745077384
-
Immunobiology of Toll-like receptors: Emerging trends
-
DOI 10.1111/j.1440-1711.2006.01444.x
-
Pandey S, Agrawal DK. Immunobiology of Toll-like receptors: emerging trends. Immunol Cell Biol 2006;84:333-41 (Pubitemid 43882838)
-
(2006)
Immunology and Cell Biology
, vol.84
, Issue.4
, pp. 333-341
-
-
Pandey, S.1
Agrawal, D.K.2
-
21
-
-
72049122659
-
Drugs targeting Toll-like receptors
-
Krishnan J, Lee G, Choi S. Drugs targeting Toll-like receptors. Arch Pharm Res 2009;32:1485-502
-
(2009)
Arch Pharm Res
, vol.32
, pp. 1485-502
-
-
Krishnan, J.1
Lee, G.2
Choi, S.3
-
22
-
-
33845786018
-
Current and future drugs targeting one class of innate immunity receptors: The Toll-like receptors
-
DOI 10.1016/j.drudis.2006.11.007, PII S1359644606004685
-
Romagne F. Current and future drugs targeting one class of innate immunity receptors: the Toll-like receptors. Drug Discov Today 2007;12:80-7 (Pubitemid 46014484)
-
(2007)
Drug Discovery Today
, vol.12
, Issue.1-2
, pp. 80-87
-
-
Romagne, F.1
-
23
-
-
37749044421
-
Synthetic agonists of Toll-like receptors 7, 8 and 9
-
Agrawal S, Kandimalla ER. Synthetic agonists of Toll-like receptors 7, 8 and 9. Biochem Soc Trans 2007;35:1461-7
-
(2007)
Biochem Soc Trans
, vol.35
, pp. 1461-7
-
-
Agrawal, S.1
Kandimalla, E.R.2
-
24
-
-
34249677845
-
Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
-
DOI 10.1038/nm1589, PII NM1589
-
Kanzler H, Barrat FJ, Hessel EM, Coffman RL. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat Med 2007;13:552-9 (Pubitemid 46830615)
-
(2007)
Nature Medicine
, vol.13
, Issue.5
, pp. 552-559
-
-
Kanzler, H.1
Barrat, F.J.2
Hessel, E.M.3
Coffman, R.L.4
-
25
-
-
53849109907
-
Putting endotoxin to work for us: Monophosphoryl lipid A as a safe and effective vaccine adjuvant
-
Casella CR, Mitchell TC. Putting endotoxin to work for us: monophosphoryl lipid A as a safe and effective vaccine adjuvant. Cell Mol Life Sci 2008;65:3231-40
-
(2008)
Cell Mol Life Sci
, vol.65
, pp. 3231-40
-
-
Casella, C.R.1
Mitchell, T.C.2
-
26
-
-
43049115295
-
Functional diversification of the toll-like receptor gene family
-
Hughes AL, Piontkivska H. Functional diversification of the toll-like receptor gene family. Immunogenetics 2008;60:249-56
-
(2008)
Immunogenetics
, vol.60
, pp. 249-56
-
-
Hughes, A.L.1
Piontkivska, H.2
-
27
-
-
0033592748
-
The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
-
Underhill DM, Ozinsky A, Hajjar AM, et al. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 1999;401:811-15
-
(1999)
Nature
, vol.401
, pp. 811-15
-
-
Underhill, D.M.1
Ozinsky, A.2
Hajjar, A.M.3
-
28
-
-
0033618630
-
Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
-
Aliprantis AO, Yang RB, Mark MR, et al. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science 1999;285:736-9
-
(1999)
Science
, vol.285
, pp. 736-9
-
-
Aliprantis, A.O.1
Yang, R.B.2
Mark, M.R.3
-
29
-
-
0033618562
-
Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
-
Brightbill HD, Libraty DH, Krutzik SR, et al. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science 1999;285:732-6
-
(1999)
Science
, vol.285
, pp. 732-6
-
-
Brightbill, H.D.1
Libraty, D.H.2
Krutzik, S.R.3
-
30
-
-
33947629255
-
Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors
-
DOI 10.1016/j.smim.2006.12.002, PII S1044532306001229, TLR-Mediated Innate Immune Recognition
-
Miyake K. Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors. Semin Immunol 2007;19:3-10 (Pubitemid 46498750)
-
(2007)
Seminars in Immunology
, vol.19
, Issue.1
, pp. 3-10
-
-
Miyake, K.1
-
31
-
-
69949088965
-
Innate immune sensing and activation of cell surface Toll-like receptors
-
Tapping RI. Innate immune sensing and activation of cell surface Toll-like receptors. Semin Immunol 2009;21:175-84
-
(2009)
Semin Immunol
, vol.21
, pp. 175-84
-
-
Tapping, R.I.1
-
32
-
-
34548293833
-
Recent advances with TLR2-targeting lipopeptide-based vaccines
-
DOI 10.2174/138920307781369436
-
Eriksson EM, Jackson DC. Recent advances with TLR2-targeting lipopeptide-based vaccines. Curr Protein Pept Sci 2007;8:412-17 (Pubitemid 47317044)
-
(2007)
Current Protein and Peptide Science
, vol.8
, Issue.4
, pp. 412-417
-
-
Eriksson, E.M.Y.1
Jackson, D.C.2
-
33
-
-
41549111496
-
Self-adjuvanting lipopeptide vaccines
-
DOI 10.2174/092986708783503249
-
Moyle PM, Toth I. Self-adjuvanting lipopeptide vaccines. Curr Med Chem 2008;15:506-16 (Pubitemid 351472417)
-
(2008)
Current Medicinal Chemistry
, vol.15
, Issue.5
, pp. 506-516
-
-
Moyle, P.M.1
Toth, I.2
-
34
-
-
70350440469
-
Toll-like receptor 2 dependent immunogenicity of glycoconjugate vaccines containing chemically derived zwitterionic polysaccharides
-
Gallorini S, Berti F, Mancuso G, et al. Toll-like receptor 2 dependent immunogenicity of glycoconjugate vaccines containing chemically derived zwitterionic polysaccharides. Proc Natl Acad Sci USA 2009;106:17481-6
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 17481-6
-
-
Gallorini, S.1
Berti, F.2
Mancuso, G.3
-
35
-
-
67649518029
-
In vivo and in vitro adjuvant activities of the B subunit of Type 2b heat-labile enterotoxin (LT-IIb-B5) from Escherichia coli
-
Liang S, Hosur KB, Nawar HF, et al. In vivo and in vitro adjuvant activities of the B subunit of Type 2b heat-labile enterotoxin (LT-IIb-B5) from Escherichia coli. Vaccine 2009;27:4302-8
-
(2009)
Vaccine
, vol.27
, pp. 4302-8
-
-
Liang, S.1
Hosur, K.B.2
Nawar, H.F.3
-
36
-
-
38349075841
-
The PorB porin from commensal Neisseria lactamica induces Th1 and Th2 immune responses to ovalbumin in mice and is a potential immune adjuvant
-
Liu X, Wetzler LM, Massari P. The PorB porin from commensal Neisseria lactamica induces Th1 and Th2 immune responses to ovalbumin in mice and is a potential immune adjuvant. Vaccine 2008;26:786-96
-
(2008)
Vaccine
, vol.26
, pp. 786-96
-
-
Liu, X.1
Wetzler, L.M.2
Massari, P.3
-
38
-
-
44449120076
-
Activation of Toll-like receptor 2 by a novel preparation of cell wall skeleton from Mycobacterium bovis BCG Tokyo (SMP-105) sufficiently enhances immune responses against tumors
-
DOI 10.1111/j.1349-7006.2008.00832.x
-
Murata M. Activation of Toll-like receptor 2 by a novel preparation of cell wall skeleton from Mycobacterium bovis BCG Tokyo (SMP-105) sufficiently enhances immune responses against tumors. Cancer Sci 2008;99:1435-40 (Pubitemid 351761735)
-
(2008)
Cancer Science
, vol.99
, Issue.7
, pp. 1435-1440
-
-
Murata, M.1
-
39
-
-
77954904799
-
Identification of novel synthetic toll-like receptor 2 agonists by high throughput screening
-
Guan Y, Omueti-Ayoade K, Mutha SK, et al. Identification of novel synthetic toll-like receptor 2 agonists by high throughput screening. J Biol Chem 2010;285:23755-62
-
(2010)
J Biol Chem
, vol.285
, pp. 23755-62
-
-
Guan, Y.1
Omueti-Ayoade, K.2
Mutha, S.K.3
-
40
-
-
0034123135
-
Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: Selective expression of TLR3 in dendritic cells
-
Muzio M, Bosisio D, Polentarutti N, et al. Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. J Immunol 2000;164:5998-6004 (Pubitemid 30389848)
-
(2000)
Journal of Immunology
, vol.164
, Issue.11
, pp. 5998-6004
-
-
Muzio, M.1
Bosisio, D.2
Polentarutti, N.3
D'amico, G.4
Stoppacciaro, A.5
Mancinelli, R.6
Van't Veer, C.7
Penton-Rol, G.8
Ruco, L.P.9
Allavena, P.10
Mantovani, A.11
-
41
-
-
0037080024
-
Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines
-
Zarember KA, Godowski PJ. Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J Immunol 2002;168:554-61 (Pubitemid 34049553)
-
(2002)
Journal of Immunology
, vol.168
, Issue.2
, pp. 554-561
-
-
Zarember, K.A.1
Godowski, P.J.2
-
42
-
-
37549051320
-
Immunoadjuvant effects of polyadenylic: Polyuridylic acids through TLR3 and TLR7
-
Sugiyama T, Hoshino K, Saito M, et al. Immunoadjuvant effects of polyadenylic: polyuridylic acids through TLR3 and TLR7. Int Immunol 2008;20:1-9
-
(2008)
Int Immunol
, vol.20
, pp. 1-9
-
-
Sugiyama, T.1
Hoshino, K.2
Saito, M.3
-
43
-
-
33645755382
-
TLR3 can directly trigger apoptosis in human cancer cells
-
Salaun B, Coste I, Rissoan MC, et al. TLR3 can directly trigger apoptosis in human cancer cells. J Immunol 2006;176:4894-901
-
(2006)
J Immunol
, vol.176
, pp. 4894-901
-
-
Salaun, B.1
Coste, I.2
Rissoan, M.C.3
-
44
-
-
63849285296
-
Therapeutic applications of nucleic acids as ligands for Toll-like receptors
-
Panter G, Kuznik A, Jerala R. Therapeutic applications of nucleic acids as ligands for Toll-like receptors. Curr Opin Mol Ther 2009;11:133-45
-
(2009)
Curr Opin Mol Ther
, vol.11
, pp. 133-45
-
-
Panter, G.1
Kuznik, A.2
Jerala, R.3
-
45
-
-
67349117313
-
Ampligen: A potential toll-like 3 receptor adjuvant for immunotherapy of cancer
-
Jasani B, Navabi H, Adams M. Ampligen: a potential toll-like 3 receptor adjuvant for immunotherapy of cancer. Vaccine 2009;27:3401-4
-
(2009)
Vaccine
, vol.27
, pp. 3401-4
-
-
Jasani, B.1
Navabi, H.2
Adams, M.3
-
46
-
-
14744274494
-
Differential role for TLR3 in respiratory syncytial virus-induced chemokine expression
-
DOI 10.1128/JVI.79.6.3350-3357.2005
-
Rudd BD, Burstein E, Duckett CS, et al. Differential role for TLR3 in respiratory syncytial virus-induced chemokine expression. J Virol 2005;79:3350-7 (Pubitemid 40327923)
-
(2005)
Journal of Virology
, vol.79
, Issue.6
, pp. 3350-3357
-
-
Rudd, B.D.1
Burstein, E.2
Duckett, C.S.3
Li, X.4
Lukacs, N.W.5
-
47
-
-
23044445303
-
Structural biology: Crystal structure of human toll-like receptor 3 (TLR3) ectodomain
-
DOI 10.1126/science.1115253
-
Choe J, Kelker MS, Wilson IA. Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science 2005;309:581-5 (Pubitemid 41033635)
-
(2005)
Science
, vol.309
, Issue.5734
, pp. 581-585
-
-
Choe, J.1
Kelker, M.S.2
Wilson, I.A.3
-
48
-
-
33744521498
-
The adjuvant effects of the toll-like receptor 3 ligand polyinosinic-cytidylic acid poly (I:C) on antigen-specific CD8+ T cell responses are partially dependent on NK cells with the induction of a beneficial cytokine milieu
-
DOI 10.1016/j.vaccine.2006.04.010, PII S0264410X06004373
-
Salem ML, El-Naggar SA, Kadima A, et al. The adjuvant effects of the toll-like receptor 3 ligand polyinosinic-cytidylic acid poly (I:C) on antigen-specific CD8+ T cell responses are partially dependent on NK cells with the induction of a beneficial cytokine milieu. Vaccine 2006;24:5119-32 (Pubitemid 43818196)
-
(2006)
Vaccine
, vol.24
, Issue.24
, pp. 5119-5132
-
-
Salem, M.L.1
El-Naggar, S.A.2
Kadima, A.3
Gillanders, W.E.4
Cole, D.J.5
-
49
-
-
77957753966
-
Poly(I:C) is an effective adjuvant for antibody and multi-functional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and alphaDEC-CSP in non human primates
-
Tewari K, Flynn BJ, Boscardin SB, et al. Poly(I:C) is an effective adjuvant for antibody and multi-functional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and alphaDEC-CSP in non human primates. Vaccine 2010;28:7256-66
-
(2010)
Vaccine
, vol.28
, pp. 7256-66
-
-
Tewari, K.1
Flynn, B.J.2
Boscardin, S.B.3
-
50
-
-
49249128648
-
Paired Toll-like receptor agonists enhance vaccine therapy through induction of interleukin-12
-
Zheng R, Cohen PA, Paustian CA, et al. Paired Toll-like receptor agonists enhance vaccine therapy through induction of interleukin-12. Cancer Res 2008;68:4045-9
-
(2008)
Cancer Res
, vol.68
, pp. 4045-9
-
-
Zheng, R.1
Cohen, P.A.2
Paustian, C.A.3
-
51
-
-
67650445798
-
Dendritic cells require a systemic type i interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant
-
Longhi MP, Trumpfheller C, Idoyaga J, et al. Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant. J Exp Med 2009;206:1589-602
-
(2009)
J Exp Med
, vol.206
, pp. 1589-602
-
-
Longhi, M.P.1
Trumpfheller, C.2
Idoyaga, J.3
-
52
-
-
0037290876
-
Mammalian Toll-like receptors
-
DOI 10.1016/S0952-7915(02)00013-4
-
Akira S. Mammalian Toll-like receptors. Curr Opin Immunol 2003;15:5-11 (Pubitemid 35454185)
-
(2003)
Current Opinion in Immunology
, vol.15
, Issue.1
, pp. 5-11
-
-
Akira, S.1
-
53
-
-
34250854079
-
The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4
-
DOI 10.1126/science.1138963
-
Mata-Haro V, Cekic C, Martin M, et al. The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4. Science 2007;316:1628-32 (Pubitemid 46982038)
-
(2007)
Science
, vol.316
, Issue.5831
, pp. 1628-1632
-
-
Mata-Haro, V.1
Cekic, C.2
Martin, M.3
Chilton, P.M.4
Casella, C.R.5
Mitchell, T.C.6
-
54
-
-
33947187647
-
Toll-free vaccines?
-
DOI 10.1038/nbt0307-303, PII NBT0307303
-
Krieg AM. Toll-free vaccines? Nat Biotechnol 2007;25:303-5 (Pubitemid 46398765)
-
(2007)
Nature Biotechnology
, vol.25
, Issue.3
, pp. 303-305
-
-
Krieg, A.M.1
-
55
-
-
34248350674
-
Case-control study of human papillomavirus and oropharyngeal cancer
-
DOI 10.1056/NEJMoa065497
-
D?souza G, Kreimer AR, Viscidi R, et al. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 2007;356:1944-56 (Pubitemid 46740304)
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.19
, pp. 1944-1956
-
-
D'Souza, G.1
Kreimer, A.R.2
Viscidi, R.3
Pawlita, M.4
Fakhry, C.5
Koch, W.M.6
Westra, W.H.7
Gillison, M.L.8
-
56
-
-
19444386768
-
Antitumour effect of OM-174 and Cyclophosphamide on murine B16 melanoma in different experimental conditions
-
DOI 10.1016/j.intimp.2005.02.013, PII S1567576905000585
-
D?Agostini C, Pica F, Febbraro G, et al. Antitumour effect of OM-174 and cyclophosphamide on murine B16 melanoma in different experimental conditions. Int Immunopharmacol 2005;5:1205-12 (Pubitemid 40725714)
-
(2005)
International Immunopharmacology
, vol.5
, Issue.7-8
, pp. 1205-1212
-
-
D'Agostini, C.1
Pica, F.2
Febbraro, G.3
Grelli, S.4
Chiavaroli, C.5
Garaci, E.6
-
57
-
-
33751184377
-
The radiosensitizing effect of immunoadjuvant OM-174 requires cooperation between immune and tumor cells through interferon-gamma and inducible nitric oxide synthase
-
De Ridder M, Verovski VN, Chiavaroli C, et al. The radiosensitizing effect of immunoadjuvant OM-174 requires cooperation between immune and tumor cells through interferon-gamma and inducible nitric oxide synthase. Int J Radiat Oncol Biol Phys 2006;66:1473-80
-
(2006)
Int J Radiat Oncol Biol Phys
, vol.66
, pp. 1473-80
-
-
De Ridder, M.1
Verovski, V.N.2
Chiavaroli, C.3
-
58
-
-
33845874634
-
Pollinex® Quattro: A novel and well-tolerated, ultra short-course allergy vaccine
-
DOI 10.1586/14760584.5.5.617
-
Patel P, Salapatek AM. Pollinex Quattro: a novel and well-tolerated, ultra short-course allergy vaccine. Expert Rev Vaccines 2006;5:617-29 (Pubitemid 46021044)
-
(2006)
Expert Review of Vaccines
, vol.5
, Issue.5
, pp. 617-629
-
-
Patel, P.1
Salapatek, A.M.F.2
-
59
-
-
34447542505
-
Pollinex® Quattro Ragweed: Safety evaluation of a new allergy vaccine adjuvanted with monophosphoryl lipid A (MPL®) for the treatment of ragweed pollen allergy
-
DOI 10.1002/jat.1223
-
Baldrick P, Richardson D, Woroniecki SR, Lees B. Pollinex Quattro Ragweed: safety evaluation of a new allergy vaccine adjuvanted with monophosphoryl lipid A (MPL) for the treatment of ragweed pollen allergy. J Appl Toxicol 2007;27:399-409 (Pubitemid 47066769)
-
(2007)
Journal of Applied Toxicology
, vol.27
, Issue.4
, pp. 399-409
-
-
Baldrick, P.1
Richardson, D.2
Woroniecki, S.R.3
Lees, B.4
-
60
-
-
27244449289
-
Randomized phase IIB trial of BLP25 liposome vaccine in stage IIIB and IV non-small-cell lung cancer
-
DOI 10.1200/JCO.2005.13.011
-
Butts C, Murray N, Maksymiuk A, et al. Randomized phase IIB trial of BLP25 liposome vaccine in stage IIIB and IV non-small-cell lung cancer. J Clin Oncol 2005;23:6674-81 (Pubitemid 46190262)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.27
, pp. 6674-6681
-
-
Butts, C.1
Murray, N.2
Maksymiuk, A.3
Goss, G.4
Marshall, E.5
Soulieres, D.6
Cormier, Y.7
Ellis, P.8
Price, A.9
Sawhney, R.10
Davis, M.11
Mansi, J.12
Smith, C.13
Vergidis, D.14
Ellis, P.15
MacNeil, M.16
Palmer, M.17
-
61
-
-
33847106037
-
A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin
-
DOI 10.1084/jem.20061400
-
Andersen-Nissen E, Smith KD, Bonneau R, et al. A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin. J Exp Med 2007;204:393-403 (Pubitemid 46294554)
-
(2007)
Journal of Experimental Medicine
, vol.204
, Issue.2
, pp. 393-403
-
-
Andersen-Nissen, E.1
Smith, K.D.2
Bonneau, R.3
Strong, R.K.4
Aderem, A.5
-
62
-
-
37449031125
-
Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin
-
DOI 10.1016/j.vaccine.2007.10.062, PII S0264410X0701256X
-
Huleatt JW, Nakaar V, Desai P, et al. Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin. Vaccine 2008;26:201-14 (Pubitemid 50008089)
-
(2008)
Vaccine
, vol.26
, Issue.2
, pp. 201-214
-
-
Huleatt, J.W.1
Nakaar, V.2
Desai, P.3
Huang, Y.4
Hewitt, D.5
Jacobs, A.6
Tang, J.7
McDonald, W.8
Song, L.9
Evans, R.K.10
Umlauf, S.11
Tussey, L.12
Powell, T.J.13
-
63
-
-
42049095095
-
An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models
-
DOI 10.1126/science.1154986
-
Burdelya LG, Krivokrysenko VI, Tallant TC, et al. An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models. Science 2008;320:226-30 (Pubitemid 351521417)
-
(2008)
Science
, vol.320
, Issue.5873
, pp. 226-230
-
-
Burdelya, L.G.1
Krivokrysenko, V.I.2
Tallant, T.C.3
Strom, E.4
Gleiberman, A.S.5
Gupta, D.6
Kurnasov, O.V.7
Fort, F.L.8
Osterman, A.L.9
DiDonato, J.A.10
Feinstein, E.11
Gudkov, A.V.12
-
64
-
-
67649422321
-
Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer
-
O?Neill LA, Bryant CE, Doyle SL. Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer. Pharmacol Rev 2009;61:177-97
-
(2009)
Pharmacol Rev
, vol.61
, pp. 177-97
-
-
Oneill, L.A.1
Bryant, C.E.2
Doyle, S.L.3
-
65
-
-
37849014248
-
Toll-like receptors and immune regulation: Implications for cancer therapy
-
Wang RF, Miyahara Y, Wang HY. Toll-like receptors and immune regulation: implications for cancer therapy. Oncogene 2008;27:181-9
-
(2008)
Oncogene
, vol.27
, pp. 181-9
-
-
Wang, R.F.1
Miyahara, Y.2
Wang, H.Y.3
-
66
-
-
37848999304
-
TLR7 and TLR8 as targets in cancer therapy
-
Schon MP, Schon M. TLR7 and TLR8 as targets in cancer therapy. Oncogene 2008;27:190-9
-
(2008)
Oncogene
, vol.27
, pp. 190-9
-
-
Schon, M.P.1
Schon, M.2
-
67
-
-
43049102416
-
The antiviral activity of toll-like receptor 7 and 7/8 agonists
-
DOI 10.1358/dnp.2008.21.2.1188193
-
Miller RL, Meng TC, Tomai MA. The antiviral activity of Toll-like receptor 7 and 7/8 agonists. Drug News Perspect 2008;21:69-87 (Pubitemid 351628232)
-
(2008)
Drug News and Perspectives
, vol.21
, Issue.2
, pp. 69-87
-
-
Miller, R.L.1
Meng, T.-C.2
Tomai, M.A.3
-
68
-
-
34447632621
-
Pharmacokinetics of 852A, an imidazoquinoline toll-like receptor 7-specific agonist, following intravenous, subcutaneous, and oral administrations in humans
-
DOI 10.1177/0091270007303766
-
Harrison LI, Astry C, Kumar S, Yunis C. Pharmacokinetics of 852A, an imidazoquinoline Toll-like receptor 7-specific agonist, following intravenous, subcutaneous, and oral administrations in humans. J Clin Pharmacol 2007;47:962-9 (Pubitemid 47094102)
-
(2007)
Journal of Clinical Pharmacology
, vol.47
, Issue.8
, pp. 962-969
-
-
Harrison, L.I.1
Astry, C.2
Kumar, S.3
Yunis, C.4
-
69
-
-
38949100471
-
An exploratory study of systemic administration of the toll-like receptor-7 agonist 852A in patients with refractory metastatic melanoma
-
DOI 10.1158/1078-0432.CCR-07-1938
-
Dummer R, Hauschild A, Becker JC, et al. An exploratory study of systemic administration of the toll-like receptor- 7 agonist 852A in patients with refractory metastatic melanoma. Clin Cancer Res 2008;14:856-64 (Pubitemid 351231170)
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.3
, pp. 856-864
-
-
Dummer, R.1
Hauschild, A.2
Becker, J.C.3
Grob, J.-J.4
Schadendorf, D.5
Tebbs, V.6
Skalsky, J.7
Kaehler, K.C.8
Moosbauer, S.9
Clark, R.10
Meng, T.-C.11
Urosevic, M.12
-
70
-
-
34347399259
-
Oral resiquimod in chronic HCV infection: Safety and efficacy in 2 placebo-controlled, double-blind phase IIa studies
-
DOI 10.1016/j.jhep.2007.02.025, PII S0168827807002565
-
Pockros PJ, Guyader D, Patton H, et al. Oral resiquimod in chronic HCV infection: safety and efficacy in 2 placebo-controlled, double-blind phase IIa studies. J Hepatol 2007;47:174-82 (Pubitemid 47021257)
-
(2007)
Journal of Hepatology
, vol.47
, Issue.2
, pp. 174-182
-
-
Pockros, P.J.1
Guyader, D.2
Patton, H.3
Tong, M.J.4
Wright, T.5
McHutchison, J.G.6
Meng, T.-C.7
-
71
-
-
32444441329
-
Activation of anti-hepatitis C virus responses via Toll-like receptor 7
-
DOI 10.1073/pnas.0510801103
-
Lee J, Wu CC, Lee KJ, et al. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci USA 2006;103:1828-33 (Pubitemid 43228778)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.6
, pp. 1828-1833
-
-
Lee, J.1
Wu, C.C.N.2
Lee, K.J.3
Chuang, T.-H.4
Katakura, K.5
Liu, Y.-T.6
Chan, M.7
Tawatao, R.8
Chung, M.9
Shen, C.10
Cottam, H.B.11
Lai, M.M.C.12
Raz, E.13
Carson, D.A.14
-
72
-
-
33747622584
-
Masked oral prodrugs of toll-like receptor 7 agonists: A new approach for the treatment of infectious disease
-
Fletcher S, Steffy K, Averett D. Masked oral prodrugs of toll-like receptor 7 agonists: a new approach for the treatment of infectious disease. Curr Opin Investig Drugs 2006;7:702-8 (Pubitemid 44263174)
-
(2006)
Current Opinion in Investigational Drugs
, vol.7
, Issue.8
, pp. 702-708
-
-
Fletcher, S.1
Steffy, K.2
Averett, D.3
-
73
-
-
67650526658
-
Current and future treatment options for HCV
-
Kronenberger B, Zeuzem S. Current and future treatment options for HCV. Ann Hepatol 2009;8:103-12
-
(2009)
Ann Hepatol
, vol.8
, pp. 103-12
-
-
Kronenberger, B.1
Zeuzem, S.2
-
74
-
-
0034619794
-
A Toll-like receptor recognizes bacterial DNA
-
DOI 10.1038/35047123
-
Hemmi H, Takeuchi O, Kawai T, et al. A Toll-like receptor recognizes bacterial DNA. Nature 2000;408:740-5 (Pubitemid 32015992)
-
(2000)
Nature
, vol.408
, Issue.6813
, pp. 740-745
-
-
Hemmi, H.1
Takeuchi, O.2
Kawai, T.3
Kaisho, T.4
Sato, S.5
Sanjo, H.6
Matsumoto, M.7
Hoshino, K.8
Wagner, H.9
Takeda, K.10
Akira, S.11
-
75
-
-
8344245939
-
Flavor decomposition of the sea-quark helicity distributions in the nucleon from semiinclusive deep inelastic scattering
-
Airapetian A, Akopov N, Akopov Z, et al. Flavor decomposition of the sea-quark helicity distributions in the nucleon from semiinclusive deep inelastic scattering. Phys Rev Lett 2004;92:012005
-
(2004)
Phys Rev Lett
, vol.92
, pp. 012005
-
-
Airapetian, A.1
Akopov, N.2
Akopov, Z.3
-
76
-
-
61749098024
-
Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists
-
Vollmer J, Krieg AM. Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists. Adv Drug Deliv Rev 2009;61:195-204
-
(2009)
Adv Drug Deliv Rev
, vol.61
, pp. 195-204
-
-
Vollmer, J.1
Krieg, A.M.2
-
77
-
-
67651021180
-
Primary leukocyte screens for innate immune agonists
-
Goodchild A, Nopper N, Craddock A, et al. Primary leukocyte screens for innate immune agonists. J Biomol Screen 2009;14:723-30
-
(2009)
J Biomol Screen
, vol.14
, pp. 723-30
-
-
Goodchild, A.1
Nopper, N.2
Craddock, A.3
-
78
-
-
37849002321
-
Toll-like receptor 9 (TLR9) agonists in the treatment of cancer
-
Krieg AM. Toll-like receptor 9 (TLR9) agonists in the treatment of cancer. Oncogene 2008;27:161-7
-
(2008)
Oncogene
, vol.27
, pp. 161-7
-
-
Krieg, A.M.1
-
79
-
-
63849177560
-
Vaccine adjuvants: Scientific challenges and strategic initiatives
-
Harandi AM, Davies G, Olesen OF. Vaccine adjuvants: scientific challenges and strategic initiatives. Expert Rev Vaccines 2009;8:293-8
-
(2009)
Expert Rev Vaccines
, vol.8
, pp. 293-8
-
-
Harandi, A.M.1
Davies, G.2
Olesen, O.F.3
-
80
-
-
67650487106
-
Phase II study of a TLR-9 agonist (1018 ISS) with rituximab in patients with relapsed or refractory follicular lymphoma
-
Friedberg JW, Kelly JL, Neuberg D, et al. Phase II study of a TLR-9 agonist (1018 ISS) with rituximab in patients with relapsed or refractory follicular lymphoma. Br J Haematol 2009;146:282-91
-
(2009)
Br J Haematol
, vol.146
, pp. 282-91
-
-
Friedberg, J.W.1
Kelly, J.L.2
Neuberg, D.3
-
81
-
-
48649102652
-
Anti-tumor effect of DNA-based vaccination and dSLIM immunomodulatory molecules in mice with Ph+ acute lymphoblastic leukaemia
-
Kochling J, Prada J, Bahrami M, et al. Anti-tumor effect of DNA-based vaccination and dSLIM immunomodulatory molecules in mice with Ph+ acute lymphoblastic leukaemia. Vaccine 2008;26:4669-75
-
(2008)
Vaccine
, vol.26
, pp. 4669-75
-
-
Kochling, J.1
Prada, J.2
Bahrami, M.3
-
82
-
-
38649089811
-
Clinical application of CpG-, non-CpG-, and antisense oligodeoxynucleotides as immunomodulators
-
Dorn A, Kippenberger S. Clinical application of CpG-, non-CpG-, and antisense oligodeoxynucleotides as immunomodulators. Curr Opin Mol Ther 2008;10:10-20 (Pubitemid 351170590)
-
(2008)
Current Opinion in Molecular Therapeutics
, vol.10
, Issue.1
, pp. 10-20
-
-
Dorn, A.1
Kippenberger, S.2
-
83
-
-
33749265163
-
Strategies for targeting T-cells in allergic diseases and asthma
-
DOI 10.1016/j.pharmthera.2006.05.005, PII S0163725806000921
-
Heijink IH, Van Oosterhout AJ. Strategies for targeting T-cells in allergic diseases and asthma. Pharmacol Ther 2006;112:489-500 (Pubitemid 44486416)
-
(2006)
Pharmacology and Therapeutics
, vol.112
, Issue.2
, pp. 489-500
-
-
Heijink, I.H.1
Van Oosterhout, A.J.M.2
-
86
-
-
0038454645
-
Activation of mammalian Toll-like receptors by endogenous agonists
-
DOI 10.1615/CritRevImmunol.v23.i12.20
-
Johnson GB, Brunn GJ, Platt JL. Activation of mammalian Toll-like receptors by endogenous agonists. Crit Rev Immunol 2003;23:15-44 (Pubitemid 36875472)
-
(2003)
Critical Reviews in Immunology
, vol.23
, Issue.1-2
, pp. 15-44
-
-
Johnson, G.B.1
Brunn, G.J.2
Platt, J.L.3
-
87
-
-
26844467349
-
Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
-
DOI 10.1084/jem.20050914
-
Barrat FJ, Meeker T, Gregorio J, et al. Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med 2005;202:1131-9 (Pubitemid 41464506)
-
(2005)
Journal of Experimental Medicine
, vol.202
, Issue.8
, pp. 1131-1139
-
-
Barrat, F.J.1
Meeker, T.2
Gregorio, J.3
Chan, J.H.4
Uematsu, S.5
Akira, S.6
Chang, B.7
Duramad, O.8
Coffman, R.L.9
-
88
-
-
38849127573
-
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis
-
DOI 10.1126/science.1150110
-
Asagiri M, Hirai T, Kunigami T, et al. Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science 2008;319:624-7 (Pubitemid 351197065)
-
(2008)
Science
, vol.319
, Issue.5863
, pp. 624-627
-
-
Asagiri, M.1
Hirai, T.2
Kunigami, T.3
Kamano, S.4
Gober, H.-J.5
Okamoto, K.6
Nishikawa, K.7
Latz, E.8
Golenbock, D.T.9
Aoki, K.10
Ohya, K.11
Imai, Y.12
Morishita, Y.13
Miyazono, K.14
Kato, S.15
Saftig, P.16
Takayanagi, H.17
-
89
-
-
0038448226
-
Bacterial lipopolysaccharide signaling through Toll-like receptor 4 suppresses asthma-like responses via nitric oxide synthase 2 activity
-
Rodriguez D, Keller AC, Faquim-Mauro EL, et al. Bacterial lipopolysaccharide signaling through Toll-like receptor 4 suppresses asthma-like responses via nitric oxide synthase 2 activity. J Immunol 2003;171:1001-8 (Pubitemid 36871416)
-
(2003)
Journal of Immunology
, vol.171
, Issue.2
, pp. 1001-1008
-
-
Rodriguez, D.1
Keller, A.C.2
Faquim-Mauro, E.L.3
De Macedo, M.S.4
Cunha, F.Q.5
Lefort, J.6
Vargaftig, B.B.7
Russo, M.8
-
90
-
-
38049029104
-
Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids
-
Liu X, Ukai T, Yumoto H, et al. Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids. Atherosclerosis 2008;196:146-54
-
(2008)
Atherosclerosis
, vol.196
, pp. 146-54
-
-
Liu, X.1
Ukai, T.2
Yumoto, H.3
-
91
-
-
33646478589
-
Therapeutic targeting of pattern-recognition receptors
-
Rezaei N. Therapeutic targeting of pattern-recognition receptors. Int Immunopharmacol 2006;6:863-9
-
(2006)
Int Immunopharmacol
, vol.6
, pp. 863-9
-
-
Rezaei, N.1
-
92
-
-
34548443465
-
Targeting toll-like receptors for drug development: A summary of commercial approaches
-
DOI 10.1038/sj.icb.7100102, PII 7100102
-
Gearing AJ. Targeting toll-like receptors for drug development: a summary of commercial approaches. Immunol Cell Biol 2007;85:490-4 (Pubitemid 47367512)
-
(2007)
Immunology and Cell Biology
, vol.85
, Issue.6
, pp. 490-494
-
-
Gearing, A.J.H.1
-
93
-
-
85047690873
-
Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes
-
DOI 10.1172/JCI200420762
-
Meng G, Rutz M, Schiemann M, et al. Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes. J Clin Invest 2004;113:1473-81 (Pubitemid 39071703)
-
(2004)
Journal of Clinical Investigation
, vol.113
, Issue.10
, pp. 1473-1481
-
-
Meng, G.1
Rutz, M.2
Schiemann, M.3
Metzger, J.4
Grabiec, A.5
Schwandner, R.6
Luppa, P.B.7
Ebel, F.8
Busch, D.H.9
Bauer, S.10
Wagner, H.11
Kirschning, C.J.12
-
94
-
-
47149084387
-
Bridging innate immunity and myocardial ischemia/reperfusion injury: The search for therapeutic targets
-
DOI 10.2174/138161208784246090
-
Arslan F, de Kleijn DP, Timmers L, et al. Bridging innate immunity and myocardial ischemia/reperfusion injury: the search for therapeutic targets. Curr Pharm Des 2008;14:1205-16 (Pubitemid 351997833)
-
(2008)
Current Pharmaceutical Design
, vol.14
, Issue.12
, pp. 1205-1216
-
-
Arslan, F.1
De Kleijn, D.P.V.2
Timmers, L.3
Doevendans, P.A.4
Pasterkamp, G.5
-
95
-
-
70349342913
-
Identification and characterization of oligonucleotides that inhibit Toll-like receptor 2-associated immune responses
-
Chang YC, Kao WC, Wang WY, et al. Identification and characterization of oligonucleotides that inhibit Toll-like receptor 2-associated immune responses. FASEB J 2009;23:3078-88
-
(2009)
FASEB J
, vol.23
, pp. 3078-88
-
-
Chang, Y.C.1
Kao, W.C.2
Wang, W.Y.3
-
96
-
-
49249138761
-
TLR4-induced IFN-gamma production increases TLR2 sensitivity and drives Gram-negative sepsis in mice
-
Spiller S, Elson G, Ferstl R, et al. TLR4-induced IFN-gamma production increases TLR2 sensitivity and drives Gram-negative sepsis in mice. J Exp Med 2008;205:1747-54
-
(2008)
J Exp Med
, vol.205
, pp. 1747-54
-
-
Spiller, S.1
Elson, G.2
Ferstl, R.3
-
97
-
-
33846456617
-
A phase II, double-blind, placebo-controlled, ascending-dose study of eritoran (E5564), A aipid a antagonist, in patients undergoing cardiac surgery with cardiopulmonary bypass
-
Bennett-Guerrero E, Grocott HP, Levy JH, et al. A phase II, double-blind, placebo-controlled, ascending-dose study of Eritoran (E5564), a lipid A antagonist, in patients undergoing cardiac surgery with cardiopulmonary bypass. Anesth Analg 2007;104:378-83
-
(2007)
Anesth Analg
, vol.104
, pp. 378-83
-
-
Bennett-Guerrero, E.1
Grocott, H.P.2
Levy, J.H.3
-
98
-
-
33747881274
-
Therapeutic efficacy and safety of chaperonin 10 in patients with rheumatoid arthritis: A double-blind randomised trial
-
DOI 10.1016/S0140-6736(06)69210-6, PII S0140673606692106
-
Vanags D, Williams B, Johnson B, et al. Therapeutic efficacy and safety of chaperonin 10 in patients with rheumatoid arthritis: a double-blind randomised trial. Lancet 2006;368:855-63 (Pubitemid 44292809)
-
(2006)
Lancet
, vol.368
, Issue.9538
, pp. 855-863
-
-
Vanags, D.1
Williams, B.2
Johnson, B.3
Hall, S.4
Nash, P.5
Taylor, A.6
Weiss, J.7
Feeney, D.8
-
99
-
-
61849150375
-
Results of a phase IIa clinical trial of an anti-inflammatory molecule, chaperonin 10, in multiple sclerosis
-
Broadley SA, Vanags D, Williams B, et al. Results of a phase IIa clinical trial of an anti-inflammatory molecule, chaperonin 10, in multiple sclerosis. Mult Scler 2009;15:329-36
-
(2009)
Mult Scler
, vol.15
, pp. 329-36
-
-
Broadley, S.A.1
Vanags, D.2
Williams, B.3
-
100
-
-
33645097021
-
A novel cyclohexene derivative, ethyl (6R)-6-N-(2-Chloro-4-fluorophenyl) sulfamoyl.cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling
-
Ii M, Matsunaga N, Hazeki K, et al. A novel cyclohexene derivative, ethyl (6R)-6-N-(2-Chloro-4-fluorophenyl) sulfamoyl.cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling. Mol Pharmacol 2006;69:1288-95
-
(2006)
Mol Pharmacol
, vol.69
, pp. 1288-95
-
-
Ii, M.1
Matsunaga, N.2
Hazeki, K.3
-
101
-
-
34447529270
-
Ibudilast (AV-411): A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes
-
DOI 10.1517/13543784.16.7.935
-
Ledeboer A, Hutchinson MR, Watkins LR, Johnson KW. Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes. Expert Opin Investig Drugs 2007;16:935-50 (Pubitemid 47078775)
-
(2007)
Expert Opinion on Investigational Drugs
, vol.16
, Issue.7
, pp. 935-950
-
-
Ledeboer, A.1
Hutchinson, M.R.2
Watkins, L.R.3
Johnson, K.W.4
-
102
-
-
67049095880
-
A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis
-
Ungaro R, Fukata M, Hsu D, et al. A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis. Am J Physiol Gastrointest Liver Physiol 2009;296:G1167-79
-
(2009)
Am J Physiol Gastrointest Liver Physiol
, vol.296
-
-
Ungaro, R.1
Fukata, M.2
Hsu, D.3
-
103
-
-
28544449709
-
Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8
-
DOI 10.1084/jem.20051696
-
Vollmer J, Tluk S, Schmitz C, et al. Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8. J Exp Med 2005;202:1575-85 (Pubitemid 41746603)
-
(2005)
Journal of Experimental Medicine
, vol.202
, Issue.11
, pp. 1575-1585
-
-
Vollmer, J.1
Tluk, S.2
Schmitz, C.3
Hamm, S.4
Jurk, M.5
Forsbach, A.6
Akira, S.7
Kelly, K.M.8
Reeves, W.H.9
Bauer, S.10
Krieg, A.M.11
-
104
-
-
33748472865
-
Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus
-
DOI 10.1016/j.immuni.2006.07.013, PII S1074761306003906
-
Christensen SR, Shupe J, Nickerson K, et al. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 2006;25:417-28 (Pubitemid 44354217)
-
(2006)
Immunity
, vol.25
, Issue.3
, pp. 417-428
-
-
Christensen, S.R.1
Shupe, J.2
Nickerson, K.3
Kashgarian, M.4
Flavell, RichardA.5
Shlomchik, M.J.6
-
105
-
-
33750378268
-
Systemic lupus erythematosus: All roads lead to type I interferons
-
DOI 10.1016/j.coi.2006.09.014, PII S0952791506001993
-
Pascual V, Farkas L, Banchereau J. Systemic lupus erythematosus: all roads lead to type 1 interferons. Curr Opin Immunol 2006;18:676-82 (Pubitemid 44635182)
-
(2006)
Current Opinion in Immunology
, vol.18
, Issue.6
, pp. 676-682
-
-
Pascual, V.1
Farkas, L.2
Banchereau, J.3
-
106
-
-
37549066665
-
Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms
-
Barrat FJ, Meeker T, Chan JH, et al. Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms. Eur J Immunol 2007;37:3582-6
-
(2007)
Eur J Immunol
, vol.37
, pp. 3582-6
-
-
Barrat, F.J.1
Meeker, T.2
Chan, J.H.3
-
107
-
-
34249915031
-
Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus
-
DOI 10.1681/ASN.2006101162
-
Pawar RD, Ramanjaneyulu A, Kulkarni OP, et al. Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus. J Am Soc Nephrol 2007;18:1721-31 (Pubitemid 46870309)
-
(2007)
Journal of the American Society of Nephrology
, vol.18
, Issue.6
, pp. 1721-1731
-
-
Pawar, R.D.1
Ramanjaneyulu, A.2
Kulkarni, O.P.3
Lech, M.4
Segerer, S.5
Anders, H.-J.6
-
109
-
-
79956214544
-
Molecular modeling-based evaluation of dual function of IkappaBzeta ankyrin repeat domain in toll-like receptor signaling
-
[Epub ahead of print]
-
Manavalan B, Govindaraj R, Lee G, Choi S. Molecular modeling-based evaluation of dual function of IkappaBzeta ankyrin repeat domain in toll-like receptor signaling. J Mol Recognit 2010. [Epub ahead of print]
-
(2010)
J Mol Recognit
-
-
Manavalan, B.1
Govindaraj, R.2
Lee, G.3
Choi, S.4
-
110
-
-
77958589003
-
Molecular modeling-based evaluation of hTLR10 and identification of potential ligands in Toll-like receptor signaling
-
Govindaraj RG, Manavalan B, Lee G, Choi S. Molecular modeling-based evaluation of hTLR10 and identification of potential ligands in Toll-like receptor signaling. PLoS One 2010;5:e12713
-
(2010)
PLoS One
, vol.5
-
-
Govindaraj, R.G.1
Manavalan, B.2
Lee, G.3
Choi, S.4
-
111
-
-
78650811457
-
Structure-Function Relationship of Cytoplasmic and Nuclear IkappaB Proteins: An in silico analysis
-
Manavalan B, Basith S, Choi YM, et al. Structure-Function Relationship of Cytoplasmic and Nuclear IkappaB Proteins: an in silico analysis. PLoS One 2010;5:e15782
-
(2010)
PLoS One
, vol.5
-
-
Manavalan, B.1
Basith, S.2
Choi, Y.M.3
-
112
-
-
56749185827
-
Adding fuel to fire: MicroRNAs as a new class of mediators of inflammation
-
Sheedy FJ, O?Neill LA. Adding fuel to fire: microRNAs as a new class of mediators of inflammation. Ann Rheum Dis 2008;67(Suppl 3):iii50-5
-
(2008)
Ann Rheum Dis
, vol.67
, Issue.SUPPL. 3
-
-
Sheedy, F.J.1
Oneill, L.A.2
-
114
-
-
7944219649
-
Immunotherapeutic utility of stimulatory and suppressive oligodeoxynucleotides
-
Ishii KJ, Gursel I, Gursel M, Klinman DM. Immunotherapeutic utility of stimulatory and suppressive oligodeoxynucleotides. Curr Opin Mol Ther 2004;6:166-74
-
(2004)
Curr Opin Mol Ther
, vol.6
, pp. 166-74
-
-
Ishii, K.J.1
Gursel, I.2
Gursel, M.3
Klinman, D.M.4
-
116
-
-
34748851858
-
Application of β-lactamase enzyme complementation to the high-throughput screening of Toll-like receptor signaling inhibitors
-
DOI 10.1124/mol.107.038349
-
Lee HK, Brown SJ, Rosen H, Tobias PS. Application of beta-lactamase enzyme complementation to the high-throughput screening of toll-like receptor signaling inhibitors. Mol Pharmacol 2007;72:868-75 (Pubitemid 47481410)
-
(2007)
Molecular Pharmacology
, vol.72
, Issue.4
, pp. 868-875
-
-
Lee, H.-K.1
Brown, S.J.2
Rosen, H.3
Tobias, P.S.4
-
117
-
-
33847369756
-
Cutting edge: Differential inhibition of TLR signaling pathways by cell-permeable peptides representing BB loops of TLRs
-
Toshchakov VY, Fenton MJ, Vogel SN. Cutting Edge: Differential inhibition of TLR signaling pathways by cell-permeable peptides representing BB loops of TLRs. J Immunol 2007;178:2655-60 (Pubitemid 46333141)
-
(2007)
Journal of Immunology
, vol.178
, Issue.5
, pp. 2655-2660
-
-
Toshchakov, V.Y.1
Fenton, M.J.2
Vogel, S.N.3
-
118
-
-
10344256237
-
Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors
-
DOI 10.1001/archderm.140.12.1490
-
Gilliet M, Conrad C, Geiges M, et al. Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors. Arch Dermatol 2004;140:1490-5 (Pubitemid 39627441)
-
(2004)
Archives of Dermatology
, vol.140
, Issue.12
, pp. 1490-1495
-
-
Gilliet, M.1
Conrad, C.2
Geiges, M.3
Cozzio, A.4
Thurlimann, W.5
Burg, G.6
Nestle, F.O.7
Dummer, R.8
-
119
-
-
1542317578
-
Species-Specific Recognition of Single-Stranded RNA via Till-like Receptor 7 and 8
-
DOI 10.1126/science.1093620
-
Heil F, Hemmi H, Hochrein H, et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 2004;303:1526-9 (Pubitemid 38314424)
-
(2004)
Science
, vol.303
, Issue.5663
, pp. 1526-1529
-
-
Heil, F.1
Hemmi, H.2
Hochrein, H.3
Ampenberger, F.4
Kirschning, C.5
Akira, S.6
Lipford, G.7
Wagner, H.8
Bauer, S.9
-
120
-
-
33750823681
-
Cutting edge: Activation of murine TLR8 by a combination of imidazoquinoline immune response modifiers and polyT oligodeoxynucleotides
-
Gorden KK, Qiu XX, Binsfeld CC, et al. Cutting edge: activation of murine TLR8 by a combination of imidazoquinoline immune response modifiers and polyT oligodeoxynucleotides. J Immunol 2006;177:6584-7 (Pubitemid 44715019)
-
(2006)
Journal of Immunology
, vol.177
, Issue.10
, pp. 6584-6587
-
-
Gorden, K.K.B.1
Qiu, X.X.2
Binsfeld, C.C.A.3
Vasilakos, J.P.4
Alkan, S.S.5
-
121
-
-
64149101404
-
Morphological study on Mycobacterium bovis BCG Tokyo 172 cell wall skeleton (SMP-105)
-
Uenishi Y, Kawabe K, Nomura T, et al. Morphological study on Mycobacterium bovis BCG Tokyo 172 cell wall skeleton (SMP-105). J Microbiol Methods 2009;77:139-44
-
(2009)
J Microbiol Methods
, vol.77
, pp. 139-44
-
-
Uenishi, Y.1
Kawabe, K.2
Nomura, T.3
-
122
-
-
70350689747
-
The potential use of Toll-like receptor (TLR) agonists and antagonists as prophylactic and/or therapeutic agents
-
Makkouk A, Abdelnoor AM. The potential use of Toll-like receptor (TLR) agonists and antagonists as prophylactic and/or therapeutic agents. Immunopharmacol Immunotoxicol 2009;31:331-8
-
(2009)
Immunopharmacol Immunotoxicol
, vol.31
, pp. 331-8
-
-
Makkouk, A.1
Abdelnoor, A.M.2
-
123
-
-
67650004027
-
Toll-like receptor 9 activation with CpG oligodeoxynucleotides for asthma therapy
-
Kline JN, Krieg AM. Toll-like receptor 9 activation with CpG oligodeoxynucleotides for asthma therapy. Drug News Perspect 2008;21:434-9
-
(2008)
Drug News Perspect
, vol.21
, pp. 434-9
-
-
Kline, J.N.1
Krieg, A.M.2
-
124
-
-
38049098060
-
Influence of plasma cholesterol and triglyceride concentrations and eritoran (E5564) micelle size on its plasma pharmacokinetics and ex vivo activity following single intravenous bolus dose into healthy female rabbits
-
Wasan KM, Risovic V, Sivak O, et al. Influence of plasma cholesterol and triglyceride concentrations and eritoran (E5564) micelle size on its plasma pharmacokinetics and ex vivo activity following single intravenous bolus dose into healthy female rabbits. Pharm Res 2008;25:176-82
-
(2008)
Pharm Res
, vol.25
, pp. 176-82
-
-
Wasan, K.M.1
Risovic, V.2
Sivak, O.3
-
125
-
-
34447515697
-
The glial modulatory drug AV411 attenuates mechanical allodynia in rat models of neuropathic pain
-
DOI 10.1017/S1740925X0700035X, PII S1740925X0700035X
-
Ledeboer A, Liu T, Shumilla JA, et al. The glial modulatory drug AV411 attenuates mechanical allodynia in rat models of neuropathic pain. Neuron Glia Biol 2006;2:279-91 (Pubitemid 47074741)
-
(2006)
Neuron Glia Biology
, vol.2
, Issue.4
, pp. 279-291
-
-
Ledeboer, A.1
Liu, T.2
Shumilla, J.A.3
Mahoney, J.H.4
Vijay, S.5
Gross, M.I.6
Vargas, J.A.7
Sultzbaugh, L.8
Claypool, M.D.9
Sanftner, L.M.10
Watkins, L.R.11
Johnson, K.W.12
|