TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression

Oncotarget

Volumn 6, Issue 29, 2015, Pages 27252-27266

  Ho, Victor ^a   Lim, Tong Seng ^a   Lee, Justin ^a   Steinberg, Jeffrey ^c   Szmyd, Radoslaw ^d,e   Tham, Muly ^a   Yaligar, Jadegoud ^c   Kaldis, Philipp ^d,e   Abastado, Jean Pierre ^a,f   Chew, Valerie ^a,b  

^a AGENCY FOR SCIENCE   (Singapore)

^b Singapore Health Services   (Singapore)

^c AGENCY FOR SCIENCE   (Singapore)

^d INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^f IRIS Institut de Recherches Internationales Servier   (France)

Author keywords

Cancer immunotherapy; Combinatorial treatment; Hepatocellular carcinoma; Local immune activation; Tumor microenvironment

Indexed keywords

LYSINE STABILIZED POLYINOSINICPOLYCYTIDYLIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SORAFENIB; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CARBANILAMIDE DERIVATIVE; CARBOXYMETHYLCELLULOSE; CARBOXYMETHYLCELLULOSE POLYCYTIDYLIC POLYINOSINIC ACID POLYLYSINE; IMMUNOSUPPRESSIVE AGENT; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; NICOTINAMIDE; POLYINOSINIC POLYCYTIDYLIC ACID; POLYLYSINE; TLR3 PROTEIN, HUMAN; TOLL LIKE RECEPTOR 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER INHIBITION; CELL VIABILITY; CONTROLLED STUDY; DENDRITIC CELL; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; LYMPHOCYTE ACTIVATION; MACROPHAGE; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; SIGNAL TRANSDUCTION; TRANSPOSON; TUMOR MICROENVIRONMENT; AGONISTS; ANALOGS AND DERIVATIVES; ANIMAL; APOPTOSIS; C57BL MOUSE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DISEASE COURSE; IMMUNE SYSTEM; LIVER TUMOR; METABOLISM; NONOBESE DIABETIC MOUSE; PATHOLOGY; PHOSPHORYLATION; SCID MOUSE; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CARBOXYMETHYLCELLULOSE SODIUM; CARCINOMA, HEPATOCELLULAR; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DISEASE PROGRESSION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; IMMUNE SYSTEM; IMMUNOSUPPRESSIVE AGENTS; LIVER NEOPLASMS; MALE; MAP KINASE KINASE KINASES; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, SCID; NIACINAMIDE; PHENYLUREA COMPOUNDS; PHOSPHORYLATION; POLY I-C; POLYLYSINE; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 3;

EID: 84944448024     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.4583     Document Type: Article

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