Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease

Brain

Volumn 139, Issue 2, 2016, Pages 526-546

  Haas, Laura T ^a,b   Salazar, Santiago V ^a   Kostylev, Mikhail A ^a   Um, Ji Won ^a   Kaufman, Adam C ^a   Strittmatter, Stephen M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Alzheimer's disease; amyloid beta oligomers; cellular prion protein; homer; metabotropic glutamate receptor 5

Indexed keywords

AMYLOID BETA PROTEIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CELL PROTEIN; FOCAL ADHESION KINASE 1; METABOTROPIC RECEPTOR 5; OLIGOMER; PRION PROTEIN; PROTEIN HOMER 1B; PRION; PRNP PROTEIN, MOUSE; PROTEIN BINDING;

ADULT; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE INTERACTION; GENE PRODUCT; GENETIC LINKAGE; GLIOSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; LOSS OF FUNCTION MUTATION; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SURVIVAL; SYNAPSE; ANIMAL; C57BL MOUSE; FRONTAL LOBE; GENETICS; HEK293 CELL LINE; INTRACELLULAR FLUID; KNOCKOUT MOUSE; METABOLISM; ORGAN CULTURE TECHNIQUE; PATHOLOGY; PHYSIOLOGY; PRION; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; ANIMALS; FRONTAL LOBE; HEK293 CELLS; HUMANS; INTRACELLULAR FLUID; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORGAN CULTURE TECHNIQUES; PRION PROTEINS; PRIONS; PROTEIN BINDING; RECEPTOR, METABOTROPIC GLUTAMATE 5; SIGNAL TRANSDUCTION;

EID: 84976883249     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awv356     Document Type: Article

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