A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease

Alzheimer's Research and Therapy

Volumn 7, Issue 1, 2015, Pages

  Nygaard, Haakon B ^a,c   Wagner, Allison F ^a   Bowen, Garrett S ^a   Good, Susan P ^a   MacAvoy, Martha G ^a   Strittmatter, Kurt A ^a   Kaufman, Adam C ^a   Rosenberg, Brian J ^a   Sekine Konno, Tomoko ^a   Varma, Pradeep ^a   Chen, Kewei ^b   Koleske, Anthony J ^a   Reiman, Eric M ^b   Strittmatter, Stephen M ^a   Van Dyck, Christopher H ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BANNER ALZHEIMER S INSTITUTE   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ABELSON KINASE; CREATININE; FLUORODEOXYGLUCOSE F 18; PLACEBO; SARACATINIB; STAT5 PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ALZHEIMER DISEASE ASSESSMENT SCALE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANOREXIA; ARTICLE; BASAL CELL CARCINOMA; CLINICAL ARTICLE; CLINICAL DEMENTIA RATING; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; COUGHING; CREATININE BLOOD LEVEL; DAILY LIFE ACTIVITY; DIARRHEA; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG BIOAVAILABILITY; DRUG BRAIN LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DOSE COMPARISON; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG FEVER; DRUG INDUCED HEADACHE; DRUG PENETRATION; DRUG SAFETY; DRUG TOLERABILITY; DYSPNEA; ENZYME INHIBITION; FATIGUE; FLU LIKE SYNDROME; GLUCOSE METABOLISM; HUMAN; KIDNEY FAILURE; MEDICATION COMPLIANCE; MEMORY DISORDER; MINI INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW; MINI MENTAL STATE EXAMINATION; MOUSE; MYALGIA; NAUSEA; NONCARDIAC CHEST PAIN; NONHUMAN; PATIENT COMPLIANCE; PHASE 1 CLINICAL TRIAL (TOPIC); PNEUMONIA; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SQUAMOUS CELL CARCINOMA; TINNITUS; TREATMENT DURATION; UPPER RESPIRATORY TRACT INFECTION; VOMITING; WRIST PAIN;

EID: 84927614039     PISSN: None     EISSN: 17589193     Source Type: Journal    
DOI: 10.1186/s13195-015-0119-0     Document Type: Article

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