Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites

Nature Communications

Volumn 2, Issue 1, 2011, Pages

  Freir, Darragh B ^a   Nicoll, Andrew J ^b   Klyubin, Igor ^c   Panico, Silvia ^d   Mc Donald, Jessica M ^a   Risse, Emmanuel ^b   Asante, Emmanuel A ^b   Farrow, Mark A ^b   Sessions, Richard B ^e   Saibil, Helen R ^d   Clarke, Anthony R ^b,e   Rowan, Michael J ^c   Walsh, Dominic M ^a   Collinge, John ^b  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c TRINITY COLLEGE DUBLIN   (Ireland)

^d UNIVERSITY OF LONDON   (United Kingdom)

^e UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; LIGAND; MONOCLONAL ANTIBODY; PRION PROTEIN;

AGED; ALZHEIMER DISEASE; ANIMAL TISSUE; ANTIGEN BINDING; ARTICLE; BINDING SITE; EX VIVO STUDY; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MALE; NERVE CELL PLASTICITY; NONHUMAN; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN INTERACTION; RAT; SCREENING; SYNAPSE; ANIMAL; CHEMICAL STRUCTURE; ELECTRON MICROSCOPY; ELECTROPHYSIOLOGY; GEL CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOLOGY; LONG TERM POTENTIATION; METABOLISM; MOUSE; MOUSE MUTANT; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRION; ULTRACENTRIFUGATION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ELECTROPHYSIOLOGY; HUMANS; LIGANDS; LONG-TERM POTENTIATION; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON; MODELS, MOLECULAR; NEURONAL PLASTICITY; PRIONS; SYNAPSES; ULTRACENTRIFUGATION;

EID: 79958249995     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms1341     Document Type: Article

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