Amyloid-β and proinflammatory cytokines utilize a prion protein-dependent pathway to activate NADPH oxidase and induce cofilin-actin rods in hippocampal neurons

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Walsh, Keifer P ^a   Minamide, Laurie S ^a   Kane, Sarah J ^a   Shaw, Alisa E ^a   Brown, David R ^b   Pulford, Bruce ^a   Zabel, Mark D ^a   Lambeth, J David ^c   Kuhn, Thomas B ^a,d   Bamburg, James R ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b University of Bath   (United Kingdom)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF ALASKA FAIRBANKS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; AMYLOID BETA PROTEIN; COFILIN; CYTOKINE; DIMER; INTERLEUKIN 1BETA; INTERLEUKIN 6; PRION PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TUMOR NECROSIS FACTOR ALPHA; ACTIN DEPOLYMERIZING FACTOR; DACTINOMYCIN; GLUTAMIC ACID; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ARTICLE; CELL HYPOXIA; CELL SUBPOPULATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GENE OVEREXPRESSION; HIPPOCAMPUS; NONHUMAN; OXIDATIVE STRESS; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SYNAPSE; SYNAPTIC MEMBRANE; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; INFLAMMATION; METABOLISM; MOUSE; NEURITE; RAT; SYNAPTIC TRANSMISSION;

ACTIN DEPOLYMERIZING FACTORS; ACTINS; AMYLOID BETA-PEPTIDES; ANIMALS; CELLS, CULTURED; DACTINOMYCIN; FEMALE; GENE EXPRESSION REGULATION; GLUTAMIC ACID; HIPPOCAMPUS; HUMANS; INFLAMMATION; MICE; NADPH OXIDASE; NEURITES; PRPC PROTEINS; RATS; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84899730580     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0095995     Document Type: Article

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