Disassembly of shank and homer synaptic clusters is driven by soluble b-amyloid 1-40 through divergent NMDAR-dependent signalling pathways

PLoS ONE

Volumn 4, Issue 6, 2009, Pages

  Roselli, Francesco ^a,b   Hutzler, Peter ^a,c   Wegerich, Yvonne ^a   Livrea, Paolo ^b   Almeida, Osborne F X ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b UNIVERSITY OF BARI   (Italy)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CALCINEURIN; CYCLOHEXIMIDE; DIZOCILPINE; GLUTAMATE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEASOME; PROTEIN HOMER 1B; PROTEIN SHANK 1; SCAFFOLD PROTEIN; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; UO 126; VERAPAMIL; VOLTAGE GATED CALCIUM CHANNEL; AMYLOID BETA PROTEIN; CARRIER PROTEIN; DLGH4 PROTEIN, RAT; MEMBRANE PROTEIN; METABOTROPIC RECEPTOR; NMDA RECEPTOR A1; PEPTIDE FRAGMENT; PROTEIN HOMER; SHANK1 PROTEIN, RAT; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; NERVE CELL; NONHUMAN; ORBITAL CORTEX; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; RAT; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SYNAPTIC INHIBITION; ALZHEIMER DISEASE; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; CONFOCAL MICROSCOPY; METABOLISM; PHYSIOLOGY; WISTAR RAT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; CARRIER PROTEINS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICROSCOPY, CONFOCAL; MODELS, NEUROLOGICAL; PEPTIDE FRAGMENTS; RATS; RATS, WISTAR; RECEPTORS, GLUTAMATE; RECEPTORS, METABOTROPIC GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION;

EID: 67650330252     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0006011     Document Type: Article

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