Cellular prion protein and Alzheimer disease: Link to oligomeric amyloid-β and neuronal cell death

Prion

Volumn 7, Issue 2, 2013, Pages 114-116

  Kudo, Wataru ^a   Petersen, Robert B ^a   Lee, Hyoung Gon ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Amyloid ; Neurotoxicity; NMDA receptor; Oligomer; PrPC

Indexed keywords

AMYLOID BETA PROTEIN; CELLULAR PRION PROTEIN; PRION PROTEIN; PROTEIN KINASE FYN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN BINDING; APOPTOSIS; BINDING SITE; EXCITOTOXICITY; IN VITRO STUDY; MOUSE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION;

AMYLOID-Β; NEUROTOXICITY; NMDA RECEPTOR; OLIGOMER; PRPC;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; CELL DEATH; HUMANS; MICE; NEURONS; PRION DISEASES; PRIONS;

MUS;

EID: 84875503806     PISSN: 19336896     EISSN: 1933690X     Source Type: Journal    
DOI: 10.4161/pri.22848     Document Type: Review

References (24)

1. Tomiyama T, Matsuyama S, Iso H, Umeda T, Takuma H, Ohnishi K, et al. A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. J Neurosci 2010; 30:4845-56; PMID:20371804; http://dx.doi.org/10.1523/ JNEUROSCI.5825-09.2010.
2. Laurén J, Gimbel DA, Nygaard HB, Gilbert JW, Strittmatter SM. Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature 2009; 457:1128-32; PMID:19242475; http://dx.doi.org/10.1038/nature07761.
3. Gimbel DA, Nygaard HB, Coffey EE, Gunther EC, Laurén J, Gimbel ZA, et al. Memory impairment in transgenic Alzheimer mice requires cellular prion protein. J Neurosci 2010; 30:6367-74; PMID:20445063; http://dx.doi.org/10.1523/ JNEUROSCI.0395-10.2010.
4. Calella AM, Farinelli M, Nuvolone M, Mirante O, Moos R, Falsig J, et al. Prion protein and Abetarelated synaptic toxicity impairment. EMBO Mol Med 2010; 2:306-14; PMID:20665634; http://dx.doi.org/10.1002/emmm.201000082.
5. Balducci C, Beeg M, Stravalaci M, Bastone A, Sclip A, Biasini E, et al. Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein. Proc Natl Acad Sci U S A 2010; 107:2295-300; PMID:20133875; http://dx.doi.org/10.1073/pnas.0911829107.
6. Kessels HW, Nguyen LN, Nabavi S, Malinow R. The prion protein as a receptor for amyloid-beta. Nature 2010; 466:E3-4, discussion E4-5; PMID:20703260; http://dx.doi.org/10.1038/nature09217.
7. Barry AE, Klyubin I, Mc Donald JM, Mably AJ, Farrell MA, Scott M, et al. Alzheimer's disease brain-derived amyloid-β-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein. J Neurosci 2011; 31:7259-63; PMID:21593310; http://dx.doi.org/10.1523/JNEUROSCI.6500-10.2011.
8. Freir DB, Nicoll AJ, Klyubin I, Panico S, Mc Donald JM, Risse E, et al. Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites. Nat Commun 2011; 2:336; PMID:21654636; http://dx.doi.org/10.1038/ncomms1341.
9. Bate C, Williams A. Amyloid-β-induced synapse damage is mediated via cross-linkage of cellular prion proteins. J Biol Chem 2011; 286:37955-63; PMID:21900234; http://dx.doi.org/10.1074/jbc. M111.248724.
10. Kudo W, et al. Cellular prion protein is essential for oligomeric amyloid-beta-induced neuronal cell death. Hum Mol Genet 2012; 21:1138-44; PMID:22100763.
11. Resenberger UK, Harmeier A, Woerner AC, Goodman JL, Müller V, Krishnan R, et al. The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication. EMBO J 2011; 30:2057-70; PMID:21441896; http://dx.doi.org/10.1038/emboj.2011.86.
12. Renner M, Lacor PN, Velasco PT, Xu J, Contractor A, Klein WL, et al. Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5. Neuron 2010; 66:739-54; PMID:20547131; http://dx.doi.org/ 10.1016/j.neuron. 2010.04.029.
13. Khosravani H, Zhang Y, Tsutsui S, Hameed S, Altier C, Hamid J, et al. Prion protein attenuates excitotoxicity by inhibiting NMDA receptors. J Cell Biol 2008; 181:551-65; PMID:18443219; http://dx.doi.org/10.1083/jcb.200711002.
14. Li S, Jin M, Koeglsperger T, Shepardson NE, Shankar GM, Selkoe DJ. Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors. J Neurosci 2011; 31:6627-38; PMID:21543591; http://dx.doi.org/10.1523/JNEUROSCI. 0203-11.2011.
15. Rönicke R, Mikhaylova M, Rönicke S, Meinhardt J, Schröder UH, Fändrich M, et al. Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors. Neurobiol Aging 2011; 32:2219-28; PMID:20133015; http://dx.doi.org/10.1016/j. neurobiolaging. 2010.01.011.
16. Fernandes HB, Raymond LA. NMDA Receptors and Huntington's Disease. In: Van Dongen AM, ed. Biology of the NMDA Receptor. Boca Raton, FL: CRC Press; 2009:Chapter 2
17. Wang YT, Salter MW. Regulation of NMDA receptors by tyrosine kinases and phosphatases. Nature 1994; 369:233-5; PMID:7514272; http://dx.doi.org/10.1038/ 369233a0.
18. Nakazawa T, Komai S, Tezuka T, Hisatsune C, Umemori H, Semba K, et al. Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-Daspartate receptor. J Biol Chem 2001; 276:693-9; PMID:11024032; http://dx.doi.org/10.1074/jbc. M008085200.
19. Tezuka T, Umemori H, Akiyama T, Nakanishi S, Yamamoto T. PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A. Proc Natl Acad Sci U S A 1999; 96:435-40; PMID:9892651; http://dx.doi.org/10.1073/pnas.96.2.435.
20. Mouillet-Richard S, Ermonval M, Chebassier C, Laplanche JL, Lehmann S, Launay JM, et al. Signal transduction through prion protein. Science 2000; 289:1925-8; PMID:10988071; http://dx.doi.org/10.1126/science.289.5486.1925.
21. Chin J, Palop JJ, Yu GQ, Kojima N, Masliah E, Mucke L. Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice. J Neurosci 2004; 24:4692-7; PMID:15140940; http://dx.doi.org/10.1523/JNEUROSCI.0277-04.2004.
22. Chin J, Palop JJ, Puoliväli J, Massaro C, Bien-Ly N, Gerstein H, et al. Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease. J Neurosci 2005; 25:9694-703; PMID:16237174; http://dx.doi.org/10.1523/JNEUROSCI.2980-05.2005.
23. Um JW, Nygaard HB, Heiss JK, Kostylev MA, Stagi M, Vortmeyer A, et al. Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons. Nat Neurosci 2012; 15:1227-35; PMID:22820466; http://dx.doi.org/10.1038/nn.3178.
24. Chung E, Ji Y, Sun Y, Kascsak RJ, Kascsak RB, Mehta PD, et al. Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse. BMC Neurosci 2010; 11:130; PMID:20946660; http://dx.doi.org/10.1186/1471-2202-11-130.