Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1

Journal of Biological Chemistry

Volumn 288, Issue 13, 2013, Pages 8935-8951

  Rushworth, Jo V ^a   Griffiths, Heledd H ^a   Watt, Nicole T ^a   Hooper, Nigel M ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEINS; CELLULAR PRION PROTEINS; COLOCALIZATION; EPIGALLOCATECHIN GALLATE; GREEN TEA POLYPHENOLS; LOW DENSITY LIPOPROTEINS; POTENTIAL TARGETS;

CELL MEMBRANES; CYTOTOXICITY; FLUORESCENCE MICROSCOPY; GLYCOPROTEINS; NEURONS; PROTEINS; TOXICITY;

OLIGOMERS;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; CASPASE 3; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; OLIGOMER; PRION PROTEIN; PROTEIN KINASE FYN;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; INTERNALIZATION; LIPID RAFT; LYSOSOME MEMBRANE; MEMBRANE BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; RAT;

AMYLOID BETA-PEPTIDES; ANIMALS; CASPASE 3; CATECHIN; CELL LINE, TUMOR; CELL MEMBRANE; HIPPOCAMPUS; HUMANS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-1; MEMBRANE MICRODOMAINS; MICROSCOPY, FLUORESCENCE; NEURONS; PRIONS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-FYN; RATS; RATS, WISTAR; RNA INTERFERENCE; STILBENES; TEA;

EID: 84875981923     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.400358     Document Type: Article

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