Optimization of genome editing through CRISPR-Cas9 engineering

Bioengineered

Volumn 7, Issue 3, 2016, Pages 166-174

  Zhang, Jian Hua ^a   Adikaram, Poorni ^a   Pandey, Mritunjay ^a   Genis, Allison ^a   Simonds, William F ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

CRISPR Cas9; efficiency; genome editing; specificity

Indexed keywords

CRISPR ASSOCIATED PROTEIN; CRISPR ASSOCIATED PROTEIN 9; GENOMIC RNA; HETERODUPLEX; SPACER DNA; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; CAS9 ENDONUCLEASE STREPTOCOCCUS PYOGENES; DNA; ENDONUCLEASE; GUIDE RNA;

ADENO ASSOCIATED VIRUS; CATALYTIC EFFICIENCY; CLINICAL TRIAL (TOPIC); CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONFORMATIONAL TRANSITION; DNA END JOINING REPAIR; DNA FLANKING REGION; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVITY; ENZYME SPECIFICITY; GENE CONTROL; GENE EXPRESSION PROFILING; GENE TARGETING; GENETIC ENGINEERING; GENETIC MANIPULATION; GENOME EDITING; HIGH THROUGHPUT SEQUENCING; HUMAN; HYDROGEN BOND; NONHUMAN; NOTE; NUCLEOTIDE MOTIF; PHYLOGENETIC TREE; PROCESS OPTIMIZATION; PROTEIN DNA INTERACTION; PROTEIN NUCLEIC ACID INTERACTION; PROTOSPACER ADJACENT MOTIF; RECOMBINATION REPAIR; REPORTER GENE; RNA SEQUENCE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; ANIMAL; CHEMISTRY; CRISPR CAS SYSTEM; GENE EDITING; GENETICS; GENOME; METABOLISM; MOLECULAR MODEL; PROCEDURES;

ANIMALS; BACTERIAL PROTEINS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-CAS SYSTEMS; DNA; DNA END-JOINING REPAIR; ENDONUCLEASES; GENE EDITING; GENOME; HUMANS; MODELS, MOLECULAR; NUCLEOTIDE MOTIFS; RECOMBINATIONAL DNA REPAIR; RNA, GUIDE;

EID: 84976408145     PISSN: 21655979     EISSN: 21655987     Source Type: Journal    
DOI: 10.1080/21655979.2016.1189039     Document Type: Note

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